Gene 87854.m00199 (T.vaginalis)

87854.m00199

Species: T.vaginalis
Alias: TvagK0591, 87854.m00199
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
87854.m00199.AA Protein None 308 None Fasta, JSON
87854.m00199.kin_dom Protein Kinase Domain None 282 None Fasta, JSON

Protein domain

Protein domains of 87854.m00199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87854.m00199.AA CDC2 6-287 61 2.1e-206 641.03 In-house 1-301 (301) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-301/301
Sequence Identity: 61% (185 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEG--IPPTSIREISILKELH-HPNVVGLNEVINSQGKLTLVFEYLEYDLKKFLD-SQRV--P
||| ||.||||||||.|..|..|||.||||.|||.||.||  .| |.|||||.||||  |||.| | .|| .  || .|||||..||||..| |.    .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYT--HEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEM
. |.|.|||.|||| |...|| .||.||| ||||.||.| | ||.|||||||||.||.|.||  |||.|||||.||||||.|.||.|||.|| | | |||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ISRKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKFRKRNLADILPG---------ADPLAIDLIEKMLIYDPAKRISAKDALDHP
   ...||||.||||||.|| ||.|||||.|.||||||.|| | .|||.... .| .|.|          .|| .|||...||.|||.||||||.||.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase 87854.m00199.AA CDK 6-287 52 7.70000000001e-178 573.73 In-house 1-284 (284) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-284/284
Sequence Identity: 52% (167 aa)

YQKQEKLGEGTYGVVFKAIDKRTN-----QVVALKRIRLDQ-----EEEGIPPTSIREISILKELHHPNVVGLNEVINSQ-----------GKLTLVFEY
|.| ||.||||||||.||.||.|.     |.||||.||...     |.||.| |.|||||.|||| |||.| | .|. .             ||..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LEYDLKKFLDSQRVPLKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGL-----IKLADFGLARAFTI------PLRNYTHEVITLWYRPPE
...||||..|          ||.|..|.| || ||| ..|.|||.||||.|||. |      .|.||||||||| |      |.| |||||.|||||.||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLGSKFYS--LPVDIWSTGAIVAEMIS---RKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKFRKRNLADILPGADPLAIDLIEKML
.||||| ||   |.|.|| | | |||.    |||||||||||| || ||.|.|||||..|||||.|| |                        ||..|||
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

IYDPAKRISAKDALDHPYF
 |||.|||||..||.||||
CYDPKKRISAEQALQHPYF
Kinase 87854.m00199.AA CDK5 6-287 56 2.1e-171 546.3 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-287/287
Sequence Identity: 56% (161 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIREISILKELHHPNVVGLNEVINSQGKLTLVFEYLEYDLKKFLDSQRVPLKPDLI
|.| ||.||||||.|.|| .| |  .|||||.|||.| ||.| | ||||..|||| |.|.| |  || |  |||||||..  ||||..||  . . ...|
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEMI-SRKPLF
||. || | || .|| |.. |||.||||||||| |  ||||||||||| || |.|.|||.||||||| .|.||| || ..|.|| | | |||. . .|||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDSEIDELFSIFKILGTPTEETWPGVTELPSYS---STFPKFRKRN-LADILPGADPLAIDLIEKMLIYDPAKRISAKDALDHPYF
|| .. |.|. ||||.|||.|..||..|.|| |      .|..  .  .. | |. |    || .|||...|..|||||.|| ||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 87854.m00199.AA CDK7 6-287 43 1.3e-152 410.03 In-house 1-288 (288) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-288/288
Sequence Identity: 43% (124 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIR----LDQEEEGIPPTSIREISILKELHHPNVVGLNEVINSQGKLTLVFEYLEYDLKKFLDSQRVPLK
|.| ...|||....|.|| |. |.|.|| |.|.     .. . ||  | |||| ||.|..|.||.||  ..  .  . |||.... ||      . . |.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

PDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEMISRK
|  ||.|. ..| || ||| . | |||.|| |||.|. | .|.|||||||..  | |.||| |.| ||| || | | . |   ||.|| | | || . | 
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSS--TFPKFRKRNLADILPGADPLAIDLIEKMLIYDPAKRISAKDALDHPYF
| .||||.|| |  ||..|||||||.||.......|     || . .  | .|   |   ..||...|.  .| ||... ..| .|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 87854.m00199.AA CMGC 6-287 30 4.4e-152 503.65 In-house 1-513 (513) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-513/513
Sequence Identity: 30% (155 aa)

YQKQEKLGEGTYGVVFKAIDKRTN--------------QVVALKRIRLDQ---------EEEGIPPTSIREISILKEL-----------------HHPNV
|.. .|.||||||||.|..|||||              ..||.|.|....         |..|.| ...|||.|||.|                 ||.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VGLNEVINSQG-----------------KLTLVFEYLEYDLKKFLDSQR--------VPLKPDL------------IKSYT------YQILAGLC--YCH
|.| ... . .                 .| |||||...||........        .||..              ||...      |||| ||   |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

CHR--IIHRDMKPQNLLINKL--------------------GLIKLADFGLARAFTIP---------------------LRNYTHEVITLWYRPPEILLG
 |.  |||||.||.|.|||.                     | .|..||||||.. ..                     .| |||.| |.|||.||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SKFYS---------LPVDIWSTGAIVAEMISR--------KPLFPGDSE-----------IDELFSIFKILGTPT---------------EETWPGVTEL
.| |.          |.|.|| | | |||. .        ||||||.||           || || |||.|||||               ||.||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PSY----------------SST----------FPKFRKRNLADILPG-----------------------------------ADPLAIDLIEKMLIYDPA
| |                |.           ||....... .. |.                                   .||.||||..|||.|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAKDALDHPYF
|||.|..||.||||
KRITAEQALQHPYF
Kinase 87854.m00199.AA PFTAIRE 6-287 49 1.1e-122 413.82 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-287/287
Sequence Identity: 49% (142 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIREISILKELHHPNVVGLNEVINSQGKLTLVFEYLEYDLKKFLDSQRVPLKPDLI
|.| ||||||.|  |.|.| . ..|.|||| ||| |.||| | | ||| | ||.| | |.| |  .|  .  ||.||||.. ||....|.    ..|. .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRL-QQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEMISRKPLFP
. . .| | || |||  |. |||.||||||| ..|  ||||||||||  .| . | |||.||||||| .||||  ||  .|.|  | |  ||.  .|.||
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GD-SEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPK---FRKRNLADILPGAD--PLAIDLIEKMLIYDPAKRISAKDALDHPYF
|     | |  |||.||||||.|||||..|| |     .   .. ..|  ..|  .  | | ||. ||| . | .|.||..|. ||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 87854.m00199.AA PCTAIRE 6-287 47 2.3e-119 402.87 In-house 1-291 (291) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-291/291
Sequence Identity: 47% (140 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIREISILKELHHPNVVGLNEVINSQGKLTLVFEYLEYDLKKFLDSQRVPLKPDLI
| | .|||||||  |.|   | |. .|||| ||| . ||| | | |||.| ||.| | |.| |  .|  .  |||||||.. |||...|     .    .
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

KSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEMISRKPLFP
| . .|.| || |||  .| |||.||||||||  |  ||||||||||  .| . | |||.|||||||..|.||  || ..|.|  | | .|| . .||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFP

GDS------EIDELFSIFKILGTPTEETWPGVTELPSYSS-TFPKFRKRNLADILPGAD---PLAIDLIEKMLIYDPAKRISAKDALDHPYF
|          |.|  ||.|||||.|.|||||. .. . .  ||..|.  |    |  |      .||....| | . .|.|| .|. ||||
GSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 87854.m00199.AA PITSLRE 6-287 47 2.9e-118 399.2 In-house 1-295 (295) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-295/295
Sequence Identity: 47% (139 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLD--QEEEGIPPTSIREIS-ILKELHHPNVVGLNEVI--NSQGKLTLVFEYLEYDLKKFLDSQR---
.|.  . .|||||||..| ||||. .|||||. ..  .| ||.| ||.|||. ||..| |||.| . |..      |  .|.||.| |||  ..  .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

VPLKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTGAIVAEM
 | ||  ||. . | | |  . | . |.||| |  |||..  |  |..|||||| .  |.. ||  |.||||| ||.|||.| || |||.|| | | ||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ISRKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSS-T-FPKFRKRNLADILP---GADPLAIDLIEKMLIYDPAKRISAKDALDHPYF
|. ||||.|.||||..  ||| .|||||  |||.||||     . ||.    ||  . |        . ||  .|| |.|..||.| |||.||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 87854.m00199.AA S_TKc 6-287 31 1.1e-105 358.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-231/231
Sequence Identity: 31% (95 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIREISILKELHHPNVVGLNEVINSQGKLTLVFEYLEY---DLKKFLDSQRVP---
|.. .|.|.|..|.|.|...|.|...||.|.|.          . .|||.|||. ||||.| | .|. . ..| .|.||..    ||........ .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSL-PVDIWSTGAIVAE
  . .  ...|.|||. .| ||| |.||||| ||.|.|...   ||..|||||| .       |. . |.||..||.|     |.  ..|.|| | |..|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MISRKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKFRKRNLADILPGADPLAIDLIEKMLIYDPAKRISAKDALD-------HPYF
|....|.||      ... .||..|                                   .| |.|.|.|.| .||.||..| .||        ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87854.m00199.AA CRK7 6-287 35 1.3e-104 353.89 In-house 1-343 (343) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-343/343
Sequence Identity: 35% (122 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQE---EEGIPPTSIREISILKELHHPNVVGLNEVINSQ----------GKLTLVFEYLEYDLKKF
|.. .  |||||| | || .|.|.. ||||..|.| |   .|| | |.|||| ||..|.|.|.| | |.. .           |   .||||   ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDSQ-RVPLKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPL--RNYTHEVITLWYRPPEILLGSKFY--------
|.|   .   .. .|..  |.| |. |||   ..||| |  |.|.|  | .|.||||||| .      | ||  |||||||||| ||| . |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------SLPVDIWSTGAIVAEMISRKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKF--RKRNL
                                 .|.||.| | .|  ..||.|.|  |.. | .|.|| |.|. . || |..|| .    ||   . | .
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

ADILP-----GADPLAIDLIEKMLIYDPAKRISAKDALDHPYF
 .          .. . ||  ||| .|| ||..|...|.|..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 87854.m00199.AA Pkinase 6-287 33 2.2e-104 357.9 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIR--EISILKELHHPNVVGLNEVINSQGKLTLVFEYLEY-----DLKKFLD-SQR
|.. .|.|.|..|.|.|...| |...||.|.|... |... . | .|  ||.|.|.|.|||.| | ..  . ... .|.||.|      ||. ..  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VPL--KPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLI----KLADFGLARAF-TIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWST
 ..   .. .|.| |||| || ||| ..|||||.||.|.||.. | |    |..|||||. | . . . .|. . |.||..||...|.. |. .||.|| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GAIVAEMISRKPLFPGD----SEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKFRKRNLADILPGADPLAIDLIEKMLIYDPAKRISAKDALDHPY
| |..||....|.|||.    . .|... |..|.|.|... ||   . . .. ...   .. .    . ... ..|.|...| .||.||..|...| ||.
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase 87854.m00199.AA CDK4 6-287 44 8.8e-104 351.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-290/290
Sequence Identity: 44% (132 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEE--GIPPTSIREISILKELH---HPNVVGLNEVIN------SQGKLTLVFEYLEYDLKKFLD
||.   .||| || |..| |  | . ||||..|   .||  |.|   |||||... |    |||.| | .|        .. |.|.|||  . ||. .||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SQRVPL---KPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLRNYTHEVITLWYRPPEILLGSKFYSLPVDIWSTG
  ..|     |  ||  . |.| |. . | ||||||| ||||.|..  | .||||||||| .       |  |.||||| ||.|| |  |  |||.|| |
--KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQSY-YNTPVDMWSVG

AIVAEMISRKPLFPGDSEIDELFSIFKILGTPTEETWPGVTELPSYSSTFPKFRKRNLADILPGADPLAIDLIEKMLIYDPAKRISAKDALDHPYF
 |.|||  |.|||.| || | |  ||.. |.|.|. ||    ||  .  ||  . |.. |. |  . ...||..||| |...||.||  .| ||||
CIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDH--FPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 87854.m00199.AA Pkinase_Tyr 6-152 31 3.4e-20 69.02 Pfam 1-160 (270) Show / Hide 
Range on Protein: 6-152
Range on HMM: 1-160/270
Sequence Identity: 31% (52 aa)

YQKQEKLGEGTYGVVFKAIDK----RTNQVVALKRIRLDQEEEGIPPTS------IREISILKEL-HHPNVVGLNEVIN-SQGK--LTLVFEYLEY-DLK
 .. .||||| .|.|.|.. |     |.. || | ..     ||  .        .||..|.|.| ||||.| |  |.   ..   . .|.|| .. ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KFLDSQ---RVPLKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARA
..| ..   . ||..  . .. .|| .|. | . ...||||    | |... . .| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 87854.m00199.AA TyrKc 6-287 23 1.5e-14 12.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-287
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

YQKQEKLGEGTYGVVFKAIDKRTNQVVALKRIRLDQEEEGIPPTSIREISILKEL--HHPNVVGLNEVINSQ-------GKLTLVFEYLEY-DLKKFLDS
 .. .||||| .|.|.|.. |   . || | .. |  .| .    .||..|...|  ||||.| |  |. .|       . | .|.|| .. |||..| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDF----MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QRVPLKPDLIKSYTYQILAGLCYCHCHRIIHRDMKPQNLLINKLGLIKLADFGLARAFTIPLR--------NYT-----HEV--ITLWYRPPEILLGSKF
 |  |...   |. .|| .|  | | ...||||    | |... . .| .||||.|.  |            |.     ..   . .   .|| .  .||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRD--IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

YSLPVDIWSTGAIVAEMISR-KPLFPG-------DSEIDELFSIFKILGTPTE----ETWPGVTELPSYSSTFPKFRKRNLADILPGADPLAIDLIEKML
 .   |.|| |    |. .. ..  ||       ..|. |.    . .  | .                                ... .   .....  
TTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------F-VCCPDEMYQIMKQCW

IYDPAKRISAKDALDHPYF
 .||..| . ..   | .|
HEDPEDRPTFSEI--HECF