Gene 92757.m00268 (T.vaginalis)

92757.m00268

Species: T.vaginalis
Alias: 92757.m00268, TvagK0687
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
92757.m00268.AA Protein None 913 None Fasta, JSON
92757.m00268.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of 92757.m00268.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 92757.m00268.AA NEK 4-258 48 1e-155 523.61 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 48% (140 aa)

YEQVKTLGEGGYGKAILVRRKKDNQM-----FVIKSVKLKGLKEEEKKEAL-YEVQVLSYLRHPNIITYIDSFQEKE--VLHIVMEYAD-AGDLGTK---
|| .|..|.| .||. .||||.|...     .|.| .......|.||..|.  ||..|. |.||||..|.|||.|..   |.|||||..  |||  |   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

VQKQ--GRTLFSEDYILNIFTQIALAIKYMHDR-----KILHRDLKLQNIFLMKSGI----AKLGDFGIAKALDKTNQFLKT-QIGTPYYLSPEICEGKN
 .||   ...|.|..|...|.|..||.||||||     ||||||.| ||||| |...    .|.|||||.| |..|.....| |.|||||.|||.|..| 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNTKTDIWSLGCILYEMCTL--RHAFEGR--NINNLLVNIIRG-QFTPISNQ--YSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
|| | |||||||.|||||||  .|.||.   |...| ..|..| |. ||. .  |||||.||.|.|| ||| .|||.|||| .|||
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 92757.m00268.AA NEK1 4-258 50 2.2e-141 475.98 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 50% (138 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSFQEKEV--LHIVMEYADAGDLGTKVQKQ--GRTL
|.  |..||| .|||.||..| |.|..|||. ..   .|.|. |.. || .|. ..||||..| .||.|     | |||||.|.|||  | ..|     |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FSEDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLM--KSG---------------IAKLGDFGIAKALDKTNQFLKTQIGTPYYLSPEICEGKNYNT
|||| |.. |.|| || ...|||||||||.| |||||   |.|               ..||||||||. |  |  . .| ||||||||||||. | || 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KTDIWSLGCILYEMCTLRHAFEGRNINNLLVNIIRGQFTPISNQYSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
|.|||||||.||| ||| |.||..|  ||   |..| ..||.. ||..|..|||.|....| .|||.||||. |||
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 92757.m00268.AA NEK8 4-258 43 6.8e-138 396.33 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

YEQVKTLGEGGYGKAILVRRKKDN--QMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSFQEKEVLHIVMEYADAGDLGTKVQKQGRTLFS
|| . ..| |  | ..| ||| |.  .  ..| . . .. |.|   |. |.|||| | ||||| |.|.| |  .| |.||||| | |  . |.|  .||.
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

ED-----------------YILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKS-GIAKLGDFGIAKAL-DKTNQFL-KTQIGTPYYLSPEICEGKNYN
|                  .||  |.|. .|. .||.  ||||||| ||||. .. .. |.|||||.| . .|.     || .|||||.|||.|||| ||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

TKTDIWSLGCILYEMCTLRHAFEGRNINNLLVNIIRG-QFTPISNQYSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
 | |.|.|||.|||||.|. |||. |  .| . |...  ..||| .|| ..| ||.. |..|| .|||| ||.  | .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 92757.m00268.AA NEK4 4-258 46 4.2e-116 392.02 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 46% (120 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSFQEKEV--LHIVMEYADAGDLGTKVQKQGRTLFS
|. .|  | | ||   ||| ..|   .|.| ..||    .|.|.|. |.|.|| |.||||..| .|..  .   | ||| . . ||| .| ..|   . .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAKALDKTNQFLKTQIGTPYYLSPEICEGKNYNTKTDIWSLGCILYEMCTLRH
|  ... | |||.|  |||...||||||| ||||| |  | |.|||||.. |.   .. || ||||||.|||.   . |. | ||||||| .||| ||.|
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFEGRNINNLLVNIIRGQFTPISNQYSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
||. ...| |.  || ||  |.. .||||| |||  ||.| |..|||  .|.  |.|
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 92757.m00268.AA S_TKc 4-258 32 1e-94 321.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSFQEKEVLHIVMEYADA--GDLGTKVQKQGR----
|| ....|.|..||  ..| ||... . || .|         . .. |.|.|.  .||||....|.||. . |..||||.|   ||| .  .|.||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

TLFSEDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAKALDKTNQFLKTQIGTPYYLSPEICEGKNYNT-KTDIWSLGCILYEM
  |.|  .  .. ||..|..|.|...|.||||| .||.| .    |..|||.|. |       .|..|||.|..||..    |.. | |.||.|||||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTLRHAFEGRNINNLLVNIIRGQFTPISNQYSQDLRNLVSSMLSKDPNNRPSANQILT-------LPFI
.. .  |.     ... ..|.          |........ .| |||..||.| ..|.        |..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 92757.m00268.AA Pkinase 4-258 29 4.3e-92 317.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALY--EVQVLSYLRHPNIITYIDSFQEKEVLHIVMEYADAG----DLGTKVQ-KQG
|. ....|.|..|.  . ..|........| .|... |........   |.|..  |.||||....|.|..|  ...||||.. |    || . .. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RTL-FSEDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIA----KLGDFGIAKAL-DKTNQFLKTQIGTPYYLSPEICE-GKNYNTKTDIWSL
... |||. . ....||. ...|.|...|.|||||..||.. . |      |..|||.|| .    |. ..|  |||.|..||..  |. | .| |.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYEMCTLRHAFEGR----NINNLLVNIIRGQFTPISNQYS-----------------------QDLRNLVSSMLSKDPNNRPSANQILTLPFI
|||||||.. |  | |.    | .. .. | |   .|.. ...                       .... .....| |||. ||.| |||  |..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 92757.m00268.AA CAMK 9-258 21 2.7e-83 268.12 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

TLGEGGYGKAILVRRKKDN------------QMFVIKSVKLKGLKE-------------------------EEKKEALY-EVQVLSY-------LRHPNI
|||.|..||  |...|...            | . || .. | ||.                         ..... .. |.....        |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITYIDSFQEKEV-------------------LHIVM---EYADAG----DLGTKVQKQGR-------------TLFSEDYILNIFTQIALAIKYMHDRKI
|  .. .. ...                   ...||   ||.. |    ||  .....|.               |.|.    .| ||. |..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKLQNIFLMKS-----------------GIAKLGDFGIAKALDK-----------------------TNQFLKTQIGTPYYLS-PEICEGKN----
 |||||. || | ..                 .  |. ||| |. .|.                       ..| .||. |||.| . ||. .||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNTKTDIWSLGCILYEMCTLRHAFEGR-------------NINNLLVNIIRGQFT-P------------------ISNQ----YSQDLRN
          |. |.|.||.|.||| | . .  |.|              |...|. .|..|... |                  ||..     ||. ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVSSMLSKDPNNRPSANQILTLPFI
|...|| .||..|... |.|  |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 92757.m00268.AA NEK-Unclassified 4-258 38 8.3e-80 263.87 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSFQEKEVLHIVMEYADAGDLGTKVQKQGRT--LFS
|... ||| || |   ||| .      | .  | |      ||     . .|| |||| |.|| ||| |   |    .| | |.|  ..||.      | 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRK-----KKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAKALDKTNQFLKTQIGTPYYLSPEICEGKNYNTKTDIWSLGCILYEMCTLRH
|  |   . |.  |. | | |||.||||| ||||| .. .  .|||||.. .| |    .| .||. ..|||.|. . || . |.||||||.|||||   
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

AFEGRNINNLLVNIIRGQF------TPISNQYSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
.|  .|.  ..  | ..         |.|  || || ...  || .... ||||  |. ...|
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 92757.m00268.AA NEK2 4-258 32 5.4e-76 255.38 In-house 1-319 (319) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-319/319
Sequence Identity: 32% (104 aa)

YEQVKTLGEGGYGKAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYLRHPNIITYIDSF--QEKEVLHIVMEYADAGDLGTKVQK--QGRTL
||  .|.|.| .|.   |||| |   .| |  .   . | |.     |. .|. |.||||. | |     ....| |||||   |||.  ..|  . |. 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FSEDYILNIFTQIALAIKYMHD---------------------RKILHRDLKLQNIFLMKSGI-------------------------------------
. | .|. |..|. .| .  |                      . |||||.|  ||||   .                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--AKLGDFGIAKALDKTNQFLKTQIGTPYYLSPEICEGKNYNTKTDIWSLGCILYEMCTLRHAFEGRNINNLLVNIIRGQFTPISNQYSQDLRNLVSSML
  .|||||| |. | .  .| .| .||||| |||  .|  || | ||||.||..||||.|.  |...|   | . |  | | .|  |||..|  ....|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

SKDPNNRPSANQILTLPFI
  |.  ||| . ||  |.|
NVDHYHRPSIEEILQHPQI
Kinase 92757.m00268.AA Ciliate-E2 4-258 23 1.3e-74 254.14 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YEQVKTLGEGGYG-----KAILVRR------------------KKDNQMFVIKSVKLKGLKEEEKKEALY-----------EVQVLSYLRHPNIITYIDS
|. .| .|.|..|     | ..|..                  | ..... .|..| ..... .... ..           | ..|. | ||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--EKEVLHIVMEYADAGDLGTKVQKQ----------GRTLFSEDYILNIFTQIAL---------------AIKYMHDRK-ILHRDLKLQNIFLMKSGI
||   .. . .||||.. |||    ...          .   |.|  |..|..||.                |..|.| .. |.|||.|..||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

AKLGDFGIAKALDKTNQ-------------------------------FLKTQIGTPYYLSPEICEGKN---------YNTKTDIWSLGCILYEMCTLRH
 |. |||..| .|. ||                                 .|..|||.|..||| .||.         |..| ||||||.|||||.. ..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

AFEGRNINNLLVNIIRGQFTP-------------ISNQYSQDLRNLVSS----MLSKDPNNRPS-ANQILTLPFI
 |    ... . . |. ..               . .. ||.  .| .     || |||..|.. ..|||  |..
PF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 92757.m00268.AA STE 4-258 23 2.8e-73 249.78 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

YEQVKTLGEGGYGKAILVRRKK---------------DNQMFVIKSVKLKGLK---------------EEEKKEALYEVQVLSYLR--HPNIITYIDSFQ
.| .. .|.|..|.  . ...|                .... || ..|.  .               .||... | |..... ..  ||||..|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EK-------EVLHIVMEYADAGDLGTKVQ---KQGRTL---------FSEDYILNIFTQIALA-IKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAK
 .       . |.|.||| |.| |   ..   . |..|         |.|. |  |  ||  .  .| |. .| |||.| .||.|     .|| |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALDK---------------TNQ-FLKTQIGTPYYLSPEICEG------KNYNTKTDIWSLGCILYEMCTLRHAFEGRNINNLLVNIIRG-----------
 |..               |.|   .| .||| . .||. ..      | |.|| ||||||| . ||.| .. .   .    . .|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----QFTPISN-------------------QYSQDLRNLVSSMLSKDPNNRPSANQILT--LPFI
    .  |. .                   ..|..... ..  | ||||.||.|.| |    |||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 92757.m00268.AA Ciliate-E2-Unclassified 4-258 25 1.6e-70 240.62 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

YEQVKTLGEGGYGKAILVRRKKDN------QMFVIKSVKLKGLKEE----EKKEALYEVQ-------------VLSYLRHPNIITYIDSFQEKEVLHIVM
|. .|..|.||.||  ....||..      .| .|...| |  ...     ..... . .              |. . ||.|. ... || |. . |||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYADAGDLGTKVQKQGR---------------TLFSEDYIL-----NIFTQIALAIKYMHDRK-ILHRDLKLQNIFLMKSG---IAKLGDFGIAKALDKT
||.. |||    .|..                  |.|  ..     ..| || ....|.|  . |.|||.|..||.. ..|     |. ||||.| ... 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

NQF---------------LKTQIGTPYYL----SPEICEGKNYN----TKTDIWSLGCILYEMCTLRHAFEGRNINN----------------LLVNIIR
|..               ..|..|||.|.    .||. .|.||.     | ||||||.|||||.. .. |...| .                 |. ||. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

GQFTPIS-------NQYSQDLRNLVS----SMLSKDPNNRPSANQILTLPFI
...   .        . |.   ....    .|| |.||.|....|||  |..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 92757.m00268.AA Pkinase_Tyr 4-199 26 8e-21 71.15 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-210/270
Sequence Identity: 26% (57 aa)

YEQVKTLGEGGYGKAILVRRK----KDNQMFVIKSVKLKGLKEEE--KKEALYEVQVLSYL-RHPNIITYIDSFQ-EKEV--LHIVMEYADAGDLGTKVQ
 .  |.|||| .|.  . . |    ....   .|..   |  .|.  ... . |..... | .||||. ..     ..|   . |||||.  ||| .  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KQ---GRTLFSEDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAKALDKTNQF-LKTQ---IGTPYYLSPE-ICEGKNYNTKTD
|.   .. |  .| .|.. .||| .  | ..... ||||   |. . .....| .||| |... .. .   |..   .  . . .|| | .|| ..||.|
KHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGK-FTTKSD

IWSLGCILYEMCTL
.|| |  ..|..|.
VWSFGVLMWEIFTY
Kinase 92757.m00268.AA TyrKc 4-258 20 7e-18 66.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YEQVKTLGEGGYG---KAILVRRKKDNQMFVIKSVKLKGLKEEEKKEALYEVQVLSYL--RHPNIITYIDSFQEK-------EVLHIVMEYADAGDLGTK
 .  |.|||| .|   |...       ..  .|..|        ... . | .... |  .||||.  .    ..       | | |||||.. |||   
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

VQKQGRTLFSEDYILNIFTQIALAIKYMHDRKILHRDLKLQNIFLMKSGIAKLGDFGIAKALDKT-------NQFLKTQ-IGTP-----YYLSPEICEGK
 .| ... .. .  |.. .|||    | |.... ||||   |. . . ...| .||| .....             |..  |.        ..||    .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

NYNTKTDIWSLGCILYEMCTL-RHAFEG-----RNINNLLVNIIRGQFTPISNQ--------YSQDLRNLVSSMLSKDPNNRPSANQILTLPFI
 ..||.|.|| |  ..|..|.     .|      .   .. .. .|   |.            .... .. ..    ||..||. ..|    ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF