Gene 108279.m00003 (T.vaginalis)

108279.m00003

Species: T.vaginalis
Alias: TvagK0445, 108279.m00003
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
108279.m00003.AA Protein None 323 None Fasta, JSON
108279.m00003.kin_dom Protein Kinase Domain None 187 None Fasta, JSON

Protein domain

Protein domains of 108279.m00003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 108279.m00003.AA CK1 10-263 26 3.2e-75 256.19 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-339/339
Sequence Identity: 26% (92 aa)

YKILEPIGHGGFG-QVYLV-----KSTEDD-----QYYAMKIEKLDSK--IKSLEFEVTVIKRLHNS-------------------DRFPRILSSGKEGD
.|. ..|| |||| |.|.|     |.....     . ||||.|. .|.    .|. |. ..| |..                      .|...  ..|.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--LNYFVMELFGPSLHTIAE--WMPSGYINRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGT--------------FPLALLDFGISK-QYI
   || ||.|.||.|  . .   |. . ..   ....|. ||. .|..| .|.||||||| ||.. .|.                 . ..|||... .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DRDGN------------HLPARD---SVHIAW-SPYYASLNSHKHKELSRRDDLISWLFSVMALTEFK--LPWQTDDHVDD-----IERFKQK----YEL
|.||.            | |.|.    .      . |.|.|.|..||..||||| ||.. .. ..  .  |||| ..  .      .|. |..     ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

AMVVNPLGQP---------FKDIATYIQSLDYSDTPDYAKI
 . .. |. |         | .|..|| ||.|.|.|||..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 108279.m00003.AA TTBKL 10-267 29 3.9e-61 205.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-288/288
Sequence Identity: 29% (86 aa)

YKILEPIGHGGFGQVYLVKSTED-DQYYAMKIEKLD-SKI-KSLEFEVTVIKRLH--NSDRFPRILSSGKEGDLNYFVMELFGPSLHTIAEWMPSGY-IN
..| . || |||||||.|....| ....|||.||   ... . ...|| | ..|   .|  ||... |||..| |..||.| ||.|  .   || .  ..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

RLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGT-----FPLALLDFGISKQYIDRDGNH-----------LPARD---SVHIAWSPYYASLNS
.  ..|..   | ..  .| .|.||||.|| |... ...        . |.|||...||.. ||.             ..|.   ..    .. |.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HKHKELSRRDDLISWLFSVMALTEFKLPWQTDDHVDDIERFKQKYELAMVV--NP----LGQPFKDIATYIQSLDYSDTPDYAKIHKLI
| .||..| ||| ||..... | .  |||.  .. ..||  |..  .  .    |    . . | ...... ||.| |.||| .| ...
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 108279.m00003.AA TTBK 10-263 33 2e-42 147.3 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-257/257
Sequence Identity: 33% (85 aa)

YKILEPIGHGGFGQVYLVKSTEDD-QYYAMKIEKLDSKIKSLEFEVTVIKRLHNSDRFPRILSSGKEGDLNYFVMELFGPSLHTIAEWMPSGYINRLYIY
 |..  || |||| .|  |    .    |.|.|. . .   |  || | |.|   |   |    | . . || ||.| | .|       | |  .     
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLADEMLSCIEHLHKNGYIHRDIKPHNFVL-RLNGTFPLA-LLDFGISKQYIDRDGNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDLISWLFSVMAL
||   .|  ||  |  |. |||||| || . |.  |     .||||   ||.   |.  |.| .        ||| |.|. .|. |.||| |  .     
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

TEFKLPWQTDDHVDDIERFKQKYELAMVVNPLGQPFKDIATYIQSLDYSDTPDYAKI
 .  |||      |.. . |.||.. | .. . . |.     |.||.| |.|||. |
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 108279.m00003.AA CK1-A 10-263 30 1.6e-41 144.23 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-261/261
Sequence Identity: 30% (81 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRLHNSDRFPRILSSGKEGDLNYFVMELFGPSLHTIAEWMPSGYINRLYIYR
|... .|| | || .||  .... .  |.|.|. . .   | .|  | . |.    .|...  |.| | | .||.| ||||  .       .  .  .  
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKT-VLM

LADEMLSCIEHLHKNGYIHRDIKPHNFVLRLN-GTFPLALLDFGISKQYID-RDGNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDLISWLFSVMALT
||| |.. || .|. ..||||||| ||.. ..     | |.|||..|.| | |   |.| |.  ..     |||.| |   | |||||. |  . .|   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

EFKLPWQ------TDDHVDDIERFKQKYELAMVVNPLGQPFKDIATYIQSLDYSDTPDYAKI
  |||||           . |   |    ....       |  . .|...| . ..|||  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 108279.m00003.AA CK1-D 10-263 31 8.2e-40 138.09 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRLHNSDRFPRILSSGKEGDLNYFVMELFGPSLHTIAEWMPSGYINRLYIYR
|.|   || | ||..|. .  . .   |.|.| . .|   |..|  . | ..     |.|   |.||| |  ||.| ||||  .  .    .  .  .  
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM-

LADEMLSCIEHLHKNGYIHRDIKPHNFVLRL--NGTFPLALLDFGISKQYIDRD-GNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDLISWLFSVMAL
||| |.. ||..| . .||||||| ||.. |   |     ..|||..|.| |     |.| |.   .     |||.| |.  | |||||| |  . .|  
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

TEFKLPWQ------TDDHVDDIERFKQKYELAMVVNPLGQPFKDIATYIQSLDYSDTPDYAKI
    ||||        .  . |   | . ..  . . . . |..   | ..| . | |||. .
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 108279.m00003.AA Worm6 10-136 36 7.1e-34 118.86 In-house 1-135 (279) Show / Hide 
Range on Protein: 10-136
Range on HMM: 1-135/279
Sequence Identity: 36% (49 aa)

YKILEPIGHGGFGQVYLVKSTEDDQ--YYAMKIEK--LDSKIKSLEFEVTVIKRL--HNSDRFPRILSSGKEGD--LNYFVMELFGPSLHTIAEWMPSGY
.|....|| |||| ||.|. ..|     .||| ||    .|.. | .|. | |..  |..  |..|   || .    || ||.|.|..|. . .  | . 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

INRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNF
.     ...| ..|  ||.||..|.||||.|| ||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNF
Kinase 108279.m00003.AA CK1-Unclassified 10-90 34 6.1e-30 85.56 In-house 1-90 (244) Show / Hide 
Range on Protein: 10-90
Range on HMM: 1-90/244
Sequence Identity: 34% (31 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRLHNSD-------RFPRILSSGKE--GDLNYFVMELFGPSL
|...| || | ||..|... ..... .|.|.|| .||.. | .|. . ..|.|          .|..  .|.|  || |. ||.| ||||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 108279.m00003.AA CK1-Unclassified 110-196 45 1.2e-27 78.7 In-house 109-199 (244) Show / Hide 
Range on Protein: 110-196
Range on HMM: 109-199/244
Sequence Identity: 45% (41 aa)

LADEMLSCIEHLHKNGYIHRDIKPHNFVLR-LNGTFP-LALLDFGISKQYI--DRDGNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDL
.|| |.. ||.||....||||||| ||.   |..    . . |||.|| ||  |..|.| | |.         |||.|.|. .| ||||||
IADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 108279.m00003.AA CK1 10-90 34 7.2e-25 82.68 In-house 1-91 (271) Show / Hide 
Range on Protein: 10-90
Range on HMM: 1-91/271
Sequence Identity: 34% (31 aa)

YKILEPIGHGGFGQVYLVKSTEDDQY--YAMKIEKLDSKIKSLEFEVTVIKRLHN------SDRFPRILSSGKE--GDLNYFVMELFGPSL
|.. . || | ||..||.. . . ..  .|.|.|| .||   | .|. . |.|..      .  .|..  .|.|  || |. ||.| ||||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 108279.m00003.AA CK1 110-196 38 2e-22 74.18 In-house 110-199 (271) Show / Hide 
Range on Protein: 110-196
Range on HMM: 110-199/271
Sequence Identity: 38% (35 aa)

LADEMLSCIEHLHKNGYIHRDIKPHNFVLRL-NGTFP-LALLDFGISKQYID-RDGNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDL
.|| |.. ||..|....||||||| ||.  . .     . . |||..|.|.| ....| | |.         |||.|.|  .| |||||.
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM
Kinase 108279.m00003.AA Pkinase 10-164 26 5.3e-22 78.88 Pfam 1-168 (293) Show / Hide 
Range on Protein: 10-164
Range on HMM: 1-168/293
Sequence Identity: 26% (47 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEF-------EVTVIKRLHNSDRFPRILSSGKEGDLNYFVMELFGP-----SLH----TI
|.|...|| |.||.||. .   . . .|.|| |.. ..|| .        |. . ||| |..   |.. .  ..|  |.|||. .      .|.    | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

AEWMPSGYI--NRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGTF--PLALLDFGISKQY-IDRDGNH
   . .| .      . . . ..|. .|..|..| ||||.|| |. .  ||.   .. . |||..||. . ...  
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-M
Kinase 108279.m00003.AA Worm6 148-263 28 3.5e-21 72.93 In-house 153-279 (279) Show / Hide 
Range on Protein: 148-263
Range on HMM: 153-279/279
Sequence Identity: 28% (36 aa)

LLDFGISK--QYIDRDGNHLPAR-DSVHIAWSPYYASLNSHKHKELSRRDDLISWLFSVMALTEFKLPWQTDDHVDDIE-RFKQK-YEL-----AMVVNP
.||||...  .|.....   . | . ..    . ||.|..||..|..|.||. ||.  .  .. ..|||.  .  |. | ..|.. ...     .|. .|
MLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGP

LGQ-PFKDIATYIQSLDYSDTPDYAKI
  .  |.|| .|| ...| |.|||..|
CPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 108279.m00003.AA CK1-Unique 10-206 22 3.8e-20 66.55 In-house 1-223 (337) Show / Hide 
Range on Protein: 10-206
Range on HMM: 1-223/337
Sequence Identity: 22% (50 aa)

YKILEPIGHGGFGQVYLVKSTEDD------QYYAMKIEKLDSKIK--SLEFEVTVIKRLHNSD-------RFPRILSSGKEGDLNYFVMELFGPSLHTIA
... . || ||.| |. |    .         |.|| |    .     |  |  | | .   .        |. .  ..  .|  . || . |||.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

EWMPS---GYI---NRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNG---TFPLALLDFGISKQ--YIDRDGNHLPARDSVHIAWSPYYASLN
. |     .     | | . ...   |  ||  |. |..||..|| |...  .     . .  ||.||..    ..  .   . |  .  .  . |..  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

SHKHKELSRRDDLISWLFSVMAL
.|. .|..||||. ||... . |
CHQCREHGRRDDMESWFYMLYHL
Kinase 108279.m00003.AA CK1-G 10-196 30 5.4e-20 64.38 In-house 1-191 (266) Show / Hide 
Range on Protein: 10-196
Range on HMM: 1-191/266
Sequence Identity: 30% (59 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRLHNS-DRFPRILSSGKEGDLNYFVMELFGPSLHTIAEWMPSGYINRLYIY
|..   || | || ... |      . | |.|   |.   |  |    | |    .  |..   | .|  |  ||.| ||||    .|    .  .  . 
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKT-VC

RLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGTFP---LALLDFGISKQYIDRDGN-HLPARDSVHIAWSPYYASLNSHKHKELSRRDDL
 .|  |.. .| .|.   | ||.|| ||     ..     . . |||. ||||| . . | | |          | | | |  .| |||||.
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase 108279.m00003.AA S_TKc 10-267 16 9.9e-15 39.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRLHNSDRFPRILSSGKEGDLNYFVMELFGP---SLHT-IAEWMPSGY---I
|.||..||.|.||.||... .......|.|| |     .... |. . |.  . .   ... .  . |  |.|||. .    .|.. | .  . |.   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGTFPLALLDFGISKQYIDRDGNHLPARDSVHIAWSPYYASLNSHKHKELSRRDDLISWLF-
.   . ... .... .|..|..| ||||.|| |  |       . . |||...|.              ..  .|.| .                .. . 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------GYGKC

---------SVMALTEFKLPWQTDDHVDDIERFKQKYELAMVVNPLGQPFKDIATYIQSLDYSD--TPDYAKI-------HKLI
          .  .   . |..   ... . .               ...||.   .   | ..  |   |         |  .
KCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 108279.m00003.AA TyrKc 10-267 16 0.000276 -153.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-267
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)

YKILEPIGHGGFGQVYLVKSTEDDQYYAMKIEKLDSKIKSLEFEVTVIKRL--------------HNS-------DRFPRILSSGKEGDLNYFVMELFGP
 . .. .|.| ||.||. . .   .  | |  | |. .. .  |  . ..|                .       .    ..   . |||. .  .  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SLHTIAEWMPSGYINRLYIYRLADEMLSCIEHLHKNGYIHRDIKPHNFVLRLNGTFPLALLDFGISKQYIDR-------DGNHL----PARDSVHIAWSP
             ..       .    .  |.||....||||.   |  .  |.       ||| |.   |        |  .      ... . | | .
-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

YYASLNSHKHKELSRRDDLISWLFSVM---ALTEFKLPWQT-----DDHVDDIERFKQKYELAMVVNPLGQ-----PFKDIATYIQS---LDYSDTPDYA
  .     .... .   |   | | |.    .|  . |.        .  . ||. || | .    |..         ... . ...    | .| |  .
PECI----NYGKFTTKSDV--WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

KIHKLI
 ||...
EIHECF
Kinase 108279.m00003.AA CK1 247-261 33 0.013182 5.03 In-house 257-271 (271) Show / Hide 
Range on Protein: 247-261
Range on HMM: 257-271/271
Sequence Identity: 33% (5 aa)

TYIQSLDYSDTPDYA
.|. .|.. ..|||.
NYCRQLHFEEKPDYM
Kinase 108279.m00003.AA CK1-G 248-263 37 0.081018 1.84 In-house 251-266 (266) Show / Hide 
Range on Protein: 248-263
Range on HMM: 251-266/266
Sequence Identity: 37% (6 aa)

YIQSLDYSDTPDYAKI
|. .||. ..|||  .
YVRRLDFFECPDYDYL