93357.m00043

Species: T.vaginalis
Alias: TvagK0667, 93357.m00043
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: YAK

Sequence

Name Sequence Type Origin Length Description Download
93357.m00043.AA Protein None 379 None Fasta, JSON
93357.m00043.kin_dom Protein Kinase Domain None 328 None Fasta, JSON

Protein domain

Protein domains of 93357.m00043.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93357.m00043.AA CMGC 49-376 15 2.6e-40 129.53 In-house 1-513 (513) Show / Hide
Range on Protein: 49-376
Range on HMM: 1-513/513
Sequence Identity: 15% (83 aa)

YKIIKVIGRGNSAYAFQAESRLISQS--------ILERKVVVLKIFRSNPLSTT-------------MANDEYRFINNAIHGHSAEET----------VS
|.|||.||.|  .  ...  ..  |         .   ..| .|......  ..             .|..| ..  .    | . ..            
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-FPKIYDFFTYKG-----------------HPVIVMEQYGPSLYDHFMNIFKMEEIKSQDNP----NLHGMEILH------------VQYLM------RQ
   |.||.|..|.                 |  .|.|  . .||         . ||.. ..    . ....  |            ..|.|      .|
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLY---------QYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQ

LVKALS--LLHPTG--CIHADIKPENILFDH---LPKRFQN--------------FVLIDFSSSFSTEWK------------------------CTYPIT
. ..|    .|  .   || |.||||||..|   |..|. .                ..|| .. ...                           |  . 
ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-MWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV

TSFYRPPEVSLCLP----------YNQSLDIWSLGCVAYEAFVG--------APLFPQFDD-----------DKLLANFEKSLGPIPKEMIEQ-------
| .||.||. |  .          |... |.||.||. .| . |         ||||  ..              |.   | ||... .||..       
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNF

SPVRTRYFDGLNLKVQIE--------------DSIHHDYIRMISELYYTRAQSKEQFQRELE---------------------------------LRAQL
..    ... ..|   .               ..    ||..   .   . .. ...   .                                  .  |.
CKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQA

ADFVSSCLKYSPADRPTVQDLLKHPFI
 |... .|.| |..|.|... |.||..
IDLLKKMLQYDPDKRITAEQALQHPYF

S_TKc 93357.m00043.AA S_TKc 49-376 20 6.6e-37 129.85 SMART 1-231 (231) Show / Hide
Range on Protein: 49-376
Range on HMM: 1-231/231
Sequence Identity: 20% (70 aa)

YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFRSNPLSTTMANDEYRFINNAIHGHSAEETVSFPKIYDFFTYKGHPVIVMEQYGP---SLYDH
|.|...||.|  .  ...  .         ..| .|| .       ..  | .   .              |.||.|   .|  .|||  .    .|.|.
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK------EHIRREIQILKK--------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDY

FMNIFKMEEIKSQDNPNL-HGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEWKCTYPITTSFYRPPEVSLC
         ||..  . | ...   |....|.|...||  .|  | || |.||||||.|.      .  ..|| ..       |  . | .|..|||   
---------IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LPYNQ-SLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQFQREL
 .|.  . |.||.||. || ..| |.||  ...... .                                                              
-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------------------------------------------

ELRAQLADFVSSCLKYSPADRPTVQDLLK-------HPFI
    .. ||.. ||.. |..|||. ..|.       ||..
--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 93357.m00043.AA DYRK 49-376 24 1.1e-34 121.53 In-house 1-320 (320) Show / Hide
Range on Protein: 49-376
Range on HMM: 1-320/320
Sequence Identity: 24% (85 aa)

YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFRSNPLSTTMANDEYRFINNAIHGHSAEETVSFPKIYDFFTYKGHPVIVMEQYGPSLYDHFMN
|.|...||.|  .  .... .         . | .|| |.|.     | .| . .   .. .  ...  . ..||.|....|  || | .  .||.   |
YEILEYIGKGSFGQVVKCWDHK------TNEMVAIKIIRNNKRFHRQAQIEIKIL-EYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKN

IFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPT-GCIHADIKPENILFDHLPKRFQNFVLIDF-SSSFSTEWKCTYPITTSFYRPPEVSLCLP
  . .            . . .|.   .|....| .||     ||.|.|||||.  .  .  ..  .||| ||.|  . ...  |   ||| ||| | .|
NHFQGF-----------FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCP

YNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQS--PVRTRYFDGLNLKVQIEDSIHHDY-----------IRMISELYYTRA
|. . |.|||||. .| | | ||||  .   .|| .   ||..||.||...  . ....||    . .....  ...           .  . . ...  
YCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPG

QSKEQFQRELELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI
...     .   . |. ||.  ||.. |. |.| .. |.||..
RRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF

Kinase 93357.m00043.AA Ciliate-E2 120-376 17 2.9e-26 87.16 In-house 96-365 (365) Show / Hide
Range on Protein: 120-376
Range on HMM: 96-365/365
Sequence Identity: 17% (60 aa)

KIYDFFT--YKGHPVIVMEQY-GPSLYDHFM--NIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVK---------------ALSLLHPTG-CIHADIKPE
|.|..|    . .  .||| . | .|.|.    .... .||.       . . . ...|.|.|...               ||  ||  . .|| |||||
KMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE---K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NILFDHLPKRFQNFVLIDFS-SSFSTEW-----------KCTYPI-----------------------TTSFYRPPEVSLCLP---------YNQSLDIW
||||           .|||  | . ..            ....                          |  | .||.    .         |. . |||
NILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW

SLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQ----FQRE--------
|||.. ||   | | |                                                               | ..|    |. .        
SLGVILYEMLFGKPPF--------------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQC

--------LELRAQLADFVSS----CLKYSPADRPT-VQDLLKHPFI
        ...  .  |. .     .|.. |  |.|  ...|.||..
IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase 93357.m00043.AA DYRK2 120-271 33 2.2e-23 72.61 In-house 65-203 (318) Show / Hide
Range on Protein: 120-271
Range on HMM: 65-203/318
Sequence Identity: 33% (52 aa)

KIYDFFTYKGHPVIVMEQYGPSLYDHFMNIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFV-LIDF-
.. |.|.. .|  |. | .. .||.          ||     . .|     |    ......|..||    ||.| ||||||   | .. .. . .||| 
HMLDYFYFRNHHCITFELLSMNLYEY---------IKKN---HFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL---LKQWNRSGIKVIDFG

SSSFSTE-WKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLGCVAYEAFVGAPLFP
|| |  .    || | . ||| ||| | ..|. . |.||.||.. | . | ||||
SSCFEHQYRIYTY-IQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFP

Kinase 93357.m00043.AA DYRK1 160-305 35 3.6e-22 74.27 In-house 93-238 (321) Show / Hide
Range on Protein: 160-305
Range on HMM: 93-238/321
Sequence Identity: 35% (52 aa)

NPNLHGMEILHVQYLMRQLVKALSLLHP--TGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEWKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLG
| . .|. .  .. . .|...||  .       || |.||||||    ||| .   .||| ||  .. .    |   ||| ||| | ..|. ..|.||||
NTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL-CNPKRSA-IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLG

CVAYEAFVGAPLFPQFDDDKLLANFEKSLGPIPKEMIEQSPVRTRYFD
|.  |  .| |||   ..   .      ||  ||.||.|.|   .||.
CILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

Kinase 93357.m00043.AA Ciliate-E2-Unclassified 120-376 19 8.8e-20 65.32 In-house 85-352 (352) Show / Hide
Range on Protein: 120-376
Range on HMM: 85-352/352
Sequence Identity: 19% (65 aa)

KIYDFFTYKGHPVIVMEQY-GPSLYDHFMN-------------------IFKMEEIKSQDNPNLHGMEILHVQ---YLMRQLVKALSLLHPTG-CIHADI
| .. |. | .. ||||.  | .| ..  .                   ||  ...|.              .   ....|....|. ||  . .|| ||
KMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY--------------KKAKFYFAQILQGLEYLHHKNNIIHRDI

KPENILFDHLPKRFQNFV--LIDFSSS---------------------FSTEWKCT-YPITTSFYRPPEVSLCLPYNQS----LDIWSLGCVAYEAFVGA
||||||||   |   |.   .|||..|                     .   | ..  |.. ..| .|||     |..|     ||||||...||   | 
KPENILFDNNGK---NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

PLFPQFDDDK---------------LLANFEKSLGPIPKEMIEQSPVRTRYFDGLNLKVQIEDSIHHDYIRMISELYYTRAQSKEQFQRELELRAQLADF
. |.. ....                | .  |   .  ... .|.                                               .  . .||
YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQ-------------------------------------------IPKHWSPEAKDF

VS----SCLKYSPADRPTVQDLLKHPFI
..    ..||. |  |.| ...|.||..
INDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 93357.m00043.AA Pkinase 233-376 20 2.8e-18 65.71 Pfam 174-293 (293) Show / Hide
Range on Protein: 233-376
Range on HMM: 174-293/293
Sequence Identity: 20% (30 aa)

TSFYRPPEVSL-CLPYNQSLDIWSLGCVAYEAFVGAPLFPQF----DDDKLLANFEKSLGPIPKEMIEQS-PVRTRYFDGLNLKVQIEDSIHHDYIRMIS
|..|..||| . . .| .. |.||.||. || . | |.||.     . .  .. ... .||.... .... ...... .                     
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------

ELYYTRAQSKEQFQRELELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI
          . ...  ..   . ||...||.. |..||| ...|.||..
----------F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 93357.m00043.AA CLK 236-317 36 6.8e-16 43.44 In-house 213-300 (350) Show / Hide
Range on Protein: 236-317
Range on HMM: 213-300/350
Sequence Identity: 36% (32 aa)

YRPPEVSLCLPYNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSLG-PIPKEMIEQSP---VRTRYF--DGLNLKVQIEDSI
||.||| | |...|  |.|| ||. .|  .|  ||.  |    ||  |. .| |||. ||  .    | ..||  ..|.  ..  |..
YRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

Kinase 93357.m00043.AA STE 171-291 23 2.2e-15 50.9 In-house 153-302 (359) Show / Hide
Range on Protein: 171-291
Range on HMM: 153-302/359
Sequence Identity: 23% (38 aa)

VQYLMRQLVKA-LSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDFSSSFSTEW-------------------KCTYPITTSFYRPPEVSLC------
. |  ||..|. |..||  . || |||| |||.           |.||  . . .                    |..  . |  .  ||| ..      
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRD

LPYNQSLDIWSLGCVAYEAFVGAPLFPQFDDDKLLANFEKSL-------------GPIPK
 .|. . |||||||.. |   | | .  . . . . .. ..              ||.|.
KGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPP

Kinase 93357.m00043.AA CDK4 165-271 34 3e-15 48.55 In-house 106-210 (290) Show / Hide
Range on Protein: 165-271
Range on HMM: 106-210/290
Sequence Identity: 34% (38 aa)

GMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDHLPKRFQNFVLIDF--SSSFSTEWKCTYPITTSFYRPPEVSLCLPYNQSLDIWSLGCVAYE
||    .. .|.||. ..  ||    || | ||.|||      . .   | ||  .  .| . . |  . |  || ||| |  .||   |.||.||.  |
GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV----TSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFAE

AFVGAPLFP
 .   |||.
MYCRRPLFC

Kinase 93357.m00043.AA STE 349-376 50 2.7e-12 39.84 In-house 330-359 (359) Show / Hide
Range on Protein: 349-376
Range on HMM: 330-359/359
Sequence Identity: 50% (15 aa)

LADFVSSCLKYSPADRPTVQDLLK--HPFI
. ||.. ||.. | .|||...|||  ||||
FKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase 93357.m00043.AA CLK 120-202 38 1.1e-10 27.51 In-house 70-147 (350) Show / Hide
Range on Protein: 120-202
Range on HMM: 70-147/350
Sequence Identity: 38% (33 aa)

KIYDFFTY-KGHPVIVMEQYGPSLYDHFMNIFK--MEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILF
|..| | | .||  ||.| || |.|| ||   .  |       |    . .| |.. . .|| .|.  ||  . .| | |||||.|
KMNDWFDYGHGHICIVFELYGLSIYD-FMKSNNSKMP------N-KYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF

Kinase 93357.m00043.AA Pkinase 120-204 27 1.8e-09 34.57 Pfam 64-143 (293) Show / Hide
Range on Protein: 120-204
Range on HMM: 64-143/293
Sequence Identity: 27% (25 aa)

KIYDFFTYKGHPVIVMEQYGP-----SLYDHFMNIFKMEEIKSQDNPNLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENILFDH
..||.|..|.|. .|||  .      .|.|. .          ... ..  ..  ...  |.|....|  .|  |.|| |.||||||.|.
RLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN

Kinase 93357.m00043.AA CDKL 162-201 45 3.6e-08 24.02 In-house 91-130 (286) Show / Hide
Range on Protein: 162-201
Range on HMM: 91-130/286
Sequence Identity: 45% (18 aa)

NLHGMEILHVQYLMRQLVKALSLLHPTGCIHADIKPENIL
. .| .   |.  | |. ||.. .|   ||| ||||||||
YPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENIL

Kinase 93357.m00043.AA CDKL 343-376 28 3.7e-08 23.98 In-house 252-286 (286) Show / Hide
Range on Protein: 343-376
Range on HMM: 252-286/286
Sequence Identity: 28% (10 aa)

LELR-AQLADFVSSCLKYSPADRPTVQDLLKHPFI
...  . ..||. .||. .|..|.|...|..||. 
PNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF

Kinase 93357.m00043.AA CLK 348-376 44 2.2e-07 17.45 In-house 322-350 (350) Show / Hide
Range on Protein: 348-376
Range on HMM: 322-350/350
Sequence Identity: 44% (13 aa)

QLADFVSSCLKYSPADRPTVQDLLKHPFI
|| | .. .| | |. |.| .| |.||| 
QLFDLIRKMLEYDPSKRITCKDALQHPFF

Kinase 93357.m00043.AA DYRK2 349-376 39 7.6e-07 17.93 In-house 291-318 (318) Show / Hide
Range on Protein: 349-376
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

LADFVSSCLKYSPADRPTVQDLLKHPFI
..||.. |..  |. | | .. ||||.|
FIDFIKRCFEWDPSERMTPSQALKHPWI

Kinase 93357.m00043.AA CDKL 236-271 43 2.2e-05 14.34 In-house 165-201 (286) Show / Hide
Range on Protein: 236-271
Range on HMM: 165-201/286
Sequence Identity: 43% (16 aa)

YRPPEVSLC-LPYNQSLDIWSLGCVAYEAFVGAPLFP
|| ||  .    |  . |||..|||  | . | ||.|
YRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWP

Kinase 93357.m00043.AA CDK4 344-376 24 4.3e-05 13.18 In-house 258-290 (290) Show / Hide
Range on Protein: 344-376
Range on HMM: 258-290/290
Sequence Identity: 24% (8 aa)

ELRAQLADFVSSCLKYSPADRPTVQDLLKHPFI
..  | .|..  .| | .. |..    |.||. 
HMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF

Kinase 93357.m00043.AA DYRK1 351-376 34 0.016849 4.02 In-house 296-321 (321) Show / Hide
Range on Protein: 351-376
Range on HMM: 296-321/321
Sequence Identity: 34% (9 aa)

DFVSSCLKYSPADRPTVQDLLKHPFI
| .   |.| |. | |  . |.|.|.
DLIKRMLQYDPKQRITPYYALQHSFF

Kinase 93357.m00043.AA Ciliate-E2 49-59 72 0.019051 4.19 In-house 1-11 (365) Show / Hide
Range on Protein: 49-59
Range on HMM: 1-11/365
Sequence Identity: 72% (8 aa)

YKIIKVIGRGN
||.||.||.||
YKFIKKIGQGN

Kinase 93357.m00043.AA Ciliate-E2-Unclassified 49-59 72 0.023577 4.0 In-house 1-11 (352) Show / Hide
Range on Protein: 49-59
Range on HMM: 1-11/352
Sequence Identity: 72% (8 aa)

YKIIKVIGRGN
|||||.||.|.
YKIIKQIGQGG

Kinase 93357.m00043.AA STE 49-60 33 0.146616 1.43 In-house 1-12 (359) Show / Hide
Range on Protein: 49-60
Range on HMM: 1-12/359
Sequence Identity: 33% (4 aa)

YKIIKVIGRGNS
...|..||.|..
WEGIEKIGKGAF

Kinase 93357.m00043.AA DYRK2 49-58 60 0.179624 0.17 In-house 1-10 (318) Show / Hide
Range on Protein: 49-58
Range on HMM: 1-10/318
Sequence Identity: 60% (6 aa)

YKIIKVIGRG
| | .|||.|
YEILEVIGKG

Kinase 93357.m00043.AA Pkinase 49-87 20 2.316736 2.36 Pfam 1-33 (293) Show / Hide
Range on Protein: 49-87
Range on HMM: 1-33/293
Sequence Identity: 20% (8 aa)

YKIIKVIGRGNSAYAFQAESRLISQSILERKVVVLKIFR
|.|...||.|...  ...  .  ..      .|..||..
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIK