Gene 85851.m00039 (T.vaginalis)
85851.m00039
Species: T.vaginalis
Alias: TvagK0531, 85851.m00039
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
85851.m00039.AA | Protein | None | 264 | None | Fasta, JSON |
85851.m00039.kin_dom | Protein Kinase Domain | None | 239 | None | Fasta, JSON |
Protein domains of 85851.m00039.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 85851.m00039.AA | CAMKL | 21-263 | 30 | 7.7e-76 | 241.47 | In-house | 1-289 (297) | Show / Hide |
Range on Protein: 21-263 Range on HMM: 1-289/297 Sequence Identity: 30% (89 aa) YKVIKTIGKGGFAVVVLAIDTRN-QQKVAIKIIDRKEVEK-------------QELLTYLENELRLSARFD---HPNIVKVYDILYDPER------IMII |...||.|||.|..| ||...|. ..||||||||.| . . . .. | .. ... ||||.| |.....|| | .. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV MEYVPNGD--LQTLI--FRGIS--FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF--HPKIIDFGLSKE-K-C-----EKLHTYCGTTLY |||...|. |. | .. .. .| . |. |..|.| .|| |||.||||||.| . ||||||.| . . | .||.| ||. | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY MAPEVILC--DTYDGSKADVWAFGVTAHILAAQAFPWGLKS-------EAQYLKCIQMQ--DISIDVIPKGIIGLIISKSLIFDPAQRANVD ||||... . ||| |.|.|. ||. . ..|. . ||. ..|. . | . . .|.| | .| .|.... MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIH |
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Pkinase | 85851.m00039.AA | Pkinase | 21-217 | 35 | 5.9e-73 | 253.47 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 21-217 Range on HMM: 1-212/293 Sequence Identity: 35% (77 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLE-NELRLSARFDHPNIVKVYDILYDPERIMIIMEYVPNG----DLQTLIF--RG |.....||.|.|..| .... ....||.|||.... ..... | . .|... .|..|||||. ||. .|. .| ..|||...| || ..| |. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH ISF--TLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHP----KIIDFGLS----KEKCEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAF .| . .| ...|.||..|.|.| .|| ||||||||||.| . |. ||.||||. . . ..|.||| |||||||. ..|.|.|.|.|.. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVTAHILAAQAFPW |.. .... .|. GCILYEMLCGRPPF |
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Kinase | 85851.m00039.AA | CAMK | 26-217 | 23 | 1.3e-71 | 229.82 | In-house | 1-334 (425) | Show / Hide |
Range on Protein: 26-217 Range on HMM: 1-334/425 Sequence Identity: 23% (78 aa) TIGKGGFAVVVLAIDTRNQ------------QKVAIKIIDRKEVEK-------------------------QELLTYLENELRLSAR-------FDHPNI |.|.|.|..| |.|..... |||||||||.| . . .. . ...|... . ||||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKVYDILYD-------------------PERIMIIM---EYVPNG----DLQTLIFRG---------------ISFTLEEQLNICYEILQALQYLHHRGI .| |.. | .... ..| ||...| || | . || .| . |..|..|.| ..| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI SHRDLKPENILFDLK-----------------FHPKIIDFGLSKEKCE--------------------------KLHTYCGTTLYMA-PEVILC------ ||||||||||.| . . ||||||..... . |..|.||| ||| |||.. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM -------DTYDGSKADVWAFGVTAHILAAQAFPW .|.| |.|.|. || |. .|. QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF |
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Kinase | 85851.m00039.AA | S_TKc | 21-264 | 30 | 1.3e-68 | 235.17 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 21-264 Range on HMM: 1-231/231 Sequence Identity: 30% (81 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARFDHPNIVKVYDILYDPERIMIIMEYVPN--GDLQTLIFRGIS--- |.....||||.|..| ...... ...||||||. ...|... . .|||||| ||. .| ... ..|||... ||| ..| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSKEKCEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAFGVTAHILAA |. . ..|.|..||.|.| .|| ||||||||||.| | ||.||||... .|.||| ||||||. |.. |.|.|..|.. .... RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC QAFPWGLKSEAQYLKCIQMQDISIDVIPKGIIGLIISKSLIFDPAQRANV---D----------V |. ... .| | .. . .|.| | .||..| . . GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | 85851.m00039.AA | MARK | 21-205 | 39 | 2.9e-61 | 199.06 | In-house | 1-194 (262) | Show / Hide |
Range on Protein: 21-205 Range on HMM: 1-194/262 Sequence Identity: 39% (77 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARFDHPNIVKVYDILY--DPER-IMIIMEYVPNGDLQTLIFRG--IS ||..||||.|..|.| ||.... ..||||||.... . . . .. |... . |||||.| ... .... | .||||...|.| | YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF--HPKIIDFGLSKEK--CEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAFGV . || |. |. |..|.| ..| |||.|||||| | . ||||||.| . .|| | ||| |||||..| ||| |.|.|. || LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV |
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Kinase | 85851.m00039.AA | Ciliate-E2 | 21-228 | 27 | 2.2e-60 | 205.97 | In-house | 1-303 (365) | Show / Hide |
Range on Protein: 21-228 Range on HMM: 1-303/365 Sequence Identity: 27% (85 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRK-----------------EVEKQELLTYLENELRLS----------------ARFDHPNIVKVYDI ||.|| ||.|.|..| .. . ..|...||||||.| .. |. . ....|... . .||||.| |. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC LY--DPERIMIIMEYVPNGDLQTLI------FRGI-----SFTLEEQLNICYEILQ---------------ALQYLHHRG-ISHRDLKPENILFDLKFHP . | . | ..|||. |||. .| . . .||..| ..| ..||| ||.||| .. | |||.||||||| . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KIIDFGLSK---------------EKCEKLH--------------------TYCGTTLYMAPEVILCDTYDG--------SKADVWAFGVTAHILAAQAF ||||||||| ... . |.||| |||||.. ||. |.|.|..||. ... . KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PWGLKSEAQYLKC |. . | ..| PF----QQQIKQC |
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Kinase | 85851.m00039.AA | ULK | 21-205 | 27 | 7.9e-59 | 201.75 | In-house | 1-240 (324) | Show / Hide |
Range on Protein: 21-205 Range on HMM: 1-240/324 Sequence Identity: 27% (67 aa) YKVIKTIGKGGFA-VVVLAIDTRN---QQKVAIKIIDRKEVEKQELL-------TYLENELRLSARFD---HPN--IVKVYDILYDPER--IMIIMEYVP | ... .||| |. .| ... .. .|.||.|.||.|. |.... |.|| .. .. ||| ||| ||..... | ||||| . YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN NGDLQTLIF---------RGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF------------HPKIIDFGLSKE-KC-----EKLHT |||...| .. .. .| ..... |......|| ..| |||.||.||| .. . || |||..| . ...| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT YC------GTTLYMAPEVIL----CDTYDGSKADVWAFGV .. || |||||... . |. .|.|.| .|. CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC |
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Kinase | 85851.m00039.AA | ULK | 21-205 | 27 | 1.2e-58 | 201.11 | In-house | 1-244 (329) | Show / Hide |
Range on Protein: 21-205 Range on HMM: 1-244/329 Sequence Identity: 27% (66 aa) YKVIKTIGKGGFAVVVLAIDTRN----QQKVAIKIIDRKEVEKQELLTY-------LENELRLSARFD--------HPNIVKVYDILYDPER--IMIIME | ... .||| |..| ... .. ..|||.|.||... ... . . |.|| .. . . |||||| ||..... | |||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YVPNGDLQTLIF----------RGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF------------HPKIIDFGLSKE-KCE----- | . |||...| .. .. .| ..... ||.....|| ..| |||.||.||| . .. . || |||..| .. YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ KLHTYC------GTTLYMAPEVIL----CDTYDGSKADVWAFGV ..|. || |||||... . |. .|.|.| .|. MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC |
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Kinase | 85851.m00039.AA | Ciliate-E2-Unclassified | 21-243 | 26 | 3e-55 | 189.87 | In-house | 1-317 (352) | Show / Hide |
Range on Protein: 21-243 Range on HMM: 1-317/352 Sequence Identity: 26% (83 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKV-----AIKIIDRK-EVEKQELLTYLENELRLSAR------------------FDHPNIVKVYDILYDPERIMI ||.||.||.|||..| .... .. .. ..||...| ... .. ..... . ..||.||| ... | . | | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI IMEYVPNGDLQTLI-----------------FRGISFTLEEQL-----NICYEILQALQYLHHRG-ISHRDLKPENILFDLK---FHPKIIDFGLSK--E .|||...|||. | .. || .. . .....|||.|.|||| . | |||.|||||||| . ...||||||.|| . VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ KC----------------EKLHTYCGTTLYM----APEVILCDTYDGS---KADVWAFGVTAHILAAQAFPWGLKSEAQ----------------YLKCI .. ....| ||| || ||||. ||.| |.|.|..|| .. . . .| . ... | ... | QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI QMQDISIDV-----IPKGI . ..|... |||.. KQKNIQFPKFPWQQIPKHW |
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Kinase | 85851.m00039.AA | STE | 21-207 | 25 | 3.2e-54 | 186.44 | In-house | 1-258 (359) | Show / Hide |
Range on Protein: 21-207 Range on HMM: 1-258/359 Sequence Identity: 25% (68 aa) YKVIKTIGKGGFAVVVLAIDT------RNQQK---------VAIKIIDRKEVEK--------------QELLTYLENELRLSARFD--HPNIVKVYDILY .. |. ||||.| .|..|.. ..... .|||... .. .. .| . ...|... ... |||||| |. . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF DP-------ERIMIIMEYVPNGDLQTLIFR--GISFTL-----------EEQL-NICYEILQA-LQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSK . . . |.|||...| | .| . |. ..| |.|. ||..||.. |.||| .| |||.|| |||. |..|||... KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG EKCE-------------------KLHTYCGTTLYMAPEVILC-----DTYDGSKADVWAFGVTA . | | .|| .||||||.. | . |.|.| .| |. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI |
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Kinase | 85851.m00039.AA | CAMK-Unique | 21-211 | 23 | 4.2e-53 | 173.55 | In-house | 1-287 (363) | Show / Hide |
Range on Protein: 21-211 Range on HMM: 1-287/363 Sequence Identity: 23% (69 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLT-----------------YLENELRLSARFDHPNIVKVYDI----LYDPE------- || .. ||.|.| .| ..| . | |.|.. . .. ... |..|... . |||||.|.||. |.. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------RIMIIMEYVPNGDLQTLIFR--------------------GISFTL--EEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHP---- .. |.|||.. |||. .| . ..|. . ..|. ..|.|. |.| .| |||||.|||.. | IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH ------------KIIDFGLSKEKC--EKLH---TYCGTTLYMAP--------------EVILCDTYDGSKA----DVWAFGVTAHILA |..||||.... .. | |.||| .|||| ||| . || .. | |. ||...... RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYD-QQCSPASDIWSLGVIMYYML |
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Kinase | 85851.m00039.AA | TKL | 27-205 | 21 | 8.7e-49 | 168.4 | In-house | 1-277 (364) | Show / Hide |
Range on Protein: 27-205 Range on HMM: 1-277/364 Sequence Identity: 21% (62 aa) IGKGGFAVVVLAIDTRNQ--------QKVAIKIIDRKEV------------------------EKQELLTYLENELRLSARFDHPNIVKVYDILYDPER- ||.|||..| .. . . ||.|.. .... | . . .|.|... |..|||||. . . .|. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------IMIIMEYVPNGD-LQTLIFRGISFTLEEQLNICYEILQALQYLHH--------RGISHRDLKPENILFDLKFH--------------P ..|.|||.|.|. | .|. .. ......| ....||| ..| |||||..||| | ... . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC KIIDFGLSKEKCE----------------------KLHTYCGTTLYMAPEVILCDTYDGSKA---------------DVWAFGV || |||||..... ...| |||. .|||||. .... .|. ||..||. KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI |
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Kinase | 85851.m00039.AA | Pkinase_Tyr | 21-145 | 25 | 7.8e-19 | 64.41 | Pfam | 1-137 (270) | Show / Hide |
Range on Protein: 21-145 Range on HMM: 1-137/270 Sequence Identity: 25% (35 aa) YKVIKTIGKGGFAVVVLAIDT----RNQQKVAIKIIDRKEVEKQE-LLTYLENELRLSARF-DHPNIVKVYDILY-DPER--IMIIMEYVPNGDLQTLIF . .|..|.| | .|.... . ....||.|.. . ... .. . .|... . .|||||. | . . . | |.|.|||.|.||| . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR R----GISFTLEEQLNICYEILQALQYLHHRGISHRDL . . ..|... |..|..| ....||. ... |||| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | 85851.m00039.AA | TyrKc | 21-264 | 23 | 8e-16 | 33.15 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 21-264 Range on HMM: 1-280/280 Sequence Identity: 23% (67 aa) YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARF--DHPNIVKVYDILYDP-------ERIMIIMEYVPNGDLQTLI- . .|..| | | .|.... . ..||.| . . . .|.|. .. .|||||. | . .. | .||.|||.|.|||. . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR FRGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSKEKCEK-------LHTYC----GTT--L---YMAPEVILCDTYD .. ..... |..|. | . .|||.... |||| |.| . ... || |||||.. .. |. | ||||.| .. KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT GSKADVWAFGVTAH-ILAAQAFPWGL-----KSEAQYLKCIQMQ--DISIDV--------IPKGIIGLIISKSLIFDPAQRAN-----VDV .| |||.|||. |. . |. .| .. ..... . |. . |... .||..| . . -TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 85851.m00039.AA | Pkinase_Tyr | 183-206 | 50 | 0.058467 | 7.26 | Pfam | 181-203 (270) | Show / Hide |
Range on Protein: 183-206 Range on HMM: 181-203/270 Sequence Identity: 50% (12 aa) MAPEVILCDTYDGSKADVWAFGVT ||||.| . .| |||.|||. MAPECINYGKFT-TKSDVWSFGVL |