Gene 97324.m00300 (T.vaginalis)

97324.m00300

Species: T.vaginalis
Alias: 97324.m00300, TvagK0613
External Links:
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
97324.m00300.AA Protein None 307 None Fasta, JSON
97324.m00300.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of 97324.m00300.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 97324.m00300.AA CDK 6-289 42 8.4e-138 443.55 In-house 1-284 (284) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-284/284
Sequence Identity: 42% (136 aa)

YEKQEKLGEGSYGVVYRATDTRDK-----STVALKILKIDN-----LEDGVPSTLLREISILKTLNHINIIGLKDVCTSS-----------LPIFLAFEY
||| ||.|||.|||||.| |....       |||| ....|      ..|.|.| .||||.|| | | ||. |.|||...             ... |||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MDSDLRTLLNHIRRPLKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGL-----LKICDFGMSRYFTV------PMRPYTKGVVTLWYKAPE
|| || ...           ||.| .||. |....||..|.|||.|| |.|... |      ||| ||| .| | .      |.|.||. |||||| |||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLV-STPYD--LSIDMWSVGCIIYEMAT---GSPLFPGDGHIDQLMKIISILGTPTEDAYPGFYNKVKNELGFDMPNVERVGLAREFGDKCDYAMIDLIE
||  |. |.   .|||||||||..||.|   . ||||||  |||| ||. |.||||||  ||.                                 ||..
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLN

KVLVYDPAKRLSAKDALNHPYF
| |.|||.||.||..||.||||
KMLCYDPKKRISAEQALQHPYF
Kinase 97324.m00300.AA CDC2 6-289 43 2.4e-137 424.92 In-house 1-301 (301) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-301/301
Sequence Identity: 43% (131 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDG--VPSTLLREISILKTLN-HINIIGLKDVCTSSLPIFLAFEYMDSDLRTLLN---HIRRP
|.| ||.|||.|||||.. |....  ||||  .... ..|  |||| .||||.|| |. | ||. |.||  .   ... |||.| ||. ..      . .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYT--KGVVTLWYKAPELLV-STPYDLSIDMWSVGCIIYEM
. ....|||..|.. |..| |..||.|||.||.|.|..|.| .|| ||| .| |..|.|.||  . |||||| |||.|  .  |....||||.|||..||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ATGSPLFPGDGHIDQLMKIISILGTPTEDAYPGFYNKV--KNELG-FDMPNVERVGLA----REFGDKCDYAMIDLIEKVLVYDPAKRLSAKDALNH
   .|  |||.||  |||| ||  |||||.|. .|| ..    ||  . . . . ...       ...   .|   |||... |.|||.||.|||.||.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase 97324.m00300.AA CMGC 6-289 26 2.7e-127 420.71 In-house 1-513 (513) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-513/513
Sequence Identity: 26% (136 aa)

YEKQEKLGEGSYGVVYRATDTR--------------DKSTVALKILKIDN---------LEDGVPSTLLREISILKTLN-----------------HINI
||. .|.|||.|||||...|.|              ..  ||.|..| .          ..||.|.. ||||.||| ||                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IGLKDVCTSSL-----------------PIFLAFEYMDSDLRTLLNHIR--------RPLKESI------------IKSYA------FQLIAGIN--FIH
..|.|.....                   ..| ||||| ||  .. . .        .||.|              ||..       .|.. |..  ..|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SHR--IIHRDIKPDNLLLSKSGLL--------------------KICDFGMSRYFTVP---------------------MRPYTKGVVTLWYKAPELLVS
||.  |||||.|| |.|... . |                    ||||||..|.. ..                     .||||  |||.||.|||.|..
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

TP----------YDLSIDMWSVGCIIYEMATG--------SPLFP-----------GDGHIDQLMKIISILGTPT---------------EDAYPGFYNK
 .          |. .|||||||||..|| ||         ||||           |. ||||| ||. .|||||               |. .|.. ..
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

VKNEL------------------------GFDMPNVERVGLAREFGD----------------------------------KCDYAMIDLIEKVLVYDPA
  ...                        ... |.. .  . . | .                                  .||   |||..| |.|||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRLSAKDALNHPYF
||..|..||.||||
KRITAEQALQHPYF
Kinase 97324.m00300.AA CDK5 6-289 44 6.30000000001e-114 361.47 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-287/287
Sequence Identity: 44% (129 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLREISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDSDLRTLLNHIRRPLKESII
||| ||.||| ||.||.| .   .  ||||  ..|.   ||||| .|||..|| | | ||. | ||  |   . | ||..| ||.  .. .   .   ||
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

KSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLV-STPYDLSIDMWSVGCIIYEMA-TGSPLF
||. .||  |. | |.|.. ||| || ||| .| | ||  |||. | | .| | |.  |||||| .|  |  |  |  ||||||.|||. ||| .| |||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGDGHIDQLMKIISILGTPTEDAYPGFYNKVKNE-LGFDMPNVERVGLAREFGDKCDYAMIDLIEKVLVYDPAKRLSAKDALNHPYF
|| .  |||..|  |.|||.||  |.  .  .   .  . |  .      .   | |    || .| |...|..|.|||.||.||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 97324.m00300.AA CDK7 6-289 39 3.4e-110 294.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-288/288
Sequence Identity: 39% (116 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILK----IDNLEDGVPSTLLREISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDSDLRTLLNHIRRPLK
||| ...||| ...||.|.|.     || |  |     .  .||.  | .||| ||. . | |.||| |.      | | |..|| ||          |.
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

ESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLV-STPYDLSIDMWSVGCIIYEMATGS
 . ||.|. ..  |. . | . | |||.|| |||... | ||| |||  | .  | | ||  ||| || |||||     |  ..||||||||. |     
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PLFPGDGHIDQLMKIISILGTPTEDAYPGF-----YNKVKNELGFDMPNVERVGLAREFGDKCDYAMIDLIEKVLVYDPAKRLSAKDALNHPYF
| .|||. |||| .| ..||||||   |.      |.| |     | |   |. |   |    |.. .||... .  .| ||... ..|..|||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFK-----DFPGYSRTPLRHIFTAASDDL-LDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 97324.m00300.AA S_TKc 6-289 30 2.4e-101 343.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLREISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDS---DLRTLLNHIRRP---
||. .|.|.|..|.||........  ||.||.|          ...|||.|||  .| ||. |.||. .   ... .||.|    ||.... . .|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLVSTPYDL-SIDMWSVGCIIYEM
  . |  ...|. |.. .....|||.|||||.||.|.||..   .||||||..| .       |  ..|.|| |||.|   .|.  ..|.||.|||.|||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ATGSPLFPGDGHIDQLMKIISILGTPTEDAYPGFYNKVKNELGFDMPNVERVGLAREFGDKCDYAMIDLIEKVLVYDPAKRLSAKDALN-------HPYF
..| |.||   ......|.|                                          .  ..|.|.| |..||.||..| .||.       ||.|
LCGYPPFP---QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 97324.m00300.AA PITSLRE 6-289 40 7.7e-98 331.34 In-house 1-295 (295) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-295/295
Sequence Identity: 40% (120 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKID--NLEDGVPSTLLREIS-ILKTLNHINIIGLKDVC--TSSLPIFLAFEYMDSDLRTLLNHIR---
...  . .|| ||||||| |.|    |||| ||..     .| | | ||||. ||. |.| ||. .| .   .    |....||.. ||. |.  ..   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

RPLKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLVSTP-YDLSIDMWSVGCIIYEM
 | |.. ||.   ||  |. . |.. |.||| |  |||.| .| |||||||  | .  |..|||..|||||| |||||  .. |   .||||||||  |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ATGSPLFPGDGHIDQLMKIISILGTPTEDAYPGFYNKVKNELGFD-MPNVERVGLAREFG--DKCDYAMIDLIEKVLVYDPAKRLSAKDALNHPYF
 |. |||.|.. |||...|   .|||||   || ... ..   .  .|..    | . |.   .      ||  . | |.|..|..| ||| ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPG-WTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 97324.m00300.AA Pkinase 6-289 31 1.9e-94 324.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLR--EISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDS-----DLRTLLN-HIR
|.. .|.|.||.|.||....  .  .||.||.| .. ..... |..|  ||.|.| ||| ||. |.|.....  | . .||..      || ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--KESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLL----KICDFGMSRYF-TVPMRPYTKGVVTLWYKAPELLV-STPYDLSIDMWSV
...   |  .|.|. |.. |....||..|||||.||.|.|... | .    |||||| .. | . . . .|  ..|.|| |||..  ...|. ..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIIYEMATGSPLFPGD----GHIDQLMKIISILGTPTEDAYPGFYN--------KVKNELGFDMPNVERVGLAREFGDKCDYAMIDLIEKVLVYDPAKR
|||.|||..| |.|||.    . .||. .|  |.|.|..  .|  ..        . .               ...| .. . ...|.|.. | .||.||
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H-------------F-HWTF-HNWSEECKDFIKWCLCKDPKKR

LSAKDALNHPYF
..|...|.||.|
PTAEQILQHPWF
Kinase 97324.m00300.AA MAPK 6-289 32 4.4e-87 295.6 In-house 1-328 (328) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

YEKQEKLGEGSYGVVYRATDTR------DKSTVALKILK--IDNLEDGVPSTLLREISILKTL-NHINIIGLKDVCTSS-----LP------IFLAFEYM
|. ....|.|.||||  |.|.|      .. .||.| .    .|. .      .||| .|. . .| |||.|.|. | .      .      | . .|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

DSDLRTLLNHIRRPLKESIIKSYAFQLIAG--INFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTV-PMRPY-------------TKGVVTLWY
..||. ...  . || .  |..  .|.. |  . .||| ..||||.|| |.|. . ..|||||||..| .      ..             |  |.| ||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

KAPELLVS---TPYDLSIDMWSVGCIIYEMAT-GSPLFPGDGHIDQLMKIISILGTPTEDAYPGFY-NKVKNELGFDM---PNVERVGLAREFGD---KC
 |||.. .   . |. ..||||||||  || | . |||||. .|||. .|...||||.|. .     ..   ..   .   |.  .. ..  | .   ..
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNA

DYAMIDLIEKVLVYDPAKRLSAKDALNHPYF
.   |||.|| || || ||.....||.||||
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 97324.m00300.AA PFTAIRE 6-289 40 6e-84 285.2 In-house 1-287 (287) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-287/287
Sequence Identity: 40% (119 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLREISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDSDLRTLLNHIRRPLKESII
||| ||||||||  ||..     .  ||||  .... | |.| |  || | || | | ||. | |.        . |||.. || . ..     ..   .
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ-EEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

KSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPE-LLVSTPYDLSIDMWSVGCIIYEMATGSPLFP
. . |||. |  ..|  |. |||.|| |||.|. | ||  |||. |   || . | . ||||||  |  || || |  ..||| ||||  || .| |.||
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFP

GD-GHIDQLMKIISILGTPTEDAYPGF-----YNKVKNELGFDMPNVERVGLAREFGDKCD--YAMIDLIEKVLVYDPAKRLSAKDALNHPYF
|     ||| ||  .||||||| .||      |......  |  |      | . . .. .      ||. | | . | .|.||..|. ||||
GMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKK----LCHQW-PRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 97324.m00300.AA CDKL 6-289 38 2e-81 276.83 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-286/286
Sequence Identity: 38% (110 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLREISILKTLNHINIIGLKDVCTSSLPIFLAFEYMDSDLRTLLNHIRRPLKESII
|||  |.||||||||.   .      || |. |    .  |  . .||| .||.| | || .|. |.     ..| |||.|  .  .| .  . . |. .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

KSYAFQLIAGINFIHSHRIIHRDIKPDNLLLS-KSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLVS-TPYDLSIDMWSVGCIIYEMATGSPLF
..| .|.. .||| |.| .||||||| |.|.. |.| .|.||||  |  . |   ||  | | ||.||||||  | |  ..|.|..||.. ||..| ||.
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLW

PGDGHIDQLMKIISILGTPTEDAYPGFYNKVKNEL--GFDMPNVERV-GLAREFGDKCDYAMIDLIEKVLVYDPAKRLSAKDALNHPYF
||.. |||| .|.  ||. . .    |.   ||..  |  .| .|..  | . . .| ... .|...| |  ||..|........||||
PGQSDIDQLYHIQKCLGPLIPRHQEIFS---KNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 97324.m00300.AA CDK4 6-228 43 1.4e-77 264.03 In-house 1-234 (290) Show / Hide 
Range on Protein: 6-228
Range on HMM: 1-234/290
Sequence Identity: 43% (102 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLED--GVPSTLLREISILKTL---NHINIIGLKDVCT------SSLPIFLAFEYMDSDLRTLLN
|..   .||| || |||| |. .   ||||  .| . |.  |.|   .||||... |   .| ||. |.|||.      . . | . ||  | ||.|.| 
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

HIRRP-LKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVPMRPYTKGVVTLWYKAPELLVSTPYDLSIDMWSVGCII
 . .| . .  ||   .||. |. | ||||||||| ||.|.|.. .| .|. ||| .| .   |   |  |||||| ||| |   .|   .||||||||.
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIF

YEMATGSPLFPGDGHIDQLMKIISILGTPTEDAYP
 ||    |||.|    ||| ||  . |.|.||  |
AEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWP
Kinase 97324.m00300.AA Pkinase_Tyr 6-152 32 2e-28 96.89 Pfam 1-160 (270) Show / Hide 
Range on Protein: 6-152
Range on HMM: 1-160/270
Sequence Identity: 32% (54 aa)

YEKQEKLGEGSYGVVYRATDT----RDKSTVALKILKIDNLEDGVPST-----LLREISILKTL-NHINIIGLKDVCT-SSLP--IFLAFEYMDS-DLRT
 .. .|||||..|.||..| .     .| .|| |.||    |.  ..      ..||..|.|.| .| ||. |  |||  . |  |.. .|||   ||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

LLNHI---RRPLKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRY
 |      ..||. . . ....|  .| .. .|...||||.   | |.....  ||||||..|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 97324.m00300.AA TyrKc 6-289 23 2e-17 59.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-289
Range on HMM: 1-280/280
Sequence Identity: 23% (77 aa)

YEKQEKLGEGSYGVVYRATDTRDKSTVALKILKIDNLEDGVPSTLLREISILKTL--NHINIIGLKDVCTSS-------LPIFLAFEYMDS-DLRTLL-N
 .. .||||| .|.||..| .    .|| | || |         ..||..|.. |  .| ||. |  |||..        |... .|||.  ||.  | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HIRRPLKESIIKSYAFQLIAGINFIHSHRIIHRDIKPDNLLLSKSGLLKICDFGMSRYFTVP---------MRP----YTKGVVTLWYKAPELLVSTPYD
| .. |. .   |...|  .| ...||...||||.   | |... .  ||.|||.||. .            |.     .|... .   ||| .    . 
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

LSIDMWSVGCIIYEMAT-GSPLFPG----------------DGHIDQLMKI---ISILGTPTEDAYPGFYNKVKNELGFDMPNVERVGLAREFGDKCDYA
   | || |  ..|. | | .  ||                .|.    ..    .|                                    |   |  .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------F-VCCPDE

MIDLIEKVLVYDPAKRLSAKDALNHPYF
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MYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 97324.m00300.AA CDK4 263-289 51 5.9e-12 37.09 In-house 264-290 (290) Show / Hide 
Range on Protein: 263-289
Range on HMM: 264-290/290
Sequence Identity: 51% (14 aa)

IDLIEKVLVYDPAKRLSAKDALNHPYF
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DDLLQKMLCYNHHKRMSAYQCLQHPYF