Gene 81845.m00219 (T.vaginalis)

81845.m00219

Species: T.vaginalis
Alias: TvagK0578, 81845.m00219
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK20

Sequence

Name Sequence Type Origin Length Description Download
81845.m00219.AA Protein None 319 None Fasta, JSON
81845.m00219.kin_dom Protein Kinase Domain None 288 None Fasta, JSON

Protein domain

Protein domains of 81845.m00219.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81845.m00219.AA CMGC 8-295 21 8.99999999999e-104 341.96 In-house 1-513 (513) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

YGEVTAIDCGRFSTVYKAQE--------------LSTKITFAIKSISLTSRSNDTIAP------------YREIQALSVCE-----------------HQ
|  .  | .| ...|||..                 |.   ||| |..    ... |             .|||. |                     | 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF--YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NIVKLHEVVQSAS-----------------AINLVMEYIPYNLSKVLSSN----------IVSESL------------AKGFI------LQLFRGLA--H
|||||......                    ..||.||....| ... .|            ||               | |.       |..|||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

MHSLG--MIHRDIKPQNLLVTKQ--------------------GVLKICDLGLCRLLTDHSNQ--------------QGYDDSHAWTLQVGTHYYRSPEL
.|| .   ||||.||.|.|....                    |.||||| ||.| . .||..               . . ... | .| | .||.||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEI

LYGD---------RNYGYPIDIWAAGCVMAEILTG--------SPLFP-----------GTGDVELLAMISDLLGDAS---------------EKNWPGI
| |.         ..|..|||.|..||..||..||         ||||           |. ... |..| ..||  .               |..||..
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

SQLSDFGK-------------IC------------FKEKPAKDFHEIFQS-----------------------------------LSEEAIDLLQKIIVY
..| .. |             ..            |...| |.....|                                     ....|||||.|. .|
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPAKRISAAEALKHPWF
||.|||.|..||.||.|
DPDKRITAEQALQHPYF
Kinase 81845.m00219.AA CDK 8-295 33 4.6e-101 324.09 In-house 1-284 (284) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-284/284
Sequence Identity: 33% (106 aa)

YGEVTAIDCGRFSTVYKAQELSTK-----ITFAIKSISLTS--RSN-DTIAP---YREIQALSVCEHQNIVKLHEVVQSA-----------SAINLVMEY
|  .  |  | . .||||. . |.        |.| | . .  |.. ..  |    |||  |  . |.||||||.|. .            . . .|.||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

IPYNLSKVLSSNIVSESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGV-----LKICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPE
... |.|...         | ...|| |||...|| . .|||.||||.|....|.     ||| | || |.    .. .. . . . | .| |  ||.||
MDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ-MS-EPNRTYTHEVVTLWYRAPE

LLYGDRNYG--YPIDIWAAGCVMAEILT---GSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDFHEIFQSLSEEAIDLLQKI
|| |...|.   |||.|..||..||..|   . |||||. . . | .|....|  .|.||||...| |.                         |||.| 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

IVYDPAKRISAAEALKHPWF
 .|||.||||| .||.||.|
LCYDPKKRISAEQALQHPYF
Kinase 81845.m00219.AA S_TKc 8-295 29 4.1e-87 296.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-231/231
Sequence Identity: 29% (91 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRSNDTIAPYREIQALSVCEHQNIVKLHEVVQSASAINLVMEYIPY---NLSKVLSSNI------
|  .  |  | |..|||... .|.  .||| |.        .  .|||| |.   | |||||..| |. . . .||||..    .| ... ..       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VSESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGY-PIDIWA
  .|  |. .. |....|...||.| ||||.||.|.|...  ..|||| ||.|.|               | ..|| .|..||.|     ||. ..|.|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL----GYGKCKCDWWS

AGCVMAEILTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDFHEIFQSLSEEAIDLLQKIIVYDPAKRISAAEALK-----
 ||...| |.| |.||       ..|. ...|                                    |.||.|...|. ..||.||..| |||.     
CGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPWF
  ||||
KCHPWF
Kinase 81845.m00219.AA CDK7 8-295 33 8.3e-86 228.42 In-house 1-288 (288) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-288/288
Sequence Identity: 33% (100 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSIS---LTSRSNDTI--APYREIQALSVCEHQNIVKLHEVVQSASAINLVMEYIPYNLSKVL--SSNIVS
|  .  |  | | |||||....|    ||| |     .|   | |     |||  |   .| |.. |  .    | |.||.....  |  |   .| |  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGYPIDIWAAGCV
 .  | . ... .|| ..|     |||.|| |||. . |.||| | || |               ..| || | .||.||||.| | ||  .|.|. ||.
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSP--------NRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCI

MAEILTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPA---KDFHEIFQSLSEEAIDLLQKIIVYDPAKRISAAEALKHPWF
.|| .   | .||..|.  |  |   ||  .|..||..... |.  | ||. |.     ...||   |....||....   .| ||......||.| |
FAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDY--IKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 81845.m00219.AA CDK-Unclassified 8-295 29 1.3e-82 271.6 In-house 1-324 (324) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-324/324
Sequence Identity: 29% (97 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRS-----------NDTIAPYREIQALSVCEHQNIVKLHEVVQSASAIN-------------LVM
| .   .  | |  |.||  . |    ||| |..               |  |   |||  |  |.| || |. ... ...                .||
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

EYIPYNLSKVLSSNIVSES--LAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQG-----VLKICDLGLCRLLT---DHSNQQGYDD-SHAWTLQVG
||.|| .. .| .|  . |    . | .|.. |.| .|. ...||||||||...| ..     .||| | |. ..        | |.  | .   . || 
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

THYYRSPELLYGDRNYGYPIDIWAAGCVMAEILTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDF-HEIFQSLSEEAIDL
|  ||.|||| |.. |.. .|||..||..||.. | |.|.|. ..| .. |...||. .| .|| .... | .|| || |. .    ..   ...  ...
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENNC

LQKIIVYDPAKRISAAEALKHPWF
.    .|.| .| .. |.|.||||
EFQMVMYQPYNRWKCMEILQHPWF
Kinase 81845.m00219.AA Pkinase 17-295 30 4.5e-81 280.44 Pfam 10-293 (293) Show / Hide 
Range on Protein: 17-295
Range on HMM: 10-293/293
Sequence Identity: 30% (91 aa)

GRFSTVYKAQELSTKITFAIKSISLTSRSNDT------IAPYREIQALSVCEHQNIVKLHEVVQSASAINLVMEYIPY-----NLSKVLS---SNIV--S
| |..|||... .| ...|.| |.. ... .       .   .||| .  . | |||.|...... . | .|||| .       |. ..|   .. .  |
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

ESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVL----KICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGYPIDIWA
|  .| ...|..|||...|| | ||||.||.|.|. ..|..    |||| ||....        |  ..  |  .|| .|..||.. |.. ||...|.|.
EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCVMAEILTGSPLFPGT----GDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDFHEIFQSLSEEAIDLLQKIIVYDPAKRISAAEALKH
.||...| |.| |.|||     . .. ..||   .|   . .||  .  |.|  . . . . . . .    .|||..|.. ... .||.||..|...|.|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PWF
|||
PWF
Kinase 81845.m00219.AA CDC2 8-295 34 3.2e-73 224.22 In-house 1-301 (301) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-301/301
Sequence Identity: 34% (107 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRSND----TIAPYREIQALSVCE-HQNIVKLHEVVQSASAINLVMEYIPYNLSKVLS-SNI---
|  .  |  | .  |||.... |.   |.| | |.. . .    . |  |||  |     |.||||||.|. . . . .| ||. ..| | .  |.    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTA-IREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

-VSESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGYPIDIWAA
 ....| | .. |. .|... |. . .|||.||||.|. |.|..|| | || |  .  ...   .        | |  ||.||.| |.. |  |.|.|. 
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTE------HEVVTLWYRAPEILLGCKRYSTPVDMWSI

GCVMAEI---LTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDFHEIFQS---------LSEEAIDLLQKIIVYDPAKRIS
||..||.    |  |||.|    . |  |   || ..|..|||..|| |. |  | . ...|. .|. .         | .|.||||.....|||.||||
GCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDY-KNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

AAEALKHPWF
| |||.||.|
AKEALQHPYF
Kinase 81845.m00219.AA MAPK 8-295 30 4.4e-70 239.15 In-house 1-328 (328) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-328/328
Sequence Identity: 30% (100 aa)

YGEVTAIDCGRFSTVYKAQELS------TKITFAIKSIS-LTSRSNDTIAPYREIQALSVC-EHQNIVKLHEVVQSA-----------SAINLVMEYIPY
|  .  |  | . .| .|   .      .. . ||| ||   .   ..   ||||  |  . .| ||.|| .. .               | .|||.   
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLSKVLSSNI-VSESLAKGFILQLFRG--LAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSNQQGYDDSH------AWTLQVGTHYYRSP
.| ... |.   |.   . |. |. ||  | ..|| . ||||.|| |.||.. . ||||| || | . ..... . .|          |  | | .||.|
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLYGD--RNYGYPIDIWAAGCVMAEILT-GSPLFPGTGDVELLAMISDLLGDASEKNWPGIS---QLSDFGKIC--FKEKPAKDFHEIFQS----LSEE
|.. .   ..|   .|.|..|| .|| || . |||||.  .. . .| ..||  ||  .  |.      .. . .  .. .|.|.....|       . .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLQKIIVYDPAKRISAAEALKHPWF
|||||.|  | || |||...||| || |
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 81845.m00219.AA CCRK 8-295 37 6.2e-69 235.32 In-house 1-285 (285) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-285/285
Sequence Identity: 37% (109 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRSNDTI--APYREIQALS-VCEHQNIVKLHEVVQSASAINLVMEYIPYNLSKVL--SSNIVSES
|  .  |  |    |.||. . |    |.| ..|  | .| |     |||.||  . . | .|.| .|    .   || |..   |. |.  .   ..| 
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALR-RLDDGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLAEA

LAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGYPIDIWAAGCVMA
  | ... | .|.|| |   ..|||.|| |||. . | ||| | || |   .       |..  .| || | .|| |||||| | |   .|.|| ||.| 
QVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSN-------DEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMG

EILTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFGKICFKEKPAKDFHEIFQSLSEEAIDLLQKIIVYDPAKRISAAEALKHPWF
|.| .||.|||  |.| | ..  .||  ..| ||.. .| |. || |||.|     ..    | .|.|||.. .|| | .||.|..|| |..|
ELLNNSPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase 81845.m00219.AA CAMK 13-295 18 1.3e-67 216.73 In-house 1-425 (425) Show / Hide 
Range on Protein: 13-295
Range on HMM: 1-425/425
Sequence Identity: 18% (82 aa)

AIDCGRFSTVYKAQELSTK------------ITFAIKSIS---LTS------------------------RSNDTIAPYREIQALSVCE-------HQNI
 .  |.|..|..... .|.              .||| |.   |..                        | .|    .|||. .. .        | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLHEVVQ------------SASA--------INLVM---EYIPYN------LSKVLSS---------------NIVSESLAKGFILQLFRGLAHMHSLG
.||.|| .            . |         . .||   ||..        .... .                  ..|. |. .. |.  .....||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

MIHRDIKPQNLLVTKQ-----------------GVLKICDLGLCRLLTDHSNQQGY---------------DDSHAWTLQVGTHYYRS-PELLYG-----
 .|||.|| |.|...                  . .||.| |. . ... .|.                  .. .  . ..|| .| . ||.| |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------DRNYGYPIDIWAAGCVMAEILTGSPLFPGT-------------GDVELLAMISDLLGDASEKN------------WPGISQLSDFGKICFKE
         . ||...|.|..|...   |.| | | |               | ||. .|     |  ..             | .||.           
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDE----------

KPAKDFHEIFQS--LSEEAIDLLQKIIVYDPAKRISAAEALKHPWF
         | .  .|.|..||..|. ..|| ||......|.|||.
---------F-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 81845.m00219.AA PITSLRE 53-295 36 4.1e-65 222.64 In-house 49-295 (295) Show / Hide 
Range on Protein: 53-295
Range on HMM: 49-295/295
Sequence Identity: 36% (93 aa)

REIQ-ALSVCEHQNIVKLHEVV--QSASAINLVMEYIPYNLSKVLSSNIV------SESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKI
|||.  |    | |||.. |.|       | .||||.   | | |  |.       ...  | ...|| || .|||..  .||| |  ||| . .|.|||
REINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDL-KSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKI

CDLGLCRLLTDHSNQQGYDDSHAWTLQVGTHYYRSPELLYGDRNYGYPIDIWAAGCVMAEILTGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSD
|| || |   .           . |. | |  ||.|||| | . |  |.|.|  ||..||..|. |||.| .... .  |  ..|  .|| |||.. |  
CDFGLAREYGSP--------IKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPH

FGKIC-FKEKPAKDFHEIFQ---SLSEEAIDLLQKIIVYDPAKRISAAEALKHPWF
. ..  |.. |     ..|.    .|. . |||..   |.|..||.| .|||||||
WKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 81845.m00219.AA CDK5 171-295 38 5.9e-48 149.33 In-house 159-287 (287) Show / Hide 
Range on Protein: 171-295
Range on HMM: 159-287/287
Sequence Identity: 38% (50 aa)

VGTHYYRSPELLYGDRNYGYPIDIWAAGCVMAEIL-TGSPLFPGTGDVELLAMISDLLGDASEKNWPGISQLSDFG--KICFKEKPAKD-FHEIFQSLSE
| |  || |  | | . |  .||.| .||..||.  .| |||||... . |  | ...|  .| .||.|..|.|.      .   ||.  . .| ..|.|
VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE

EAIDLLQKIIVYDPAKRISAAEALKHPWF
.  |||||.....|..||||..||.||.|
KGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 81845.m00219.AA CDK5 8-150 38 2.3e-31 95.98 In-house 1-146 (287) Show / Hide 
Range on Protein: 8-150
Range on HMM: 1-146/287
Sequence Identity: 38% (56 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRSNDT-IAPYREIQALSVCEHQNIVKLHEVVQSASAINLVMEYIPYNLSKVLSSNIV--SESLA
|  .  |  | . |||||..  |.  .|.| . | |    .  .  |||  |    |.||| || |. |   . || |..   | | . |  .  .  ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCR
| |..|| .|||  |.    ||| ||||||. |.| ||  | || |
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLAR
Kinase 81845.m00219.AA Pkinase_Tyr 17-157 28 3.7e-14 48.56 Pfam 10-166 (270) Show / Hide 
Range on Protein: 17-157
Range on HMM: 10-166/270
Sequence Identity: 28% (45 aa)

GRFSTVYKAQEL----STKITFAIKSISLTSRSND--TIAPYREIQALSVC-EHQNIVKLHEVVQ-SASA--INLVMEYIPY-NLSKVLSSN-----IVS
| | .|||.       .|||. |.|..  .. . .    .  ||.. ..    |.|||.|. |.        | .|||| |. .| . | ..      ..
GAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLT

ESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDHSN
 .   .. .|  .|... .| ..||||.   | |||...| |||| ||.|.... ..
MKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase 81845.m00219.AA TyrKc 8-295 21 9.4e-14 -0.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-295
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YGEVTAIDCGRFSTVYKAQELSTKITFAIKSISLTSRSNDTIAPYREIQALSVC--EHQNIVKLHEVVQSA-------SAINLVMEYIPY-NLSKVLSSN
      . .| | .|||..     |. |.|..   .      . .||.. ..    .|.|||.|. |. .          . .|||| |. .| . | ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

I--VSESLAKGFILQLFRGLAHMHSLGMIHRDIKPQNLLVTKQGVLKICDLGLCRLLTDH----SNQQGYDDS---HAWT-LQVGTHYYRSPELLYGDRN
   .. .    | .|  .| .. || . ||||.   | ||..... ||.| ||.| ..|.     ... |. .   .. | | .      .|| .  .. 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPECI-NYGK

YGYPIDIWAAGCVMAEILT-GSPLFPG-----TGDVELLAMISDLLGDASEKN-WPGISQLSDFGKICFKEKPAKDFHEIFQSLSEEAIDLLQKIIVYDP
.    |.|. | .| ||.| | .  ||       . |... . .       .|  | .|                     |   ..|  .. ..   .||
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS---------------------FVCCPDEMYQIMKQCWHEDP

AKRISAAEALKHPWF
..| . .|   |  |
EDRPTFSEI--HECF