Gene 81909.m00091 (T.vaginalis)

81909.m00091

Species: T.vaginalis
Alias: TvagK0648, 81909.m00091
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
81909.m00091.AA Protein None 433 None Fasta, JSON
81909.m00091.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 81909.m00091.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81909.m00091.AA DYRK 143-430 33 2.4e-84 286.52 In-house 1-320 (320) Show / Hide 
Range on Protein: 143-430
Range on HMM: 1-320/320
Sequence Identity: 33% (107 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWKDTYTCQKDENFVGY-
|. .  | .| || | ||.||||...||.|.|. ... |.|.. |   |. . ..||  .. .|   | ||.|...|  ||||  . |   |  .| |. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

EDGLLKTVSKQICDSLIFFHSL-GLVHCDIKPENIVWTND-QKTTVNLIDFGCCCHEGNPLFKYMQSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLG
   | ... .||...| | |..  ..|||.|||||.  .  .| |. .||||  |.|.  ...| |||||||||||| . .  |||.||.| .. || .|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

HPLYAGNNEKEQLGMYYSSLGPPDEKYLRSS--PRFSEFFGD------------DA----------------SIKNEYSYPLFDELVVGLDPDLVDLVRK
.||..|.|| .|| .    ||.| .. ....  .|  .|| .            .                 ...   . .. ...    | ...|...|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKK

CLEWDPNKRIKMTEVLKHPYL
||.|||.|||.  . |.|| .
CLQWDPHKRITPSQALQHPWF
Kinase 81909.m00091.AA DYRK2 143-377 39 2.8e-66 214.43 In-house 1-241 (318) Show / Hide 
Range on Protein: 143-377
Range on HMM: 1-241/318
Sequence Identity: 39% (96 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWKDTYTCQKDENFVGYE
|     | .| ||.|.||||||||. ||.|.|  . . |.|...|   |. | . |.  |. .|   | ||||..||  ||||  . |   |  .| |. 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

DGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCHEGN-PLFKYMQSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLGHP
  |     ..|  .| | |   ..||| |||||.     . .. .||||  | |   ... | |||||||||||| . .  ||| |||| .. ||  |.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LYAGNNEKEQLGMYYSSLGPPDEKYLRSS-----PRFSEFF
| .| ||..|...    || |..| .  .      |   ||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF
Kinase 81909.m00091.AA DYRK1 143-377 35 5.5e-61 208.92 In-house 1-237 (321) Show / Hide 
Range on Protein: 143-377
Range on HMM: 1-237/321
Sequence Identity: 35% (84 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWKDTYTCQKDENFVGYE
|. .  | .| || | | |||.... ||.|.|| .     | ..|   |... ..|.     || .   | ||   |  ||||    |   .  .| |  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

DGLLKTVSKQICDSLIFFHS--LGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCHEGNPLFKYMQSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLGH
  | .   .|.| .|.|. .  | ..|||.|||||.  | ..  . .||||  |. |. ...|.||||||.|||.| |..  |||.|| | ...|.  | 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLYAGNNEKEQLGMYYSSLGPPDEKYLRSSPRFSEFF
||..| || .|.      || | .. . ..|.   .|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF
Kinase 81909.m00091.AA CMGC 143-430 17 1.1e-59 194.37 In-house 1-513 (513) Show / Hide 
Range on Protein: 143-430
Range on HMM: 1-513/513
Sequence Identity: 17% (92 aa)

YQQIVEICRGNFGSVLKCYD--------------HKTKKIVAVKLIKDRPKIHKQ-------------ILMEKVALDMIQEADPKFT-----------HF
|. |  | .| .| | ||.|              |.|..|||.| || ..  . |             .| |   | ...... .             | 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-IVPVIDKFYFRG-----------------FHCFCFELLWKDTYTCQKDENF-------VGYEDGL------------LKTVS------KQICDSLI--F
 ||  .| ||...                   .. ||.. .| |   |. .|       .. ..               |  .      .||. .|   .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

FHSLG--LVHCDIKPENIVWTND------------------QKTTVNLIDFGCCCHEGNP------------------------LFKYMQSRFYRAPEVI
 || .   .|.|.|||||  ...                  .. .. ..||| .......                        .  | ..|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LHIS----------FTRAIDVWSFGLVIIELKLG--------HPLYAGNNE-----------KEQLGMYYSSLGPPDEKYLRS-------SPRFSEFFGD
|  .          .| .||.||.| .. |. .|        .||  |..|            .|| .    ||.|. . ...       ...  |... 
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

DA--------------------SI-----------KNEYSYPLFDELVVG-----------------------------------LDPDLVDLVRKCLEW
                      |.           . .. .. . .|. .                                   .||...||. |.|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPNKRIKMTEVLKHPYL
||.|||.  . |.|||.
DPDKRITAEQALQHPYF
Kinase 81909.m00091.AA S_TKc 143-430 24 4.6e-52 180.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 143-430
Range on HMM: 1-231/231
Sequence Identity: 24% (73 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWK---DTYTCQKDENFV
|. . .| .| ||.| ||...||..|||.| ||      ..|. |   | .          .||  .| |.  .. ....|..     | ..  |. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----YEDGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCHEGNPLFKYMQSRFYRAPEVILHISFTR-AIDVWSFGLVII
|    .     . . .|||. | . ||.| .|.|.|||||  ..    .. ..||| ...       .  ...|.||||.   .... ..|.||.| ...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELKLGHPLYAGNNEKEQLGMYYSSLGPPDEKYLRSSPRFSEFFGDDASIKNEYSYPLFDELVVGLDPDLVDLVRKCLEWDPNKRIKMTEVLK-------H
|.  | |..       |. | .  .|                                       .|.. |..||||..||.||.   |.|.       |
EMLCGYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PYL
|..
PWF
Kinase 81909.m00091.AA HIPK 143-384 33 1.4e-47 147.59 In-house 1-244 (329) Show / Hide 
Range on Protein: 143-384
Range on HMM: 1-244/329
Sequence Identity: 33% (81 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWKDTYTCQKDENFVGYE
|  .  . || || | ||  . |. .||.|..|. |   .|. .|   |  ... ..   ||.    . |  .   |  ||.|    |  ||. .|    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVR-AYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

DGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKT--TVNLIDFGCCCHEGNPLFK-YMQSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLG
   .... .|.   |.   .|||.| |.|||||     ..    |  ||||   |  .   . |.|||.|||||.|| . |  ..|.|| | || || ||
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

HPLYAGNNEKEQLGMYYSSLGPPDEKYLRSSPRFSEFFGDDASIK
 ||| |..| .|   .    . | |  | .  .   ||  |  .|
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSK
Kinase 81909.m00091.AA Pkinase 143-430 24 3.6e-45 160.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 143-430
Range on HMM: 1-293/293
Sequence Identity: 24% (78 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVA---LDMIQEADPKFTHFIVPVIDKFYFRGFHCFCFELLWK-----DTY----
|. .  | .|.||.| ||....| |||||| || | ..... .....    . . .. .     .||  .| |. ..  ....|.. .     | .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

TCQKDENFVGYEDGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKT--TVNLIDFGCCCH--EGNPLFKYMQ--SRFYRAPEVIL-HISFTRA
| ... .|   ..  .| . .||.  | . || | .|.|.|||||   |.  .  .| ..|||....  . |    .    ...|.|||||. .   ...
T-WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDVWSFGLVIIELKLGHPLYAGN----NEKEQLGMYYSSLG---PPDEKYLRSSPRFSEFFGDDASIKNEYSYPLFDELVVGLDPDLVDLVRKCLEWDPN
.|.||.|....|. .|.|.. |     |  .|. |..  .|   . |. ...| ..|. |.  . .       . . .. . ..... |....||..||.
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEECKDFIKWCLCKDPK

KRIKMTEVLKHPYL
||.  ...|.||..
KRPTAEQILQHPWF
Kinase 81909.m00091.AA YAK 146-352 34 1.4e-43 145.75 In-house 2-214 (347) Show / Hide 
Range on Protein: 146-352
Range on HMM: 2-214/347
Sequence Identity: 34% (74 aa)

IVE--ICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMI-QEADPKFTH---FIVPVIDKFYFRGFHCFCFELLWKDTYTCQKDENFV
||.    .| || | ||    |. ..||| || |.    |   |   | .  |  ||   .    |.  .| | ..   |  ||.|    |   |  .| 
IVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKFC

GYEDGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCHEGNPLFKYMQSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLG
|    | ..  ||| |...   .  ..||| |||||   .  |  . .||||  | |   . .| |.|.||.||.|. . .. .|| || | .. || ||
GFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLG

HPLYAGNNEKEQL
 |.. || | .|.
LPIFPGNSEYNQI
Kinase 81909.m00091.AA CLK 143-275 30 4.1e-22 62.44 In-house 1-145 (350) Show / Hide 
Range on Protein: 143-275
Range on HMM: 1-145/350
Sequence Identity: 30% (44 aa)

YQQIVEICRGNFGSVLKCYDHKT-KKIVAVKLIKDRPKIHKQILMEKV-ALDMIQEA-DPKFTHF--IVPVIDKFYF-RGFHCFCFELLWKDTYTCQKDE
|  .     | || |..| |||  || ||.| |.   |   .   |    .  |.|. ||  ..   ..  .| | .  |  |  |||. . .|   |. 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FVGYEDGLLKTVSKQICDSLIFFHSLGLVHCDIKPENI
|      . .|.    .  ..|.| .. | |...|.| | |||||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENI
Kinase 81909.m00091.AA PRP4 263-336 42 6.9e-20 69.52 In-house 125-198 (320) Show / Hide 
Range on Protein: 263-336
Range on HMM: 125-198/320
Sequence Identity: 42% (32 aa)

LGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCH-EGNPLFKYMQSRFYRAPEVILHISFTRAIDVWSFGLVIIEL
.. .| |||| ||.  |  |.|  ..|||   | . | . .| .||||||||.|. ...  .||.|| |  . ||
CNILHADIKPDNIL-VNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYEL
Kinase 81909.m00091.AA RCK 251-348 32 3.5e-18 54.03 In-house 112-219 (298) Show / Hide 
Range on Protein: 251-348
Range on HMM: 112-219/298
Sequence Identity: 32% (35 aa)

KQICDSLIFFHSLGLVHCDIKPENIVWTND-------QKTTVNLIDFGCC-CHEGNP-LFKYMQSRFYRAPEVILHI-SFTRAIDVWSFGLVIIELKLGH
.||. .| . |. |  | |.|||||  |..          .. ..||| | . . .|    |  .| |||||..|.    .  .|.|..| ...||   .
YQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLR

PLYAGNNE
||..|..|
PLFPGSSE
Kinase 81909.m00091.AA CLK 305-354 42 2.2e-13 35.8 In-house 209-258 (350) Show / Hide 
Range on Protein: 305-354
Range on HMM: 209-258/350
Sequence Identity: 42% (21 aa)

QSRFYRAPEVILHISFTRAIDVWSFGLVIIELKLGHPLYAGNNEKEQLGM
..| ||||||||   .    ||||.| ...|| .|  |. .....| | |
STRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAM
Kinase 81909.m00091.AA STE 245-344 25 3.1e-13 43.21 In-house 152-269 (359) Show / Hide 
Range on Protein: 245-344
Range on HMM: 152-269/359
Sequence Identity: 25% (32 aa)

LLKTVSKQICDS-LIFFHSLGLVHCDIKPENIVWTNDQKTTVNLIDFGCCC-------------------HEGNPLFKYMQSRFYRAPEVILH------I
..... .||.   | . ||.. .| |||| ||         | |.|||.|                      .        .  . |||||.        
QIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDK

SFTRAIDVWSFGLVIIELKLGHPLYA
  ..  |.||.|..|||.  |.| ..
GYDTKCDIWSLGCTIIEMATGKPPWH
Kinase 81909.m00091.AA CLK 403-430 53 5.5e-13 34.56 In-house 323-350 (350) Show / Hide 
Range on Protein: 403-430
Range on HMM: 323-350/350
Sequence Identity: 53% (15 aa)

LVDLVRKCLEWDPNKRIKMTEVLKHPYL
| ||.||.|| ||.|||.  ..|.||. 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 81909.m00091.AA RCK 401-430 46 7.4e-13 36.84 In-house 269-298 (298) Show / Hide 
Range on Protein: 401-430
Range on HMM: 269-298/298
Sequence Identity: 46% (14 aa)

PDLVDLVRKCLEWDPNKRIKMTEVLKHPYL
.|...|..|.| |||.|||   ..|.||| 
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 81909.m00091.AA DYRK2 400-430 38 1.3e-11 33.65 In-house 288-318 (318) Show / Hide 
Range on Protein: 400-430
Range on HMM: 288-318/318
Sequence Identity: 38% (12 aa)

DPDLVDLVRKCLEWDPNKRIKMTEVLKHPYL
|....| ...|.|||| .|..  . ||||..
DENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 81909.m00091.AA STE 143-187 21 9.6e-09 27.13 In-house 1-78 (359) Show / Hide 
Range on Protein: 143-187
Range on HMM: 1-78/359
Sequence Identity: 21% (17 aa)

YQQIVEICRGNFGSVLKCYDHK---------------TKKIVAVKLIK---DRP---------------KIHKQILME
.. | .| .|.||.| |...||               |..|.|.| ..   ...               ....|||.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKE
Kinase 81909.m00091.AA PRP4 405-430 57 1.2e-07 24.15 In-house 295-320 (320) Show / Hide 
Range on Protein: 405-430
Range on HMM: 295-320/320
Sequence Identity: 57% (15 aa)

DLVRKCLEWDPNKRIKMTEVLKHPYL
||  |||  || ||| . |.||||..
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase 81909.m00091.AA TyrKc 143-430 18 1.8e-07 -101.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 143-430
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEADPKFTHF------IVPVIDKFYFR-------GFHCFCFELLWK--
 . . .. .|.|| | |.        |||| .|.               |...||    ...      ||  .             . ..  .|.  .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREAR-IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

-DTYTCQKDENFVGYEDGLLKTVSKQICDSLIFFHSLGLVHCDIKPENIVWTNDQKTTVNLIDFGCCCHEGNP-------LFKYM----QSR-----FYR
 . |   . ..        |   . ||..   . || ...| |.   |.  ....  ||   ||| .   ..          . .    ...        
LKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVILHISFTRAIDVWSFGLVIIEL-KLGHPLYAG-------NNEKEQLGMYYSSLGPPDEKYLRSSPRFSEFFGDDASIKNEYSYPLFDELVVGLDPD
|||.| .  || . |||||| .. |.  .| . | |       | |  .. .    . .|.. |    |  |                 |    |.  ..
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY----P-MS-----------------F----VCCPDE

LVDLVRKCLEWDPNKRIKMTEVLKHPYL
. .. ..| . ||..|  ..|.  | ..
MYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81909.m00091.AA STE 401-430 43 3.9e-07 21.36 In-house 328-359 (359) Show / Hide 
Range on Protein: 401-430
Range on HMM: 328-359/359
Sequence Identity: 43% (14 aa)

PDLVDLVRKCLEWDPNKRIKMTEVLK--HPYL
|.. | ..|||. ||||| . .. ||  || .
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 81909.m00091.AA DYRK1 405-430 34 1e-06 18.52 In-house 296-321 (321) Show / Hide 
Range on Protein: 405-430
Range on HMM: 296-321/321
Sequence Identity: 34% (9 aa)

DLVRKCLEWDPNKRIKMTEVLKHPYL
||... |..||..||.  ..|.|...
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase 81909.m00091.AA RCK 143-172 40 4e-06 14.95 In-house 1-30 (298) Show / Hide 
Range on Protein: 143-172
Range on HMM: 1-30/298
Sequence Identity: 40% (12 aa)

YQQIVEICRGNFGSVLKCYDHKTKKIVAVK
|| | .. .| .|.|.|  . .|..||| |
YQIIKQLGDGTYGCVMKAQNKETGEIVAIK
Kinase 81909.m00091.AA HIPK 402-430 37 0.00011 10.14 In-house 301-329 (329) Show / Hide 
Range on Protein: 402-430
Range on HMM: 301-329/329
Sequence Identity: 37% (11 aa)

DLVDLVRKCLEWDPNKRIKMTEVLKHPYL
. |.. .| . ||..|||   | |.||. 
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 81909.m00091.AA PRP4 143-225 25 0.000588 10.47 In-house 1-86 (320) Show / Hide 
Range on Protein: 143-225
Range on HMM: 1-86/320
Sequence Identity: 25% (22 aa)

YQQIVEICRGNFGSVLKCY-DHKTKKIVAVKLIKDRPKIHKQILMEKVALDMIQEA--DPKFTHFIVPVIDKFYFRGFHCFCFELL
|. .  .  | |. | .|    .... ||.| |  ..  ||  | |.  |  . .|  |.     .|   . |..|   |  || .
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECM
Kinase 81909.m00091.AA YAK 403-430 25 0.00127 7.74 In-house 320-347 (347) Show / Hide 
Range on Protein: 403-430
Range on HMM: 320-347/347
Sequence Identity: 25% (7 aa)

LVDLVRKCLEWDPNKRIKMTEVLKHPYL
..|..   |. .|..| |     .||..
FIDFINQLLQLNPRERWKPMQAMQHPFI