Gene 93494.m00054 (T.vaginalis)

93494.m00054

Species: T.vaginalis
Alias: TvagK0424, 93494.m00054
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
93494.m00054.AA Protein None 416 None Fasta, JSON
93494.m00054.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 93494.m00054.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 93494.m00054.AA PH 1-93 20 3.1e-08 32.36 Pfam 3-92 (92) Show / Hide 
Range on Protein: 1-93
Range on HMM: 3-92/92
Sequence Identity: 20% (19 aa)

MEGWLIKRSGLPHIWHRRYCVIKDDGFFIYLDESKTKLTNSFVITPKSQVSLIETR-WRVGFKITQPEGKIFSFQVKDNKDFHNWLSHILVLSI
.|||| |..     |..|..|....  ..| |..  ..  |. .    ||  ...  .. .|.|.  ... . || .. .... |...|  .. 
KEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 93494.m00054.AA PH 1-95 22 3.8e-08 34.3 SMART 3-82 (82) Show / Hide 
Range on Protein: 1-95
Range on HMM: 3-82/82
Sequence Identity: 22% (21 aa)

MEGWLIKRSGLPHIWHRRYCVIKDDGFFIYLDESKTKLTNSFVITPKSQVSLIETRWRVGFKITQPEGKIFSFQVKDNKDFHNWLSHILVLSIPE
.|||| |.|     |..|..|...| ...| |.   |.  |. ..   .|.  .     .|.|.  ..  . || .. .... |...|  .. . 
KEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 93494.m00054.AA AGC 103-355 28 2.7e-141 367.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-395/395
Sequence Identity: 28% (116 aa)

YKIISELGRGFYGKVVLARHK------ETGKFCAIKSIHKKS-LVDMA--KVDTIMSE------------REILKTTK----------SPFIVS-LLSSF
....  .|.| .||| |.|.|       |||..|.| . ||   |..   .|. .|.|            |.||.. .          .||||. | .||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPSK--FYLVLEYVS---------GG-DLFQHMS---KSNAITVDQIKLYTAE-------IATALQQLHK-ERIIYRD-LKPENILICEDGHIKLTDFG
|....   |.|.||..         || .||.|.    |.   . .... |.||       |. ||. ||.   ||.|| |||||||. |||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

ISKMLDSDK--------------------------------------------------DTTKTLCG--TSEYLAPEVIQGKEYTEAIDWWQ--VGILLY
 .|.. .|.                                                  |.|.|.||  | ||.|||..    |. | |||   .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMFAGRTPFEDPN----------RTTLYSNILN-----KNPNYFP------------ITDENTRTLIASLLKKDPTKRAG----------YNEIRNSKFF
|| .|..|| . |          .  .. .|.|     ...  ||            ...|  . ||  ||.|||.|| |          ..||.| ..|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPE-AKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 93494.m00054.AA Akt 103-355 41 1.4e-109 351.47 In-house 1-264 (264) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-264/264
Sequence Identity: 41% (110 aa)

YKIISELGRGFYGKVVLARHKETGKFC-AIKSIHKKSLVDMAKVDTIMSEREILKTTKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNAITVD
  ..  ||.| .|||.|.. | |.|.  |.|.. |. .... .|  .. || ||.....||||.|  ||||. | |.|..|..||.||.|... . .. |
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

QIKLYTAEIATALQQLHKERIIYRD-LKPENILICEDGHIKLTDFGISKML-DSDKDTTKTLCGTSEYLAPEVIQGKEYTEAIDWWQ-VGILLYEMFAGR
... | |||  |.. ||.  ||||| |||||||. .||||.||||| .|.   .| |.|||.||| ||||||...|. .| | |||  .|...|||  ||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFEDPNRTTLYSNILNKNPNYF--PITDENTRTLIASLLKKDPTKRAG--YN---EIRNSKFF
 || . .. ... .|.|.. ..   .  . . ..|| .||.|||.|| |  .|   ||..  .|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 93494.m00054.AA SGK 103-355 39 5.4e-108 334.65 In-house 1-283 (283) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

YKIISELGRGFYGKVVLARHKET------------------GKFCAIKSIHKKSLV-------DMAKVDTIMSER-EILKTTKSPFIVSLLSSFQTPSKF
 .... .| | .||| ...||..                  .|| |.| . |.. .          ..  ||.||  |||  |.||||.|  .|||. | 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVLEYVSGGDLFQHMSKSNAITVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSDKDTTKTLCGTSEYLAPEVIQGK
|.|..|| ||..| |. . .    |. . |.|||. ||  ||.  ||||||||||||   .||..||||| .|    ..|||.| ||| |||||||....
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

EYTEAIDWWQVGILLYEMFAGRTPFEDPNRTTLYSNILNKNPNYFPITDENTRTLIASLLKKDPTKRAGYN----EIRNSKFF
..  . |||  |..||||  |  ||.. |. ..| ||.|.  .  |      . ||  ||.|||.|| | .    ||.|  ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 93494.m00054.AA PKA 103-355 43 3e-97 329.39 In-house 1-263 (263) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-263/263
Sequence Identity: 43% (115 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIMSEREILKTTKSPFIV-SLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNAITVD
..||  ||.| .|.| |.|||..|...|.| . |   |..  |. ...|. ||. .|.|||| .. ..||.... |.|.|||.||..| .. ||   . .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

QIKLYTA-EIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSDKDTTKTLCGTSEYLAPEVIQGK-EYTEAIDWWQVGILLYEMFAGRT
. |.| | .|  ||. ||.. ||||||||||||| ..||||.|||| .| .|.    |.||||| ||||||.||.|  .  ..|||  ||| ||| || .
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFEDP--NRTTLYSNILNKNPNYFPITDENT---RTLIASLLKKDPTKRA-----GYNEIRNSKFF
||.|   .   .|  |.|   .. .  | .    . || .|| .|.|||      | | |.| |.|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 93494.m00054.AA S_TKc 103-355 34 1.8e-96 327.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-231/231
Sequence Identity: 34% (92 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIMSEREILKTTKSPFIVSLLSSFQTPSKFYLVLEYVSG--GDLFQHMSKSNA---
|.|. ..|.| .||| ..|||.||. .||| |.          ..|..|..|||  . |.|| |. .||. ...|.|.||..|  ||||... | .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSDKDTTKTLCGTSEYLAPEVIQGKEYTE-AIDWWQVGILLYE
   ..  ... |...|. ||. .|. .||.|||||||||..|  |||..|||... |       .|.||| .|.||||.    |.  ..||| .|..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MFAGRTPFEDPNRTTLYSNILNKNPNYFPITDENTRTLIASLLKKDPTKRAGYNEIRN-------SKFF
|..|..||.  .  ... .|.          ..  . .|  .|.|||.|| .  |. .         .|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93494.m00054.AA AktR 103-355 39 4e-94 318.99 In-house 1-268 (268) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-268/268
Sequence Identity: 39% (105 aa)

YKIISELGRGFYGKVVLARHK-ETGKFCAIKSIHKKSLVDMAKVDTIMSEREILK-TTKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNAITV
....  ||.| .|||.|...| ...|. |.|.|.|| ...  . . .  || |..   . |||| |  .||| .| ....||. ||.|||| .|.. .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DQIKLYTAEIATALQQLHKE-RIIYRDLKPENILICEDGHIKLTDFGISK--MLDSDKDTTKTLCGTSEYLAPEVIQG-KEYTEAIDWWQVGILLYEMFA
.|.. | |.|  ||. ||..  ||||||||||||. ||||.|.|||| ||    ... ......||| ||.|||.|.  | .. ..|||..||..||| .
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRTPFEDPNRTTLYSNILNKNPNYFPIT---DENTRTLIA-SLLKKDPTKRAG-----YNEIRNSKFF
| .||.. |..... .|..|. |.||..    .. . ||   ||.|.|.|| |       ||.. ..|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 93494.m00054.AA PKC 103-355 38 8.7e-91 294.5 In-house 1-262 (262) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-262/262
Sequence Identity: 38% (100 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIMSEREILKT-TKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNAITVD
 . .  ||.| .|||.||..|.| ...||| . |   ..   |.  | |. .| . .| || ..| ..|||... . |.||| ||||  |. ..    . 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

QIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSDKDTTKTLCGTSEYLAPEVIQGKEYTEAIDWWQVGILLYEMFAGRTPF
. . | |||. ||| ||.  ||||||| .|.|. ..||||..||| .|    . |||.| ||| .|.|||..|..||....|||  |.|.||| ||. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EDPNRTTLYSNILNKNPNYFPITDENTRTLIASLLKKDPTKRAGY--------NEIRNSKFF
.  . ..|  .|...|| |     .    .. ....|.|.|| |         ..||   ||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 93494.m00054.AA RSK 106-355 37 1.6e-88 300.38 In-house 1-278 (278) Show / Hide 
Range on Protein: 106-355
Range on HMM: 1-278/278
Sequence Identity: 37% (105 aa)

ISELGRGFYGKVVLARHK---ETGKFCAIKSIHKKSLVDMAK-VDTIMSEREILKTTK-SPFIVSLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNA---
...||.| |||| | | .    ||.  | | ..|. .|  .| . . | ||.||.... .||||.|  .|||..|.||..||..||.|| | .|      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

ITVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICE---DGHIKLTDFGISKMLDSD-KDTTKTLCGTSEYLAPEVIQ----GKEYTEAIDWWQVGI
.. |  . | |||. |.. ||.  ||.|||||||||  .   .||||||||| .| .. | .  |.| |.| ||.|||..     .. ...| |||  |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMFAGRTPFED---PNRTTLYSNILNKN--PNYF--PITDENTRTLIASLLKKDPTKRAG-----YNEIRNSKFF
|.|||..|..||      ||  .  .|....  ..    .   .. . ||  .|..|| || |      .||.....|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 93494.m00054.AA Ciliate-E2 103-355 23 3.5e-86 292.62 In-house 1-365 (365) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YKIISELGRGFYGKVVLARHKETG-----------------------KFCAIKSIHKKSLVDMAKVDTIM----------SEREILKTTKSPFIVSLLSS
||.|  .|.| .|.| ........                       |. |.|...|. .  . ... ||           |..||.. ..|.|. .  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TPSKFYLVLEYVSGGDLFQHMSKS-----------NAITVDQIKLYTAEIAT---------------ALQQLHKER-IIYRDLKPENILICEDGHI
||  . ...|||.||..|||||... ..           . .|  .|| ....|.                ||. ||..  ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGISK----------------MLDSDK----------------DTTKTLCGTSEYLAPEVIQGKE---------YTEAIDWWQVGILLYEMFAGRT
|..|||.||                ..   |                ....|.||| .|.|||...||.         |....|.| .|..||||  |..
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEDPNRTTLYSNILNKNPNYFPI------------------TDENTRTLIAS----LLKKDPTKRAG-YNEIRNSKFF
||        . .|.... ....                    ....  ||      .|.||| || . ...| | ..|
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 93494.m00054.AA Ciliate-E2-Unclassified 103-355 29 6.8e-86 291.67 In-house 1-352 (352) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-352/352
Sequence Identity: 29% (103 aa)

YKIISELGRGFYGKVVLARHKETGKFC-----AIKSIHKKSLVDMAKVDTIMSEREILKTTK-------------------SPFIVSLLSSFQTPSKFYL
||||  .|.| .||| ...||... .      ..|....|..  | |   || | ....  |                   .|||| ..  ||.  ..|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLEYVSGGDLFQHMSKS-----------------NAITVDQIK-----LYTAEIATALQQLHKE-RIIYRDLKPENILICEDG---HIKLTDFGISKMLD
|.||. ||||.|...|.                 . .|  |.|      |.|.|  .|..||..  ||.||.||||||. ..|   .||..|||||| ..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

SD---------------KDTTKTLCGTSEYL----APEVIQGKEYT----EAIDWWQVGILLYEMFAGRTPFEDPNRTT----------------LYSNI
..               .. ..| ||| .|.    ||||.||..|     ...|.| .|..||||  |. ||.|.|..                 ||.||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LNKNPNYFP--------ITDENTRTLIA----SLLKKDPTKRAGYNEIRNSKFF
..||.....        . ...   .|     ..|||.| || ....| |  .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 93494.m00054.AA Pkinase 103-355 31 1.2e-85 295.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIM-SEREILKTTKSPFIVSLLSSFQTPSKFYLVLEYVSGG----DLFQHMS--KS
|.|.. .|.| .|.| ...|| |||  |.| | |..  .  ..  .  || .|.|  ..|.|| |. .|..... |.|.||. ||    ||| ..|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NAI--TVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHI----KLTDFGISKML-DSDKDTTKTLCGTSEYLAPEVIQ-GKEYTEAIDWWQV
...  . ...| |  .|. .|. .|...||.|||||||||| ..|||    |..|||..| .    .  ..|.|||..|.|||||. |..|. ..|.| .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILLYEMFAGRTPFEDP------NRTTLYSNILNKNPNYFPITD---------------------ENTRTLIASLLKKDPTKRAGYNEIRNSKFF
|..||||. ||.|| .       .   .. .|. . . .   ..                     |. . .| ..|.|||.|| .  .| ....|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 93494.m00054.AA MAST 103-355 30 1.7e-85 275.58 In-house 1-334 (334) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-334/334
Sequence Identity: 30% (102 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIMSEREILKTTKSPFIVSLLSSFQTPSKFYLVLEYVSGGDLFQHMSKSNAITVDQ
...|  ...| |||| |..||.|... |.| | |  . .   ||. ..|| ||. ...||.|.. .|||| .. ..|.||..|||......  ..  .. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

IKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKM-----------L---------------DSDKDTTKTL---------------
 |.|.||.. .|. ||.  |. |||||.|.||  .||||||||| ||.           .               ....|....                
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

------------------------CGTSEYLAPEVIQGKE-YTEAIDWWQVGILLYEMFAGRTPFEDPNRTTLYSNILNKNPN----YFP--------IT
                        ||| .|.||||| |.  .  ..||| .|| .|| ..| .|| | ... ...||||.| |    ...        ..
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

DENTRTLIASLLKKDPTKRAGYN----EIRNSKFF
 |  . ||  ||  || || | |    |. . .||
PE-AQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 93494.m00054.AA Pkinase_Tyr 103-303 25 4.6e-18 61.79 Pfam 1-218 (270) Show / Hide 
Range on Protein: 103-303
Range on HMM: 1-218/270
Sequence Identity: 25% (56 aa)

YKIISELGRGFYGKVVLARHK----ETGKFCAIKSIHKKSLVDMA-KVDTIMSEREILKTT-KSPFIVSLLSSFQ-TPSK--FYLVLEYVSGGDLFQHMS
 ... .||.| .|.|.... |    .|.  .|.|.. | .  . . . .  |.| .|.|.  . | ||.|.            |.|.||. .|||  .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----SNAITVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSDKDTT-KTLCGTSE---YLAPEVIQGKEYTEAIDWW
|     ...|. ..  . ..|| ... |.  ..| |||   |.|. |....| .||| .. .  ..|.  ..  |.      .|||.|. ...|.. | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

QVGILLYEMFA-GRTP-FED
  |.|..|.|  |..| ...
SFGVLMWEIFTYGEQPTYPG
Kinase 93494.m00054.AA TyrKc 103-355 20 7.1e-18 66.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 103-355
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YKIISELGRGFYGKVVLARHKETGKFCAIKSIHKKSLVDMAKVDTIMSEREILKTT--KSPFIVSLLSSFQTP-------SKFYLVLEYVSGGDLFQHMS
 . . .||.|..|.|.... |     .|.|.... .      .  .|.| .|..    . | || |.    ..          ..|.||...||| ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSNA-ITVDQIKLYTAEIATALQQLHKERIIYRDLKPENILICEDGHIKLTDFGISKMLDSD------KDTTKTL---CGTS----EYLAPEVIQGKEYT
|.   .....   .   ||   . ||. ..| |||   |.|. |....| .||| |. ...|      ||. ..    .| .      .|||.|. ...|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EAIDWWQVGILLYEMFA-GRTPFED-----PNRTTLYSNILNKNPNYFPIT---------DENTRTLIASLLKKDPTKRAGYNEIRNSKFF
.. | |  |....|.|  | .| ..      . . .. .. . .    |            .   ... .  . || .|   .||   ..|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF