Gene 88712.m00314 (T.vaginalis)

88712.m00314

Species: T.vaginalis
Alias: 88712.m00314, TvagK0684
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
88712.m00314.AA Protein None 448 None Fasta, JSON
88712.m00314.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 88712.m00314.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88712.m00314.AA NEK 9-261 36 1.9e-114 386.49 In-house 1-286 (286) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-286/286
Sequence Identity: 36% (104 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDY-----VVVKTIKIKGSDDSSRKTAQ-KEATLLSNLRHPNIIAYIDSFYTPQ-GDFSIVLEYAD-GKDLQKY---
|..|..||.||.||||. .. ..|.      .| | |.... ..  .. || .|. .|. |.||||..|.|||.  | . . || ||.. | ||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LESHE----EIKEKKVLQIFTQIILGLEYIHSQ-----NILHRDIKTANVFLFKRGL----VKLGDFGISREVTED-SFAQT-MIGTPYFMCPELLRGDP
.. .      . |.... .|.|..|.| |.|..     .|||||||..|.|| |..     ||.||||||..   . ..|.| ..||||.|.||.... |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSFPADIWAAGCVLFELLTH--KHAFTGK--SREELFTNIKSG-NMSMMPSG--YSKELIELLMSMLQQDPNDRPTCKEILASNII
|.. .|||. ||||.|. |   ||.| ..  . ..|...|. | . .  ||   ||..| .|. .||| || .||.|..||.  .|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 88712.m00314.AA S_TKc 9-261 30 1.1e-91 311.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQKEATLLSNLRHPNIIAYIDSFYTPQGDFSIVLEYADG--KDLQKYLESHEE---
|. ...||||..||||. ...| | .| .| ||         .....|  .|.. .||||. ..|.|..  ... .|.||.||   || .|....     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRGLVKLGDFGISREVTEDSFAQTMIGTPYFMCPELLRGDPYSF-PADIWAAGCVLFEL
   . |  .  .. ||...|||.||..|.|||.| .|..| .   .|..|||..|..       |..|||..| ||.|   .|.. ..|.|. ||.|.|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTHKHAFTGKSREELFTNIKSGNMSMMPSGYSKELIELLMSMLQQDPNDRPTCKEILA-------SNII
|. .  |     ...| .|.           |.|...... .|| ||..|||. |.|.          .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88712.m00314.AA NEK8 9-261 33 1e-89 256.32 In-house 1-278 (278) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-278/278
Sequence Identity: 33% (93 aa)

YKRIQQIGKGSYGKVYLMKDNKNG--DYVVVKTIKIKGSDDSSRKTAQKEATLLSNLRHPNIIAYIDSFYTPQGDFSIVLEYADGKDLQKYLESHEE---
| ||  .|.|. | . |      .    |. | |   . . . |  || |  .|| | |||||.|.|.|    .   |..|||||  |  .. .      
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME-DNTLMIEMEYADGGTLYQMIQHQQNKLF

IKEK----------------KVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKR-GLVKLGDFGISREVTEDSFAQT---MIGTPYFMCPELLRGDPY
  |.                 .|  |.|. ... ..|. ||||||.||.|.|. .. ..||.|||||| .   .. .||    .|||| | ||.  | ||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

SFPADIWAAGCVLFELLTHKHAFTGKSREELFTNIKSG-NMSMMPSGYSKELIELLMSMLQQDPNDRPTCKEILASNII
 .  |.|| ||||.|... | || .    .| . | .. ..   ...||.|.. |  . |||||  ||.  .|.|   .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 88712.m00314.AA NEK1 9-261 37 2.5e-87 296.43 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-276/276
Sequence Identity: 37% (104 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQKEATLLSNLRHPNIIAYIDSFYTPQGD--FSIVLEYADGKDLQKYLESH----E
| .|.|||.||.||..| |.   |   | | |..  . .. | .. .|. .|....||||..| .||    |     || ||.|| || .  .       
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEE-NGCGILYIVMEYCDGGDLMQKINRQKRKGK

EIKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLF--KRG---------------LVKLGDFGISREVTE-DSFAQTMIGTPYFMCPELLRGDPYS
 . |   .. |.|| |.| .||...|||||||. |.||   | |               |||||||||.|   . ...|.| |||||   ||.    || 
LFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

FPADIWAAGCVLFELLTHKHAFTGKSREELFTNIKSGNMSMMPSGYSKELIELLMSMLQQDPNDRPTCKEILASNII
   |||..|||| ||.| ||.| ...   |   | .|  .  |. ||.|| .|. .|.. .| .||    || . .|
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 88712.m00314.AA Pkinase 9-261 28 5.2e-85 293.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQK--EATLLSNLRHPNIIAYIDSFYTPQGDFSIVLEYADGK----DLQKYLE--S
|.....||.||.|.||. .. ..|. |.||.|| .. ... ..|. .  |. .. .|.||||. ..|.|..  ..  .|.||..|     ||  |..  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

HEEI--KEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRGLV----KLGDFGISRE--VTEDSFAQTMIGTPYFMCPELLR-GDPYSFPADIWA
|  .   |. .  ...||. ||||.||..|.|||.| .|... ..| .    |..|||...      .| ..|  |||..| ||..| | .|. ..|.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCVLFELLTHKHAFTGK------SREELFTNIKS-GNMSMMPSGYS-------------------KELIELLMSMLQQDPNDRPTCKEILASNII
.||.|.|.|. .  | |.      .  ... .|..  ...  |  .|                   .|..... ..|..||..|||...|| .  .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 88712.m00314.AA NEK4 9-261 39 1.6e-84 287.12 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQKEATLLSNLRHPNIIAYIDSFYTPQG-DFSIVLEYADGKDLQKYLESH--EEIK
|  ....|||||| |.| .  . .   |.| .. |  .   || | .|| ||| |.||||. | .|.    |    ||. . .| || . |     . ..
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRGLVKLGDFGISREVT-EDSFAQTMIGTPYFMCPELLRGDPYSFPADIWAAGCVLFELLTHKH
|. |.  | || ..| |.| ..||||| || |.|| |. ..|.|||||||       .|.|||||||.| ||.    || .  |||. || ..|. | ||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFTGKSREELFTNIKSGNMSMMPSGYSKELIELLMSMLQQDPNDRPTCKEILASNII
||  |    |   |  | .  ||  ||..| .|.  ||.. |..||   .|.    |
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 88712.m00314.AA CAMK 14-257 19 1.6e-81 262.3 In-house 1-421 (425) Show / Hide 
Range on Protein: 14-257
Range on HMM: 1-421/425
Sequence Identity: 19% (82 aa)

QIGKGSYGKVYLMKDNKNG------------DYVVVKTIKIKGSD--------------------------DSSRKTAQKEATLLSN-------LRHPNI
..|.||.|||.| .. ...              | .| |. |  .                          ...||  ..|  ....       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYIDSFY------------TPQG-------DFSIVL---EYADGK----DLQKYLESHEE---------------IKEKKVLQIFTQIILGLEYIHSQN
|  .. .             | .        .. .|.   ||..|     ||  |. .|.                ..|. . ..| ||. ...|.||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKTANVFLFKR-----------------GLVKLGDFGISREVTE------------------------DSFAQTMIGTPYFMC-PELLRG-----
| |||.|  |. | ..                 . .|. ||| ......                        .   .|. |||..|. ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------DPYSFPADIWAAGCVLFELLTHKHAFTGK-------------SREELFTNIKSGNMSMMPSGYSK-----------------------ELI
         ..|....|.|..|..|. .|. .  | |.             . .||| .|..|. .. |.  |.                       | .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

ELLMSMLQQDPNDRPTCKEILA
 |. .||| ||..|.|....|.
DLIRKMLQVDPEKRMTIEQCLN
Kinase 88712.m00314.AA CAMKL 9-256 27 7.3e-76 241.54 In-house 1-292 (297) Show / Hide 
Range on Protein: 9-256
Range on HMM: 1-292/297
Sequence Identity: 27% (80 aa)

YKRIQQIGKGSYGKVYLMKD-NKNGDYVVVKTIK--IKGSDDSSRKT-----------AQKEATLLSNLR---HPNIIAYIDSFYTPQ-----GDFSIVL
|. ....||||.||| | ..   .|  | .| |.   .  |. ..|             ..|. ... |.   |||||   . ..||.     ... .|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYADGKD--LQKYLESHEE----IKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRG--LVKLGDFGISREVTE-----DSFAQTMIGTPYFM
||..| .  |. |...|..    ..|.   ..|.||. ...|.||..| |||||  |. | ..|   .|. ||| | . ..     . .  |  |.| .|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

CPELLRG--DPYS-FPADIWAAGCVLFELLTHKHAFTGKSRE-------ELFTNIKSGNMSM-MPSGYSKELIELLMSMLQQDPNDRPTCKEIL
.||.. |  .||  ...|||..| .|. ... .  | . . .       .|.  |..|   .  ..  | ... |. .||| .|..|||...|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM
Kinase 88712.m00314.AA Ciliate-E2 9-261 23 7.1e-73 248.42 In-house 1-365 (365) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-365/365
Sequence Identity: 23% (87 aa)

YKRIQQIGKGSYGKVYLMKDNKNGD-----------------------YVVVKTI-----KIKGSDDSSRKTAQ------KEATLLSNLRHPNIIAYIDS
|| |..||.|..|.||..|. |..                        .. .|..     ... . ..  .. .      .|  .|..| ||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYT-PQGDFSIVLEYADGKDLQKYLE-----SHEEIK------EKKVLQIFTQIIL---------------GLEYIHSQN-ILHRDIKTANVFLFKRGLV
|..  .  . .|.||..|.||..|..     ...||.      ||....|..||.                .|||.||.| |.|||||  |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGISREVTED--------------------------------SFAQTMIGTPYFMCPELLRGDP---------YSFPADIWAAGCVLFELLTHKHA
|. |||.|.....|                                  ..| .|||..|.|| |.| .         |.. .|||..|..|.|.|. |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FTGKSREELFTNIKSGNMSMM-----------------PSGYSKELIELLMS----MLQQDPNDRPT-CKEILASNII
|        . .|| .. .                   .   |.| . |.      ||| ||. |.|  ..||   ..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 88712.m00314.AA STE 9-261 21 4.9e-68 232.35 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

YKRIQQIGKGSYGKVYLMKDNK---------------NGDYVVVKTIKIKGSD---------------DSSRKTAQKEATLLSNLR--HPNIIAYIDSFY
...|..||||..|.||. ...|               .|... .| .... ..               .. ..  .||  ......  ||||. |.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TP------QGDFSIVLEYADGKDLQKYLE---SHEE-----------IKEKKVLQIFTQIILG-LEYIHSQNILHRDIKTANVFLFKRGLVKLGDFGISR
         ..  |..|| ||  | . ..   .. .           ..|. .  |  ||. | |.|.||..| ||||| ||..|     ||| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

EVTE-----------------DSFAQTMIGTPYFMCPELLRG------DPYSFPADIWAAGCVLFELLTHKHAF-TGKSREELFTNIKSGNMSM------
 .|.                 ..  .|..||| .| || ...      ..|.. .|||  ||.. |..| |. . ...  . .|  .... |..      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----------M-----------------PSGYSKELIELLMSMLQQDPNDRPTCKEILA--SNII
                            |. .|.|... .   || |||.||| .. |      |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 88712.m00314.AA Ciliate-E2-Unclassified 9-261 25 6.8e-67 228.55 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQ----------------------KEAT-LLSNLRHPNIIAYIDSFYTPQGDFSIV
|| |.|||.|..||||.....|.. | . |..| . ....  .  .                      |..  .|.|. ||.|. ... | . .  . ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQD-KQNIYIV

LEYADGKDLQKYLESHEE-----------------IKEKKVL-----QIFTQIILGLEYIHSQN-ILHRDIKTANVFLFKRG---LVKLGDFGISR----
.||..|.||..|... .                  . |....     ..| ||..||||.|..| |.|||||  |... . |    .|. |||||.    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----EVTE---------DSFAQTMIGTPYFM----CPELLRGDPYS----FPADIWAAGCVLFELLTHKHAFTGKSREE----------------LFTNI
    . |.         .  ..|..|||..|     ||.|.|  |.    . .|||. |..|.|.|. .. | ....|.                |. ||
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KSGNMSMMP-------SGYSKELIELLM----SMLQQDPNDRPTCKEILASNII
| .| .  .        . |.| ....     .||. .|| |.| ..||   ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 88712.m00314.AA ULK 9-261 25 1.1e-65 224.53 In-house 1-329 (329) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YKRIQQIGKGSYGKVYLMKDNKN----GDYVVVKTIKIKGSDDSSRKTA--------QKEATLLSNLR--------HPNIIAYIDSFYTPQG-DFSIVLE
|  ....||||.||||  ...|.    . .|..| | ..  . ..            ..|  ..  |         ||||. ..| |.|..   . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGKDLQKYLESHEE----------IKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKR------------GLVKLGDFGISREVTED----S
| .| ||..|.. . .          . |....|.| ||. |. ..|..|| ||||| .|. . .             | .|..||| .. |..|     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FAQTMI------GTPYFMCPELLRGD----PYS-FPADIWAAGCVLFELLTHKHA----FTGKS---REELFTN-------IKSGNMSMMPSG----YSK
 ..|.       |||..|.|..| |     ||. . .|||  ||...|.|. |      |.       ..|. |       ||. .    ..|     |.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

ELIELLMSMLQQDPNDRPTCKEILASNII
|...|.  ||| |..|| .  |...  ..
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 88712.m00314.AA Pkinase_Tyr 9-260 27 4.3e-26 89.0 Pfam 1-270 (270) Show / Hide 
Range on Protein: 9-260
Range on HMM: 1-270/270
Sequence Identity: 27% (74 aa)

YKRIQQIGKGSYGKVYLMKDN----KNGDYVVVKTIKIKGSDDSS--RKTAQKEATLLSNL-RHPNIIAYIDSFYTPQGD--FSIVLEYADGKDLQKYLE
 . ....|.|..|.||. . .    ...  | ||..|  |....   |.   .|| ....| .||||. ..   .  ..     ||.||. . || .|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SH----EEIKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRGLVKLGDFGISREVTEDSFA-QTMIGTPYF----MCPELLRGDPYSFPADIW
.|    . .. |  ||. .||  |.|| .|.|. |||. . |. . . . || .||| .| ...|.   ..  |.. .    | || ..   ..   |.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVW

AAGCVLFELLT--HKHAFTGKSREELFTNI-KSGNMSMMPSGYSKELIELLMSMLQQDPNDRPTCKEILASNI
. | ...|..|   . .. | | ||..  | ..|.   .| . ..|. .|...  ..||.|||| .||  . .
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI-HEQL
Kinase 88712.m00314.AA TyrKc 9-261 25 6e-24 86.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

YKRIQQIGKGSYGKVYLMKDNKNGDYVVVKTIKIKGSDDSSRKTAQKEATLLSNL--RHPNIIAYIDSFYTPQ------GDFSIVLEYADGKDLQKYLES
 . ....| | .|.||. . .     | ||..|        |.   .|| ....|  .||||.. .    ...      .   ||.||... ||..|| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HEE-IKEKKVLQIFTQIILGLEYIHSQNILHRDIKTANVFLFKRGLVKLGDFGISREVTED-----SFAQTMI----GTP-----YFMCPELLRGDPYSF
|.. .. |. |.. .||  | ||.||.|. |||. . |. . ... || .||| ||....|     |    .     |.        | || ..   ...
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

PADIWAAGCVLFELLTH-KHAFTG-----KSREELFTNIKSGNMSMMPSG--------YSKELIELLMSMLQQDPNDRPTCKEILASNII
  |.|. | ...|..|  .    |     .| .|.. ..|.|.. . |           ..|. ..  .  . ||.|||| .||    ..
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF