Gene 95725.m00244 (T.vaginalis)
95725.m00244
Species: T.vaginalis
Alias: 95725.m00244, TvagK0860
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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95725.m00244.AA | Protein | None | 1065 | None | Fasta, JSON |
95725.m00244.kin_dom | Protein Kinase Domain | None | 206 | None | Fasta, JSON |
Protein domains of 95725.m00244.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 95725.m00244.AA | Ciliate-E2 | 37-265 | 17 | 1.1e-38 | 130.39 | In-house | 44-365 (365) | Show / Hide |
Range on Protein: 37-265 Range on HMM: 44-365/365 Sequence Identity: 17% (62 aa) KNSINYIAIKSI---DIKRQDDAYNLYN-------------FLKDQNHPHILKIYHWYK--TANHFWYYIEYCPGGTLLDLLE----------------- |. |...|.|.. .|. . .... |. |||.|.|.| ... . |.. . ||| ||.|.|... KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFT --QDVRLPESIIK-------IFAVDILDALFYLHTNG-VILKDMQPRNILINECGSLKIADFTRAESIDKP--------QSLNVIVDE------------ . .. . |.. ... |..|| ||| .. .| | | |||. .||.|| . .|.. |. . . EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQ -----------DMIEYLAPELLLENGI--------GSFASDLYSFGALLYRMAAGQVPFKSSLARDPESALFHEAPPLLPGYSNDFN------------- . .|.||| | .. ....|..|.| .||.| |. || . . . IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------------QQQIKQCKIDFPCPEWQKD -------------------DLVQA----LLRKNPATRPQ-WAEVIKHPFW || . .| |.| |.. | ....||. TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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S_TKc | 95725.m00244.AA | S_TKc | 9-265 | 27 | 2.6e-38 | 134.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 9-265 Range on HMM: 1-231/231 Sequence Identity: 27% (75 aa) VQTYTKIGTGRPSPTGEYQPTITYKGRLKNSINYIAIKSIDIKRQDDAYNLYNFLKDQNHPHILKIYHWYKTANHFWYYIEYCPG--GTLLDLLEQDVR- . ||| | . ||.| |.. . ||| |. ..... . || .||.| |.| .. . .|.. |||.| |.|.|.... | YEILRKIGKGAFG--------KVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH -----LPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINECGSLKIADFTRAESIDKPQSLNVIVDEDMI---EYLAPELLLENGIGSFASDLYSF .|| .. .. |..|| |.| .|.| | | |||..| .||.|| | . .. .|.|||.| | | ...| .|. GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GALLYRMAAGQVPFKSSLARDPESALFHEAPPLLPGYSNDFNDLVQALLRKNPATRPQWAEVIK-------HPFW | .|| |..|. || . ..|. | .. |... .|.|.|. || |. . ||. GCILYEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 95725.m00244.AA | STE | 31-265 | 20 | 4.4e-35 | 121.37 | In-house | 15-359 (359) | Show / Hide |
Range on Protein: 31-265 Range on HMM: 15-359/359 Sequence Identity: 20% (74 aa) TYKGRLKN---------------SINYIAIKSIDIKR--------------------QDDAYNLYNFLKDQN--HPHILKIYHWYKTA-------NHFWY .||.. .. . ...||| ..... ... . ...|. | ||.| | | | .. | VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWI YIEYCPGGTLLDLLE------QD--------VRLPESIIKIFAVDILDA-LFYLHTNGVILKDMQPRNILINECGSLKIADFTRAESIDK---------- . ||..||.| |... .. |.|||.|......|| . | ||| ...| | | |||. |..|| . .... CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNI -------PQSLNVIVDEDMIEYLAPELLLENGIG-----SFASDLYSFGALLYRMAAGQVPFKS-SLARDPESALFH--------------EAPPLLPG- | | .| . ||| .. || | .. .| .|.| .. || |..|. . | ..| . || || IDCIETMQQKRNTFVGTP---WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDH -------------------YSNDFNDLVQALLRKNPATRPQWAEVIK--HPFW .| .|.| .. |.|.| || . .| ||| LSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 95725.m00244.AA | Ciliate-E2-Unclassified | 32-265 | 16 | 6.4e-32 | 108.02 | In-house | 16-352 (352) | Show / Hide |
Range on Protein: 32-265 Range on HMM: 16-352/352 Sequence Identity: 16% (57 aa) YKGRLKNSINYIAIKSIDIKRQDDAYNLYNF----------LKDQN-------------------HPHILKIYHWYKTANHFWYYIEYCPGGTLLDLLEQ || . |. ..... . .| |... ..... .. .. ||.|.| ... .. ... |||.||.|.. ... YKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKK -----------------DVRLPESIIK-----IFAVDILDALFYLHTNG-VILKDMQPRNILINECG---SLKIADFTRAESID---------------- . ...| .| .. ||..| ||| .. .| | .| |||... | .||.|| . .. RKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIW KPQSLNVIVDEDMIE--YLAPELLLENGIGS---FASDLYSFGALLYRMAAGQVPFKS-SLARDP--------------ESALFHEAPPLLPGYSN---- |.| .. .. . |.|||.| ... . ...| .|.| .|| | |. ||.. . . ... .. | ... KQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIP -DFNDLVQALLR--------KNPATRPQWAEVIKHPFW . .. .. ... ||| |... ....||. KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 95725.m00244.AA | ULK | 32-153 | 28 | 1e-25 | 88.29 | In-house | 17-182 (324) | Show / Hide |
Range on Protein: 32-153 Range on HMM: 17-182/324 Sequence Identity: 28% (47 aa) YKGRLKNS---INYIAIKSIDIKRQDDAYNLYN-------------FLKDQN---HPH--ILKIYHWYKTA--NHFWYYIEYCPGGTLLDLLEQDVR--- |||| |.. |.|.| ||.| . . .|... .| . ||. | | |.|..|. |... |||.||.| ...... . YKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE ------LPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINE------------CGSLKIADF |.|.....| .|. .. .|| ...| |. | ||||.. | |||||| TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |
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Kinase | 95725.m00244.AA | ULK | 32-153 | 27 | 3.3e-24 | 81.46 | In-house | 16-186 (329) | Show / Hide |
Range on Protein: 32-153 Range on HMM: 16-186/329 Sequence Identity: 27% (47 aa) YKGRLKNS----INYIAIKSIDIKRQDDAYNLYN-------------FLKDQN--------HPHILKIYHWYKTA--NHFWYYIEYCPGGTLLDLLEQD- |||| |.. ..|.| ||.. .. .|... .| . ||.| | |.|..|. |... |||.||.| ...... YKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNK ---------VRLPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINEC------------GSLKIADF ||.|.....| .|| .. .|| ...| |. | ||||.. | |||||| KLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADF |
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Kinase | 95725.m00244.AA | AktR | 63-265 | 28 | 3.1e-22 | 80.18 | In-house | 54-268 (268) | Show / Hide |
Range on Protein: 63-265 Range on HMM: 54-268/268 Sequence Identity: 28% (63 aa) LK-DQNHPHILKIYHWYKTANHFWYYIEYCPGGTLLDLLEQDVRLPESIIKIFAVDILDALFYLHTN-GVILKDMQPRNILINECGSLKIADF--TRAES .. .||| | | ... .| .. . .|||||| |.. | .. .. |. ...... || || ||| . .| |. | |||. | | .||.|| .. MEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--- IDKPQSLNVIVDEDM-------IEYLAPELLLE-NGIGSFASDLYSFGALLYRMAAGQVPFKS-SLARDPESALFHE--APPLLPGYSNDFNDLVQ-ALL ......... ||.||| ... | . ...|...||...| | .|. || . . .. .. .... .| . |. . ||.| || -----LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHN-KSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLL RKNPATRPQ-----WAEVIKHPFW ||| |. | |. .||. CKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | 95725.m00244.AA | CAMK | 44-153 | 17 | 2.9e-21 | 64.63 | In-house | 35-240 (425) | Show / Hide |
Range on Protein: 44-153 Range on HMM: 35-240/425 Sequence Identity: 17% (37 aa) AIKSIDIKRQDD-------------------------------AYNLYNFLKDQN-------HPHILKIYHWYK------------TANH--------FW ||| || |. .| .. .. .| . ||.|.|.|..| | .. .. AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMY YYI---EYCPGG----TLLDLLEQD---------------VRLPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINEC-----------------G |||.|| |.| . . |..|. . . |..|. |.| .... | | |||... . MVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNN SLKIADF .||.|| NIKIIDF |
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Kinase | 95725.m00244.AA | AGC | 175-265 | 23 | 5.3e-20 | 46.99 | In-house | 272-395 (395) | Show / Hide |
Range on Protein: 175-265 Range on HMM: 272-395/395 Sequence Identity: 23% (30 aa) EYLAPELLLENGIGSFASDLYS--FGALLYRMAAGQVPFKS-SLA------RDPESALFHEA--------PPLLP-----------GYSNDFNDLVQALL ||.||| | ..| | .| .|.|.| | .|. || . . |.|. .. .| |.. ||.. || EYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLL RKNPATRPQ----------WAEVIKHPFW |.|. |. |. .||. CKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | 95725.m00244.AA | ULK | 176-265 | 21 | 1.7e-17 | 57.73 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 176-265 Range on HMM: 217-329/329 Sequence Identity: 21% (25 aa) YLAPELLLENG----IGSFASDLYSFGALLYRMAAGQVPFKSSLARDPE-----SALFH---------EAPPLLPG------YSNDFNDLVQALLRKNPA | ||..| ..| ... .|..|.| ..| | |..||... ..| . . |. | |... || . .| ... YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK TRPQWAEVIKHPFW | | |...||.. DRISWEELFNHPWF |
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Kinase | 95725.m00244.AA | AGC | 66-153 | 27 | 6.3e-17 | 38.85 | In-house | 78-199 (395) | Show / Hide |
Range on Protein: 66-153 Range on HMM: 78-199/395 Sequence Identity: 27% (33 aa) QN---------HPHILK-IYHWYKTANH--FWYYIEYCP---------GG-TLLDLLE---QDVRLPESIIKIFAVD-------ILDALFYLHT-NGVIL .. || | | .. ... .| ||.| || |. | . |..|. ....| |. || ||| .|.| NHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIH KD-MQPRNILINECGSLKIADF | . | |||..| | .|..|| RDYLKPENILLDEDGHIKLTDF |
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Kinase | 95725.m00244.AA | ULK | 176-265 | 23 | 4.9e-16 | 53.45 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 176-265 Range on HMM: 213-324/324 Sequence Identity: 23% (27 aa) YLAPELLLENG----IGSFASDLYSFGALLYRMAAGQVPFKSSLARDPE-------------------SALFHEAPPLLPGYSNDFNDLVQALLRKNPAT | ||..| ..| ... .|..|.| ..| | |..||.|. ..| . . . || | |... || . .| ... YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD RPQWAEVIKHPFW | | |...||.. RISWEEIFNHPWF |
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Kinase | 95725.m00244.AA | Pkinase | 32-153 | 28 | 1.3e-15 | 56.3 | Pfam | 16-156 (293) | Show / Hide |
Range on Protein: 32-153 Range on HMM: 16-156/293 Sequence Identity: 28% (40 aa) YKGRLKNSINYIAIKSIDIKRQDDAY--------NLYNFLKDQNHPHILKIYHWYKTANHFWYYIEYCPGG----TLLDLLE--QDVRL--PESIIKIFA ||.. |.. |.| |. ..... .. .. |||.|...|.|. . .| . |||.|| | |... .. .. .| .| .. YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYM VDILDALFYLHTNGVILKDMQPRNILINECGSL----KIADF || .| |.| .|.| |. | ||||.. | . ||.|| YQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF |
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Kinase | 95725.m00244.AA | Pkinase | 174-265 | 20 | 1.4e-15 | 56.22 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 174-265 Range on HMM: 175-293/293 Sequence Identity: 20% (25 aa) IEYLAPELLL-ENGIGSFASDLYSFGALLYRMAAGQVPFKSS----LARDPESALFHEAPPLLPGYS------------------------NDFNDLVQA ..|.|||... ...|. ..| .|.| .|| |. |. ||... .|. .. .| |. . .. |.. PWYMAPEVIRGGQYYGP-KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW LLRKNPATRPQWAEVIKHPFW .|.|.|. || .... .||.. CLCKDPKKRPTAEQILQHPWF |
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Kinase | 95725.m00244.AA | RSK | 174-265 | 25 | 6.2e-15 | 51.34 | In-house | 172-278 (278) | Show / Hide |
Range on Protein: 174-265 Range on HMM: 172-278/278 Sequence Identity: 25% (27 aa) IEYLAPELLL---ENGIGSFASDLYSFGALLYRMAAGQVPFKS---SLARDPESALFHEA--PPLL--PGYSNDFNDLVQALLRKNPATRPQ-----WAE |||.|||.| .| . | |..|.|.|.| | .|..||.. . . . . ... . |... ||....| ..|. |. .| IEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE VIKHPFW . .||.. IKQHPWF |
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Kinase | 95725.m00244.AA | RSK | 46-153 | 26 | 7e-15 | 49.74 | In-house | 38-149 (271) | Show / Hide |
Range on Protein: 46-153 Range on HMM: 38-149/271 Sequence Identity: 26% (30 aa) KSIDIKRQDDAYNLYNFLKDQNHPHILKIYHWYKTANHFWYYIEYCPGGTLLDLLEQDVRLPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINEC ...|.| .. . . . | . .|| | | . . .. . . . || |.| | . ..|. .|. . |. |. |||. |.. | | |||. . ATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDE ----GSLKIADF |..||.|| SGNPGHIKICDF |
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Kinase | 95725.m00244.AA | RSK | 66-153 | 29 | 4.9e-12 | 40.62 | In-house | 58-151 (278) | Show / Hide |
Range on Protein: 66-153 Range on HMM: 58-151/278 Sequence Identity: 29% (28 aa) QNHPHILKIYHWYKTANHFWYYIEYCPGGTLLDLLEQDVR---LPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINE---CGSLKIADF |.|| | . .. ..| ... |||.|| |.. |.. .. . |. .. . | |. .||. |.| | | ||| .. |..|. || QQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDF |
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TyrKc | 95725.m00244.AA | TyrKc | 30-265 | 19 | 1.2e-09 | -66.64 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 30-265 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) IT-------------YKGRLKNSINYIAIKSIDIKRQDDAYNLY---NFLKDQ--NHPHILKIYHWYKTA-------NHFWYYIEYCPGGTLLDLLEQDV || |||..| |.|.. .. . .. .||.|...| . . ||.|.| |.| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR R-LPESIIKIFAVDILDALFYLHTNGVILKDMQPRNILINECGSLKIADF--TRAESID----KPQSLNVI---VDEDM---IEYLAPELLLENGIGSFA . |. . |...| . ||| ...| | ||.|..| . ||.|| .|. | .. . .... | .||| . |. ... PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTK SDLYSFGALLYRMAA-GQVPFKS---------SLARDPESALFHEAPPL-----LPGYSNDFNDLVQALLRKNPATRPQWAEVIKHPFW || .||| ... . || | . .. .. . || .. . . .. . . .|. || .|. | .. SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 95725.m00244.AA | RSK | 174-265 | 25 | 2.6e-09 | 29.62 | In-house | 169-271 (271) | Show / Hide |
Range on Protein: 174-265 Range on HMM: 169-271/271 Sequence Identity: 25% (26 aa) IEYLAPELLLENGIGSFASDLYSFGALLYRMAAGQVPFKSSLARDPESALFHEAPPL-------LPGYSNDFNDLVQALLRKNPATRPQW-----AEVIK ..|.||| | | . |.| .|||.|.| | .| || . .|. . . .| ||. ..| .|. |. ... . ANYMAPEVLKRQGH-DQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQ HPFW ||. HPWF |
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Kinase | 95725.m00244.AA | CAMK | 175-265 | 18 | 2.4e-08 | 22.26 | In-house | 284-425 (425) | Show / Hide |
Range on Protein: 175-265 Range on HMM: 284-425/425 Sequence Identity: 18% (26 aa) EYLA-PELLLE-------------NGIGSFASDLYSFGALLYRMAAGQVPFKSS-----------------LARDPESALFHEAPPLLPG---------- || | ||.|. . ....| | | .|| | | || .. | . .. .. || ... EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW ----------YSNDFNDLVQALLRKNPATRPQWAEVIKHPFW | . ||.. .|...| |. ... .||. DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |