Gene 82569.m00140 (T.vaginalis)
82569.m00140
Species: T.vaginalis
Alias: 82569.m00140, TvagK0619
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 82569.m00140.AA | Protein | None | 2262 | None | Fasta, JSON |
| 82569.m00140.kin_dom | Protein Kinase Domain | None | 149 | None | Fasta, JSON |
Protein domains of 82569.m00140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 82569.m00140.AA | PIKK | 1874-2142 | 36 | 3.9e-89 | 302.42 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 1874-2142 Range on HMM: 1-290/290 Sequence Identity: 36% (105 aa) RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQ-TYFSGNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVE ||. . | .|| || . || || .| ||.|||||||.|.|.||.|.|.| | | . . .| | | |||.|.. ||..|| ...||. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK TYRKLYS---RDPMQE----------------FKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVG ... . ... | | ... .|. .| .|....| |.| .. .|.| .|. . .|. ...|.| ..|| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIF |..|||||||.||.||...|...|||||.|||.| .| || |||||||.|| |||..|. | || . .. . ..|..| | |. | YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | 82569.m00140.AA | FRAP | 1904-2152 | 40 | 4.8e-78 | 265.6 | In-house | 2-251 (251) | Show / Hide |
Range on Protein: 1904-2152 Range on HMM: 2-251/251 Sequence Identity: 40% (101 aa) YQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFS-GNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETYRKLYSRDPMQEFKLLEEYSYSSYDYMLP | .| |||||.| |||.|| | ||| |. .. || | .|||||. ||. ||. |||. . ||| | |...... . . || . YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL IQKQQVLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLT ..| . . .| | .|..|| || . |. . | | |..||..||||||||||...|..||..||||||||| | .| .|| .||||| MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT RMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIFVHEPLVDPDS ||.| || ..| |..| . ...||.. .. || || || RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | 82569.m00140.AA | PI3_PI4_kinase | 1903-2152 | 23 | 5.9e-64 | 223.59 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 1903-2152
Range on HMM: 1-300/300
Sequence Identity: 23% (75 aa)
FYQYLVKGHEDLR--LDERIMQFF-----------------------RLINSFLKKQTYFSGNL----IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETY
|....||..||| |.|.||.. ||.| ..|| . . . .||.. ..|...|| ..|.... ||
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGC--DRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY
R----------------KLYSRDPMQEFKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADST-STWLKQQHTFAISTAMTSIVGYVIG
. |.. . .. . .||..| |... ..| ... ..|. . . .|.. ..|. | | ..|.|..|
MVKCKHKHFNKEHKMWMKMWPDWWHLM----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILG
LGDRHPSNILI--DRLSGKVIHIDFGDCFE-KAAKRKFLPEVVPFRLTR------MMVSAM------GVTGTMGTFRTAFVQMANILRENRRVLVMVL--
.||||..||.. |. .|...|||||.||. . |. . || ||||.|. .||.|| ...| .|.||. ... ..||.. ......|
NGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKK
-----SIFVHEPLVDPDS
...|| .|.. |
AVMRGECMVHDGLPMWRS
|
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| Kinase | 82569.m00140.AA | PI3Kc | 1905-2220 | 22 | 3.8e-54 | 187.1 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 1905-2220 Range on HMM: 1-336/336 Sequence Identity: 22% (78 aa) QYLVKGHEDLRLDERIMQFFRLINSFLKKQ-TYFSGNL-IGTMGVIPLSMQHGLVQWVRGTDTLRHVVETYRKLYS--------------------RDPM . ..|...||| |.|.||.|||.| ..|. . .| . ....||.. ..|...|| ..||. . .|.| . . .| AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM QEFKLLEEYSYSSYDYMLPIQKQQVLEKVMRNVPSNDIAKLFILKADSTS-TWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGD ... .. .|. | ...... |.. ... ..... |. . . . | . . .|. |.| ..|.|. |.||||..||..|. .|...|||||. MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH CFEKAAKRKFLP-----EVVPFRLTRMMVSAMG----VTGTMGTFRTAFVQMANILRENRRVLVMVLSIFVHEPLVDPDSIEDSNIDTVDMPESVPPDPP .|... ..|... |.||||||..|| .|| ..| | ||| .. ...|... ... .....|. |. .|. . . IFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPI-MPCWRMM---------------EK QQGYAKERPQVN-NNLMLAGSIMEK----SRIMLANNPAAQSSLEMRHRVNQK | ..| ... . .| ... | |. .| |...| DIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | 82569.m00140.AA | ATR | 1874-2142 | 32 | 2e-47 | 159.46 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 1874-2142 Range on HMM: 2-267/267 Sequence Identity: 32% (88 aa) RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGNL--IGTMGVIPLSMQHGLVQWVRGTDTLRHVVE | | . | |.|| . ..| || || . | ..||| | | |.| ||| ..|. . | |||| | ... || | ||| ... YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD TYRKLYSRDPMQEFKLLEEYSYSSYDYMLPIQKQQVL-EKVMRNVPSNDIAKLFILKA--DSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILID ||. .. | . . . .||.|. | .. |. | . . .. |... | . . |.| ..|||.||||||| ||||| ---KLW-KEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPP--IFHDWFNRRFPDPQQ-WYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILID RLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRRVLVMVLSIF .. | ..|.|. | . . . ||.||||||. || .|| .| | || | . . ..|..| .. |. | KINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 82569.m00140.AA | ATM | 2034-2149 | 41 | 1.3e-28 | 88.26 | In-house | 133-247 (304) | Show / Hide |
Range on Protein: 2034-2149 Range on HMM: 133-247/304 Sequence Identity: 41% (48 aa) WLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANILRENRR | . . | | |||||..|||||| |||| | ..||| | ||. | || ||||||| .| ||.|| | || . ..| WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ-GKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE VLVMVLSIFVHEPLVD |. . . . .|| | TLLTIVEVLLYDPLFD |
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| Kinase | 82569.m00140.AA | SMG1 | 2007-2094 | 45 | 1.1e-19 | 61.8 | In-house | 156-242 (242) | Show / Hide |
Range on Protein: 2007-2094 Range on HMM: 156-242/242 Sequence Identity: 45% (40 aa) VLEKVMRNVPSNDIAKLFILKADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPE ||| .| | | .|| | . .| |||. |.|||.||||||| |.||| | |.|||. |||| | . || VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE |
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| Kinase | 82569.m00140.AA | DNAPK | 2028-2152 | 28 | 4.2e-18 | 62.32 | In-house | 177-301 (301) | Show / Hide |
Range on Protein: 2028-2152 Range on HMM: 177-301/301 Sequence Identity: 28% (35 aa) ADSTSTWLKQQHTFAISTAMTSIVGYVIGLGDRHPSNILIDRLSGKVIHIDFGDCFEKAAKRKFLPEVVPFRLTRMMVSAMGVTGTMGTFRTAFVQMANI . . |.| . |. . |. | ... | |||| | .. | .| |||| | | || |||||| . | . | .. . STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA LRENRRVLVMVLSIFVHEPLVDPDS .| | .|. .|. .|..| FRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | 82569.m00140.AA | SMG1 | 1882-1928 | 48 | 7.2e-14 | 42.18 | In-house | 1-47 (242) | Show / Hide |
Range on Protein: 1882-1928 Range on HMM: 1-47/242 Sequence Identity: 48% (23 aa) FSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLIN . | .|| .. | || | || || ||| |||||||| ..| ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVN |
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| Kinase | 82569.m00140.AA | DNAPK | 1874-1967 | 33 | 3.5e-12 | 40.45 | In-house | 3-98 (301) | Show / Hide |
Range on Protein: 1874-1967 Range on HMM: 3-98/301 Sequence Identity: 33% (32 aa) RIQYFVGQFSVYMSKQQPKDVIVRGEDGNFYQYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGNLIG--TMGVIPLSMQHGLVQWVRGTDTLR || | | | || .|.|| | ...|| ||||.| || | | | . . | .||. ||. || | .|. RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLK |
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| Kinase | 82569.m00140.AA | ATM | 1905-1963 | 37 | 2.5e-07 | 19.04 | In-house | 1-61 (304) | Show / Hide |
Range on Protein: 1905-1963 Range on HMM: 1-61/304 Sequence Identity: 37% (23 aa) QYLVKGHEDLRLDERIMQFFRLINSFLKKQTYFSGN--LIGTMGVIPLSMQHGLVQWVRGT |||| .||| | . | | . | |.. | | | |.||| | . | || RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT |
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| FATC | 82569.m00140.AA | FATC | 2230-2262 | 48 | 4.4e-17 | 57.75 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2230-2262 Range on HMM: 1-33/33 Sequence Identity: 48% (16 aa) TPLSVEEQAGLLISNSVSTYNLAMMYSGWCSFW .|||||.|. ||. ....||..||.|||..| EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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