Gene 92419.m00028 (T.vaginalis)

92419.m00028

Species: T.vaginalis
Alias: 92419.m00028, TvagK0490
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1y

Sequence

Name Sequence Type Origin Length Description Download
92419.m00028.AA Protein None 443 None Fasta, JSON
92419.m00028.kin_dom Protein Kinase Domain None 233 None Fasta, JSON

Protein domain

Protein domains of 92419.m00028.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92419.m00028.AA CK1 10-268 51 2.8e-151 508.86 In-house 1-271 (271) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-271/271
Sequence Identity: 51% (139 aa)

YHLQKQIGSGSFATLYEGEDIRDGTK--IAIKLEPLNSSYPQLNFESKLYTLFSG------SFQVPRMHLFTKE--SRENAMVIDLLGPSLEDLFNLCGQ
| . . ||.|||  .|.|... .| .  .|||||. .|  |||..|.|.|. . |      .  .|.|. . .|  .  |.||.||||||||||||.|..
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

QLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGL-GSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALNGIRQSRRDDME
....|||||. ||||  ....|.|.||| ||||||||||. | ...|||||||||.|.|||. .|.| || |...|||| ||||||.  || ||||||||
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SLGYVWLYLLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAG-YPKEFVEYFKDVRNLKYDEEPHYA
||||| .|.|||||||.|. | . .||| .||| |. ...|.||.| .|.||..|.. .|.|...|.| |.
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 92419.m00028.AA CK1-Unclassified 10-242 52 4.6e-148 440.04 In-house 1-244 (244) Show / Hide 
Range on Protein: 10-242
Range on HMM: 1-244/244
Sequence Identity: 52% (127 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSGSF-------QVPRMHLFTKE--SRENAMVIDLLGPSLEDLFNLCGQQ
| . . ||.|||   |.. .. .... |||||  || .||| .| |... . . .        .|.|. . .|  .. | || ||||||||||||.|...
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

LTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMG-LGSNKNQVYIIDFGLSKKYRDP-TSHKHLPYEEGRSLTGTPRYASINALNGIRQSRRDDME
...|||||. ||||  ....|.|.||| |||||||||| || |..|||||||||||.|.|.   .|| || |...|||| |||||||  || ||||||.|
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SLGYVWLYLLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLC
||||| .|.|.|||||..| | | ..|| .||| |. ...| ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 92419.m00028.AA CK1-D 10-270 53 5.3e-127 428.23 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 53% (140 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSGSFQVPRMHLFTKESRENAMVIDLLGPSLEDLFNLCGQQLTIKTVLML
| . ..||||||  .| |..|  .  .|||||.. .  |||..|||.| ...|   .|... . .|   |.||.|||||||||||| |. .  .||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

TDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALNGIRQSRRDDMESLGYVWLYLLR
.||||  ...|| ..||| ||||||||||||   | ||||||||.|.|||. .|.|.|| | ..|||| ||||||   || ||||||.|||||| .|  |
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAGYPKEFVEYFKDVRNLKYDEEPHYAKY
||||| |. | .  |||  |.| |. .. ..||.|||.||..|.  .||||.|. | |.  
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 92419.m00028.AA CK1-A 10-270 52 4.90000000001e-123 415.06 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-261/261
Sequence Identity: 52% (138 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSGSFQVPRMHLFTKESRENAMVIDLLGPSLEDLFNLCGQQLTIKTVLML
|.| ..||||||  .| |  |..|  .|||.|  .  .|||..|.|.|.. .|   .|.|. . .|   |.||.||||||||||||.|  . |.||||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

TDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALNGIRQSRRDDMESLGYVWLYLLR
.||||  . ..|||.||| ||||||||||.|   |....|||||.|||||. ...|.|| | . |||| |||||||  || |||||||||.||| .|  |
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAGYPKEFVEYFKDVRNLKYDEEPHYAKY
|.||| |. | .  |||  | | |  .. | || |.| ||  |.. .|||...|.| |   
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 92419.m00028.AA CK1-G 10-270 45 2.7e-108 366.08 In-house 1-266 (266) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-266/266
Sequence Identity: 45% (120 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSGSF-QVPRMHLFTKESRENAMVIDLLGPSLEDLFNLCGQQLTIKTVLM
|   | || |.|  |.||. .  .  .|||.||  |  |||  | . | . .|    .|. . |  .   |.||.|||||||||||..|. . ..|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQ--VYIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALNGIRQSRRDDMESLGYVWLY
.  |||. .. .|... |  |.|||||| |  |||.|  ..|||||. |.|.||   .| || | .||||| || |||   |  ||||||||.|| . .|
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAG--YPKEFVEYFKDVRNLKYDEEPHYAKY
 ||||||| |  | |  ..|  | . |  . .|||| .  .|..|  | . ||.|...|.| |   
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 92419.m00028.AA CK1 10-270 30 1.6e-104 353.56 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-339/339
Sequence Identity: 30% (105 aa)

YHLQKQIGSGSFA-TLYEG-----EDIRDG-----TKIAIKLEPLNSS--YPQLNFESKLYTLFSGS-------------------FQVPRMHLFTKESR
. . |.||.|.|  . |..     .|. ..     .. |.|.|| .|   .|||  |...| .. |                       |.|. . .|  
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--ENAMVIDLLGPSLEDLFN---LCGQQLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGL------GSNKN--------QVYIIDFGLSK-KY
   | ||..||||.||||..   .|.. .. ||.||. .||..|....|.. ||| |||||||.||.      | . .        |||.||||... ||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

RDP-----------TSHKHLPYEE---GRSLTG-TPRYASINALNGIRQSRRDDMESLGYVWLYLLRGS--LPWMGINARNT-------DQKYSMIMEAK
||.             ..| |. |    ....| |.||.|||. .|. |.||||..|..|. ...|.|.  |||..... .        ..|| .|.| |
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

AGISPEDLCAG-----YPKEFVEYFKDVRNLKYDEEPHYAKY
   ... || .     .|.|| ...| .|.|||...| |.. 
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 92419.m00028.AA TTBKL 10-274 26 5.7e-40 132.68 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-288/288
Sequence Identity: 26% (78 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNS-SYPQ--LNFESKLYTLFS--GSFQVPRMHLFTKESRENAMVIDLLGPSLEDLFNLCGQQ--LT
.. .|.||.| |.. |...|. | .. |.. |..|. .     . .| .. .. .  ||  .|..|.  |. . | ||  |.||.| || .   ..  ..
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

IKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSN----KNQVYIIDFGLSKKYRDPTSH-------KHLPYEEGRS------LTGTPRYASINA
  |.. .  | . |.. .|.. ||| |.|| |. .|. ..       ||.||||....|... .        . .   . |.      . ||.||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

LNGIRQSRRDDMESLGYVWLYLLRGSLPWMGINARN--TDQKYSMIMEAKAGISPEDLCAGYPKEFVEYFKDVRNLKYDEEPHYAKYRQLF
 ..  |.| ||. |. |.  .|. | ||| ... .      | .|..|. .. .| |  .. |.|| . .| .|.|.| ..| | . ...|
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRD--HDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 92419.m00028.AA Worm6 81-270 26 7.2e-33 115.32 In-house 80-279 (279) Show / Hide 
Range on Protein: 81-270
Range on HMM: 80-279/279
Sequence Identity: 26% (53 aa)

MVIDLLGPSLEDLFNLC-GQQLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGL-----GSNKNQVYIIDFGLSK--KYRDPTSHKHLPY-EEG
.|. |.|..|.||   . .. ..  | | .  |...|..  |   ||| |.|| ||  |        .  ..|..|||...  ||..     . |  .. 
IVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTAC

RSLTGTPRYASINALNGIRQSRRDDMESLGYVWLYLLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAG-YPK-EFVEYFKDVRNLKYDEEPHYAK
    ||.|||.... .|. |.|.||.||  |. . ...| |||....... ..|. .    .     . .  |  || ||.. .. . ...| ..| |..
G-FRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKF

Y
 
I
Kinase 92419.m00028.AA Pkinase 10-233 20 1.3e-32 116.44 Pfam 1-234 (293) Show / Hide 
Range on Protein: 10-233
Range on HMM: 1-234/293
Sequence Identity: 20% (52 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQL---NF---ESKLYTLFSGSFQVPRMHLFTKESRENAMVIDLLGPSLEDLFNLC------
||. ..||||||.. |.. .. .| . |.|  .. .  ..    ..   | ..   ..  . |   . |.  ...  || ....  |. .. |.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

-GQQL--TIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQV----YIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALN-GI
 .  .  . ... .   |.. .....|....|| |.||.|.|.   .|....     |.||||.|...      . ...   ...|||.|..   .. | 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI---DNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQ

RQSRRDDMESLGYVWLYLLRGSLPWMGI----NARNTDQKYSMIMEAK
  ... || |.| .  ..| | .|. |     | .. .|.. .||...
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPP
Kinase 92419.m00028.AA VRK 81-215 37 2.7e-29 91.29 In-house 106-241 (284) Show / Hide 
Range on Protein: 81-215
Range on HMM: 106-241/284
Sequence Identity: 37% (52 aa)

MVIDLLGPSLEDLFN-LCGQQLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEG--RSLTGT
||.. .| .|. .    .|  .. |||| |  .|... ...||.   |.|||  | | |.  |..||| .|.||. .| .  . || .|.|.  |   ||
MVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP--NGKHRQYKEDPRRCHNGT

PRYASINALNGIRQSRRDDMESLGYVWLYLLRGSLPWM
. . |. | .|   ||| | |.|||  .. | |.||||
CEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWM
Kinase 92419.m00028.AA TTBK 79-270 33 9.6e-23 77.23 In-house 71-257 (257) Show / Hide 
Range on Protein: 79-270
Range on HMM: 71-257/257
Sequence Identity: 33% (65 aa)

NAMVIDLLGPSLEDL-FNLCGQQLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMG-LGSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEGRSLTG
| || .|.| .| ||  .   .  .. | | |  |...... ||.  | | |||| || || . |. ...|..||||  .|   .     | |      |
NYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVA-GFRG

TPRYASINALNGIRQSRRDDMESLGYVWLYLLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAGYPKEFVEYFKDVRNLKYDEEPHYAKY
| |||||||       |.||. || |.    . | |||  |  .  ||    . | |      .|    |.||  . . .. |.| . | |.  
TVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKI--KDKDQ----VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 92419.m00028.AA S_TKc 10-292 15 1e-14 38.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-292
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSGSFQVPRMHLFTKESRENAMVIDLLGP---SLEDLFNLCGQQ-----L
|.. ..||.|.|.. | . ....| . |||  .      ..  | ..     .   . ... .  .  .  || ....    .| |.   .| .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQVYIIDFGLSKKYRDPTSHKHLPYEEGRSLTGTPRYASINALNGIRQSR-RDDMESL
.  ..  .. |...|....|.. .|| |.||.| |.       .. |.||||....              ... ||| | .   |     .. . |. |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVWLYLLRGSLPWMGINARNTDQKYSMIMEAKAGISPEDLCAGYPKEFVEYFKDVRNLKYDEEPHYAKYRQLFRDAFI-----RYGYKFDYN-------
| .   .| |  |.      . .. . .|.                                        ... |  .      |..     .       
GCILYEMLCGYPPFP-----QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

YDWL
  |.
HPWF
Kinase 92419.m00028.AA Worm6 10-53 31 7e-06 17.46 In-house 1-48 (279) Show / Hide 
Range on Protein: 10-53
Range on HMM: 1-48/279
Sequence Identity: 31% (15 aa)

YHLQKQIGSGSFATLYEGEDIRDGT--KIAIKLEP--LNSSYPQLNFE
. . | ||.|.| . |. ||  |..  ..|.|.|    |.. ..| .|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKME
Kinase 92419.m00028.AA TyrKc 10-212 15 4.2e-05 -140.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-212
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

YHLQKQIGSGSFATLYEGEDIRDGTKIAIKLEPLNSSYPQLNFESKLYTLFSG--SFQ--VPRMHLFTKESR-----ENAMVIDLLGP--SLEDLFNLCG
 .| |..|.| | . |.|. .   .. |.|    ..   .  | . .  . .   . .  |      |...|     |  |..  . |  .| |    ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

QQLTIKTVLMLTDQMINAVQFIHEKSFIHNDIKPDNFLMGLGSNKNQVYIIDFGLSKKYRDP----------TS----HKH--LPY--------EEGR--
 .|. |. |    |  .  ...|.| .|| |.   | | | .    .| | |||||..  |           ..    ...  ||.         .|.  
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------SLTGTPRYA-------SINALNGIRQSRRDDMESLGY-----------------VWLY---------LLRGSL
                .. ..| .         . ... ..| .| .    .|                  | .          ..  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 92419.m00028.AA TTBK 10-41 36 8.4e-05 12.93 In-house 1-33 (257) Show / Hide 
Range on Protein: 10-41
Range on HMM: 1-33/257
Sequence Identity: 36% (12 aa)

YHLQKQIGSGSFATLYEGEDIRDG-TKIAIKLE
    | || | |   ||..|.     ..|||.|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE