Gene 83481.m00038 (T.vaginalis)

83481.m00038

Species: T.vaginalis
Alias: TvagK0524, 83481.m00038
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
83481.m00038.AA Protein None 226 None Fasta, JSON
83481.m00038.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of 83481.m00038.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 83481.m00038.AA Pkinase 20-216 34 6.1e-70 243.46 Pfam 1-212 (293) Show / Hide 
Range on Protein: 20-216
Range on HMM: 1-212/293
Sequence Identity: 34% (74 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYL---ENKLRLCVRFNHPNIVKIYDIIYTEKFIMMVMEYIENG----DLQSLIN--
|...|.||.|.|..| .. . .|...||.||...... ..  .  .   | .. . ..  |||||..||. .... | ||||| |.|    || ..|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

RNFHF--SIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHA----KLIDFGLS----KENSDILSTYCGTPFNMAPDLVMNSAYDGTKADIW
|.  |  | .|  ...|..|....|.|..|| |||.||||||.|.. |     |..||||.      |.  ..|.||||. ||| ... . |.|.|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AFGVTFHVLATKQFPF
..|.... ......||
SCGCILYEMLCGRPPF
Kinase 83481.m00038.AA CAMKL 20-220 32 1.2e-69 221.34 In-house 1-240 (297) Show / Hide 
Range on Protein: 20-220
Range on HMM: 1-240/297
Sequence Identity: 32% (79 aa)

YQVIRQIGKGGFAVVVLGFD-PKTNQKVAIKIFDREEIAKGGFMKY------------LENKLRLCVRFN---HPNIVKIYDIIYTEKF------IMMVM
|......|||.|..| |. .   |..|||||| |.. | .  .||             ..   ..  ..|   ||||.|.|..|.|...      | .||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYIENGD--LQSLINRNFH----FSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDF--HAKLIDFGLSKE---N----SDILSTYCGTPFNM
||...|.  |.  | .. |    ..  |  ..   ..||..|.|..|| ||||||||||.|..    .|.||||.| .   .     . |.| ||.|  |
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APDLVMN--SAYDGTKADIWAFGVTFHVLATKQFPFEVKN
|| ..      ||| |.|||. ||.  .. . ..||.  .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDT
Kinase 83481.m00038.AA CAMK 25-225 19 8.6e-65 207.43 In-house 1-356 (425) Show / Hide 
Range on Protein: 25-225
Range on HMM: 1-356/425
Sequence Identity: 19% (71 aa)

QIGKGGFAVVVLGFDPKTN------------QKVAIKIFDREEIAK------------------------GGFMKY-LENKLRLCVR-------FNHPNI
..|.|.|..| |... .|.            ||||||| |.. . .                         ....  ... .... .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIYDIIYT-------------------EKFIMMVM---EYIENG----DLQSLINRN---------------FHFSIQEQLKIAYEVLSAIDYLHKRGI
.|.|... .                   .|.. |||   ||...|    || . | ..               ..|. .|  ..   ..||..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

SHRDIKPENILFDQD-----------------FHAKLIDFGLS--KEN------------------------SDILSTYCGTPFNMA-PDLVMN------
 |||.||||||.|..                 .  |.||||..  ..                          . ..|.||||  || | ..        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------SAYDGTKADIWAFGVTFHVLATKQFPFEVK-------------NEVEFL
         |.| |.|.|. ||   .. .  .||. .             |. | .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELF
Kinase 83481.m00038.AA AMPK 20-217 33 1e-60 179.0 In-house 1-201 (254) Show / Hide 
Range on Protein: 20-217
Range on HMM: 1-201/254
Sequence Identity: 33% (68 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYLENKLRLCVRFNHPNIVKIYDII-YTEKFIMMVMEYIENGDLQSLINRNFHFSIQ
|..   ||.| |  | .|    |..|||||| ... |..   .. ... ...   |.||.|.. |..|  |.. | |||||. .|.| . | ..   ...
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLS---KENSDILSTYCGTPFNMAPDLVMNSAYDGTKADIWAFGVTFHVLATKQFP
|  .    ..|...|.|. .|.||| ||||.|.|.. . |. |||||   |.. . |.| || |   || .. .  | |.. |||  ||   ..     |
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG-EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLP

FE
|.
FD
Kinase 83481.m00038.AA MARK 20-223 35 1.9e-60 196.36 In-house 1-215 (262) Show / Hide 
Range on Protein: 20-223
Range on HMM: 1-215/262
Sequence Identity: 35% (77 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYLENKLRLCVRFNHPNIVKIYDIIY--TEKF-IMMVMEYIENGDLQSLINRNFHFS
| ....||.|..|.| |. . .|..|||||| ... . .   || ..  ...  . .||||.| ...|   ||.  | ..|||...|.| . |    .  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

IQEQL--KIAYEVLSAIDYLHKRGISHRDIKPENILFDQDF--HAKLIDFGLSKEN--SDILSTYCGTPFNMAPDLVMNSAYDGTKADIWAFGVTFHVLA
..| .  .|   ..||. |.|...| |||||||||| |..    .|.||||.| .      |.| ||||  ||| ..    |||.|.|||. ||   .. 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TKQFPFE--VKNEVE
. .|||.   ....|
CGYFPFDGDTQDYKE
Kinase 83481.m00038.AA Ciliate-E2 20-216 25 8e-59 200.55 In-house 1-296 (365) Show / Hide 
Range on Protein: 20-216
Range on HMM: 1-296/365
Sequence Identity: 25% (78 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQ------------------KVAIKIFDREEI-AKGGFMKYLENKLR--------------LCVRFNHPNIVKIYDI
| .|..||.|.|..| .. . |...                  ||.|||.  . .  .. ...  |...               .. . |||||.|.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IY--TEKFIMMVMEYIENGDLQSLIN-----RNFH------FSIQEQLKIAYEVLS---------------AIDYLHKRG-ISHRDIKPENILFDQDFHA
 .  ... | .||||.. |||...|.     ||..      |...| ..| ...|.               |. |||... | |||||||||||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDFGLSKENS----------------------------------DILSTYCGTPFNMAPDLVMNSAYDG--------TKADIWAFGVTFHVLATKQFP
|.|||||||...                                  ..  |.||||  |||  ...  ||.        .|.|||..||... . ....|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

F
|
F
Kinase 83481.m00038.AA ULK 20-217 28 2.8e-58 199.95 In-house 1-253 (324) Show / Hide 
Range on Protein: 20-217
Range on HMM: 1-253/324
Sequence Identity: 28% (73 aa)

YQVIRQIGKGGFA-VVVLGFDPKT---NQKVAIKIFDREEIAKGGFM-------KYLENKLRLCVRFN---HPN--IVKIYDIIYTE--KFIMMVMEYIE
|......||| |. .|  |.. ||   ||.||.|. |. .. |   .       . |.|  ..   ..   |||  ||| ||. .|   ..| ..||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLQSLINRNFH---------FSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDF------------HAKLIDFGLSKE-NS-----DILST
 |||...|..| .         .| || ... .  ...  .|||..| ||||||.|||   ..            ..|. |||..|  ..     ... |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

YC------GTPFNMAPDLVM----NSAYDGTKADIWAFGVTFHVLATKQFPFE
..      |||  ||| ...    .  |.  |.||| .|. |. . . . ||.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFF
Kinase 83481.m00038.AA ULK 20-217 28 4.4e-58 199.27 In-house 1-257 (329) Show / Hide 
Range on Protein: 20-217
Range on HMM: 1-257/329
Sequence Identity: 28% (74 aa)

YQVIRQIGKGGFAVVVLGFDPKT----NQKVAIKIFDREEIAKGG-------FMKYLENKLRLCVRFN--------HPNIVKIYDIIYTE--KFIMMVME
|......||| |..|  |.. ||    |.|||.|. |.... .         ... |.|  ..  . .        |||||| ||. .|   . | ..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YIENGDLQSLINRNFH----------FSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDF------------HAKLIDFGLSKE-NSD-----
| . |||...|..| .          .| || ... .  |..  .|||..| ||||||.||| . ..            ..|. |||..|  ..|     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

ILSTYC------GTPFNMAPDLVM----NSAYDGTKADIWAFGVTFHVLATKQFPFE
.. |.       |||  ||| ...    .  |.  |.||| .|. |. . . . ||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY
Kinase 83481.m00038.AA S_TKc 20-225 28 1.8e-55 191.48 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-225
Range on HMM: 1-231/231
Sequence Identity: 28% (71 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYLENKLRLCVRFNHPNIVKIYDIIYTEKFIMMVMEYIEN--GDLQSLINRNFH---
|...|.||||.|..| .. . ||...||||| .          . ... .... . .||||||.||.... ... |||||...  ||| ..| .. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLSKENSDILSTYCGTPFNMAPDLVMNSAYDGTKADIWAFGVTFHVLAT
   |.  .  ...|....|..|.|..|| |||.||||||.|.  | |..||||...     .|.||||. ||| ..    |.. |.|.|..|...  ...
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

KQFPFE----------------------VKN----------E-------VEFL
 . ||.                      .|.          .        ...
GYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 83481.m00038.AA Ciliate-E2-Unclassified 20-226 24 5e-50 171.71 In-house 1-296 (352) Show / Hide 
Range on Protein: 20-226
Range on HMM: 1-296/352
Sequence Identity: 24% (73 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKV-----AIKIFDRE-EIAKGGFMKYLENKLRLCVR------------------FNHPNIVKIYDIIYTEKFIMM
| .|.|||.|||..| .  . |.. ..     ..|| ..   . .     .. ...... .                  ..||.||| ...  ... | .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYIENGDLQSLINRNFH-----------------FSIQEQL-----KIAYEVLSAIDYLHKRG-ISHRDIKPENILFDQD---FHAKLIDFGLSK---
||||.|.|||.  |. . .                 |. |. .     ......|....|||. . | ||||||||||||..   .. |.||||.||   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

EN---------------SDILSTYCGTPFNM----APDLVMNSAYDG---TKADIWAFGVTFHVLATKQFPFEVKNEVE----------------FLN
.|               .....| ||||  |    || . ..  ||.    |.|||..|| .. . . ..||. .|. .                ...
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ
Kinase 83481.m00038.AA QIK 20-220 33 1.4e-48 167.69 In-house 1-222 (272) Show / Hide 
Range on Protein: 20-220
Range on HMM: 1-222/272
Sequence Identity: 33% (74 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYLENKLRLCVRFNHPNIVKIYDIIYTEKFIMMVMEYIENGDLQSLINRNFH-----
| . | |||| |||| |.    | .|||||| |.. . .  . | ..    .  . .||.|.| |... |.. . .|.|| .||..   .. . .     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQK-CYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------FSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLS--KENSDILSTYCGTPFNMAPDLVMNSAYDGTKA
                . .|  ..  ...||..|.|||.| |||.| ||||.|..   |..|||.|   ..   |.|.||.|   || .     ||| |.
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DIWAFGVTFHVLATKQFPFEVKN
|||  ||   || .  .||  |.
DIWSMGVVLYVLVCGALPFDGKT
Kinase 83481.m00038.AA STE 20-205 25 6.5e-46 158.86 In-house 1-257 (359) Show / Hide 
Range on Protein: 20-205
Range on HMM: 1-257/359
Sequence Identity: 25% (67 aa)

YQVIRQIGKGGFAVVVLG-------FDPKTNQK---------VAIKIFDREEIAK--------------GGFMKYLENKLRLCVRFN--HPNIVKIYDII
.. |..||||.| .|...       .. ||...         .|||. . |.  .                 |. ... .... ..|  |||||| |.  
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YTE-------KFIMMVMEYIENGDLQSLINRNFHFSI-------------QEQL-KIAYEVLSA-IDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLS
. |         . ..|||...| | ..|....                  .|. .|....| .  .|||. .| |||||| |||.     .||.|||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KENSDILS-------------------TYCGTPFNMAPDLVMN------SAYDGTKADIWAFGVT
.  .|...                   | .|||  |||  ...      . || ||.||| .| |
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCT
Kinase 83481.m00038.AA Pkinase_Tyr 20-166 23 1.5e-13 46.49 Pfam 1-159 (270) Show / Hide 
Range on Protein: 20-166
Range on HMM: 1-159/270
Sequence Identity: 23% (37 aa)

YQVIRQIGKGGFAVVVLGFDP----KTNQKVAIKIFDREEIAKGG-FMKYLENKLRLCVRF-NHPNIVKIYDIIY-TEKF--IMMVMEYIENGDLQSLIN
 . ....|.| | .|..|       .|...||.|.  .|   .   ... . . ...   . .|||||. | ...  ..   |..|||| ..||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----NFHFSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLSK
.    . ...... |...... .. .||. ... |||.   |.| . ....|  ||||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 83481.m00038.AA TyrKc 20-225 18 9.9e-13 -16.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-225
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YQVIRQIGKGGFAVVVLGFDPKTNQKVAIKIFDREEIAKGGFMKYLENKLRLCVRF--NHPNIVKIYDIIYTE-------KFIMMVMEYIENGDLQSLI-
 . ....| | | .|..|      ..||.|    .       .. . . .|.  ..  .|||||..| .. ..       . .|.|||| ..|||.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

-NRNFHFSIQEQLKIAYEVLSAIDYLHKRGISHRDIKPENILFDQDFHAKLIDFGLSKENSDI------LSTYC-----GTP--FN---MAPDLVMNSAY
 .|.  .. .. |.... . .  .|||.... |||.   |.| . ....|  |||||..  |        ..|      |.   .    |||   . . .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DGTKADIWAFGVT-----------FHV-----LATKQFPFEVKNE------------------------------------------VEFL
  || |.|.|||.                   .  ..    ||.                                           .|..
T-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 83481.m00038.AA Pkinase_Tyr 195-205 63 1.715384 2.29 Pfam 193-203 (270) Show / Hide 
Range on Protein: 195-205
Range on HMM: 193-203/270
Sequence Identity: 63% (7 aa)

TKADIWAFGVT
|| |.|.|||.
TKSDVWSFGVL