Gene 96145.m00178 (T.vaginalis)

96145.m00178

Species: T.vaginalis
Alias: TvagK0897, 96145.m00178
External Links:
Annotation:

Classification

Group: Other
Family: Uni1

Sequence

Name Sequence Type Origin Length Description Download
96145.m00178.AA Protein None 1272 None Fasta, JSON
96145.m00178.kin_dom Protein Kinase Domain None 279 None Fasta, JSON

Protein domain

Protein domains of 96145.m00178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 96145.m00178.AA S_TKc 947-1225 21 1e-33 119.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 947-1225
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

YKNGQHIASGAFGAVMAVMVND--VKVAVKILQKSRDTFDNPKLVDVFGEISILELCKGDRRVTQLLNYGCTSDSYYIVMEFYPM---TLKTWRKSFQSN
|. ...| .|||| |. .  ..   .||.||.             ..  ||.||.   .   . .|. .  . |..|.|||. .    .|..  |. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P-----PLPTIIRLFKEFLNAATVLLDNRINHFDIKCDNVVLDKNGYPALADFGESICYKNEASSYTQLNRGTEWIKSPEMLSIAINASVNNPTFDRRKQ
.     |  .. ..... ..|   . ...| | |.| .|. ||.     ..||| .  .            || |  .||.|                  
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL------------------

VGAGP-ASDVWSIGCLFYELLTGEFLFVDTDWSRFFTRVTDPKEALITPQCMKKLPKDMRFSGFIEFVLQRSVSRRPSLTQVIA-----KFDEYF
 | |. ..|.||.||..||.|.|. .|   .  . | ..                  .  .  ||.  ||.  ..||.  .. .     | ...|
-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96145.m00178.AA STE 947-1159 15 1.1e-17 59.08 In-house 1-265 (359) Show / Hide 
Range on Protein: 947-1159
Range on HMM: 1-265/359
Sequence Identity: 15% (45 aa)

YKNGQHIASGAFG-AVMAVMVN----------------DVKVAVKILQKSRDTFDNPK--------------LVDVFGEISILELCKG-DRRVTQLLNYG
... . | .||||  . |. ..                 . .|.|.. .....  . .              . ..  ||.|.  |.     . . . . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

CTS-------DSYYIVMEFYP-MTLKTWRK---SFQSNPP----------LPTIIRLFKEFLNA-ATVLLDNRINHFDIKCDNVVLDKNGYPALADFGES
          |. .|.||. .  .|    |   . . . .           . |..  .. | .    | ...| | |||..|. |       |.||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

ICYKN---------------EASSYTQLNRGTEWIKSPEMLSIAINASVNNPTFDRRKQVGAGPASDVWSIGCLFYELLTGE
 .  .                 .. ..   ||    .||...   ..             | .  .|.||.||.  |..||.
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---------DKGYDTKCDIWSLGCTIIEMATGK
Kinase 96145.m00178.AA Ciliate-E2-Unclassified 1061-1166 23 3.1e-15 49.32 In-house 159-274 (352) Show / Hide 
Range on Protein: 1061-1166
Range on HMM: 159-274/352
Sequence Identity: 23% (31 aa)

LLDN-RINHFDIKCDNVVLDKNG---YPALADFGESI-------CYKNEA--------SSYTQLNRGTEWIK----SPEMLSI-AIN--ASVNNPTFDRR
|  .  | | |||..|...|.||   |. ..||| |.       |. ..         .  .. . ||   .    .||.|     .  ..         
LHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---------

KQVGAGPASDVWSIGCLFYELLTGEFLFVDTD
       ..|.|| |...||.|.|.. | |..
------YKCDIWSLGVILYEMLFGYYPFYDNN
Kinase 96145.m00178.AA Pkinase 1063-1162 27 2.9e-14 51.52 Pfam 126-212 (293) Show / Hide 
Range on Protein: 1063-1162
Range on HMM: 126-212/293
Sequence Identity: 27% (29 aa)

DNRINHFDIKCDNVVLDKNGYP----ALADFGESICYKNEASSYTQLNRGTEWIKSPEMLSIAINASVNNPTFDRRKQVGAGPASDVWSIGCLFYELLTG
...| | |.| .|. .|.||..     ..||| . ....  .| ..   || |  .|| .                .. . ||..|.||.||..||.|.|
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---------------GGQYYGPKVDMWSCGCILYEMLCG

EFLF
...|
RPPF
Kinase 96145.m00178.AA CMGC 947-1090 14 4.1e-11 31.82 In-house 1-249 (513) Show / Hide 
Range on Protein: 947-1090
Range on HMM: 1-249/513
Sequence Identity: 14% (35 aa)

YKNGQHIASGAFGAVMAV----------------MVNDVKVAVKILQKSRDTFDNPK---LVDVFG-----EISILELCK---------------GDRR-
|.. . | .|..| |                   . .. .||.|.. .     .  |   . |.|      ||.||.  .                ..  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VTQLLNYGCTSD-----------------SYYIVMEFYPMTLKTWRKSFQ------SNPPL-------------PTIIRLF------KEFLNA--ATVLL
. .|...  ...                 . |.|.|. ...|.   |. |       . ||             ..|  ..      .  |..     . 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNR--INHFDIKCDNVVLDKNGYP--------------------ALADFG
 ..  | | |.|  |. ...|.                       ..|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG
Kinase 96145.m00178.AA Ciliate-E2 1068-1162 21 5.4e-11 33.96 In-house 184-296 (365) Show / Hide 
Range on Protein: 1068-1162
Range on HMM: 184-296/365
Sequence Identity: 21% (28 aa)

HFDIKCDNVVLDKNGYPALADFGESICYKNE---------ASSYTQLN----------------------RGTEWIKSPEMLSIAI---NASVNNPTFDR
| ||| .|...     . ..||| |  |...         .  |.. .                       ||   ..||.|.      .          
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----------

RKQVGAGPASDVWSIGCLFYELLTGEFLF
 || | . ..|.||.|...||.|.|.. |
QKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase 96145.m00178.AA AGC 1114-1164 32 1.4e-09 19.41 In-house 275-307 (395) Show / Hide 
Range on Protein: 1114-1164
Range on HMM: 275-307/395
Sequence Identity: 32% (17 aa)

SPEMLSIAINASVNNPTFDRRKQVGAGPASDVWS--IGCLFYELLTGEFLFVD
.||.|                     |.| | ||   |||.||.|||   | .
APEIL--------------------YGKACDWWSFGLGCLMYEMLTGYPPFYG
Kinase 96145.m00178.AA GEK 1068-1159 35 3.4e-09 26.58 In-house 123-203 (269) Show / Hide 
Range on Protein: 1068-1159
Range on HMM: 123-203/269
Sequence Identity: 35% (33 aa)

HFDIKCDNVVLDKNGYPALADFGESICYKNEASSYTQLNRGTEWIKSPEMLSIAINASVNNPTFDRRKQVGAGPASDVWSIGCLFYELLTGE
| ||| |||.||.||   |||||  .  ... .   .   ||    |||.|    .            .   ||  | ||.| . ||.| ||
HRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDG-----------KGRYGPECDWWSLGVCMYEMLYGE
Kinase 96145.m00178.AA CMGC 1140-1162 35 6.4e-08 21.14 In-house 313-343 (513) Show / Hide 
Range on Protein: 1140-1162
Range on HMM: 313-343/513
Sequence Identity: 35% (11 aa)

GPASDVWSIGCLFYELLTG--------EFLF
... |.||.|| |.|..||        . ||
TTPIDMWSVGCIFAEMYTGYQSLIFRGKPLF
Kinase 96145.m00178.AA AGC 947-1028 19 6.6e-08 14.98 In-house 1-116 (395) Show / Hide 
Range on Protein: 947-1028
Range on HMM: 1-116/395
Sequence Identity: 19% (23 aa)

