Gene 84800.m00013 (T.vaginalis)
84800.m00013
Species: T.vaginalis
Alias: 84800.m00013, TvagK0461
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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84800.m00013.AA | Protein | None | 489 | None | Fasta, JSON |
84800.m00013.kin_dom | Protein Kinase Domain | None | 233 | None | Fasta, JSON |
Protein domains of 84800.m00013.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 84800.m00013.AA | CK1-Unclassified | 9-241 | 50 | 6.6e-158 | 469.59 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 9-241 Range on HMM: 1-244/244 Sequence Identity: 50% (123 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGST-------NVPRLHAHSFD--SRYNTIVIDLLGKSLEEHLNKVNRR |..|.|||||||| || . ..|. ..| ||| ... .|||..| ...|.. . ..|... . . ..|| .| ||||.|||. .|. ||. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK MSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMG-VNQNSNKLYIIDYGLAKKYRDV-NTHEHIPYIEGKSLTGTARYASINALLGCEQSRRDDME |||||||..||||. .|..|.||.||||||||||.|| ..|....||||.||.|.|.| .|..|||| |.|.|||||||||||| || |||||||.| FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE AIGYVIVYLLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLC ..|||..|.|||.|||..| . .|.| .|.| | ||.| || SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 84800.m00013.AA | CK1 | 9-267 | 49 | 2.7e-149 | 502.26 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 9-267 Range on HMM: 1-271/271 Sequence Identity: 49% (134 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLF---AAKLENSDAPIPQLLFESRLYQIMSG------STNVPRLHAHSFD--SRYNTIVIDLLGKSLEEHLNKVN |....|||||||| || . . | . | ||| ... |||..|...|.|. | . ..|... .. . || .|.||||.|||. .|. | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN RRMSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGV-NQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSRRDDM |. |||||||..||||. .|..|.||.||||||||||.||. .......||||.||||.||| .||.|||| |.|.|||||||||||. || |||||||| RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM EAIGYVIVYLLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEG-LPSEIITYIRKVRSLRFTERLHYA |..|||..|.|.|.|||.|. .|....| .|.| |. ||.| ||.| .|.| ..|.. .|.|.| |. |. ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 84800.m00013.AA | CK1-A | 9-269 | 51 | 5.5e-117 | 394.94 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 9-269 Range on HMM: 1-261/261 Sequence Identity: 51% (134 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGSTNVPRLHAHSFDSRYNTIVIDLLGKSLEEHLNKVNRRMSLKTVLML |....||| |||| ||. ... | | |.| .| |||..|...|.|..| .|... . . ||..|.|||| |||. | .|| ..|||||| YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML VDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSRRDDMEAIGYVIVYLLK .||||. .|. | ||.||||||||||.||.. |||..||.|||||||| .|..|||| | | |||||||||||| || |||||||||..|||..| . ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR GHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEGLPSEIITYIRKVRSLRFTERLHYASY |.||| |. .| . .| .| | | ||.|.|| | |.| |. .|.||| | | GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 84800.m00013.AA | CK1-D | 9-269 | 50 | 2.3e-114 | 386.23 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 9-269 Range on HMM: 1-261/261 Sequence Identity: 50% (132 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGSTNVPRLHAHSFDSRYNTIVIDLLGKSLEEHLNKVNRRMSLKTVLML | | .||| |||| || ....|. | ||| . ||| .||..|..|.| .|... .. || .|.|||| |||. | .|. |||||||| YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML VDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSRRDDMEAIGYVIVYLLK ||||. .|. |..|.||||||||||.||. . | ||||.||||.||| .||.|||| | |.||||||||||| .| |||||||.|..|||..| . ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR GHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEGLPSEIITYIRKVRSLRFTERLHYASY | ||| |. || ...| ||.| | .|....||.|.||| .|. .|.|.| .. |. GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 84800.m00013.AA | CK1 | 9-269 | 30 | 4e-104 | 352.21 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 9-269 Range on HMM: 1-339/339 Sequence Identity: 30% (105 aa) YQIIKKIGQGSFG-KIY-------IIKQVKT---GLLFAAKLENSDAP--IPQLLFESRLYQI--------------------MSGSTNVPRLHAHSFDS ....||||.|.|| || . .. . | .| |.| .. |||. |...|.. ..|. ..... | .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED R-YNTIVIDLLGKSLEEHLN---KVNRRMSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGV-------------NQNSNKLYIIDYGLAK-KYR . || .|..|||..||. .. ||..|.||.||. .||. |.|. |....||||||||||.||. |......|.||.|.|. ||| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DV-----------NTHEHIPYIE---GKSLTG-TARYASINALLGCEQSRRDDMEAIGYVIVYLLKGH--LPWMGIDGATN-------QERYRRIAECKR | .|..|.|. | |...| ||||.|||. ||.||.||||... .|.....|||. |||.... .. .. | |.| | DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM DTPLEKLCEG-----LPSEIITYIRKVRSLRFTERLHYASY ||.. ||.. .|.| ... .|||.. .| |. STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 84800.m00013.AA | CK1-G | 9-269 | 45 | 1.1e-99 | 337.46 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 9-269 Range on HMM: 1-266/266 Sequence Identity: 45% (120 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGST-NVPRLHAHSFDSRYNTIVIDLLGKSLEEHLNKVNRRMSLKTVLM |.. |||| |.|| .. | . ... | |.| ||| | | |.|..| ..|. . || .|.|||| ||| . .|. |.|||.| YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM LVDQMITAVEFFHSKNYIHRDIKPDNFVMG--VNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSRRDDMEAIGYVIVY . |||. .| ||.. | ||.||||| | |.. ....|||.|.||.|.| .| |||| | ||||||||| ||| || ||||||||||.| . | VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY LLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEG--LPSEIITYIRKVRSLRFTERLHYASY | |.||| | .| ||| .| . || |. | ||.. .| .. ||.| ||.| | | | FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 84800.m00013.AA | Worm6 | 9-252 | 26 | 1.2e-49 | 171.29 | In-house | 1-265 (279) | Show / Hide |
Range on Protein: 9-252 Range on HMM: 1-265/279 Sequence Identity: 26% (70 aa) YQIIKKIGQGSFGKIYIIKQVKTGL--LFAAKLEN--SDAPIPQLLFESRLYQIMSGST--NVPRLHAHS-FDSR-YNTIVIDLLGKSLEEHLNKV-NRR ... ||||.|.|| .| .. ... || |.|. .....| .| . . ..... . .|.| .| ||. |.||.|.. .|. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK MSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGV-----NQNSNKLYIIDYGLAK--KYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSR .|. | | . |.. |.| |. .||||.|| || |. . .. ..|..|.|... ||.. .. . | . || |||.... |.||.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDMEAIGYVIVYLLKGHLPWMGIDGATNQE-RYRRIAECKRDTPLEKLCEGLPS----EIITYI .||.| |..| ...| |||..... ..| ..... ..| . . . .. | .| .|| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYI |
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Kinase | 84800.m00013.AA | TTBKL | 9-273 | 26 | 2.2e-43 | 144.38 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 9-273 Range on HMM: 1-288/288 Sequence Identity: 26% (79 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLE--NS-DAPIPQLLFESRLYQIMS--GSTNVPRLHAHSFDSRYNTIVIDLLGKSLEEHLNKVNRR--MS ..|.|.||.| ||..| . .|. .||. | |. . . .| . .. ||. .|..|. .|| .| |.|..| . .. ... .| WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQN----SNKLYIIDYGLAKKYRDV----------NTHEHIPYIE---GKSLTGTARYASINA |.. . | . |. |.. .||||.|| |...|.... . .|.||.|.|..|.. |. .. . . .. || ||.|.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM LLGCEQSRRDDMEAIGYVIVYLLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEG------LPSEIITYIRKVRSLRFTERLHYASYRRLF ...||.| ||. . |.|..|..| ||| || | .|.. |... .|.|. . .||| . .||||. .| | . . .| HDRKEQGRHDDLWSWMYMIIELHCG-LPW------TNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 84800.m00013.AA | Pkinase | 9-260 | 19 | 2.5e-34 | 122.47 | Pfam | 1-258 (293) | Show / Hide |
Range on Protein: 9-260 Range on HMM: 1-258/293 Sequence Identity: 19% (53 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIP----QLLF--ESRLYQIMSGSTNVPRLHAHSFDSRYNTIVIDLLGK-----SLEEHLN-KV |.|..|||.||||. |. . ..|| ..| | . . . ... | .. . . .. |. ||. |... .| ..... .| ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR NRRM--SLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMG-VNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALL-GCEQSR .... | ... . . |.. ..|. ||.. ||||.||.|. . .... .. |.| ||||... . .. ....|| .|.. .. | . .. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP RDDMEAIGYVIVYLLKGHLPWMGI----DGATNQERYRRIAECKRDTPLEKLCEGLPSEIITYIRKVRSLRF . || ..| .. ..| |..|. | . .. .....|| ... . . ...|.. ... ... . . ... KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWT |
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Kinase | 84800.m00013.AA | TTBK | 9-269 | 32 | 6.4e-32 | 110.11 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 9-269 Range on HMM: 1-257/257 Sequence Identity: 32% (86 aa) YQIIKKIGQGSFGKIYIIKQVKTG-LLFAAKLENSDAPIPQLLFESRLYQIMSGSTNVPRLHAHSFDSRYNTIVIDLLGKSLEEHLNKVNRRM-SLKTVL ...||||.| || || | . . | |.| ...| | | . . | | | . ..| .| .|.||.| . | | || | | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL MLVDQMITAVEFFHSKNYIHRDIKPDNFVMGVN-QNSNKLYIIDYGLAKKYRDVNTHEHI-PYIEGKSLTGTARYASINALLGCEQSRRDDMEAIGYVIV | |.. ..| || . |||||| || || | .. .| |..|.||| .| .|.. . | | ||.||||||| . | |.||. . |. | RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQY--TNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV YLLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEGLPSEIITYIRKVRSLRFTERLHYASY ..| ||| | . | | . | . .|.|. ... ..|| . .| |. EFVQGQLPWRKIKDKDQ------VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 84800.m00013.AA | VRK | 80-214 | 36 | 1.5e-21 | 66.18 | In-house | 106-241 (284) | Show / Hide |
Range on Protein: 80-214 Range on HMM: 106-241/284 Sequence Identity: 36% (50 aa) IVIDLLGKSLEEHLN-KVNRRMSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLT--GT .|.. .| .|. . . | | |||| | .|. . |. |...| | ||| | | | .. | .||||| .| .. | .|.|.. || MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRY--CPNGKHRQYKEDPRRCHNGT ARYASINALLGCEQSRRDDMEAIGYVIVYLLKGHLPWM . |. | .|| ||| | | || . | |.|||| CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWM |
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Kinase | 84800.m00013.AA | S_TKc | 9-283 | 19 | 3.9e-16 | 59.7 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-283 Range on HMM: 1-231/231 Sequence Identity: 19% (56 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGSTNVPRLHAHSFDSRYNTIVIDLLGK---SLEEHLNKVNRR-----M |.|..|||.|.||| | . .||| ..| | . ... | .. . . |. .|. . | . .| .... .| ... | .|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQNSNKLYIIDYGLAKKYRDVNTHEHIPYIEGKSLTGTARYASINALLGCEQSR-RDDMEAI . .. .. |.. |.|. ||.. ||||.||.| . . |.| |||... ... || | . | .. . |. .. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GYVIVYLLKGHLPWMGIDGATNQERYRRIAECKRDTPLEKLCEGLPSEIITYIRKVRSLRFTERLHYASYRRLFR--GLFRAMQFT | .. .| | |. . |. ...| ..| . ||| ..|. . ... . ..... GCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRP---TA-EALQDEWDIKCHPWF |
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Kinase | 84800.m00013.AA | TyrKc | 9-244 | 19 | 3.6e-05 | -138.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 9-244 Range on HMM: 1-280/280 Sequence Identity: 19% (58 aa) YQIIKKIGQGSFGKIYIIKQVKTGLLFAAKLENSDAPIPQLLFESRLYQIMSGS----TNVPRLHAHSFDS-------RYNTIVIDLLGK-SLEEHLNKV . .||.| | ||..| . . | | ..|| . | . . .||. |. ||.. .. || . . .| ..| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREA-RIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH NRRMSLKTVLMLVDQMITAVEFFHSKNYIHRDIKPDNFVMGVNQNSNKLYIIDYGLAKKYRDV-NTHEHIPYIEGK---SLT--GTARYASINAL-LG-- .. ..|. | | |. ||||.||||. | | |. | | ||... | .. | |. | . | .. .. | RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF -------------------CEQSRRDD----MEAIGYVIVYLLKGHLPWMGIDGA------TNQERYRRIAECKRDTPLE-----KLCEGL ..| .. |... || |. .|. . .. .| |. . .| . | . ..| . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 84800.m00013.AA | VRK | 9-24 | 56 | 0.075957 | 2.2 | In-house | 1-16 (284) | Show / Hide |
Range on Protein: 9-24 Range on HMM: 1-16/284 Sequence Identity: 56% (9 aa) YQIIKKIGQGSFGKIY . . |.|||| || || WRLGKPIGQGGFGCIY |