Gene 88834.m00149 (T.vaginalis)

88834.m00149

Species: T.vaginalis
Alias: 88834.m00149, TvagK0595
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
88834.m00149.AA Protein None 360 None Fasta, JSON
88834.m00149.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 88834.m00149.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88834.m00149.AA MAPK 20-311 46 2.1e-160 539.21 In-house 1-328 (328) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-328/328
Sequence Identity: 46% (151 aa)

YQFKRLLGRGAYGVVFAAKDKQ------TGKLVAVKRVERIFETTLDAKRCLREVCILSHL-KHENITNLIDVTAN------PDYSKFESLIVVMDLMET
||  . .| ||||||..|.||       .|| ||.|...| |......|| .||. .| |. .|||| .|.|.         .. ..|. . .||.||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLYQIINSHQPITVDHHRFFIYQVLRG--LKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDSE------------FLSEYVATRWYRPP
||.|||.| || . || ..|.||.|||  ||.||||||.||||||||.|||.||||||.||||||.  |..  .            ...||||||||| |
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVLLN--YETYGPQLDVWSVGCILAELIL-RKPLFPGRSTTNQISLIVDIIGSPSEEDLASCP-SKNAVRYVKGL---GPKPKIPWKQIFRGKQ--FDDQ
|..||  .  |  . |.||||||.||..  |||||||... .|. ||....|.||||..   . |..|  |...|    ..||.||...| .     ..|
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

EIDLVDRMLTWNPDKRITVDEALEHPFM
 |||...||...|||||||.|||.||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 88834.m00149.AA ERK 20-311 50 2.9e-156 525.42 In-house 1-307 (307) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-307/307
Sequence Identity: 50% (156 aa)

YQFKRLLGRGAYGVVFAAKDKQ-----TGKLVAVKRVERIFETTLDAKRCLREVCILSHLK-HENITNLIDVTANPDYS-KFESLIVVMDLMETDLYQII
||.  ..|.||||||..|.||      ||. ||.| .|..|......|| |||  .| |.| ||||..|.|.   |... ... . .| .|||||| |||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMM-PNSPEQYNDIYCVEELMETDLHQII

NSHQPITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDS------EFLSEYVATRWYRPPEVLLNYETYGPQLD
|| |... ||  .|.|| |.|||.||||||.||||||||.|||||||||| ||||||.  .. ..      .|..|||||||||.||..|... |    |
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

VWSVGCILAELILRKPLFPGRSTTNQISLIVDIIGSP-SEEDLASCPSKNAVRYVKGLGP--KPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVD
.||.|||.||.. |||||||... .||..| .|||.| |||||   .|.||  |.| |.   .|..||. ||       | ||| ..||...|||||||.
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

EALEHPFM
|.||||. 
ECLEHPYF
Kinase 88834.m00149.AA CMGC 20-311 24 3.9e-133 440.25 In-house 1-513 (513) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-513/513
Sequence Identity: 24% (129 aa)

YQFKRLLGRGAYGVVFAAKDKQTG--------------KLVAVKRVERIFETTLDAK----------RCLREVCILSHLK-----------------HEN
|.  . .|.|.||||. ..||.|.              ..||.|.. . |  . .||          |.|||. || ||.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

ITNLIDVTANPD-------------YSKFESLIVVMDLMETDLYQIINSHQP----------------------------ITVDHHRFFIYQVLRGLK--
| .|.|.   ..               .|..|  |...|..||||.| ..|.                            ... | | ..||.|||||  
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FIHSAN--VLHRDLKPSNLLVNSNCDL--------------------KIGDFGLAR-ISQPDED------------------SEFLSEYVATRWYRPPEV
..||..  ..||||||.|.|.|.||.|                    ||.|||||| .......                  ......||.|||||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

LLNYETY---------GPQLDVWSVGCILAELILR--------KPLFP-----------GRSTTNQISLIVDIIGSP----------------SEEDLAS
||... |         ... |.||||||.||....        |||||           |.|. .|. .|....|.|                .||.   
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

CP--------------------SKNAVRYVKG---LGPKPKIPWKQIFRGKQF---------------------------------DDQEIDLVDRMLTW
 .                    |. | .|..    ....|..|||..| ....                                 |.| |||...||..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

NPDKRITVDEALEHPFM
.||||||...||.||. 
DPDKRITAEQALQHPYF
Kinase 88834.m00149.AA p38 20-311 42 8.49999999999e-118 397.65 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-289/289
Sequence Identity: 42% (127 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKL---VAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDV-TA-NPDYSKFESLIVVMDLMETDLYQIINS
||. . .| |||| | .| |..||.    ||.|.  | |.....|||  ||.  | |..|||.  |.|| |  . . . |.   .|. .|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

HQPITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDSEFLSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCIL
 . .. || .| .||.|||||.||||.. ||||||||. || .|.|.| ||||||      |.| . .|||||||| ||..||   |    |.||||||.
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDE-MTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIM

AELILRKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
|||| ...||||    .|.  |. ..|.|.|| ..   |..|  |.... . |.   ...|.  . . |.||| ..||   ||||||. ||..||..
AELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFM--GANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 88834.m00149.AA ERK5 20-311 44 2.6e-116 392.72 In-house 1-295 (295) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-295/295
Sequence Identity: 44% (133 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDV-TANPDYSKFESLIVVMDLMETDLYQIINSHQPI
|.    .| |||||| .|. ...|. ||.|..   |.    ||| .||. || | .|.||  . |.      || . .  ||.|||| || ||| | ||.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLAR-ISQ--PDEDSEFLSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCILA
|..| |.|.||.|||||..|||.|.|||||||||||| ||.|||||||.|| ..   ||.   |. ||||||||| ||...  . |   .||||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELILRKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKG-LGPKPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
|.| |. .|||.   .|..||....| |.   . .  .     |..  . ..   .|.... .   | | .||. ||| . | .|||| .|| |||.
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPK--ADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 88834.m00149.AA ERK1 20-311 49 3e-114 385.85 In-house 1-289 (289) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-289/289
Sequence Identity: 49% (144 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDVTANPDYSKFESLIVVMDLMETDLYQIINSHQPIT
|   . .| ||||.| .| |. ... ||.|..   ||     .| |||. ||   ||||| |. |.   .   ..  . .| .|||||||... . |.. 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

VDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDED-SEFLSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCILAELI
 ||  .|.||.|||||.|||||||||||||||||.|  ||||| |||||||. |. |   || ||||||||| ||..||   |   .|.|||||||||..
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

LRKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
  .|.|||.    |. .|. ..||||..||     . |  |...|  |||.||...|   . | . .||.|.|||.||.|||||.||| ||..
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFP--KADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 88834.m00149.AA ERK7 20-311 41 3e-107 362.63 In-house 1-292 (292) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-292/292
Sequence Identity: 41% (125 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHLK-HENITNLIDV-TANPDYSKFESLIVVMDLMETDLYQIINSHQP
|. .. ||.||||.|  | ||.|.. ||.|..   |    || |  ||. .|  .. |.||  ||.|  |. |      . .| . |||||  .|   . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND----RDIYLVFEFMETDLHAVIRKGNI

ITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLAR-ISQPD---EDSEFLSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCI
.   | .. .||.|| .|..||.||.||||||||.|..|.| .|. |||||| |.| .   |.   | ||||||||| ||.||  ..| .  | ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LAELILRKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
|.|..  ||.||| || ||| .|...|. |..||...  |. |.  .. .. ... . .|...  |  |. |||. |.|  ||.||.|...||.||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 88834.m00149.AA CDK 20-311 32 2.3e-104 334.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-284/284
Sequence Identity: 32% (104 aa)

YQFKRLLGRGAYGVVFAAKDKQTG-----KLVAVKRVERIF-----ETTLDAKRCLREVCILSHLKHENITNLIDVTANP----DYSKF---ESLIVVMD
|.    .|.|.||||. |.|||||     ..|| |..         | .      .||...| .| |.|| .|.||        .  |.    .|  |..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

LMETDLYQIINSHQPITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCD-----LKIGDFGLARISQP----DED-SEFLSEYVATRWYRPP
 |..||....           . ...| |||| ..|| ...||||||.|.|.|.|       |||.||||||. .     . . .  ..  | |.|||.|
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAP

EVLLNYETYG--PQLDVWSVGCILAELIL---RKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDL
|.||  ..|.  .. |.||||||.||...   |||||||.| ..|. .| .|.|.|.|..  .. .                                ||
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------DL

VDRMLTWNPDKRITVDEALEHPFM
 ..||. .|.|||. ..||.||. 
LNKMLCYDPKKRISAEQALQHPYF
Kinase 88834.m00149.AA S_TKc 20-311 28 3.3e-100 340.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-311
Range on HMM: 1-231/231
Sequence Identity: 28% (87 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDVTANPDYSKFESLIVVMDLMET---DLYQIINSHQ
|.. |..|.||.|.|. ...| ||..||.|..          .. .||. ||.. .|.|| .|.||  .      ..| .||.....   ||...| ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

P------ITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDSEFLSEYVATRWYRPPEVLLNYETYGP-QLDVWS
.      ..  | ||..||....|...|| ...||||||.|.|...   .||.||||||.          . .. |.||..||||     ||.   |.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWS

VGCILAELILRKPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDLVDRMLTWNPDKRITVDEALE--
.||||.|.. ..|.||      |. .. ..||                                       ... .|.....|...|.||.|. |||.  
CGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPFM
     ||..
WDIKCHPWF
Kinase 88834.m00149.AA nmo 21-311 40 7.8e-99 304.59 In-house 2-292 (292) Show / Hide 
Range on Protein: 21-311
Range on HMM: 2-292/292
Sequence Identity: 40% (119 aa)

QFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDVTANPDYSKFESLIVVMDLMETDLYQIINSHQPITV
|  | .| ||.|||..  |   || ||.|..  .|   . .||  ||. .|.  ||.|.  . |.   |. . |. . || .||  || .|| | |... 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDSEFLSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCILAELILR
|| . |.||.|||||..||||.||||.|| |||||||| ||| ||||||. ..|.  .   | | | .|| ||.|.    |   .|.|||||| |||. |
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQE-VVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

KPLFPGRSTTNQISLIVDIIGSPSEEDLASCPSKNAVRYVKGLGPKPKIPWKQIFRG-KQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
. ||  .|  .|. .|.|..| || ||.           ...   .|...         .     ..|. ||| ..||||| . .||.||..
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 88834.m00149.AA Pkinase 20-247 33 2.7e-78 271.23 Pfam 1-238 (293) Show / Hide 
Range on Protein: 20-247
Range on HMM: 1-238/293
Sequence Identity: 33% (83 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLR--EVCILSHLKHENITNLIDVTANPDYSKFESLIVVMDLMET-----DLYQII
|...| .|.|..|.|. ...| |||.||||....  |     .. .|  |..|. .|.|.||  |.|.  .       .. .||...|      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

N--SHQPI--TVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDL----KIGDFGLARISQPDEDSEFLSEYVATRWYRPPEVLLNYETYGPQ
   .| ..  . .. .|..||.||||...|| ...||||||.|.|...|...    ||.|||||.  .    .. .. .. |.||..|||.. .. ||| 
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

LDVWSVGCILAELILRKPLFPGR----STTNQISLIVDIIGSPSEED
 |.||.||||.|.....|.|||.    .  .|. .|. | | | ..|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFD
Kinase 88834.m00149.AA MAPK-Unclassified 20-169 45 2.1e-68 233.57 In-house 1-157 (575) Show / Hide 
Range on Protein: 20-169
Range on HMM: 1-157/575
Sequence Identity: 45% (72 aa)

YQFKRLLGRGAYGVVFAAKDKQT-GKLVAVKRVERIFETTLDAKRCLREVCILSHLKHENITNLIDVTANPDYSK--FESLIVVMDLMET---DLYQIIN
|  . ..| ||||.|  |.||.. .. || |.| .||..  |.|| |||. || .| |.|| .. |.  | . .   |  . .|||.|.|   ||.||| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SHQ-PITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLAR
| | .    | . |.|| ||||| .|||...||||||||||.| .| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 88834.m00149.AA MAPK-Unclassified 180-311 33 8.1e-52 178.46 In-house 405-575 (575) Show / Hide 
Range on Protein: 180-311
Range on HMM: 405-575/575
Sequence Identity: 33% (57 aa)

LSEYVATRWYRPPEVLLNYETYGPQLDVWSVGCILAELILR-----------KPLFPGRS--------------------TTNQISLIVDIIGSPSEEDL
...||.||||| || .|    |. | | ||.|||.||....           .|||||..                       || .|.|  |.| |||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

ASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQF-DD-------QEIDLVDRMLTWNPDKRITVDEALEHPFM
    . .|. |......|. .......  |   ||       ..||.|. ||  || |||| |.|||||..
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 88834.m00149.AA Pkinase_Tyr 20-209 28 5.8e-16 54.69 Pfam 1-199 (270) Show / Hide 
Range on Protein: 20-209
Range on HMM: 1-199/270
Sequence Identity: 28% (60 aa)

YQFKRLLGRGAYGVVFAAKDK----QTGKLVAVKRVERIFETTLDA---KRCLREVCILSHL-KHENITNLIDVTANPDYSKFES--LIVVMDLMET-DL
 .| . ||.||.|.|. .. |    .|.  |||| .     .. ..   .  .||. |...| .|.|| .|. |      .. |.  ...|| .|.  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT----DQGEPNQIYIVMEYMPHGDL

YQIINSH----QPITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPDEDS-EFLS-EYVATRWYRPPEVLLNYETYG
.    .|    ||.|. .   . .|. .|. . .| |  ||||   | ||..|   ||.||||||  ..|.      .   .  .|. .||.. ... . 
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-FT

PQLDVWS
 . ||||
TKSDVWS
Kinase 88834.m00149.AA TyrKc 20-314 23 2.4e-14 9.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-314
Range on HMM: 1-280/280
Sequence Identity: 23% (76 aa)

YQFKRLLGRGAYGVVFAAKDKQTGKLVAVKRVERIFETTLDAKRCLREVCILSHL--KHENITNLIDVTANPDYSKF---ESLIVVMDLMET-DLYQIIN
 .... ||.||.|.|. .. |     |||| .          .  .||  |...|  .|.|| .|. |   .    |   | | .|| .|.  || . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SHQP-ITVDHHRFFIYQVLRGLKFIHSANVLHRDLKPSNLLVNSNCDLKIGDFGLARISQPD-------EDSEF----LSEY-VATRWYRPPEVLLNYET
.|.| .....   | .|. .|  ..|| |. ||||   | ||..|   ||.||||.|    |       .         . . .  ||. .||.. || .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGK

YGPQLDVWSVGCILAELI-LRKPLFPG-----RSTTNQISLIVDIIGSPSEED---LASCPSKNAVRYVKGLGPKPKIPWKQIFRGKQFDDQEIDLVDRM
. .. |||| |  . |.  . ..  ||      | .  | .. .    |  ..   ..                              |     .. . |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------FVCCPDEMYQIM

LT---WNPDKRITVDEALEHPFMEKL
..    .|..| |  |       |..
KQCWHEDPEDRPTFSEI-----HECF
Kinase 88834.m00149.AA Pkinase 257-311 17 2.1e-09 34.3 Pfam 225-293 (293) Show / Hide 
Range on Protein: 257-311
Range on HMM: 225-293/293
Sequence Identity: 17% (12 aa)

VRYVKGLGPKPKIPWKQI---------------FRGKQFDDQEIDLVDRMLTWNPDKRITVDEALEHPFM
..... .||... .| .                .. .  ..  .|.....|...| ||.| ...|.||..
QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF