85851.m00039

Species: T.vaginalis
Alias: TvagK0531, 85851.m00039
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
85851.m00039.AA Protein None 264 None Fasta, JSON
85851.m00039.kin_dom Protein Kinase Domain None 239 None Fasta, JSON

Protein domain

Protein domains of 85851.m00039.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85851.m00039.AA CAMKL 21-263 30 7.7e-76 241.47 In-house 1-289 (297) Show / Hide
Range on Protein: 21-263
Range on HMM: 1-289/297
Sequence Identity: 30% (89 aa)

YKVIKTIGKGGFAVVVLAIDTRN-QQKVAIKIIDRKEVEK-------------QELLTYLENELRLSARFD---HPNIVKVYDILYDPER------IMII
|...||.|||.|..| ||...|. ..||||||||.|   .             .  .  .. | ..  ...   ||||.| |.....||       | ..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYVPNGD--LQTLI--FRGIS--FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF--HPKIIDFGLSKE-K-C-----EKLHTYCGTTLY
|||...|.  |.  |   ..    .. .|   .   |. |..|.| .|| |||.||||||.| .     ||||||.| . . |     .||.| ||.  |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPEVILC--DTYDGSKADVWAFGVTAHILAAQAFPWGLKS-------EAQYLKCIQMQ--DISIDVIPKGIIGLIISKSLIFDPAQRANVD
||||...   . ||| |.|.|. ||.   .   ..|.   .          ||. ..|.   . | . .      .|.| |  .| .|....
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIH

Pkinase 85851.m00039.AA Pkinase 21-217 35 5.9e-73 253.47 Pfam 1-212 (293) Show / Hide
Range on Protein: 21-217
Range on HMM: 1-212/293
Sequence Identity: 35% (77 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLE-NELRLSARFDHPNIVKVYDILYDPERIMIIMEYVPNG----DLQTLIF--RG
|.....||.|.|..| ....  ....||.|||.... ..... | .  .|... .|..|||||. ||. .|. .| ..|||...|    || ..|   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

ISF--TLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHP----KIIDFGLS----KEKCEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAF
 .|  . .|  ...|.||..|.|.| .|| ||||||||||.| . |.    ||.||||.      . . ..|.|||  |||||||. ..|.|.|.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTAHILAAQAFPW
|.. ....   .|.
GCILYEMLCGRPPF

Kinase 85851.m00039.AA CAMK 26-217 23 1.3e-71 229.82 In-house 1-334 (425) Show / Hide
Range on Protein: 26-217
Range on HMM: 1-334/425
Sequence Identity: 23% (78 aa)

TIGKGGFAVVVLAIDTRNQ------------QKVAIKIIDRKEVEK-------------------------QELLTYLENELRLSAR-------FDHPNI
|.|.|.|..| |.|.....            |||||||||.| . .                         .. .  ...|...  .        |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVYDILYD-------------------PERIMIIM---EYVPNG----DLQTLIFRG---------------ISFTLEEQLNICYEILQALQYLHHRGI
.| |..  |                   .... ..|   ||...|    ||   | .                  || .|   .   |..|..|.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

SHRDLKPENILFDLK-----------------FHPKIIDFGLSKEKCE--------------------------KLHTYCGTTLYMA-PEVILC------
 ||||||||||.| .                 .  ||||||..... .                          |..|.|||  ||| |||..       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------DTYDGSKADVWAFGVTAHILAAQAFPW
        .|.| |.|.|. ||   |.    .|.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF

Kinase 85851.m00039.AA S_TKc 21-264 30 1.3e-68 235.17 SMART 1-231 (231) Show / Hide
Range on Protein: 21-264
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARFDHPNIVKVYDILYDPERIMIIMEYVPN--GDLQTLIFRGIS---
|.....||||.|..| ...... ...||||||.            ...|...  . .|||||| ||. .| ... ..|||...  ||| ..| .  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSKEKCEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAFGVTAHILAA
   |.  .   ..|.|..||.|.| .|| ||||||||||.|   | ||.||||...     .|.|||  ||||||.    |.. |.|.|..|..  ....
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

QAFPWGLKSEAQYLKCIQMQDISIDVIPKGIIGLIISKSLIFDPAQRANV---D----------V
   |.    ... .| |          ..  .  .|.| | .||..|  .              .
GYPPFP--QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase 85851.m00039.AA MARK 21-205 39 2.9e-61 199.06 In-house 1-194 (262) Show / Hide
Range on Protein: 21-205
Range on HMM: 1-194/262
Sequence Identity: 39% (77 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARFDHPNIVKVYDILY--DPER-IMIIMEYVPNGDLQTLIFRG--IS
||..||||.|..|.| ||.... ..||||||....   . . .  .. |...  . |||||.| ...    .... | .||||...|.|   |       
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF--HPKIIDFGLSKEK--CEKLHTYCGTTLYMAPEVILCDTYDGSKADVWAFGV
 . ||   |.  |. |..|.| ..| |||.|||||| | .     ||||||.| .    .|| | |||  |||||..|   ||| |.|.|. ||
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

Kinase 85851.m00039.AA Ciliate-E2 21-228 27 2.2e-60 205.97 In-house 1-303 (365) Show / Hide
Range on Protein: 21-228
Range on HMM: 1-303/365
Sequence Identity: 27% (85 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRK-----------------EVEKQELLTYLENELRLS----------------ARFDHPNIVKVYDI
||.|| ||.|.|..| .. . ..|...||||||.|                 .. |.  . ....|...                  . .||||.| |. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LY--DPERIMIIMEYVPNGDLQTLI------FRGI-----SFTLEEQLNICYEILQ---------------ALQYLHHRG-ISHRDLKPENILFDLKFHP
 .  | . | ..|||.  |||. .|      .  .     .||..| ..| ..|||               ||.||| .. | |||.|||||||     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIIDFGLSK---------------EKCEKLH--------------------TYCGTTLYMAPEVILCDTYDG--------SKADVWAFGVTAHILAAQAF
|||||||||               ...   .                    |.|||  |||||..    ||.         |.|.|..||. ...    .
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PWGLKSEAQYLKC
|.    . | ..|
PF----QQQIKQC

Kinase 85851.m00039.AA ULK 21-205 27 7.9e-59 201.75 In-house 1-240 (324) Show / Hide
Range on Protein: 21-205
Range on HMM: 1-240/324
Sequence Identity: 27% (67 aa)

YKVIKTIGKGGFA-VVVLAIDTRN---QQKVAIKIIDRKEVEKQELL-------TYLENELRLSARFD---HPN--IVKVYDILYDPER--IMIIMEYVP
| ... .||| |. .|  ... ..   .|.||.|.||.|.  |....         |.|| ..   ..   |||  ||| ||.....    | ||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLQTLIF---------RGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF------------HPKIIDFGLSKE-KC-----EKLHT
 |||...|          ..  .. .| ..... |......|| ..| |||.||.|||   ..            . || |||..|   .      ...|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

YC------GTTLYMAPEVIL----CDTYDGSKADVWAFGV
..      || |||||...     .  |. .|.|.| .|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

Kinase 85851.m00039.AA ULK 21-205 27 1.2e-58 201.11 In-house 1-244 (329) Show / Hide
Range on Protein: 21-205
Range on HMM: 1-244/329
Sequence Identity: 27% (66 aa)

YKVIKTIGKGGFAVVVLAIDTRN----QQKVAIKIIDRKEVEKQELLTY-------LENELRLSARFD--------HPNIVKVYDILYDPER--IMIIME
| ... .||| |..|  ... ..    ..|||.|.||...  ... . .       |.|| ..  . .        |||||| ||.....    | ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVPNGDLQTLIF----------RGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKF------------HPKIIDFGLSKE-KCE-----
| . |||...|           ..  .. .| ..... ||.....|| ..| |||.||.||| . ..            . || |||..|   ..     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KLHTYC------GTTLYMAPEVIL----CDTYDGSKADVWAFGV
 ..|.       || |||||...     .  |. .|.|.| .|.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

Kinase 85851.m00039.AA Ciliate-E2-Unclassified 21-243 26 3e-55 189.87 In-house 1-317 (352) Show / Hide
Range on Protein: 21-243
Range on HMM: 1-317/352
Sequence Identity: 26% (83 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKV-----AIKIIDRK-EVEKQELLTYLENELRLSAR------------------FDHPNIVKVYDILYDPERIMI
||.||.||.|||..| ....  .. ..     ..||...|    ...   .. .....  .                  ..||.||| ...  | . | |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYVPNGDLQTLI-----------------FRGISFTLEEQL-----NICYEILQALQYLHHRG-ISHRDLKPENILFDLK---FHPKIIDFGLSK--E
.|||...|||.  |                  ..  || .. .     .....|||.|.|||| . | |||.|||||||| .   ...||||||.||  .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

KC----------------EKLHTYCGTTLYM----APEVILCDTYDGS---KADVWAFGVTAHILAAQAFPWGLKSEAQ----------------YLKCI
..                ....| |||  ||    ||||.    ||.|   |.|.|..|| .. .  . .| . ... |                ... |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QMQDISIDV-----IPKGI
. ..|...      |||..
KQKNIQFPKFPWQQIPKHW

Kinase 85851.m00039.AA STE 21-207 25 3.2e-54 186.44 In-house 1-258 (359) Show / Hide
Range on Protein: 21-207
Range on HMM: 1-258/359
Sequence Identity: 25% (68 aa)

YKVIKTIGKGGFAVVVLAIDT------RNQQK---------VAIKIIDRKEVEK--------------QELLTYLENELRLSARFD--HPNIVKVYDILY
.. |. ||||.| .|..|..       .....         .|||... .. ..              .| .  ...|...  ...  |||||| |.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DP-------ERIMIIMEYVPNGDLQTLIFR--GISFTL-----------EEQL-NICYEILQA-LQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSK
.        . . |.|||...| |  .| .  |. ..|           |.|.  ||..||.. |.|||  .| |||.|| |||.      |..|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EKCE-------------------KLHTYCGTTLYMAPEVILC-----DTYDGSKADVWAFGVTA
   .                   |  | .||  .||||||..     |   . |.|.| .| |.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI

Kinase 85851.m00039.AA CAMK-Unique 21-211 23 4.2e-53 173.55 In-house 1-287 (363) Show / Hide
Range on Protein: 21-211
Range on HMM: 1-287/363
Sequence Identity: 23% (69 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLT-----------------YLENELRLSARFDHPNIVKVYDI----LYDPE-------
|| .. ||.|.| .|  ..|  .  | |.|..  . ..   ...                  |..|...  . |||||.|.||.      |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RIMIIMEYVPNGDLQTLIFR--------------------GISFTL--EEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHP----
        .. |.|||.. |||. .| .                     ..|.    . ..|. ..|.|. |.|  .| |||||.|||..   |      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

------------KIIDFGLSKEKC--EKLH---TYCGTTLYMAP--------------EVILCDTYDGSKA----DVWAFGVTAHILA
            |..||||....   .. |   |.||| .||||              |||  . || ..     | |. ||......
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYD-QQCSPASDIWSLGVIMYYML

Kinase 85851.m00039.AA TKL 27-205 21 8.7e-49 168.4 In-house 1-277 (364) Show / Hide
Range on Protein: 27-205
Range on HMM: 1-277/364
Sequence Identity: 21% (62 aa)

IGKGGFAVVVLAIDTRNQ--------QKVAIKIIDRKEV------------------------EKQELLTYLENELRLSARFDHPNIVKVYDILYDPER-
||.|||..|  ..   .         . ||.|.. ....                        | . .   .|.|...  |..|||||. . .  .|.  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------IMIIMEYVPNGD-LQTLIFRGISFTLEEQLNICYEILQALQYLHH--------RGISHRDLKPENILFDLKFH--------------P
            ..|.|||.|.|. | .|.       ..  ......| ....|||         ..| |||||..||| | ...              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIIDFGLSKEKCE----------------------KLHTYCGTTLYMAPEVILCDTYDGSKA---------------DVWAFGV
|| |||||.....                      ...| |||. .|||||.  .... .|.               ||..||.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI

Kinase 85851.m00039.AA Pkinase_Tyr 21-145 25 7.8e-19 64.41 Pfam 1-137 (270) Show / Hide
Range on Protein: 21-145
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

YKVIKTIGKGGFAVVVLAIDT----RNQQKVAIKIIDRKEVEKQE-LLTYLENELRLSARF-DHPNIVKVYDILY-DPER--IMIIMEYVPNGDLQTLIF
 . .|..|.| | .|.... .     ....||.|.. .    ... ..  . .|...   . .|||||. | . . . |   |.|.|||.|.||| .   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----GISFTLEEQLNICYEILQALQYLHHRGISHRDL
.    . ..|... |..|..| ....||. ... ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL

Kinase 85851.m00039.AA TyrKc 21-264 23 8e-16 33.15 SMART 1-280 (280) Show / Hide
Range on Protein: 21-264
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YKVIKTIGKGGFAVVVLAIDTRNQQKVAIKIIDRKEVEKQELLTYLENELRLSARF--DHPNIVKVYDILYDP-------ERIMIIMEYVPNGDLQTLI-
 . .|..| | | .|.... .   ..||.| .          .  . .|.|.  ..  .|||||. | .  ..       | .||.|||.|.|||.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

FRGISFTLEEQLNICYEILQALQYLHHRGISHRDLKPENILFDLKFHPKIIDFGLSKEKCEK-------LHTYC----GTT--L---YMAPEVILCDTYD
 ..  ..... |..|. | .  .|||.... ||||   |.| . ... || |||||..  ..                |.   |    ||||.|   .. 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

GSKADVWAFGVTAH-ILAAQAFPWGL-----KSEAQYLKCIQMQ--DISIDV--------IPKGIIGLIISKSLIFDPAQRAN-----VDV
 .| |||.|||.   |.   . |.       .| .. .....        .          |. .   |...   .||..| .      . 
-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF

Kinase 85851.m00039.AA Pkinase_Tyr 183-206 50 0.058467 7.26 Pfam 181-203 (270) Show / Hide
Range on Protein: 183-206
Range on HMM: 181-203/270
Sequence Identity: 50% (12 aa)

MAPEVILCDTYDGSKADVWAFGVT
||||.|    .  .| |||.|||.
MAPECINYGKFT-TKSDVWSFGVL