YKNGQHIASGAFGAVMAVMVN--------DVKVAVKILQKSR-----D--TFDNPKLVD-------VFGEISILELCKG---------DRRVTQLLNYGC
..   .|  |.|| |. |  .        .   |.|.|.|..     .  . .. .  .       |. |  |||.|..            ....| |  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

TSDSY---YIVMEFYP
 ....   |.|||..|
QDKDHTYLYFVMEYMP
Kinase 96145.m00178.AA TyrKc 947-1221 17 9.6e-08 -97.44 SMART 1-280 (280) Show / Hide 
Range on Protein: 947-1221
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

YKNGQHIASGAFGAVMAVMVNDVKVAVKILQKSRDTFDNPKLVDVFGEISILELC-KGDRRVTQLLNYGCTS-------DSYYIVMEFYPM-TLKTWRKS
 . |. . .|||| |.  . . ..|||| |...        . |   |..|.    .    . .|. .  ..       . ..||||. |   ||   ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

FQSNPPLPTIIRLFKEFLNAATVLLDNRINHFDIKCDNVVLDKNGYPALADFGESICYKNE-----ASSYTQLNR--GTE------WIKSPEMLSIAINA
 . . .... .       .    | .... | |. . |. ...|.    .||| |   ...     ...|       |.       |  .|| .      
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI------

SVNNPTFDRRKQVGAGPASDVWSIGCLFYELLT-GEFLFVD-----TDWSRFFTRVTDPKEALITPQCMKK--------LPKDMRFSGFIEFVLQRSVSR
  |  .|         ..||||| | . .|..| |.    .      .... . .|    ..   . ...          |..|     ..   ..  . 
--NYGKFT--------TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV----KQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPED

RPSLTQVIAKF
||. .... .|
RPTFSEIHECF
Kinase 96145.m00178.AA Pkinase 947-1032 28 5.2e-07 25.88 Pfam 1-87 (293) Show / Hide 
Range on Protein: 947-1032
Range on HMM: 1-87/293
Sequence Identity: 28% (26 aa)

YKNGQHIASGAFGAV-MAVMVNDVK-VAVKILQKSRDTFDNPK----LVDVFGEISILELCKGDRRVTQLLNYGCTSDSYYIVMEFYPMTLK
|. |. | ||.|| |  .. ... | |||||. |...  . ..    |     ||.|.  .. .  . .|. .  ..|..|.|||. ...|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPN-IVRLYDWFEDKDHIYMVMEYCEGGLY
Kinase 96145.m00178.AA CAMK 952-1026 14 2e-06 15.68 In-house 1-141 (425) Show / Hide 
Range on Protein: 952-1026
Range on HMM: 1-141/425
Sequence Identity: 14% (21 aa)

HIASGAFGAVMAVMVN-D-------------VKVAVKILQKSRDTFDNP------------------------KLVDVFGEISILELCKG------DRRV
 . .|.|| |  ..   .             .|||.||. |.. . ...                        ..  |. ||.|. ...|       . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

TQLLNYGC------------TSDS--------YYIVM---EF
 .|. .              | .         .|.||   |.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEY
Kinase 96145.m00178.AA ULK 1143-1159 58 3e-06 17.84 In-house 237-253 (329) Show / Hide 
Range on Protein: 1143-1159
Range on HMM: 237-253/329
Sequence Identity: 58% (10 aa)

SDVWSIGCLFYELLTGE
.|.||.||.|||.|.|.
CDIWSLGCIFYEMLYGK
Kinase 96145.m00178.AA ULK 1143-1159 58 4e-06 17.89 In-house 233-249 (324) Show / Hide 
Range on Protein: 1143-1159
Range on HMM: 233-249/324
Sequence Identity: 58% (10 aa)

SDVWSIGCLFYELLTGE
.|.||.||.|||.|.|.
CDIWSLGCIFYEMLYGK
Kinase 96145.m00178.AA CDC2 1144-1162 50 6e-06 13.63 In-house 188-209 (301) Show / Hide 
Range on Protein: 1144-1162
Range on HMM: 188-209/301
Sequence Identity: 50% (11 aa)

DVWSIGCLFYEL---LTGEFLF
|.|||||.|.|.    | . ||
DMWSIGCIFAEMFMDVTKKPLF
Kinase 96145.m00178.AA AGC 1070-1090 45 2.1e-05 8.35 In-house 179-200 (395) Show / Hide 
Range on Protein: 1070-1090
Range on HMM: 179-200/395
Sequence Identity: 45% (10 aa)

D-IKCDNVVLDKNGYPALADFG
| .| .|..||..|.  |.|||
DYLKPENILLDEDGHIKLTDFG
Kinase 96145.m00178.AA CDC2 1021-1090 30 9.5e-05 9.94 In-house 76-148 (301) Show / Hide 
Range on Protein: 1021-1090
Range on HMM: 76-148/301
Sequence Identity: 30% (22 aa)

YIVMEFYPMTLKTWRK-SFQ--SNPPLPTIIRLFKEFLNAATVLLDNRINHFDIKCDNVVLDKNGYPALADFG
|.| |.. | ||   . |..  .. |. ..  ...  |..   .  .|| | |.| .|  .||.|   .||||
YMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFG
Kinase 96145.m00178.AA CAMK 1135-1160 34 0.000136 9.93 In-house 307-332 (425) Show / Hide 
Range on Protein: 1135-1160
Range on HMM: 307-332/425
Sequence Identity: 34% (9 aa)

KQVGAGPASDVWSIGCLFYELLTGEF
.. . ||..|.||.|.. | .|.|..
EKPYYGPKCDMWSCGVILYIMLCGYP
Kinase 96145.m00178.AA CAMK 1063-1096 21 0.000283 8.89 In-house 197-247 (425) Show / Hide 
Range on Protein: 1063-1096
Range on HMM: 197-247/425
Sequence Identity: 21% (11 aa)

DNRINHFDIKCDNVVLDKNG----------------Y-PALADFGESICYK
.. | | |.|..|. ||.|.                .   ..||| .. ..
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
Kinase 96145.m00178.AA ULK 947-1090 20 0.000335 10.88 In-house 1-183 (324) Show / Hide 
Range on Protein: 947-1090
Range on HMM: 1-183/324
Sequence Identity: 20% (38 aa)

YKNGQHIASGAFG-AVMAV--MVN---DVKVAVKILQKSRDTFDNPK------LVDVFGEISILELCK--GDRR--VTQLLNYGCTSDS--YYIVMEFYP
|   . . .|.||  |     . .   ...||.|. .|.    .. .      .     ||.|.   |        . .|. .  ||..  .||.||. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

M-TLKTWRKS--------FQSNPPLPTIIRLFKEFLNAATVLLDNRINHFDIKCDNVVLDKN------------GYPALADFG
  .|..  |         .. . . . .|  || ..|.   | .. | | ||| .|  . ..            |   .||||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 96145.m00178.AA ULK 947-1090 19 0.000378 10.48 In-house 1-187 (329) Show / Hide 
Range on Protein: 947-1090
Range on HMM: 1-187/329
Sequence Identity: 19% (37 aa)

YKNGQHIASGAFGAVMAV--MVND--VKVAVKILQKSRDTFDNPKLVD--------VFGEISILELCK---GDRR----VTQLLNYGCTSDS--YYIVME
|   . . .|.|| |     . ..  |...|.. . ....... .  .        .  || |.   |   .       . .|. .  ||..  .||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FYPM-TLKTWRKS---------FQSNPPLPTIIRLFKEFLNAATVLLDNRINHFDIKCDNVVLDKN------------GYPALADFG
. .  .|..  |          .. . . . .|  || .||.   | ...| | ||| .|. ....            |   .||||
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 96145.m00178.AA Ciliate-E2-Unclassified 947-981 29 0.114901 1.58 In-house 1-37 (352) Show / Hide 
Range on Protein: 947-981
Range on HMM: 1-37/352
Sequence Identity: 29% (11 aa)

YKNGQHIASGAFGAVMAVMVNDVK--VAVKILQKSRD
|| .. | .|.|| |  .  .. |   | |.. |...
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQI