Gene 93357.m00043 (T.vaginalis)
93357.m00043
Species: T.vaginalis
Alias: TvagK0667, 93357.m00043
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
93357.m00043.AA | Protein | None | 379 | None | Fasta, JSON |
93357.m00043.kin_dom | Protein Kinase Domain | None | 328 | None | Fasta, JSON |
Protein domains of 93357.m00043.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 93357.m00043.AA | CMGC | 49-376 | 15 | 2.6e-40 | 129.53 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 49-376 Range on HMM: 1-513/513 Sequence Identity: 15% (83 aa) YKIIKVIGRGNSAYAFQAESRLISQS--------ILERKVVVLKIFRSNPLSTT-------------MANDEYRFINNAIHGHSAEET----------VS |.|||.||.| . ... .. | . ..| .|...... .. .|..| .. . | . .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN -FPKIYDFFTYKG-----------------HPVIVMEQYGPSLYDHFMNIFKMEEIKSQDNP----NLHGMEILH------------VQYLM------RQ |.||.|..|. | .|.| . .|| . ||.. .. . .... | ..|.| .| NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLY---------QYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQ LVKALS--LLHPTG--CIHADIKPENILFDH---LPKRFQN--------------FVLIDFSSSFSTEWK------------------------CTYPIT . ..| .| . || |.||||||..| |..|. . ..|| .. ... | . ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-MWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV TSFYRPPEVSLCLP----------YNQSLDIWSLGCVAYEAFVG--------APLFPQFDD-----------DKLLANFEKSLGPIPKEMIEQ------- | .||.||. | . |... |.||.||. .| . | |||| .. |. | ||... .||.. TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNF SPVRTRYFDGLNLKVQIE--------------DSIHHDYIRMISELYYTRAQSKEQFQRELE---------------------------------LRAQL .. ... ..| . .. ||.. . . .. ... . . |. CKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQA ADFVSSCLKYSPADRPTVQDLLKHPFI |... .|.| |..|.|... |.||.. IDLLKKMLQYDPDKRITAEQALQHPYF |
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S_TKc | 93357.m00043.AA | S_TKc | 49-376 | 20 | 6.6e-37 | 129.85 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 49-376 Range on HMM: 1-231/231 Sequence Identity: 20% (70 aa) YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFRSNPLSTTMANDEYRFINNAIHGHSAEETVSFPKIYDFFTYKGHPVIVMEQYGP---SLYDH |.|...||.| . ... . ..| .|| . .. | . . |.||.| .| .||| . .|.|. YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDY FMNIFKMEEIKSQDNPNL-HGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEWKCTYPITTSFYRPPEVSLC ||.. . | ... |....|.|...|| .| | || |.||||||.|. . ..|| .. | . | .|..||| ---------IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL-- LPYNQ-SLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQFQREL .|. . |.||.||. || ..| |.|| ...... . -GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------------------------------------------ ELRAQLADFVSSCLKYSPADRPTVQDLLK-------HPFI .. ||.. ||.. |..|||. ..|. ||.. --SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 93357.m00043.AA | DYRK | 49-376 | 24 | 1.1e-34 | 121.53 | In-house | 1-320 (320) | Show / Hide |
Range on Protein: 49-376 Range on HMM: 1-320/320 Sequence Identity: 24% (85 aa) YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFRSNPLSTTMANDEYRFINNAIHGHSAEETVSFPKIYDFFTYKGHPVIVMEQYGPSLYDHFMN |.|...||.| . .... . . | .|| |.|. | .| . . .. . ... . ..||.|....| || | . .||. | YEILEYIGKGSFGQVVKCWDHK------TNEMVAIKIIRNNKRFHRQAQIEIKIL-EYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKN IFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPT-GCIHADIKPENILFDHLPKRFQNFVLIDF-SSSFSTEWKCTYPITTSFYRPPEVSLCLP . . . . .|. .|....| .|| ||.|.|||||. . . .. .||| ||.| . ... | ||| ||| | .| NHFQGF-----------FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCP YNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQS--PVRTRYFDGLNLKVQIEDSIHHDY-----------IRMISELYYTRA |. . |.|||||. .| | | |||| . .|| . ||..||.||... . ....|| . ..... ... . . . ... YCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPG QSKEQFQRELELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI ... . . |. ||. ||.. |. |.| .. |.||.. RRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF |
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Kinase | 93357.m00043.AA | Ciliate-E2 | 120-376 | 17 | 2.9e-26 | 87.16 | In-house | 96-365 (365) | Show / Hide |
Range on Protein: 120-376 Range on HMM: 96-365/365 Sequence Identity: 17% (60 aa) KIYDFFT--YKGHPVIVMEQY-GPSLYDHFM--NIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVK---------------ALSLLHPTG-CIHADIKPE |.|..| . . .||| . | .|.|. .... .||. . . . ...|.|.|... || || . .|| ||||| KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE---K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE NILFDHLPKRFQNFVLIDFS-SSFSTEW-----------KCTYPI-----------------------TTSFYRPPEVSLCLP---------YNQSLDIW |||| .||| | . .. .... | | .||. . |. . ||| NILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW SLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQ----FQRE-------- |||.. || | | | | ..| |. . SLGVILYEMLFGKPPF--------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQC --------LELRAQLADFVSS----CLKYSPADRPT-VQDLLKHPFI ... . |. . .|.. | |.| ...|.||.. IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 93357.m00043.AA | DYRK2 | 120-271 | 33 | 2.2e-23 | 72.61 | In-house | 65-203 (318) | Show / Hide |
Range on Protein: 120-271 Range on HMM: 65-203/318 Sequence Identity: 33% (52 aa) KIYDFFTYKGHPVIVMEQYGPSLYDHFMNIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFV-LIDF- .. |.|.. .| |. | .. .||. || . .| | ......|..|| ||.| |||||| | .. .. . .||| HMLDYFYFRNHHCITFELLSMNLYEY---------IKKN---HFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL---LKQWNRSGIKVIDFG SSSFSTE-WKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLGCVAYEAFVGAPLFP || | . || | . ||| ||| | ..|. . |.||.||.. | . | |||| SSCFEHQYRIYTY-IQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFP |
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Kinase | 93357.m00043.AA | DYRK1 | 160-305 | 35 | 3.6e-22 | 74.27 | In-house | 93-238 (321) | Show / Hide |
Range on Protein: 160-305 Range on HMM: 93-238/321 Sequence Identity: 35% (52 aa) NPNLHGMEILHVQYLMRQLVKALSLLHP--TGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEWKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLG | . .|. . .. . .|...|| . || |.|||||| ||| . .||| || .. . | ||| ||| | ..|. ..|.|||| NTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL-CNPKRSA-IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLG CVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFD |. | .| ||| .. . || ||.||.|.| .||. CILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE |
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Kinase | 93357.m00043.AA | Ciliate-E2-Unclassified | 120-376 | 19 | 8.8e-20 | 65.32 | In-house | 85-352 (352) | Show / Hide |
Range on Protein: 120-376 Range on HMM: 85-352/352 Sequence Identity: 19% (65 aa) KIYDFFTYKGHPVIVMEQY-GPSLYDHFMN-------------------IFKMEEIKSQDNPNLHGMEILHVQ---YLMRQLVKALSLLHPTG-CIHADI | .. |. | .. ||||. | .| .. . || ...|. . ....|....|. || . .|| || KMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY--------------KKAKFYFAQILQGLEYLHHKNNIIHRDI KPENILFDHLPKRFQNFV--LIDFSSS---------------------FSTEWKCT-YPITTSFYRPPEVSLCLPYNQS----LDIWSLGCVAYEAFVGA |||||||| | |. .|||..| . | .. |.. ..| .||| |..| ||||||...|| | KPENILFDNNGK---NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY PLFPQFDDDK---------------LLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQFQRELELRAQLADF . |.. .... | . | . ... .|. . . .|| YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-------------------------------------------IPKHWSPEAKDF VS----SCLKYSPADRPTVQDLLKHPFI .. ..||. | |.| ...|.||.. INDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 93357.m00043.AA | Pkinase | 233-376 | 20 | 2.8e-18 | 65.71 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 233-376 Range on HMM: 174-293/293 Sequence Identity: 20% (30 aa) TSFYRPPEVSL-CLPYNQSLDIWSLGCVAYEAFVGAPLFPQF----DDDKLLANFEKSLGPIPKEMIEQS-PVRTRYFDGLNLKVQIEDSIHHDYIRMIS |..|..||| . . .| .. |.||.||. || . | |.||. . . .. ... .||.... .... ...... . TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------- ELYYTRAQSKEQFQRELELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI . ... .. . ||...||.. |..||| ...|.||.. ----------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 93357.m00043.AA | CLK | 236-317 | 36 | 6.8e-16 | 43.44 | In-house | 213-300 (350) | Show / Hide |
Range on Protein: 236-317 Range on HMM: 213-300/350 Sequence Identity: 36% (32 aa) YRPPEVSLCLPYNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLG-PIPKEMIEQSP---VRTRYF--DGLNLKVQIEDSI ||.||| | |...| |.|| ||. .| .| ||. | || |. .| |||. || . | ..|| ..|. .. |.. YRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR |
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Kinase | 93357.m00043.AA | STE | 171-291 | 23 | 2.2e-15 | 50.9 | In-house | 153-302 (359) | Show / Hide |
Range on Protein: 171-291 Range on HMM: 153-302/359 Sequence Identity: 23% (38 aa) VQYLMRQLVKA-LSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEW-------------------KCTYPITTSFYRPPEVSLC------ . | ||..|. |..|| . || |||| |||. |.|| . . . |.. . | . ||| .. IAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRD LPYNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSL-------------GPIPK .|. . |||||||.. | | | . . . . . .. .. ||.|. KGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPP |
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Kinase | 93357.m00043.AA | CDK4 | 165-271 | 34 | 3e-15 | 48.55 | In-house | 106-210 (290) | Show / Hide |
Range on Protein: 165-271 Range on HMM: 106-210/290 Sequence Identity: 34% (38 aa) GMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDF--SSSFSTEWKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLGCVAYE || .. .|.||. .. || || | ||.||| . . | || . .| . . | . | || ||| | .|| |.||.||. | GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV----TSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFAE AFVGAPLFP . |||. MYCRRPLFC |
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Kinase | 93357.m00043.AA | STE | 349-376 | 50 | 2.7e-12 | 39.84 | In-house | 330-359 (359) | Show / Hide |
Range on Protein: 349-376 Range on HMM: 330-359/359 Sequence Identity: 50% (15 aa) LADFVSSCLKYSPADRPTVQDLLK--HPFI . ||.. ||.. | .|||...||| |||| FKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 93357.m00043.AA | CLK | 120-202 | 38 | 1.1e-10 | 27.51 | In-house | 70-147 (350) | Show / Hide |
Range on Protein: 120-202 Range on HMM: 70-147/350 Sequence Identity: 38% (33 aa) KIYDFFTY-KGHPVIVMEQYGPSLYDHFMNIFK--MEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILF |..| | | .|| ||.| || |.|| || . | | . .| |.. . .|| .|. || . .| | |||||.| KMNDWFDYGHGHICIVFELYGLSIYD-FMKSNNSKMP------N-KYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF |
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Kinase | 93357.m00043.AA | Pkinase | 120-204 | 27 | 1.8e-09 | 34.57 | Pfam | 64-143 (293) | Show / Hide |
Range on Protein: 120-204 Range on HMM: 64-143/293 Sequence Identity: 27% (25 aa) KIYDFFTYKGHPVIVMEQYGP-----SLYDHFMNIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDH ..||.|..|.|. .||| . .|.|. . ... .. .. ... |.|....| .| |.|| |.||||||.|. RLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN |
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Kinase | 93357.m00043.AA | CDKL | 162-201 | 45 | 3.6e-08 | 24.02 | In-house | 91-130 (286) | Show / Hide |
Range on Protein: 162-201 Range on HMM: 91-130/286 Sequence Identity: 45% (18 aa) NLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENIL . .| . |. | |. ||.. .| ||| |||||||| YPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENIL |
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Kinase | 93357.m00043.AA | CDKL | 343-376 | 28 | 3.7e-08 | 23.98 | In-house | 252-286 (286) | Show / Hide |
Range on Protein: 343-376 Range on HMM: 252-286/286 Sequence Identity: 28% (10 aa) LELR-AQLADFVSSCLKYSPADRPTVQDLLKHPFI ... . ..||. .||. .|..|.|...|..||. PNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF |
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Kinase | 93357.m00043.AA | CLK | 348-376 | 44 | 2.2e-07 | 17.45 | In-house | 322-350 (350) | Show / Hide |
Range on Protein: 348-376 Range on HMM: 322-350/350 Sequence Identity: 44% (13 aa) QLADFVSSCLKYSPADRPTVQDLLKHPFI || | .. .| | |. |.| .| |.||| QLFDLIRKMLEYDPSKRITCKDALQHPFF |
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Kinase | 93357.m00043.AA | DYRK2 | 349-376 | 39 | 7.6e-07 | 17.93 | In-house | 291-318 (318) | Show / Hide |
Range on Protein: 349-376 Range on HMM: 291-318/318 Sequence Identity: 39% (11 aa) LADFVSSCLKYSPADRPTVQDLLKHPFI ..||.. |.. |. | | .. ||||.| FIDFIKRCFEWDPSERMTPSQALKHPWI |
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Kinase | 93357.m00043.AA | CDKL | 236-271 | 43 | 2.2e-05 | 14.34 | In-house | 165-201 (286) | Show / Hide |
Range on Protein: 236-271 Range on HMM: 165-201/286 Sequence Identity: 43% (16 aa) YRPPEVSLC-LPYNQSLDIWSLGCVAYEAFVGAPLFP || || . | . |||..||| | . | ||.| YRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWP |
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Kinase | 93357.m00043.AA | CDK4 | 344-376 | 24 | 4.3e-05 | 13.18 | In-house | 258-290 (290) | Show / Hide |
Range on Protein: 344-376 Range on HMM: 258-290/290 Sequence Identity: 24% (8 aa) ELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI .. | .|.. .| | .. |.. |.||. HMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF |
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Kinase | 93357.m00043.AA | DYRK1 | 351-376 | 34 | 0.016849 | 4.02 | In-house | 296-321 (321) | Show / Hide |
Range on Protein: 351-376 Range on HMM: 296-321/321 Sequence Identity: 34% (9 aa) DFVSSCLKYSPADRPTVQDLLKHPFI | . |.| |. | | . |.|.|. DLIKRMLQYDPKQRITPYYALQHSFF |
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Kinase | 93357.m00043.AA | Ciliate-E2 | 49-59 | 72 | 0.019051 | 4.19 | In-house | 1-11 (365) | Show / Hide |
Range on Protein: 49-59 Range on HMM: 1-11/365 Sequence Identity: 72% (8 aa) YKIIKVIGRGN ||.||.||.|| YKFIKKIGQGN |
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Kinase | 93357.m00043.AA | Ciliate-E2-Unclassified | 49-59 | 72 | 0.023577 | 4.0 | In-house | 1-11 (352) | Show / Hide |
Range on Protein: 49-59 Range on HMM: 1-11/352 Sequence Identity: 72% (8 aa) YKIIKVIGRGN |||||.||.|. YKIIKQIGQGG |
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Kinase | 93357.m00043.AA | STE | 49-60 | 33 | 0.146616 | 1.43 | In-house | 1-12 (359) | Show / Hide |
Range on Protein: 49-60 Range on HMM: 1-12/359 Sequence Identity: 33% (4 aa) YKIIKVIGRGNS ...|..||.|.. WEGIEKIGKGAF |
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Kinase | 93357.m00043.AA | DYRK2 | 49-58 | 60 | 0.179624 | 0.17 | In-house | 1-10 (318) | Show / Hide |
Range on Protein: 49-58 Range on HMM: 1-10/318 Sequence Identity: 60% (6 aa) YKIIKVIGRG | | .|||.| YEILEVIGKG |
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Kinase | 93357.m00043.AA | Pkinase | 49-87 | 20 | 2.316736 | 2.36 | Pfam | 1-33 (293) | Show / Hide |
Range on Protein: 49-87 Range on HMM: 1-33/293 Sequence Identity: 20% (8 aa) YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFR |.|...||.|... ... . .. .|..||.. YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIK |