Gene 83945.m00109 (T.vaginalis)

83945.m00109

Species: T.vaginalis
Alias: TvagK0773, 83945.m00109
External Links:
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
83945.m00109.AA Protein None 531 None Fasta, JSON
83945.m00109.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 83945.m00109.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 83945.m00109.AA S_TKc 22-276 35 1.3e-90 308.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIPNDKFTTNAEREALQNEISLQKSCNHPNIVKIIHTFADSLNQYIVLEYCPG--GSMEAKYKTEGR---
|. .. || |.||||.|... ||.. .|.|.|.          | ...||.. |. .||||||.. .| |  . |.|.|||.|  |..    |  ||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNPNIKTSVSGTPSYIAPELIFKGTDGISP-KIDIWAIGICVFT
   |..  .. ...  ..|| |.| .||.|||.| .| |. |  |.|.||||.| .      |.. ||| |.|||..     | .. |.|.|..|.... 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYE

LLNGYPPFEASSAKMSFERIKNGTYRFNIAANVSYFAKEFIQKALTRDPEERPTAEELLH-------HQLL
.| |||||.    .| |..|.            |  ||.||.| |..|||.|||| |.|.       |. .
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83945.m00109.AA AGC 22-276 23 1.6e-87 225.64 In-house 1-395 (395) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YKRVDMIGAGGFGKVFKVVEQ------KTQQTYALKVIPNDK-FTTNA--EREALQNE------------ISLQKSCN----------HPNIVK-IIHTF
.. . .|| |.||||. | .        |.. ||.||.  ..    .   . |  ..|                . ||          ||.|||   ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ADSLN--QYIVLEYCP---------GG--SMEAKYK--TEGRFTPEKVAEFLKD-------ALSALCYIHA-KGIVHRD-IKLSNFLIGEDGHVKLCDFG
 |  .   |.|.||.|         ||  ..  ...   ||||. | .  ..          ..|| |.|  .||.||| .|. | |. ||||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAIKDNP----------------------------------------------------NIKTSVSG--TPSYIAPELIFKGTDGISPKIDIWA--IGIC
.. . .                                                     .  ..  |  || |.||| .       ..  |.|.   |..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL------YGKACDWWSFGLGCL

VFTLLNGYPPFEASS----------AKMSFERIKNGTYRFNIA--------------ANVSYFAKEFIQKALTRDPEERPT----------AEELLHHQL
 . .| ||||| . .           .  |..|.|| | .|                 ..|  || .|.| |..|||.|..          |||.  |  
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

L
 
F
Kinase 83945.m00109.AA CAMK 27-276 22 9.1e-83 266.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 27-276
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

MIGAGGFGKVFKVVEQKTQ------------QTYALKVIPNDKFT-------------------------TNAEREALQNEISLQKSCN-------HPNI
 .| |.||||..... .|.            | .| |.|. .| .                         .   |. ...||.. |...       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKIIHTFAD-------------------SLNQYIVL---EYCPGGSM--E-------AKYKTE----------GRFTPEKVAEFLKDALSALCYIHAKGI
.|..... |                     . |.|.   |||.|| .  .        ....|          |||| . .. . .  .||. |.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKLSNFLIGED-----------------GHVKLCDFGFAIKDNPNI-------------------------KTSVSGTPSYIA-PELIFK-G----
||||.|. | |. ..                 . .|..|||||.| .|.                           . . |||.|.| ||.. . |    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------TDGISPKIDIWAIGICVFTLLNGYPPFEAS-------------SAKMSFERIKNGTYRFN------------------IAAN----VSYFAKE
        ....||.|.|..|.  ...| |||||...             . .  ||.|..| |.|                   |  .    ||  .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FIQKALTRDPEERPTAEELLHHQLL
.|.| |..|||.|.|.|. | |. .
LIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase 83945.m00109.AA Pkinase 22-276 30 5.2e-81 280.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIPNDKFTTNAEREALQ-NEISLQKSCNHPNIVKIIHTFADSLNQYIVLEYCPGG----SME----AKYK
|...  ||.|.||.|.| ....|....|.|.|. ..   . .....  .||.. |..||||||.....| |. . |.|.|||.||    .      .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

TEGRF--TPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHV----KLCDFGFAI---KDNPNIKTSVSGTPSYIAPELIFKGTDGISPKIDI
 .|.|  ... .  ...  |..| |.|..||.|||.|..|.|| ..||.    |.||||.|      |    |.. ||| |.|||.|  |  ...||.|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDM

WAIGICVFTLLNGYPPFEAS------SAKMSFERIKNGTYRFNIAANVS-------------------YFAKEFIQKALTRDPEERPTAEELLHHQLL
|..|. .. .|.|.|||  .      . .  ..||. . ..|..    |                     .|.|| . |..||..|||||..|.|  .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83945.m00109.AA PLK 22-276 38 1.8e-77 251.89 In-house 1-258 (258) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-258/258
Sequence Identity: 38% (99 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIPNDKFTTNAEREALQNEISLQKSCNHPNIVKIIHTFADSLNQYIVLEYCPGGSMEAKYKTE-GRFTPE
|.|   .| ||| |.... . .| | || ||.|    . .  || ...|| .... .||||||..| | |. | |||||||...|.    |    |.| .
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

KVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNPN--IKTSVSGTPSYIAPELIFKGTDGISPKIDIWAIGICVFTLLNGYP
 |  ..    ..| |.| ..|.|||.||.|... .. |||..||| | . ...   |  . ||| |||||       | | ..|.|..|. . ||| | |
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFEASSAKMSFERIKNGTYRFNIAANVSYFAKEFIQKALTRDPEERPTAEELLHHQLL
|||... |   .|||.  |.|   . .|. ||..||| | ..|.||||....| |. .
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 83945.m00109.AA Ciliate-E2 22-276 23 1.8e-73 250.36 In-house 1-365 (365) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YKRVDMIGAGGFGKVFKVVE-----------------------QKTQQTYALKVI-PNDKFTTNAEREALQ---------NEISLQKSCNHPNIVKIIHT
|| . .|| |.||.|.|.                         . ... ||.|.. .|... .. |   ..         || ..... |||||.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FA--DSLNQYIVLEYCPGGSMEA-------KYKTE----GRFTPEKVAEFLKDALS---------------ALCYIHAKG-IVHRDIKLSNFLIGEDGHV
|   |  | |.|.||| ||...        | . |    ..|| ...... |  |.               || |.| |. |.|||||..| |.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGFAIKDNPN-----------IKTSVS-----------------------GTPSYIAPELIFKGTDG-------ISPKIDIWAIGICVFTLLNGYP
|..|||.. | ...           ...  .                       ||| | ||| . .. ..        . |.|||..|.. . .| |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEASSAKMSFERIKNGTYRFN----------------IAANVSYFAKEFIQK----ALTRDPEERPT-AEELLHHQLL
||        .. ||.. ..|.                .  ..|  .| .|.|     | .|||.|.| .|..| |. .
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83945.m00109.AA CAMKL 22-276 27 1.1e-72 231.3 In-house 1-297 (297) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-297/297
Sequence Identity: 27% (83 aa)

YKRVDMIGAGGFGKVFKVVE-QKTQQTYALKVIPNDKFTTNAEREA------------LQNEISLQKSCN---HPNIVKIIHTFADSLN------QYIVL
|. .. .| |.||||   .  . |.. .| |.|  .| . .   ..            .. ||...|. |   ||||.|. ... .. .       |.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCPGGS--MEAKYKTE----GRFTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDG--HVKLCDFGFA---IK--DNPNI-KTSVSGTPSYI
|||.||.  .  . . .    ||....    . .  .||. |.| .||||||||. | |. |.|   .|..||||.   ..  ..|.   .   |.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELIFKG-TDGISPKIDIWAIGICVFTLLNGYPPFEAS--------SAKMSFERIKNGTYRFNIAANVSYFAKEFIQKALTRDPEERPTAEELLHHQLL
|||.. .. .. . ||.|||..|.  .... || ||..              ...|. | |...|   ||  .. .|.| |...||.|||..... |  .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 83945.m00109.AA PLK-Unclassified 22-276 37 1.8e-72 247.04 In-house 1-264 (264) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-264/264
Sequence Identity: 37% (100 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIPNDKFTTNAEREALQNEISLQKSCNHPNIVKIIHTFADSLNQYIVLEYCPGGSMEAKYKTE-------
|.|   .| ||| |...| . .| . || |.||    | |  |. | .|| ..|| .|.||||..| | |. | ||.|||||.|..    |         
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

GRFTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNP--NIKTSVSGTPSYIAPELIFKGTDGISPKIDIWAIGICVFT
 | |   |  ..   . || |.| ..| ||| || | .....  ||.|||| | | .     |  . ||| |||||   . . | | ..|.|..|. . |
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLNGYPPFEASSAKMSFERIKNGTYRFNIAANVSYFAKEFIQKALTRDPEERPTAEELLHHQLL
|| | ||||... |  ...||.  | |   ...|  || .||. |. .|..|||  ... |  .
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 83945.m00109.AA STE 22-276 23 1e-69 237.92 In-house 1-359 (359) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YKRVDMIGAGGFGKVFKVVEQK---------------TQQTYALKVIPNDKFTT--------------NAEREALQNEISLQKSCN--HPNIVKIIHTFA
......|| |.||.|.| .  |               |.. .| |... .. ..              . |.. ...||.. | ||  |||||| . .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DSL-------NQYIVLEYCPGGSMEAKYK-TEGRFTP------------EKVA-EFLKDALSA-LCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAI
.         . .|..||..||| .  .| . |.. |            |..   .... | . | |.| ..|.||||| .| |.     |||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KDNPNI-----------------KT-SVSGTPSYIAPELIFKGT----DGISPKIDIWAIGICVFTLLNGYPPF---EASSAKMSFERIK----------
. ....                 |. .. ||| . ||| | ...    .| . | ||| .|...  ...| ||.      .| . . . .          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NGTYRFNIA-----------------ANVSYFAKEFIQKALTRDPEERPTAEELLH--HQLL
   ..  ..                     ..|   |.||.| |..||..||||..||.  |  .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83945.m00109.AA Ciliate-E2-Unclassified 22-276 26 8.9e-68 231.48 In-house 1-352 (352) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-352/352
Sequence Identity: 26% (92 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIP-----NDKFTTNAEREALQNEISLQKS------------------CNHPNIVKIIHTFADSLNQYIV
|| .  || ||||||.|... |..| ||.| .      ..|   | . | ..... ...                   ..||.||| ...| |  | |||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCPGGSMEA---KYKT--------------EGRFTPEKVA-----EFLKDALSALCYIHAKG-IVHRDIKLSNFLIGEDG---HVKLCDFGFAIKDN-
.|||.||...    |.|.                .|| ....      ...  |..|.|.| |. |.|||||..| |. ..|   ..|..|||...| . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------PNIKTSVSGTPSYI----APELIFK-GTDGIS-PKIDIWAIGICVFTLLNGYPPFEA-SSAK---------------MSFERIK
                ... ....|||.|.    |||.. . . |. .  |.|||. |.. . .| ||.||.. .. .               . .. ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NGTYRFNIAAN------VSYFAKEFIQ----KALTRDPEERPTAEELLHHQLL
.. . |. . .      .|  ||.||.    | |  .|..|.|.|..| |...
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83945.m00109.AA PLK1 22-276 34 3.1e-66 216.65 In-house 1-253 (253) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-253/253
Sequence Identity: 34% (89 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQTYALKVIPNDKFTTNAEREALQNEISLQKSCNHPNIVKIIHTFADSLNQYIVLEYCPGGSMEAKYKTEGRFTPEK
|..   .| ||| . . . ...|.. .| ||.|   .  . .|. .  ||.. .. .|..|||. | | |. | ||||| |   |.    |  .  |   
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

VAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNPN--IKTSVSGTPSYIAPELIFKGTDGISPKIDIWAIGICVFTLLNGYPP
   ...  . .  |.| . |.|||.|| |  . .. .||. ||| | | . .   |    ||| |||||.. |   | |  .|||.||  ...|| | ||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNK--KGHSFEVDIWSIGCIMYILLFGQPP

FEASSAKMSFERIKNGTYRFNIAANVSYFAKEFIQKALTRDPEERPTAEELLHHQLL
||... |  . |||.  ||  |  ..|  |...|.| |  ||..|||.|..|. . .
FETKCLKETYSRIKKNEYR--IPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 83945.m00109.AA STE20 22-276 31 4e-65 222.68 In-house 1-288 (288) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-288/288
Sequence Identity: 31% (92 aa)

YKRVDMIGAGGFGKVFKVVEQKTQQT----YALKVIPNDKFTTN-AEREALQNEISLQKSCNHPNIVKIIHTFADSLNQ----YIVLEYCPGGSMEAKYK
|. .. || |..|||.|. . .|..     .| |... .|      |.| .|.|||  | |.|||||| . ..  . .     .|| ||| |||    .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---TEG------RFTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNP----NIK---TSVSGTPSYIAPELIFKGT--
   . |      ... | .|  ....| .| |.|...|.|||||  | |..||| |||.|||.. . ..     ..    .. ||| . |||.| . .  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-DGISPKIDIWAIGICVFTLLNGYPPFEA-SSAKMSFERI--KNGTYRFNI--AANVSYFAKEFIQKALTRDPEERPTAEELLHHQLL
  |   | |||. ||.   ...| ||.   .  .. |. .  .|.. ..      . |   ..|. | |..|||.||||..||.|. .
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 83945.m00109.AA Pkinase_Tyr 22-165 25 2.4e-18 62.77 Pfam 1-156 (270) Show / Hide 
Range on Protein: 22-165
Range on HMM: 1-156/270
Sequence Identity: 25% (40 aa)

YKRVDMIGAGGFGKVFKVVEQ----KTQQTYALKVIPNDKFTTNAE--REALQNEISLQKSC-NHPNIVKIIHTFA-DSLN--QYIVLEYCPGGSMEAKY
 .   ..|.| ||.|.| .      .|... | |.. ..  ..  .  ||.. .|... |.  .|||||. .     ..     |||.||.|.|..    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KT----EGRFTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFG
..    ....|..   ..  .  ... | ..|...|||.   | |..|...|| ||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 83945.m00109.AA TyrKc 22-275 21 4.7e-16 36.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-275
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YKRVDMIGAGGFGKVFK-VVEQKTQQTYALKVIPNDKFTTNAEREALQNEISLQKSC--NHPNIVKIIHTFADS-------LNQYIVLEYCPGGSMEAKY
 .  ...| | ||.|.| .      .. | |.. .|.      ||.. .|... ..   .|||||...    ..          .||.||.|.|.     
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KTEGR-FTPEKVAEFLKDALSALCYIHAKGIVHRDIKLSNFLIGEDGHVKLCDFGFAIKDNPN--------IKTSVS--GTPS-----YIAPELIFKGTD
.  .. .....  .|  .. .   |.| |...|||.   | |.||...|| .||| . .             ... .  |. .       ||| |    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NY

GI-SPKIDIWAIGICVF-TLLNGYPPFEA-----SSAKMSFERIKNGTYRFNIAA--------NVSYFAKEFIQKALTRDPEERPTAEELLHHQL
|. ..| |.|. |.| .  . .| .| .       |..  .|..|.| ..   .           .   .  ...   .|||.||| .|. |...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF
Kinase 83945.m00109.AA Pkinase_Tyr 260-275 62 0.675871 3.66 Pfam 256-270 (270) Show / Hide 
Range on Protein: 260-275
Range on HMM: 256-270/270
Sequence Identity: 62% (10 aa)

DPEERPTAEELLHHQL
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DPEDRPTFSEI-HEQL
POLO_box 83945.m00109.AA POLO_box 350-415 27 2e-17 67.97 Pfam 1-74 (74) Show / Hide 
Range on Protein: 350-415
Range on HMM: 1-74/74
Sequence Identity: 27% (20 aa)

LSDKYGLGYLLQDGCVGAV-FNDYTRMISDPHRT-FIQYYD---SPHTVNFQIVDAKT---PSDDVSKKLIILS
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YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box 83945.m00109.AA POLO_box 454-473 38 0.652523 6.97 Pfam 7-27 (74) Show / Hide 
Range on Protein: 454-473
Range on HMM: 7-27/74
Sequence Identity: 38% (8 aa)

VLFRFDNGDIQVN-FEDSIKL
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IMYQLSNGTVQVNFFNDHTKI