Gene 82736.m00229 (T.vaginalis)

82736.m00229

Species: T.vaginalis
Alias: TvagK0448, 82736.m00229
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-D

Sequence

Name Sequence Type Origin Length Description Download
82736.m00229.AA Protein None 350 None Fasta, JSON
82736.m00229.kin_dom Protein Kinase Domain None 207 None Fasta, JSON

Protein domain

Protein domains of 82736.m00229.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 82736.m00229.AA CK1-Unclassified 19-251 49 1.4e-123 366.58 In-house 1-244 (244) Show / Hide 
Range on Protein: 19-251
Range on HMM: 1-244/244
Sequence Identity: 49% (120 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQALQGSP-------NIPRVYGLFDY--KKSQFLVMERMGQSLESVFKRNGKK
|   . .| ||||..|.. ...|.. ||.|.|  |. .|||. | | .|.||.         .||..|  .       ...||.  |.|||. |.  ..|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIG-LGKNKNQIYAIDFGVSTRYIDP-KTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSRRDDLE
|||||| ||.||.   |||.|. ...|||||| |||.| ||||..|.| |||| | ||||. ||..|  |  | .|.||  | |.|.|||  ||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SIAYVLIRFLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLC
|..|||| ||.||||||| | ..  |. |||  |||.|. ||||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 82736.m00229.AA CK1 19-277 45 2.6e-119 402.69 In-house 1-271 (271) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-271/271
Sequence Identity: 45% (124 aa)

YLARKHLGGGSFGDVYEAEDIETQTI---VALKFETGNATNPQLPNEYKCYQALQG------SPNIPRVYGLFDY--KKSQFLVMERMGQSLESVFKRNG
|   . .| |||||.|..... |..    || |.|  .. .|||. |.| |. |||      ...||..|       ..  ..||.  |.|||. |.  .
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

KKFSLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGL-GKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSRRDDL
.|||||||.||.||. . |||.|  ...|||||| |||.|. ||...|.| |||| . ||.|.||..|  |  | .|.||. | |.|||||  ||||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

ESIAYVLIRFLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWG-IPIEFKQIYEYIRRLRYDETPRYS
||..|||. |||||||||..| .   .. |||. .||.|. |||| | .| || .  .|.|.|...|.| | 
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 82736.m00229.AA CK1 19-279 31 1.5e-96 327.07 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-339/339
Sequence Identity: 31% (108 aa)

YLARKHLGGGSFG-DVYEA-----EDIETQ-----TIVALKFETGNAT--NPQLPNEYKCYQALQG--------------------SPNIPRVYGLFDYK
.   |..|.|.|| ..|..     .|....     . .|.| |  ..   .|||  ||. |..|||                    .| .....  .  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KSQ-FLVMERMGQSLESVFK--RN-GKKFSLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGL------GKNKN--------QIYAIDFGVST-RY
.   ..||.. | .||...|  |. ..|||.||..||..|.   .||.|. |..|||||| ||..|.      ||. .        |.| |||| .  .|
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

IDP-----------KTKEHAIYSP---NNGLIG-TVHYVSVNTHLGETQSRRDDLESIAYVLIRFLRGS--LPWQNMKIKDP-------NERSEKISQMK
.|.           ||..|  . .   . |..| |. |.|.|.|||  |.|||||.| .|.|| .|.|.  ||||||| ..         .  |.|. .|
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

MQTTAEQLCWG-----IPIEFKQIYEYIRRLRYDETPRYSFI
|.|. . || .     .| || .|..||| |.|...| | .|
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 82736.m00229.AA CK1-D 20-279 46 5.6e-93 315.2 In-house 3-261 (261) Show / Hide 
Range on Protein: 20-279
Range on HMM: 3-261/261
Sequence Identity: 46% (121 aa)

LARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQALQGSPNIPRVYGLFDYKKSQFLVMERMGQSLESVFKRNGKKFSLKTVIMIG
..|| .|.|||||.|  ..|.|   ||.| |.  .  |||  | | |. .||   ||..  .        .||. .| ||| .|   ..|||||||.|..
IGRK-IGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLA

DQLFRCIEYIHRSGILHRDIKPHNFLIGLGKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSRRDDLESIAYVLIRFLRG
||... |||||    .|||||| |||.||||  | .| ||||.. || |..|..|  |  |  | ||  | |.|||.|  |||||||||. |||. | ||
DQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRG

SLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWGIPIEFKQIYEYIRRLRYDETPRYSFI
||||| .|     .. |.|.. ||.|  ..|| | | ||.|  .| |.|..|. | |...
SLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 82736.m00229.AA CK1-A 19-279 44 1.6e-91 310.38 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-261/261
Sequence Identity: 44% (115 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQALQGSPNIPRVYGLFDYKKSQFLVMERMGQSLESVFKRNGKKFSLKTVIMI
|   ...| |||||.| .  |.    ||.| |  .|  |||  | | |. ||| . ||..      |    .||. .| ||| .|    ..|..|||.|.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

GDQLFRCIEYIHRSGILHRDIKPHNFLIGLGKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSRRDDLESIAYVLIRFLR
 ||.   |||.|  . .|||||| |||.|.|.  |... ||||.. .| |..|..|  |     |.||. | |.| |||  ||||||.||..||.. | |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWGIPIEFKQIYEYIRRLRYDETPRYSFI
|.|||| || .    . ||||  || |. |||| | | ||  . .|.| ||..|.| | ..
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 82736.m00229.AA CK1-G 19-279 42 3.1e-85 288.83 In-house 1-266 (266) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-266/266
Sequence Identity: 42% (112 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQALQGSP-NIPRVYGLFDYKKSQFLVMERMGQSLESVFKRNGKKFSLKTVIM
|   |  | |.|| ..| . . .   || |||      |||  ||. |. | | | .||.||      |   .||. .| |||  |   . |||.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

IGDQLFRCIEYIHRSGILHRDIKPHNFLIGL--GKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSRRDDLESIAYVLIR
.  |. . .||.|    . ||.|| |||||    |... |. ||||    ||||.|| |  |     | ||  | |.|||||  ||||||.|..  . . 
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWG--IPIEFKQIYEYIRRLRYDETPRYSFI
||||||||| .|     || .|| . | .|  | || .  .|..| .  .|.||| ..|.| | ..
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 82736.m00229.AA TTBKL 19-283 28 1.8e-54 182.34 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-283
Range on HMM: 1-288/288
Sequence Identity: 28% (85 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNA-TNPQ--LPNEYKCYQALQ--GSPNIPRVYGLFDYKKSQFLVMERMGQSLESVFKRNGKK--FS
... | .|.| || ||...|..... .| . |  |   .    .  | .   .||  ||| .|....   .|. .|.||.  | .|  . |..  |  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGLGKN----KNQIYAIDFGVSTRYIDPKT--------KEHAIYSPNN-----GLIGTVHYVSVNT
  |.  || |.. .. ..|. |..|||.|| |. .|. ..       .| |||| . .|...          ..  .  | |     .. ||. |.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGETQSRRDDLESIAYVLIRFLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWG------IPIEFKQIYEYIRRLRYDETPRYSFIRATL
|..  |.| ||| |  |..| .. | |||.||. |      ..| .||.... |.|. .      .| ||  .....|.||| ..| |. |.. .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDK------MEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 82736.m00229.AA TTBK 19-279 33 3.2e-44 153.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-257/257
Sequence Identity: 33% (90 aa)

YLARKHLGGGSFGDVYEAEDIETQ-TIVALKFETGNATNPQLPNEYKCYQALQGSPNIPRVYGLFDYKKSQFLVMERMGQSLESVFKRNGK-KFSLKTVI
    |  ||| || .|||.|. ..   ||.| |  ...   |  |    . ||| . . | .|     |  ..||.  |..|        . .||| | .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MIGDQLFRCIEYIHRSGILHRDIKPHNFLIG-LGKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNN--GLIGTVHYVSVNTHLGETQSRRDDLESIAYVL
 .| |.   || ||  | ||||||| || .| . .. ...| .|||   .|.   . .  . .| .  |  ||| | |.| |.     |.||| |. |.|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYT---NACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

IRFLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWGIPIEFKQIYEYIRRLRYDETPRYSFI
. |. | |||   ||||     ... .|| .     |   .| ||.|  . |. | | ..| | .|
VEFVQGQLPWR--KIKD----KDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 82736.m00229.AA Worm6 19-279 28 2.5e-38 133.63 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-279/279
Sequence Identity: 28% (80 aa)

YLARKHLGGGSFGDVYEAEDIETQT--IVALKFET--GNATNPQLPNEYKCYQAL--QGSPNIPRVYGLFDY--KKS---QFLVMERMGQSLESV-FKRN
.  .| .| |.||.||..|| .. .   .|.| |    |.  ..|. |.   .|.  ..... ..   ..|.  ...    ..||.  | .|.   . |.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCK---IEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP

GKKFSLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGL-----GKNKNQIYAIDFGVST--RYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGET
..|||. | . |. |  . ||  |. | .|||.|| || ||       ..  .|| .||| .   .|.. ... .    .. |  ||| | ... | |  
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQE

QSRRDDLESIAYVLIRFLRGSLPWQNMKIKDPNE-RSEKISQMKMQTTAEQLCWGIPI-EFKQIYEYIRRLRYDETPRYSFI
|.|.||.||  |... ...| |||..|| .|  | . ...   .  . ....  ..|  ||. | .||  ..| ..| | ||
QCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 82736.m00229.AA Pkinase 19-238 25 2.8e-31 111.69 Pfam 1-230 (293) Show / Hide 
Range on Protein: 19-238
Range on HMM: 1-230/293
Sequence Identity: 25% (62 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLP------NEYKCYQALQGSPNIPRVYGLFDYKKSQFLVMERMGQSLESVFKRN------
|   . .| |||| ||.. .. |. |||.|      .... .      .| .  . | ..||| | |. | .|..  .||| ..  |. |.         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

-GKKF--SLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGLGKNKNQI----YAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHL-GE
 ...|  | ......  |..| .||.|. ||.|||.|| |.||   .|...|      .|||..  .       .  .| .... || .|..   .. |.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI---DNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQ

TQSRRDDLESIAYVLIRFLRGSLPWQNM----KIKDPNERSEKI
  ... |  |.  .|. .| | .|...     .  |.... ..|
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI
Kinase 82736.m00229.AA CMGC 19-180 18 4.5e-26 81.88 In-house 1-285 (513) Show / Hide 
Range on Protein: 19-180
Range on HMM: 1-285/513
Sequence Identity: 18% (52 aa)

YLARKHLGGGSFGDVYEAED--------------IETQTIVALK------FETGNA---TNPQLP----NEYKCYQALQ----------------GSPNI
|   | .| |..| ||.. |              .||. |||.|      .|..       . .|     | |. . |.                  .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

PRVYGLFDYKK-----------------SQFLVMERMGQSLESVFKRNG---------------------------KKFSLKTVIMIGDQLFRCIE--YI
 . |  | .|.                 . .||.| |...|  . |.|                            |.|..  .  .  |..|...  |.
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HRSG--ILHRDIKPHNFLIGLGKNK-----------------NQIYAIDFGVSTRYIDP------------------KTKEHAIYSPN
|. .  |.|||.|| | ||   .                    ..  .||| .. | ..                  . |.   |...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHY
Kinase 82736.m00229.AA S_TKc 19-287 20 3e-22 81.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-287
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQALQGSPNIPRVYGLFDYKKSQFLVMERMGQ---SLESVFKRNGKK-----F
|   ...| |.|| || . ...|. |||.|         .. .| .. .   . ||| . |. |.  .. ..||| ...   .| .. |..|..     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGLGKNKNQIYAIDFGVSTRYIDPKTKEHAIYSPNNGLIGTVHYVSVNTHLGETQSR-RDDLESI
.  ..  .  |... .||.|. ||.|||.|| | |.       .|  .|||.....              . ..|| .|..         .. . |  |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

AYVLIRFLRGSLPWQNMKIKDPNERSEKISQMKMQTTAEQLCWGIPIEFKQIYEYIRR-LRYDETPRYSFIRATL-------QNLF
  .|. .| |  |..                  ||.. ....       ..  . ||. |..| . |..   |            |
GCILYEMLCGYPPFP-----------------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 82736.m00229.AA TyrKc 19-265 18 2.1e-05 -135.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-265
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

YLARKHLGGGSFGDVYEAEDIETQTIVALKFETGNATNPQLPNEYKCYQAL-QGSPNIPRVYGLFDYK-------KSQFLVMERMGQ-SLESVFKRNGKK
    | || | || ||... .   . || |    .|    . .| .    |    ||| | ||    .       .  ..||| |   .| .  .....|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FSLKTVIMIGDQLFRCIEYIHRSGILHRDIKPHNFLIGLGKNKNQIYAIDFGVSTRYIDPK---TKEHAIYSPNN--GLI--GTVHYV---SVNTH----
...|. . .  |  .  ||.|. .. |||.   | |.| ..   ..   ||| | |.|. .     ..  |..    |      .      . |..    
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

----------------LGETQSRR-----DDLESIAYVLIRFLRGSLPWQNMKIKDPNERSEKI----SQMKMQTTAEQLCWGIPIE---FKQIYEYI
                .|..          . . .   . .  |   |  .          . .       .| .  .| .   | .   |..|.|..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---------P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF