Gene 91508.m00046 (T.vaginalis)

91508.m00046

Species: T.vaginalis
Alias: TvagK0631, 91508.m00046
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
91508.m00046.AA Protein None 2266 None Fasta, JSON
91508.m00046.kin_dom Protein Kinase Domain None 121 None Fasta, JSON

Protein domain

Protein domains of 91508.m00046.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 91508.m00046.AA FAT 1320-1378 23 2.1e-09 31.69 Pfam 1-82 (408) Show / Hide 
Range on Protein: 1320-1378
Range on HMM: 1-82/408
Sequence Identity: 23% (19 aa)

APYVANAMMHLRRWDD--LDKALQSAP------------DDSL-----RCFTLRAISQL--HRKKYE--EVDKTIENAFSLL
||. |.|. .|  ||.  .|. ... .            .||      ...  .||. |  |.....  |. . |..| .||
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLL
Kinase 91508.m00046.AA PIKK 1894-2162 35 2.7e-85 289.68 In-house 1-290 (290) Show / Hide 
Range on Protein: 1894-2162
Range on HMM: 1-290/290
Sequence Identity: 35% (102 aa)

RIKYFVGQFSVYMSKQQPKDVVICGEDGNFYQYLVKGHEDLRLDERIQQFFRLINSYLKRE--TYFGAHVIQTMSVIPLSITNGLVQWVSGTDTLRSVVE
||. .     |  .|| ||  .| | || .| ||.|||||||.|.|..|.|.|.|  | ..  .   .  |.| ||||.|   ||..|| ...||.    
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

QFRR---LKQRDPIQE----------------YALTEKLSHQSFDYMLPIQKMNIIMKVMSVVPSTDLANYFYLKARSPNVWHKRISTFAISAAITSMVG
| .     ......|                 |.  ..  ... .     .|  . ...|. .|  .... | .|. .|  |  | . ...| |  .|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YVIGLGDRHPSNILIDRFTGKVIHIDFGDCFERASKRKFLPEVVPFRLTRMMVKAMGVTGTAGTFSTAFINTSRVLRENKRVLIMVLAIF
|..|||||||.||.||. ||...|||||.||| | .|   || |||||||.|| |||..|. | |  . . . ...|...  |. |.  |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 91508.m00046.AA FRAP 1924-2172 40 4.2e-74 252.49 In-house 2-251 (251) Show / Hide 
Range on Protein: 1924-2172
Range on HMM: 2-251/251
Sequence Identity: 40% (102 aa)

YQYLVKGHEDLRLDERIQQFFRLINSYLK--RETYFGAHVIQTMSVIPLSITNGLVQWVSGTDTLRSVVEQFRRLKQRDPIQEYALTEKLSHQSFDYMLP
| .| |||||.| |||. | | |||  |.   ||      ||  |.||||.  ||. ||   |||.  . ..|. ..     || . .. . . .| .  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDR-MCNDYDHLPL

IQKMNIIMKVMSVVPSTDLANYFYLKARSPNVWHKRISTFAISAAITSMVGYVIGLGDRHPSNILIDRFTGKVIHIDFGDCFERASKRKFLPEVVPFRLT
..|  |   .|      ||.   .||  .  .|  |   .  | |. ||.||..||||||||||...|.|||..||||||||| | .|  .|| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMMVKAMGVTGTAGTFSTAFINTSRVLRENKRVLIMVLAIFVHEPLVDPRE
||.| || ..|  |..  .     .|.||.|  .. ||  ||  ||   | 
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 91508.m00046.AA PI3_PI4_kinase 1923-2172 22 9.6e-61 212.91 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1923-2172
Range on HMM: 1-300/300
Sequence Identity: 22% (72 aa)

FYQYLVKGHEDLR--LDERIQQFF-----------------------RLINSYLKRETYFGAHV----IQTMSVIPLSITNGLVQWVSGTDTLRSVVEQF
 |....||..|||   |.|. |..                       ||.|  .| .   . .     .|. ..||..  .|...||  ..|.. .   .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDG--CDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

R------------RLKQRDPIQEYALTEKLSHQSFDYMLPIQKMNIIMKVMSVVPSTDLANYFYLKARSP-NVWHKRISTFAISAAITSMVGYVIGLGDR
.            . . .. .  ..|.             .||  .  ......|  .| ..|. .  ..   | .....|. | |  ..|.|..|.|||
MVKCKHKHFNKEHKMWMKMWPDWWHLM------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDR

HPSNILI--DRFTGKVIHIDFGDCFE-RASKRKFLPEVVPFRLTR------MMVKAM------GVTGTAGTFSTAFINTSRVLRENKRVLIMVL------
|..||..  |..||...|||||.||.  ..|. . || ||||.|.      .||.||      ...| .|.| .    . |.||.........|      
HNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMR

-AIFVHEPLVDPRE
 ...|| .|.. |.
GECMVHDGLPMWRS
Kinase 91508.m00046.AA PI3Kc 1925-2231 20 2.1e-60 207.9 SMART 1-336 (336) Show / Hide 
Range on Protein: 1925-2231
Range on HMM: 1-336/336
Sequence Identity: 20% (73 aa)

QYLVKGHEDLRLDERIQQFFRLINSYLKRE-TYFGAHV-IQTMSVIPLSITNGLVQWVSGTDTLRSVVEQFRRLKQ------------------RDPIQE
. ..|...||| |.|..|.|||.|  ....   .. .. ......||..   |...||. ..||...   ..  |                   . .   
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM

YALTEKLSHQSFDYMLPIQKMNI-----IMKVMSVVPSTDLANYFYLKARSPN-VWHKRISTFAISAAITSMVGYVIGLGDRHPSNILIDRFTGKVIHID
| ... .  . .. | .... ..     .... ....  .|...|. .  .|| .| .....|. | |  .||.|. |.||||..||..|. ||...|||
Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID

FGDCFERASKRKFLP-----EVVPFRLTRMMVKAMG----VTGTAGTFSTAFINTSRVLRENKRVLIMVLAIFVHEPL-VDPREKKSSASTDKEKAKSFI
||..|... ..|...     |.||||||..|| .||    ..|  | | |    . |..|... ... .....|. |.  . | .      .| ...  .
FGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM------EKDIKYLRQ

SFSEVTGSVIDKGRVLLMDP-----SDKTTDTEMRARVNTKLSGSDFG
.| .    . |. .   ..       .. .. ..  |... .     .
RFRLDH--LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 91508.m00046.AA ATR 1894-2162 30 2.2e-48 162.79 In-house 2-267 (267) Show / Hide 
Range on Protein: 1894-2162
Range on HMM: 2-267/267
Sequence Identity: 30% (84 aa)

RIKYFVGQFSVYMSKQQPKDVVICGEDGNFYQYLVKGHEDLRLDERIQQFFRLINSYLKR--ETYFGAHVIQTMSVIPLSITNGLVQWVSGTDTLRSVVE
 |  |     .  | |.|| . . | || ||  . | ..||| | | ..|  |||  ...  |   .   ..| .||||    ... ||  | |||....
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

QFRRLKQRDPIQEYALTEKLSHQSFDYMLPIQKMNII-MKVMSVVPSTDLANYFYLKARSPNVWHKRISTFAISAAITSMVGYVIGLGDRHPSNILIDRF
.  . |.    | | |      .| .     .|. ..   ..   |.    ..|  .   |  |    . .  | |. .||||.|||||||  |||||. 
KLWKEKKQY-MQFYQLRQCMDKKSREEW---EKQKVFREFLLPRHPPI-FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI

TGKVIHIDFGDCFERASKRKFLPEVVPFRLTRMMVKAMGVTGTAGTFSTAFINTSRVLRENKRVLIMVLAIF
.| ..|.|.   | .  ..   ||.||||||. || .||  .| | |  | . . ...|...  .. |.  |
NGECVHVDYNCIFNSG-EQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 91508.m00046.AA ATM 2051-2169 40 9.5e-28 85.42 In-house 130-247 (304) Show / Hide 
Range on Protein: 2051-2169
Range on HMM: 130-247/304
Sequence Identity: 40% (48 aa)

PNVWHKRISTFAISAAITSMVGYVIGLGDRHPSNILIDRFTGKVIHIDFGDCFERASKRKFLPEVVPFRLTRMMVKAMGVTGTAGTFSTAFINTSRVLRE
| .|  .   .  | |  |.|||..||||||  ||||      ..||| |  ||   |    || ||||||| .|  ||.||  | |      |  |.| 
PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN

NKRVLIMVLAIFVHEPLVD
 .  |. .  . . .|| |
SQETLLTIVEVLLYDPLFD
Kinase 91508.m00046.AA SMG1 2051-2114 51 1.1e-18 58.33 In-house 180-242 (242) Show / Hide 
Range on Protein: 2051-2114
Range on HMM: 180-242/242
Sequence Identity: 51% (33 aa)

PNVWHKRISTFAISAAITSMVGYVIGLGDRHPSNILIDRFTGKVIHIDFGDCFERASKRKFLPE
|  | .    .| | |. |||||.|||||||  |.|||  || |.|||.  |||.  | .  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLN-VPE
Kinase 91508.m00046.AA DNAPK 2072-2172 29 2.8e-18 62.96 In-house 201-301 (301) Show / Hide 
Range on Protein: 2072-2172
Range on HMM: 201-301/301
Sequence Identity: 29% (30 aa)

GYVIGLGDRHPSNILIDRFTGKVIHIDFGDCFERASKRKFLPEVVPFRLTRMMVKAMGVTGTAGTFSTAFINTSRVLRENKRVLIMVLAIFVHEPLVDPR
... | ||||  | ..   .| .| ||||  |  |      ||  ||||||  .  |   .  | .    |   . .|  . .|.    .|. .|..|  
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

E
 
N
Kinase 91508.m00046.AA SMG1 1902-1982 40 3.2e-14 43.36 In-house 1-83 (242) Show / Hide 
Range on Protein: 1902-1982
Range on HMM: 1-83/242
Sequence Identity: 40% (34 aa)

FSVYMSKQQPKDVVICGEDGNFYQYLVKGHEDLRLDERIQQFFRLINSY---LKRETYFGAHVIQTMSVIPLSITNGLVQWVSG
  .   | .|| ..  | ||  | || || ||| ||||| ||  ..|     . |      |     || ||    ||.||| |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHA-RHYSVTPLGTRSGLIQWVDG
Kinase 91508.m00046.AA DNAPK 1893-1987 32 3.4e-13 44.18 In-house 2-98 (301) Show / Hide 
Range on Protein: 1893-1987
Range on HMM: 2-98/301
Sequence Identity: 32% (32 aa)

IRIKYFVGQFSVYMSKQQPKDVVICGEDGNFYQYLVKGHEDLRLDERIQQFFRLINSYLKRETYFGAHVIQ--TMSVIPLSITNGLVQWVSGTDTLR
.||  |     |  |   || ..| | |     ...|| ||||.| || | |   |  .           |  | ..||.    ||. ||  | .|.
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLK
Kinase 91508.m00046.AA ATM 1925-1983 42 3e-10 28.52 In-house 1-61 (304) Show / Hide 
Range on Protein: 1925-1983
Range on HMM: 1-61/304
Sequence Identity: 42% (26 aa)

QYLVKGHEDLRLDERIQQFFRLINSYLKR--ETYFGAHVIQTMSVIPLSITNGLVQWVSGT
  |||| .||| |  .|| | . |  |.|  ||      | |  |.|||   | . |  ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGT
FATC 91508.m00046.AA FATC 2234-2266 60 6e-22 73.35 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2234-2266
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

KPLSIEEQAQRLIKEATDNYNIAKMYSGWCPFW
.|||.|.|..|||.||||..|...||.||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW