Gene 92995.m00075 (T.vaginalis)

92995.m00075

Species: T.vaginalis
Alias: 92995.m00075, TvagK0495
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
92995.m00075.AA Protein None 355 None Fasta, JSON
92995.m00075.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 92995.m00075.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92995.m00075.AA CK1 24-278 26 1.5e-74 254.03 In-house 1-339 (339) Show / Hide 
Range on Protein: 24-278
Range on HMM: 1-339/339
Sequence Identity: 26% (89 aa)

YIIGPKIGQGAFG-EIYCA-----IDQNTG-----ILWALKTESSLVNKKV--LPYEYQVLDKIQ----------ESPHFPR----------VGMMGTGP
. .. |||.|.|| .|| .     .| ...        |.|.|.   ....  | .|||.. | |          ...||.           ..  | ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

EYS-FFSMELLGPSISHILK--SIPGNKFTFSTAIRASYHMLKCIEALHIYGYVHRDIKPGNILTR--------------EGTEHPLCLIDFGLAR-CFV
.|  .  |.||||... ..|    ...||. .|...  . ||. .| .|  |..||||||.|..                ..... . .||||.||  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NP-----------ETGMHLLQRP---PSGFRG-TRAYASLHAHYGEDLARRDDVISWFYSAYEFITGT--LPWKKSSDSSE-----TQQMKEHFDPSEAL
..           .|..|  .|.     |||| |  |.|...| | .. ||||. ||||   |.. ||  |||.. .| ..      ..||. |     .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

ST------------IAPEMIKVWKHILTLEFMDMPNYGLC
||            . .|. |..|.| .|.. | |.|   
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 92995.m00075.AA TTBKL 24-282 28 1.2e-62 210.32 In-house 1-288 (288) Show / Hide 
Range on Protein: 24-282
Range on HMM: 1-288/288
Sequence Identity: 28% (83 aa)

YIIGPKIGQGAFGEIYCAIDQNT-GILWALKTESSLVNK--KVLPYEYQVLDKIQ--ESPHFPRVGMMGTGPEYSFFSMELLGPSISHILKSIPGNK-FT
. |  .||.|.||..| ..| .. .   |.| |.   ..  ...  | .|| | |   |||||.. . |  . |.|. |.|.||... . | .| .| |.
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

FSTAIRASYHMLKCIEALHIYGYVHRDIKPGNILTREGT-----EHPLCLIDFGLARCFVNPETG----------MHLLQRP---PSGFRGTRAYASLHA
 .|. | ..  |...  .| .|..|||.||.|. .   .     .. . |||||.|| ..... .          |.  .|.    ..||||  |.|. .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HYGEDLARRDDVISWFYSAYEFITGTLPWKKSSDSSETQQMKEHFDPSEALST------IAPEMIKVWKHILTLEFMDMPNYGLCYRAM
| . .. | ||  ||.|...|.  | |||. ..|  |. .||..       .       . .|. |. ||. .|...| |.|.  |  .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 92995.m00075.AA Worm6 24-278 27 9.6e-59 201.48 In-house 1-279 (279) Show / Hide 
Range on Protein: 24-278
Range on HMM: 1-279/279
Sequence Identity: 27% (76 aa)

YIIGPKIGQGAFGEIYCAIDQNTGI--LWALKTES--SLVNKKVLPYEYQVLDKI--QESPHFPRVGMMGTGPE--YSFFSMELLGPSISHILKSIPGNK
. .. |||.|.|| .| . |  ..     |.| |.      ...|. |. || ..  . ..||...   |. ..  . .  |.|.|.. . . |  |..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FTFSTAIRASYHMLKCIEALHIYGYVHRDIKPGNI-LTR-----EGTEHPLCLIDFGLAR--CFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLAR
|...|... .  .|. || ||  |..|||.||||    |      . .| ....|||..|   . | .. ..    .. |||||  ||.|..|.| .. |
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDVISWFYSAYEFITGTLPWKKSSDSSETQ--QMKEHFDPS----EALSTIAP--EMIKVWKHILTLEFMDMPNYGLC
.||. ||||   |.|.|.|||....|... .  ... . . .    . .  . |  |. .. . |... . | |.|  .
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 92995.m00075.AA TTBK 24-278 36 5.7e-56 192.27 In-house 1-257 (257) Show / Hide 
Range on Protein: 24-278
Range on HMM: 1-257/257
Sequence Identity: 36% (93 aa)

YIIGPKIGQGAFGEIYCAIDQNTG-ILWALKTESSLVNKKVLPYEYQVLDKIQESPHFPRVGMMGTGPEYSFFSMELLGPSISHILKSIPGNKFTFSTAI
  .  |||.|.||||| | |. .     |.| ||.   | ||  |  || | |  .|  |    |   .. .  |.|.| . .    . |  .|. ||..
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RASYHMLKCIEALHIYGYVHRDIKPGN--ILTREGTEHPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDDVISWFYSAYE
|    .|. ||. |  |. |||||| |  .     |     ..|||||| ..|  .|     |.  |||||  |||  ||   .. |.||  | ||   |
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

FITGTLPWKKSSDSSETQQMKEHFDPSEALSTIAPEMIKVWKHILTLEFMDMPNYGLC
|. | ||| |  |  .  .||| .|    |  . .|.    .||  |.. | |.| | 
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 92995.m00075.AA CK1-A 24-229 36 1.2e-37 130.55 In-house 1-206 (261) Show / Hide 
Range on Protein: 24-229
Range on HMM: 1-206/261
Sequence Identity: 36% (75 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPYEYQVLDKIQESPHFPRVGMMGTGPEYSFFSMELLGPSISHILKSIPGNKFTFSTAIR
| .  ||| |.||.|| .|  . |   |.| ||  .    | || .|   .|  . .|..   |.. .|  . |.|||||.  .   .   .||. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

ASYHMLKCIEALHIYGYVHRDIKPGNILTREGTE-HPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDDVISWFYSAYEFI
    |.  || .|  ...|||||| | |   |     | |||||||. .  ..|  |.  |      ||  |||..|| | . .||||. |  |    | 
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

TGTLPWK
 |.|||.
RGKLPWQ
Kinase 92995.m00075.AA CK1-D 24-229 33 2.1e-33 115.15 In-house 1-206 (261) Show / Hide 
Range on Protein: 24-229
Range on HMM: 1-206/261
Sequence Identity: 33% (70 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPYEYQVLDKIQESPHFPRVGMMGTGPEYSFFSMELLGPSISHILKSIPGNKFTFSTAIR
| || ||| |.||.||   . .|.   |.| |.       | .| ..   .|     |..  .|   .|    |.|||||.  .     . || . | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTVLM

ASYHMLKCIEALHIYGYVHRDIKPGNILTREGTE-HPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDDVISWFYSAYEFI
 .  |.. || .|   ..|||||| | |   |   .   .||||||. .  ..|  |.  |      ||  |||.  | | . .||||. |  |    | 
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

TGTLPWK
 |.|||.
RGSLPWQ
Kinase 92995.m00075.AA CK1 24-210 32 8.6e-33 110.3 In-house 1-198 (271) Show / Hide 
Range on Protein: 24-210
Range on HMM: 1-198/271
Sequence Identity: 32% (66 aa)

YIIGPKIGQGAFGEIYCAIDQNT----GILWALKTESSLVNKKVLPYEYQVLDKIQE------SPHFPRVGMMGTG--PEYSFFSMELLGPSISHILKSI
| .| |||||.||.|| .|.  |    . . | | |..      |.||....   |       ....|..   |.    .| .  |.|||||    .. .
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN-F

PGNKFTFSTAIRASYHMLKCIEALHIYGYVHRDIKPGNIL-TR-EGTEHPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRD
 . ||.  | .     |.. || .|  ...|||||| |.|  | .  .| . .||||||  .. ..|. |  .|   .. ||  |||. .|.|    |||
CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD

D
|
D
Kinase 92995.m00075.AA CK1-Unique 24-229 25 5.1e-28 94.22 In-house 1-233 (337) Show / Hide 
Range on Protein: 24-229
Range on HMM: 1-233/337
Sequence Identity: 25% (60 aa)

YIIGPKIGQGAFGEIYCAIDQNTG------ILWALKTESSLVNKK-----VLPYEYQVLDKIQ----ESPHFPRVGMMGTGPEYSFFSMELLGPSISHIL
...  .|| | .|  .  |. |.|         . ||| . . |      ..  .   ..|      .. ||. |  ..  . ... .| ..|||. . .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEE-C

KSIPGN-KFTFS------TAIRASYHMLKCIEALHIYGYVHRDIKPGNILTREGT---EHPLCLIDFGL-ARCFVNPETGMHLLQRPPSGFRGTRAYASL
.  ..| .|| .      .||. .|  |  ||  |  |. ||..||.|. .       .| .  .|.|   | |     .     ||   |||.. |.. 
CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC

HAHYGEDLARRDDVISWFYSAYEFITGT--LPWK
  |  ... ||||  ||||..|  . .|  | ||
SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 92995.m00075.AA Pkinase 24-196 24 1.5e-23 84.34 Pfam 1-179 (293) Show / Hide 
Range on Protein: 24-196
Range on HMM: 1-179/293
Sequence Identity: 24% (46 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPY------EYQVLDKIQESPHFPRVGMMGTGPEYSFFS--MELLGP-----SISHILKS
| || |||.|.||. | .....||...|.|. .   .|.  ..      | |.. ..  .|.   | . ..  . .     ||...      . ..... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNI--VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

IPGNKF--TFSTAIRASYHMLKCIEALHIYGYVHRDIKPGNILTREGTEHP---LCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYAS
  ...|  .  ....  | .|. .| .|  | .|||.|| |||    . |.   ....|||||..|       .  .. ...| ||. |..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 92995.m00075.AA CK1-G 24-228 31 5.8e-21 67.72 In-house 1-208 (266) Show / Hide 
Range on Protein: 24-228
Range on HMM: 1-208/266
Sequence Identity: 31% (65 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPYEYQVLDKIQESP-HFPRVGMMGTGPEYSFFSMELLGPSISHILKSIPGNKFTFSTAI
| .|.||| | |||..      ..   | | |    .   |  ||.        |   |.|   |    |    |.|||||       . . ||.  | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

RASYHMLKCIEALHIYGYVHRDIKPGNIL-TREGT--EHPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDDVISWFYSAY
  .  |.. .|..|    . ||.|| | |  |...  .| . .||||.|. .. |||. |   |      ||  | |   | |    ||||  .      
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

EFITGTLPW
 |  | |||
YFLRGSLPW
Kinase 92995.m00075.AA CK1-Unclassified 24-104 32 4.3e-20 56.0 In-house 1-90 (244) Show / Hide 
Range on Protein: 24-104
Range on HMM: 1-90/244
Sequence Identity: 32% (29 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPYEYQVLDKIQESP-------HFPRVGMMGTG--PEYSFFSMELLGPSI
| .. |||||.||||| .|. .|. . |.| |.. .  . |.|| ...   |          ..|..   |.    .| .  |.|||||.
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 92995.m00075.AA CK1-Unclassified 128-210 40 1.5e-19 54.41 In-house 113-198 (244) Show / Hide 
Range on Protein: 128-210
Range on HMM: 113-198/244
Sequence Identity: 40% (35 aa)

MLKCIEALHIYGYVHRDIKPGNIL--TREGTEHPLCLIDFGLARCFVNP-ETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDD
|.. || ||  ...|||||| |.|   ...  | . .|||||.  .. . .|| |  .|   .. ||  |||. ||.|    ||||
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD
Kinase 92995.m00075.AA S_TKc 24-270 19 5.3e-15 43.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-270
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

YIIGPKIGQGAFGEIYCAIDQNTGILWALKTESSLVNKKVLPYEYQVLDKIQESPHFPRVGMMGTGPEYSFFSMELLGP---SISHILKSIPGNK----F
| |. |||.||||. |.... .|| . |.|  .     . .  | |.| |    |.  .   .    .. .. ||...    .  ...|. ....    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TFSTAIRASYHMLKCIEALHIYGYVHRDIKPGNILTREGTEHPLCLIDFGLARCFVNPETGMHLLQRPPSGFRGTRAYASLHAHYGEDLARRDDVISWFY
.  .| .  | ... .| .|  | .|||.|| |||  |     . ..|||||| .              . | ||. | .                   |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GY

SA------------YEFITGTLPWKKSSDSSETQQMKEHFDPSEALSTIAPEMIKV-------WKHILT-------LEFM
.             ||...|  |.    .    ....    ..||.. .   . ..          .|.        ...
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF