Gene 80596.m00224 (T.vaginalis)

80596.m00224

Species: T.vaginalis
Alias: 80596.m00224, TvagK0895
External Links:
Annotation:

Classification

Group: Other
Family: Uni1

Sequence

Name Sequence Type Origin Length Description Download
80596.m00224.AA Protein None 1370 None Fasta, JSON
80596.m00224.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of 80596.m00224.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 80596.m00224.AA S_TKc 1083-1356 20 4.2e-27 97.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 1083-1356
Range on HMM: 1-231/231
Sequence Identity: 20% (61 aa)

YNNGQHIASGAFGAVMKVGNLA------VKILPKSRNEFDNPHLYEVYHEVTILELCKGDRRVTQLVDYGCTSDSYYIVMEFYPA---TLRSWRKSEGE-
|  ...| .|||| |.|. .        .||..             .. |. ||.   .   . .| |.  . |..|.|||. .    .|..  |. |  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----KPLGVMLRLFRDFLESATVLSNRHINHFDIKCDNVMLDVTGKCALADFGESMCYVDEQNGYSMLNKGTEWIKSPEMLSIALNSALTNPNFDRRQK
      |  .  ....  ..    . ...| | |.| .|..||      ..||| .  .        .   || |  .||.|                  
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL------------------

QGAGP-ASDVWSIGCLFYELLTGEFLFVDNDWSRFFLRITDPNQPLITEKDIKRLPNDVRLVPFIEFILKRSERHRPNIQQIIT-----KFDEMF
 | |. ..|.||.||..||.|.|. .|   .  . | .|                  .  .  ||. .|..  ..|| . .. .     | .. |
-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 80596.m00224.AA STE 1083-1290 17 2.9e-15 50.48 In-house 1-265 (359) Show / Hide 
Range on Protein: 1083-1290
Range on HMM: 1-265/359
Sequence Identity: 17% (49 aa)

YNNGQHIASGAFGAVMKV-------GN--------------LAVKILPKSRNEFDNPH--------------LYEVYHEVTILELCKG-DRRVTQLVDYG
. . . | .|||| | |        ..               |.|........  . .              . .. .|. |.  |.     . .  .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

CTS-------DSYYIVMEFYPA-TLRSWRKS--EGEKP------------LGVMLRLFRDFLES-ATVLSNRHINHFDIKCDNVMLDVTGKCALADFGES
          |. .|.||. .. .|..  |.  .  ||              .  .  |. |.     | . || | |||..|..|     . |.||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

MCYVDE--------------QNG-YSMLNKGTEWIKSPEMLSIALNSALTNPNFDRRQKQGAGPASDVWSIGCLFYELLTGE
 . .|.               ..  .    ||    .||...   ..           ..| .  .|.||.||.  |..||.
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---------DKGYDTKCDIWSLGCTIIEMATGK
Kinase 80596.m00224.AA Ciliate-E2 1192-1293 21 7.4e-13 40.45 In-house 176-296 (365) Show / Hide 
Range on Protein: 1192-1293
Range on HMM: 176-296/365
Sequence Identity: 21% (30 aa)

LSNRH-INHFDIKCDNVMLDVTGKCALADFGESMCYVDEQN--------GYSMLNK-----------------------GTEWIKSPEMLSIAL---NSA
| ... | | ||| .|...     . ..||| |  | |...        .  |  |                       ||   ..||.|.      .  
LHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ--

LTNPNFDRRQKQGAGPASDVWSIGCLFYELLTGEFLF
         ...| . ..|.||.|...||.|.|.. |
--------QKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase 80596.m00224.AA Ciliate-E2-Unclassified 1193-1297 23 3e-12 38.81 In-house 161-274 (352) Show / Hide 
Range on Protein: 1193-1297
Range on HMM: 161-274/352
Sequence Identity: 23% (30 aa)

SNRHINHFDIKCDNVMLDVTG---KCALADFGESM-------CYVDEQ--------NGYSMLNKGTEWIK----SPEMLSIALNSALTNPNFDRRQKQGA
.. .| | |||..|...|  |   .. ..||| |.       |. ..|        .  .  . ||   .    .||.|    ..  .            
HKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----------

GPASDVWSIGCLFYELLTGEFLFVDND
  ..|.|| |...||.|.|.. | ||.
-YKCDIWSLGVILYEMLFGYYPFYDNN
Kinase 80596.m00224.AA Pkinase 1201-1293 26 1.7e-10 38.23 Pfam 133-212 (293) Show / Hide 
Range on Protein: 1201-1293
Range on HMM: 133-212/293
Sequence Identity: 26% (26 aa)

DIKCDNVMLDVTGKC----ALADFGESMCY-VDEQNGYSMLNKGTEWIKSPEMLSIALNSALTNPNFDRRQKQGAGPASDVWSIGCLFYELLTGEFLF
|.| .|...| .| .     ..||| . ..    .  .. .  || |  .|| .                  |. ||..|.||.||..||.|.|...|
DLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR---------------GGQYYGPKVDMWSCGCILYEMLCGRPPF
Kinase 80596.m00224.AA AGC 1245-1297 30 2.5e-10 21.41 In-house 275-309 (395) Show / Hide 
Range on Protein: 1245-1297
Range on HMM: 275-309/395
Sequence Identity: 30% (17 aa)

SPEMLSIALNSALTNPNFDRRQKQGAGPASDVWS--IGCLFYELLTGEFLFVDND
.||.|                     |.| | ||   |||.||.|||   | ...
APEIL--------------------YGKACDWWSFGLGCLMYEMLTGYPPFYGDN
Kinase 80596.m00224.AA GEK 1199-1290 38 1.7e-09 27.62 In-house 123-203 (269) Show / Hide 
Range on Protein: 1199-1290
Range on HMM: 123-203/269
Sequence Identity: 38% (35 aa)

HFDIKCDNVMLDVTGKCALADFGESMCYVDEQNGYSMLNKGTEWIKSPEMLSIALNSALTNPNFDRRQKQGAGPASDVWSIGCLFYELLTGE
| ||| |||.||. |   |||||  .   ..    |    ||    |||.|  |..            |   ||  | ||.| . ||.| ||
HRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQ-AMEDG----------KGRYGPECDWWSLGVCMYEMLYGE
Kinase 80596.m00224.AA SRPK 1271-1293 43 2.8e-08 15.83 In-house 430-452 (554) Show / Hide 
Range on Protein: 1271-1293
Range on HMM: 430-452/554
Sequence Identity: 43% (10 aa)

GPASDVWSIGCLFYELLTGEFLF
..  |.||  |. .||.|| .||
NTPADIWSTACMAFELATGDYLF
Kinase 80596.m00224.AA CMGC 1271-1293 35 6.4e-08 21.14 In-house 313-343 (513) Show / Hide 
Range on Protein: 1271-1293
Range on HMM: 313-343/513
Sequence Identity: 35% (11 aa)

GPASDVWSIGCLFYELLTG--------EFLF
... |.||.|| |.|..||        . ||
TTPIDMWSVGCIFAEMYTGYQSLIFRGKPLF
Kinase 80596.m00224.AA CAMK 1194-1291 18 1.6e-07 19.58 In-house 197-332 (425) Show / Hide 
Range on Protein: 1194-1291
Range on HMM: 197-332/425
Sequence Identity: 18% (26 aa)

NRHINHFDIKCDNVMLDVT-----------------GKCALADFGESMCYV-DEQNGYSMLNKGTEWIKSP--------EMLSIALNSALTN--PNFDRR
...| | |.|..|..||                   ..  ..||| .  .  .|.| . . .|| | . .         ....    .      |   ..
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

Q------------KQGAGPASDVWSIGCLFYELLTGEF
.            |.. ||..|.||.|.. | .|.|..
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase 80596.m00224.AA CAMK 1088-1158 12 9.9e-07 16.95 In-house 1-141 (425) Show / Hide 
Range on Protein: 1088-1158
Range on HMM: 1-141/425
Sequence Identity: 12% (18 aa)

HIASGAFGAVMKVGNL------------------AVKILPKSRNEFDNP------------------------HLYEVYHEVTILELCKG------DRRV
 . .|.|| | .. .                   |.||..|..   ...                         . .|..|. |. ...|       . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

TQLVDYGC------------TSDS--------YYIVM---EF
 .| ..              | .         .|.||   |.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEY
Kinase 80596.m00224.AA CRK7 1270-1293 45 1e-06 18.57 In-house 230-253 (343) Show / Hide 
Range on Protein: 1270-1293
Range on HMM: 230-253/343
Sequence Identity: 45% (11 aa)

AGPASDVWSIGCLFYELLTGEFLF
.||. |.|| ||.. ||.|.. .|
SGPEIDMWSCGCILGELFTKKPIF
Kinase 80596.m00224.AA TyrKc 1083-1352 16 2e-06 -118.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 1083-1352
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

YNNGQHIASGAFGAVMKVGNL---AVKILPKSRNEFDNPHLYEVYHEVTILELC-KGDRRVTQLVDYGCTS-------DSYYIVMEFYPA-TLRSWRKSE
   |. . .|||| |.|       ||| | ..        . . ..|  |.    .    . .|. .  ..       . ..||||. |   |..  .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GEKPLGVMLRLFRDFLESATV----LSNRHINHFDIKCDNVMLDVTGKCALADFGESMCYVDEQ------NGYSMLNK--GTE------WIKSPEMLSIA
..|   . .. . .|   .      |. ... | |. . |....  . .  .||| |  ....         | .  .  |.       |  .|| .   
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI---

LNSALTNPNFDRRQKQGAGPASDVWSIGCLFYELLTGEFLFVDN------DWSRFFLRITDPNQPLITEKDIKRLP-----NDVRLVPFIEFILKRSERH
 |    .            ..||||| | . .|..|       .      .... . .. . . . . . |    |         .   ..   ..    
-NYGKFT------------TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPED

RPNIQQIITKF
||. ..|. .|
RPTFSEIHECF
Kinase 80596.m00224.AA ULK 1274-1290 58 4e-06 17.89 In-house 233-249 (324) Show / Hide 
Range on Protein: 1274-1290
Range on HMM: 233-249/324
Sequence Identity: 58% (10 aa)

SDVWSIGCLFYELLTGE
.|.||.||.|||.|.|.
CDIWSLGCIFYEMLYGK
Kinase 80596.m00224.AA CMGC 1083-1221 11 9.1e-05 10.58 In-house 1-249 (513) Show / Hide 
Range on Protein: 1083-1221
Range on HMM: 1-249/513
Sequence Identity: 11% (30 aa)

YNNGQHIASGAFGAVMKVGN--------------------LAVKILPKSRNEFDNPHLYE-----------VYHEVTILELCK---------------GD
| . . | .|..| | |  .                     |.|..   .|.| ...               . |. ||.  .                .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKI---KNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKH

RR-VTQLVDYGCTSD-----------------SYYIVMEFYPATLRSWRKSEGE-----KPLGV---------------MLRLF------RDFLES--AT
.  . .| |.  ...                 . |.|.|. . .|    |.        .|..                   ..      .  |..    
HNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

VLSNRH--INHFDIKCDNVMLDVTGKC--------------------ALADFG
 .  .   | | |.|  |.... ....                     ..|||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 80596.m00224.AA AGC 1083-1160 22 0.000402 4.97 In-house 1-116 (395) Show / Hide 
Range on Protein: 1083-1160
Range on HMM: 1-116/395
Sequence Identity: 22% (26 aa)

YNNGQHIASGAFGAVMKV-----------GNL-AVKILPKSR-----NEFDNPH-LYE--------VYHEVTILELCKG---------DRRVTQ-LVDYG
..   .|  |.|| |. |           | . |.|.| |..     .. .  | . |        |  |  |||.|..            ... |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

CTSDS--YYIVMEFYP
 . |    |.|||..|
QDKDHTYLYFVMEYMP
Kinase 80596.m00224.AA ULK 1141-1221 22 0.000416 10.54 In-house 79-183 (324) Show / Hide 
Range on Protein: 1141-1221
Range on HMM: 79-183/324
Sequence Identity: 22% (24 aa)

QLVDYGCTSDS--YYIVMEFYPA-TLRSWRKSEGEKPLGV----------MLRLFRDFLESATVLSNRHINHFDIKCDNVMLDV-TGK-----------C
.| |.  ||..  .||.||. .  .|..  |  ...|. .           .  |.....    | .. | | ||| .| ..   ..|           .
KLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVL

ALADFG
 .||||
KIADFG
Kinase 80596.m00224.AA AGC 1201-1221 45 0.001592 3.39 In-house 179-200 (395) Show / Hide 
Range on Protein: 1201-1221
Range on HMM: 179-200/395
Sequence Identity: 45% (10 aa)

D-IKCDNVMLDVTGKCALADFG
| .| .|..||  | . |.|||
DYLKPENILLDEDGHIKLTDFG
Kinase 80596.m00224.AA CRK7 1199-1221 47 0.007271 5.48 In-house 135-157 (343) Show / Hide 
Range on Protein: 1199-1221
Range on HMM: 135-157/343
Sequence Identity: 47% (11 aa)

HFDIKCDNVMLDVTGKCALADFG
| |||| |. ..  |.  .||||
HRDIKCSNILMNNQGEVKIADFG
Kinase 80596.m00224.AA Pkinase 1083-1163 27 0.010078 10.71 Pfam 1-86 (293) Show / Hide 
Range on Protein: 1083-1163
Range on HMM: 1-86/293
Sequence Identity: 27% (24 aa)

YNNGQHIASGAFGAV---MKVGN---LAVKILPKSRNEFDNPHLYEVYHEVTILELCKGDRRVTQLVDYGCTSDSYYIVMEFYPATL
|  |. | ||.|| |   ...|.    ||||..|.... . .       |. |.  .. .  . .| |.  ..|..|.|||. . .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGL