Gene 89386.m00160 (T.vaginalis)

89386.m00160

Species: T.vaginalis
Alias: TvagK0545, 89386.m00160
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
89386.m00160.AA Protein None 333 None Fasta, JSON
89386.m00160.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of 89386.m00160.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 89386.m00160.AA S_TKc 24-279 32 4.7e-77 263.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQIFCYLENELRLISRFDHPNIVKVYDIIYEEDIIMVVMEYLEC--GDLQKLVSQGIF---
| |...||||.|..| ...| |||..||||||.          . ...|... .. .|||||| ||.... | . .||||..   ||| ..  .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYNPKLIDFGLSRENCNALKTLCGTTDYLAPEVLRMKEYDGKKADLWSLGIVLHILSS
   |.  .   .. ||..|| |.|..|| |||.||||||.|.  . |..||||.|.     .|.||| .|.|||||    |...|.| ||.|..| .. .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

NAFPFDITSEISHINKLQNNTLILNILTPGKLGMVIKSCLEFNQNLRLDCDELIK--MLEESRPIF
   ||.      ..... .. .     .|  .   |. ||... . |. . |. .  ..  . | |
GYPPFP------QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89386.m00160.AA CAMKL 24-221 36 2.1e-74 236.81 In-house 1-237 (297) Show / Hide 
Range on Protein: 24-221
Range on HMM: 1-237/297
Sequence Identity: 36% (86 aa)

YNIVKTIGKGGFSVVVLGVH-QKTGQKVAIKIIDREEVS-KQQIFCY-----------LENELRLISRFD---HPNIVKVYDIIYEEDI------IMVVM
|.|.||.|||.|..| |..| . ||.||||||||..  . .... .            .. | .. ....   ||||.| |..|. ..       |  ||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYLECGD--LQKLVSQGIF----FNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYY--NPKLIDFGLSRE---N----CNALKTLCGTTDYL
|| . |.  |.  . .       .  ||   .  ||.||..|.|..||.||||||||||.|.    | |.||||.| .   .     . ||| ||.  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLRM--KEYDGKKADLWSLGIVLHILSSNAFPFD
|||..    |.|||.|.| ||.|..|  .   ..|||
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFD
Kinase 89386.m00160.AA CAMK 29-270 20 2.4e-74 238.77 In-house 1-421 (425) Show / Hide 
Range on Protein: 29-270
Range on HMM: 1-421/425
Sequence Identity: 20% (87 aa)

TIGKGGFSVVVLGVHQKTG------------QKVAIKIIDREEVSK-------------------------QQIFCYLENELRLISR-------FDHPNI
|.|.|.|..| |..| .|.            |||||||||.. ...                         ..    ...|... ..        |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVYDIIY--------------------EEDIIMVV--MEYLECG----D-LQKLVSQG--------------IFFNCHEQITIALQILSALSYLHKRGI
.| |...                     .....||   ||| . |    | ....|..|                |. .|  ..  ||.||. |.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDIKPENILFDKY-----------------YNPKLIDFGLSRENCN--------------------------ALKTLCGTTDYLA-PEVLRM------
.|||.||||||.|.                  .| |.||||....                              .|| |||  | | ||||.       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KEYDGKKADLWSLGIVLHILSSNAFPFD---------------ITSEISHINKLQNNTLILNILTPGK----------------------LGM
       |.|.|.|.| ||.|..| |. .  .||.                 .|. .  .  . . .   ..|                           
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VIKSCLEFNQNLRLDCDELIK
 |...|. . . |. ...  .
LIRKMLQVDPEKRMTIEQCLN
Pkinase 89386.m00160.AA Pkinase 24-272 29 5.4e-74 256.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-272
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQ------IFCYLENELRLISRFDHPNIVKVYDIIYEEDIIMVVMEYLECG----DLQKLV
| |...||.|.|..| ...|..||..||.|||.... ....      .     .|...  |..|||||. ||. ...| | .||||.|.|    ||  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

S--QGIFF--NCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYNP----KLIDFGLSR---ENCNALKTLCGTTDYLAPEVLRMKEYDGKKAD
|  ..  |    .| . ...|||..| |.|..|| |||.||||||.|. ...    |..||||..   .  | ..|.||| .|.||||.|  .|.|.|.|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVD

LWSLGIVLHILSSNAFPFDIT------SEISHINKLQNNTLILNILTP---------------------GKLGMVIKSCLEFNQNLRLDCDELIKM--L
 ||.|..|... .  .||.        ...  |..     |  .. ..                       .  .||.||... . |. .... .   .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 89386.m00160.AA Ciliate-E2 24-270 23 1.1e-62 214.04 In-house 1-361 (365) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-361/365
Sequence Identity: 23% (88 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQ------------------KVAIKIIDREEVSKQQIFCYLENELRLI----------------SRFDHPNIVKVYD
|...| ||.|.|..| .. . |...                  ||.|||.  . ..|.||. ....|....                .. .||||.| |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIE-QIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

IIY--EEDIIMVVMEYLECGDLQKLVSQG-IFFNCH----------EQITIALQILS---------------ALSYLHKRG-IAHRDIKPENILFDKYYN
  .   .. |  ||||.. |||...  .  ...|..          | ..|  |||.               || |||... | |||||||||||     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

PKLIDFGLSR----ENC------------------------------NALKTLCGTTDYLAPEVLRMKEYDG--------KKADLWSLGIVLHILSSNAF
.|.||||||.    .|.                              |  .|.|||  |.|||.|..|.||.        .|.|.||||..|... .. .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFDITSEISHINKLQNNTLILNIL---TPGKLGMV-----------------IKS----CLEFNQNLRLD-CDELIK
||        ... ... . ..      . .. ..                 ||     .|. ... |..  .....
PF--------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 89386.m00160.AA AMPK 24-221 38 1.4e-61 181.59 In-house 1-201 (254) Show / Hide 
Range on Protein: 24-221
Range on HMM: 1-201/254
Sequence Identity: 38% (77 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQIFCYLENELRLISRFDHPNIVKVYDII-YEEDIIMVVMEYLECGDLQKLVSQGIFFNCH
| | ||||.| |  | .|.|. ||.||||||....   .|.    ...|...   | ||.|.. |..|   .. | .||||   |.|   . .    . .
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYNPKLIDFGLSR--ENCNALKTLCGTTDYLAPEVLRMKEYDGKKADLWSLGIVLHILSSNAFPF
|      ||.|...|.|. .|.||| ||||.|.|. .| |. |||||   .  . ||| ||   | |||.   | | | . |.|| |..|  .     ||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

D
|
D
Kinase 89386.m00160.AA Ciliate-E2-Unclassified 24-270 24 4.3e-59 202.64 In-house 1-348 (352) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-348/352
Sequence Identity: 24% (86 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKV-----AIKIIDREEVSKQQIFCYLENELRLISRFD-----------------HPNIVKVYDIIYEEDI--IMV
|.|.|.||.|||..| . .| |.. ..     ..||...   ....    . ||.  . .                   ||....|... ...|   |  
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYLECGDLQKLVSQGIF-----------------FNCHEQI-----TIALQILSALSYLHKRG-IAHRDIKPENILFDKYY---NPKLIDFGLSRENC
||||.| |||..  ..  .                 | . . .     ... |||..|.|||. . | ||||||||||||.     ..|.||||.|... 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

NA------------------LKTLCGTTDYL----APEVLRMKEYDG---KKADLWSLGIVLHILSSNAFPF-DITSEI----------------SHINK
.                   ..| |||  |.    |||||. ..||.   .|.| ||||..|. .  . .|| | ..|.                 . |.
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LQNNTLILNIL-------TPGKLGMVIK----SCLEFNQNLRLDCDELIK
.|.|. . .          . .    |.    ..|. |.| |.. .....
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 89386.m00160.AA QIK 24-221 38 1.9e-57 197.19 In-house 1-219 (272) Show / Hide 
Range on Protein: 24-221
Range on HMM: 1-219/272
Sequence Identity: 38% (84 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQIFCYLENELRLISRFDHPNIVKVYDIIYEEDIIMVVMEYLECGDL-QKLVSQGI-----
| | .||||| | || |. |  | .||||||||..   ..  .  .. |  .. . .||.|.| |...  .| . .|.|| . |..   |...|      
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEEN-LQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

--------------FFNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYNPKLIDFGLS--RENCNALKTLCGTTDYLAPEVLRMKEYDGKKA
                .  |   .  ||.||  |.|||.|.|||.| ||||.|.  | |..|||.|   ..   |.| ||.  | |||..  ||||| |.
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DLWSLGIVLHILSSNAFPFD
| ||.|.|| .| . |.|||
DIWSMGVVLYVLVCGALPFD
Kinase 89386.m00160.AA ULK 24-211 29 3.8e-57 196.16 In-house 1-243 (324) Show / Hide 
Range on Protein: 24-211
Range on HMM: 1-243/324
Sequence Identity: 29% (71 aa)

YNIVKTIGKGGFS-VVVLGVHQKT---GQKVAIKIIDREEVSK-------QQIFCYLENELRLISRFD---HPN--IVKVYDIIYEEDI--IMVVMEYLE
|.. . .||| |  .|  | ..||   .|.||.|.||. . .|       |.. . |.|| ...  ..   |||  ||| ||. .. .   |  .||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

CGDLQKLVS---------QGIFFNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYN------------PKLIDFGLSRE-NC-----NALKT
.|||...            . ...  | | .  ||.... .|||..| ||||||.|||  .                |. |||...  ..     . ..|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LC------GTTDYLAPEVLR----MKEYDGKKADLWSLGIVLH
..      ||  | ||..|      |.|. .|.|.||||....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY
Kinase 89386.m00160.AA ULK 24-211 28 1.1e-55 191.26 In-house 1-247 (329) Show / Hide 
Range on Protein: 24-211
Range on HMM: 1-247/329
Sequence Identity: 28% (70 aa)

YNIVKTIGKGGFSVVVLGVHQKT----GQKVAIKIIDREEVSKQQ-------IFCYLENELRLISRFD--------HPNIVKVYDIIYEEDI--IMVVME
|.. . .||| | .|  | ..||    ..|||.|.||... ....       . . |.|| ... . .        |||||| ||. .. .   |  .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YLECGDLQKLVS----------QGIFFNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYN------------PKLIDFGLSRE-NCN-----
| . |||... .           . ...  | | .  |||... .|||..| ||||||.||| ..                |. |||...  ...     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

ALKTLC------GTTDYLAPEVLR----MKEYDGKKADLWSLGIVLH
 ..|        ||  | ||..|      |.|. .|.|.||||....
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY
Kinase 89386.m00160.AA TKL 30-272 19 6e-55 188.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 30-272
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

IGKGGFSVVVLGVHQK--------TGQKVAIKIIDREEVSK------------------------QQIFCYLENELRLISRFDHPNIVKVYDIIYEEDI-
||.|||..|  |...         ||. ||.|.. ......                        ....  .|.|....||..|||||. . .  ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------IMVVMEYLECGDLQKLVSQGIFFNCHEQ-ITIALQILSALSYLHK--------RGIAHRDIKPENILFDKYYN--------------P
            .. |||| ..|.|  ..        ..| . .||.| ....|||         ..|.|||.|..||| |. ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLIDFGLSRENCN----------------------ALKTLCGTTDYLAPEVLRMKEYDGKKA---------------DLWSLGIVLHILSSNAFPFD--I
|. ||||||....                      .. | |||. ..||||||..... .|.               | .| ||||  . .   |..   
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

TSEIS---------HINKLQNNTLILN------------ILTPGKLGMVIKSCLEFNQNLRLDCDELIKML
 ...           .. . .. . .               .|  .   .. | . . . |. ..|..| |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 89386.m00160.AA MARK 130-221 52 4.2e-44 142.17 In-house 112-207 (262) Show / Hide 
Range on Protein: 130-221
Range on HMM: 112-207/262
Sequence Identity: 52% (50 aa)

QILSALSYLHKRGIAHRDIKPENILFDKYY--NPKLIDFGLSREN--CNALKTLCGTTDYLAPEVLRMKEYDGKKADLWSLGIVLHILSSNAFPFD
||.||..|.|...|.|||||||||| |.    | |.||||.|..    . |.| |||  | |||..  |.|||.|.| ||||.|| .. .  ||||
QIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD
Kinase 89386.m00160.AA MARK 24-109 37 1.2e-29 94.18 In-house 1-89 (262) Show / Hide 
Range on Protein: 24-109
Range on HMM: 1-89/262
Sequence Identity: 37% (33 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQIFCYLENELRLISRFDHPNIVKVYDIIY--EEDI-IMVVMEYLECGDL
| ..||||.|....| |..|..||.||||||....  .. | .. .. |... .. |||||.| ...|   .|   | ..||| . |.|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGEL
Kinase 89386.m00160.AA Pkinase_Tyr 24-148 24 1.5e-21 73.57 Pfam 1-137 (270) Show / Hide 
Range on Protein: 24-148
Range on HMM: 1-137/270
Sequence Identity: 24% (34 aa)

YNIVKTIGKGGFSVVVLGVHQ----KTGQKVAIKIIDREEVSKQQ-IFCYLENELRLISRF-DHPNIVKVYDIIY-EEDI--IMVVMEYLECGDLQKLVS
  . |..|.| | .|..|.      .|...||.|.. .|  ...| .   . .|... . . .|||||. | ... ...   |..|||| ..||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

Q----GIFFNCHEQITIALQILSALSYLHKRGIAHRDI
.    .  .. .. . ...|| ....||. ... |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 89386.m00160.AA TyrKc 24-272 20 9.4e-16 31.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-272
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YNIVKTIGKGGFSVVVLGVHQKTGQKVAIKIIDREEVSKQQIFCYLENELRLISRF--DHPNIVKVYDIIYEE-------DIIMVVMEYLECGDLQKLV-
    |..| | | .|..|.     ..||.| .  .          . .|.|. ...  .|||||. | .. ..       . .|.|||| . |||..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SQGIFFNCHEQITIALQILSALSYLHKRGIAHRDIKPENILFDKYYNPKLIDFGLSRENCNA--------LKTLCG--TTD------YLAPEVLRMKEYD
. .  ..  . . ...|| .  .|||.... |||.   |.| .. .  |  ||||||.  .          ..  .   ..       .|||... ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

GKKADLWSLGIVLH-ILSSNAFPFDI-----TSEISHINKLQNNTLILNILT---------PGKLGMVIKSCLEFNQNLRLDCDELIKML
  | | || |...  |..  . |         | .  |.....                  | .. ...|.| ... . |    |... .
-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF