Gene 86673.m00415 (T.vaginalis)

86673.m00415

Species: T.vaginalis
Alias: TvagK0589, 86673.m00415
External Links:
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK7

Sequence

Name Sequence Type Origin Length Description Download
86673.m00415.AA Protein None 365 None Fasta, JSON
86673.m00415.kin_dom Protein Kinase Domain None 289 None Fasta, JSON

Protein domain

Protein domains of 86673.m00415.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86673.m00415.AA ERK7 19-307 52 1.7e-159 536.17 In-house 1-292 (292) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-292/292
Sequence Identity: 52% (153 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAVNNLDLYVVFELLESDVHSVIR-ANILMDV
|||  ..||||||.||||.|| |.|.||||||| ||||.||||||||||.||.....|| |. |. | .| |..|.|.||| .|.| | ||| .||| |.
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

HKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEGDI---CQSVMTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCIVAEL
||..|..|.| |.||.|| ..|||||||||.|..|.  ||.|||||||. .. ..    . ..| || |||||.||  .|| .|  ||||| .|||..|.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

YAGRPLFPGTSTLDQMERVVSLTGPPSAADIASMHSEFAETMIANLSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRMNVEQCLNHPYV
  |.|.||||||..|.|... ... |...||... |..| .|. ..  .|.| || | .|..  | || . .|||||| .|. .||.|.||||
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN-QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 86673.m00415.AA MAPK 19-307 39 4.1e-139 468.46 In-house 1-328 (328) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-328/328
Sequence Identity: 39% (129 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQM------VALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAV-----NN----LDLYVVFELLES
|.|. .||.||||||..|.|| | |       ||.|||. .|.| |...||.||| .|| ...|. |. || ....      |.     |.|.|.|| |.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DVHSVIR-ANILMDVHKRFIVWQVLVA--LKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEGDICQS-----------VMTYYVSTRWYRSP
| | .|.  ..| | |......|.| .  |||.|| . |||||||||.|.|..  .|.|||||||..   . .              || ||.|||||.|
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELIIG--SNHYNEGVDMWAVGCIVAELYA-GRPLFPGTSTLDQMERVVSLTGPPSAADIASMH-SEFAETMIANL--SYSQPRMTLPQKLPM----ADAD
|.. .  ..||...||||.|||| ||..  ..|||||....||........| ||  .|  .  || | ..| .|     .|. .. . .|     |. .
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

TIDFISKLLVFNPTQRMNVEQCLNHPYV
 ||...|.|||.| .| .||..|.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 86673.m00415.AA CMGC 19-307 24 4.90000000001e-127 419.84 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

YEIVNKIGKGAYGVVWKAMD--------------KVTHQMVALKKIFGAFRNSTDAQ----------RTFREITFLRQLR----------------GHPH
|||..|||.|.||||.|. |              . | ..||.|||. .| . ..|.          |..||| .|..|.                 |..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVDLLAVYKAVN---------------NLDLYVVFELLESDVHSVIRAN----------ILMDVH------------KRFIV------WQVLVALK--YL
|| |. ...  |               . .|| |||... | . .|. |           | . |            .....      .|.| .||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSRR--LIHRDLKPSNLLINSDSKV--------------------KLCDFGLARTFSEGDIC------------------QSVMTYYVSTRWYRSPELII
||..   |||||||.|.|||.. ..                    |.||||||| ... .                    .  .| ||.|||||.||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GS---------NHYNEGVDMWAVGCIVAELYAG--------RPLFP-----------GTSTLDQMERVVSLTGPPS---------------AADIASM--
|.         .||....|||.|||| ||.| |        .||||           |.|..||... . . |.|.                 .. .|  
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

-------------------HSEFAETMIAN---LSYSQPR--MTLPQKLP--------------------------------MADADTIDFISKLLVFNP
                   .|||| . | .   .   .|.    |  ..|                                ..| . ||...|.|...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

TQRMNVEQCLNHPYV
..|. .||.|.||| 
DKRITAEQALQHPYF
Kinase 86673.m00415.AA ERK 19-307 42 5.5e-105 355.09 In-house 1-307 (307) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-307/307
Sequence Identity: 42% (129 aa)

YEIVNKIGKGAYGVVWKAMDKV-----THQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAV---NNLDLYVVFELLESDVHSVIR
|.|...||.|||||| .| ||      | | || |||. || .  .. || ||| .|| ..||. |. |. . . .   .  |.|.|.|| |.| | .|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

AN-ILMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLAR----TFSEGDIC-QSVMTYYVSTRWYRSPELIIGSNHYNEGVDM
    | | |  . ..| | .|||.||   |||||||||.|.||.   | |||||||    ...|.  | |. || ||.|||||.||..   . |.. .|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WAVGCIVAELYAGRPLFPGTSTLDQMERVVSLTGPP-SAADIASMHSEFAETMIANLSY-SQPRMTLPQKLPMAD--ADTIDFISKLLVFNPTQRMNVEQ
|..||| ||.....||||| ....|..|. ...| | |  |.    || |  .| ||..  .|   .    | |.   . || ..|.|||.|..| .||.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

CLNHPYV
|| ||| 
CLEHPYF
Kinase 86673.m00415.AA S_TKc 19-307 28 2.4e-98 333.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAVNNLDLYVVFELLES---DVHSVIRANI--
|||..||||||.|.|.|. .| |.. ||.|.|          ... |||  |..  .||.|| |. |.      .||.|.|...    |....|. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEGDICQSVMTYYVSTRWYRSPELIIGSNHYNE-GVDMWAV
     .   | ||...|.. ||.|.||.. |||||||.|.|...   .|.||||||| .          | .. |.||..||..    .|.   .|.|..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIVAELYAGRPLFPGTSTLDQMERVVSLTGPPSAADIASMHSEFAETMIANLSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRMNVEQCLN----
|||..|...|.|.||   ....| ...                                          . . .|||.|.|...|..|. . ..|.    
GCILYEMLCGYPPFP---QMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPYV
   ||..
IKCHPWF
Kinase 86673.m00415.AA CDK 19-307 33 5e-92 294.73 In-house 1-284 (284) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-284/284
Sequence Identity: 33% (109 aa)

YEIVNKIGKGAYGVVWKAMDKVTH-----QMVALKKIFGAF---------RNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAVNNL---------DLY
||...||| |.|||| || || |.     |.||||||              ..|    . |||. |..|  ||.|| |. |.   |            ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT----AIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLY

VVFELLESDVHSVIRANILMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSK-----VKLCDFGLARTFSE---GDIC-QSVMTYYVSTRWY
 ||| .. |  ....         . . || | .| |.||.. .||||||.|.|||.. .     .|. |||||| |.    ..   . ..|  | |.||
MVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWY

RSPELIIGSNHYN--EGVDMWAVGCIVAELYA---GRPLFPGTSTLDQMERVVSLTGPPSAAD---IASMHSEFAETMIANLSYSQPRMTLPQKLPMADA
|.|||  || ||.   ..|||.|||| ||..    ..|||||.| .||....  . | |.  .   . ..                              
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

DTIDFISKLLVFNPTQRMNVEQCLNHPYV
   |...|.|...|..|.. ||.|.||| 
---DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 86673.m00415.AA p38 19-307 38 5.4e-92 311.93 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-289/289
Sequence Identity: 38% (114 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQM---VALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKA----VNNL-DLYVVFELLESDVHSVIR
|. .  .|.|||| | ||.|. | |    || ||..  |    .| ||.||.  |. .| |  ...|| |.      .|.. | |.| .. ..| . ...
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

ANILMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEGDICQSVMTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCI
   | | | .|.| |.| .||| ||   |||||||||. .| |. ..  ||||||       | . || || |||||.|| .    ||.. ||.| ||||
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCI

VAELYAGRPLFPGTSTLDQMERVVSLTGPPSAADIASMHSEFAETMIANLSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRMNVEQCLNHPYV
 |||  ||.||||.  .||..|.....| |..  .. . || | . | ...   ||. . . ...|.   || . |.|.  | .|. .|. . ||| 
MAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYP-QMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 86673.m00415.AA ERK5 19-307 39 2.3e-85 289.88 In-house 1-295 (295) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-295/295
Sequence Identity: 39% (117 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAVNNL----DLYVVFELLESDVHSVIRANIL
|.|. ||| ||||||  |. . . | ||.|||  ||   | |.|||||.  ||  | |  |. .  . .    .    | ||||.|.|||.| .| .|  
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR-HDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP

MDV-HKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSE--GDICQSVMTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCIV
. . | |. ..|.|  |||.||   |||||||||||.|    .|. |||.||  .    |  |  || || ||||| |||.. |. |   .|.|.||||.
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIF

AELYAGRPLFPGTSTLDQMERVVSLTGPPSAADIASMHSEFAETMIAN-LSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRMNVEQCLNHPYV
 |. | | .|||   ..|.. ..   | |... | .. ..     .   ..  ||   . .  | ||  ..| ....|.| | .|. | . | ||..
GEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQP-KDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 86673.m00415.AA Pkinase 19-307 32 2.8e-85 294.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-293/293
Sequence Identity: 32% (102 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFR--EITFLRQLRGHPHIVDLLAVYKAVNNLDLYVVFELLES-----DVHSVIR-
|.|. |||.|..|.|.|...| | ..||.|.|    ..|   |. .|  ||  .. | .||.|| |. ..    . ..|.|.|..|      | ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--ANIL--MDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKV----KLCDFGLARTFSEGDICQSVMTYYVSTRWYRSPELIIGSNHYNEGV
   . .   . . .|...|.| .|.|.||.. |||||||.|.||...  .    |.||||||. |.     .| || .. |.||..||.| |...|   |
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DMWAVGCIVAELYAGRPLFPGT----STLDQMERVVSLTGPPSAADIASMHS--EFAETMIANLSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRM
|||..|||..|.. |||.|||     . .|||....   |||   |.   .|   |  ...   .      . ..... .. . .|||...| ..|..| 
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------F-HWTFHNWSEECKDFIKWCLCKDPKKRP

NVEQCLNHPYV
. ||.|.||..
TAEQILQHPWF
Kinase 86673.m00415.AA ERK1 19-307 39 3.7e-81 275.92 In-house 1-289 (289) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-289/289
Sequence Identity: 39% (115 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKA--VNNL-DLYVVFELLESDVHSVIRANILM
|  .. ||.||||.|  |.|.|..| ||.|||   |   |  ||| |||. |   . |  |...  . .|  .... |.|.| .|.| |.  ....  | 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFK-HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

DVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEGDICQSVMTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCIVAELY
  |  . ..|.|  |||.||   .||||||||||.|    .|.|||||||    .      .| || ||||| ||... |  |   .|.|.||||.||. 
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

AGRPLFPGTSTLDQMERVVSLTGPPSAADIASMHSEFAETMIANLSYSQPRMTLPQKLPMADADTIDFISKLLVFNPTQRMNVEQCLNHPYV
. ||.|||   |||.  .... | || .|.  .  | |   .  | . .|.. . .  | ||.  .|.. |.| ||| .|..||. | |||.
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPH-KPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 86673.m00415.AA CDKL 19-307 36 4e-76 259.21 In-house 1-286 (286) Show / Hide 
Range on Protein: 19-307
Range on HMM: 1-286/286
Sequence Identity: 36% (108 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVYKAVNNLDLYVVFELLESDVHSVIRANI--LMD
||.  |.| |.|||| | ..| |.| || ||      .     .. ||| .|.||. |. ||.|. | .   .  |. |||  .  |  .   .   . .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVFR--RKRKLHLVFEYCDHTVLHELEEYPNGVDE

VHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLIN-SDSKVKLCDFGLARTFS-EGDICQSVMTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCIVAEL
   | ..||.| |....|.   |||| || |.||. ... |||||||.||. .  |.|     | || |||||.||| .|   |   ||.||.||..||.
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEI----YTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEM

YAGRPLFPGTSTLDQMERVVSLTGP--PSAADIASMHSEFAETMIANLSYSQPRMTLPQKLPMAD-ADTIDFISKLLVFNPTQRMNVEQCLNHPYV
  | ||.|| | .||. . .   ||  |    | |..  |.   .   .    . .|....| .  . ..||. |.|  .|..||..||...||| 
IDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE---HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 86673.m00415.AA MAPK-Unclassified 19-168 41 4e-53 182.82 In-house 1-173 (575) Show / Hide 
Range on Protein: 19-168
Range on HMM: 1-173/575
Sequence Identity: 41% (73 aa)

YEIVNKIGKGAYGVVWKAMDKVT-HQMVALKKIFGAFRNSTDAQRTFREITFLRQLRGHPHIVDLLAVY--KAVNN---LDLYVVFELLES---DVHSVI
||    || ||||.| .|||| .  | || ||. ..| | ||. |. |||  || |  || |. .  ..  |   |    |.|.| .. ..   | |..|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

RANI--LMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLAR-------------TFS
. |.  ... | . .  | |  ||||||.  ||||||||||||| |  |. ||||..|             |||
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQNLRFSFFTFS
Kinase 86673.m00415.AA MAPK-Unclassified 177-307 27 1.2e-27 96.74 In-house 405-575 (575) Show / Hide 
Range on Protein: 177-307
Range on HMM: 405-575/575
Sequence Identity: 27% (47 aa)

MTYYVSTRWYRSPELIIGSNHYNEGVDMWAVGCIVAELYAG-----------RPLFPGTS--------------------TLDQMERVVSLTGPPSAADI
|| ||.||||| ||..  .  |   ||.|..||| ||.              ||||||..                      ||    ..  | |   |.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

ASMHSEFAETMIANLSYSQPRMTLPQKLPMADA----------DTIDFISKLLVFNPTQRMNVEQCLNHPYV
    .  |   |  .    ...   .  . .            ..|||..|.|.|||  | . .| |.|||.
NFITCDSARKYIQSFK-CKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 86673.m00415.AA Pkinase_Tyr 19-166 30 9.8e-15 50.53 Pfam 1-160 (270) Show / Hide 
Range on Protein: 19-166
Range on HMM: 1-160/270
Sequence Identity: 30% (50 aa)

YEIVNKIGKGAYGVVWKAMDK----VTHQMVALKKIFGAFRNSTD--AQRTFREITFLRQLRGHPHIVDLLAVYK--AVNNLDLYVVFELLES-DVHSVI
 ..  |.|.||.|.|.|.  |     |.. || |..      . .   .  .||.  ..||  ||.|| |..|       |  .|.|.|. .  | ..  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

RAN-----ILMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLART
|..      |   ..  . ||.  .. ||.|...|||||   | |.... .|| |||||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 86673.m00415.AA TyrKc 19-310 20 3.8e-14 6.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-310
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YEIVNKIGKGAYGVVWKAMDKVTHQMVALKKIF-GAFRNSTDAQRTFREITFLRQL-RGHPHIVDLLAVYKAVNN-------LDLYVVFELLES-DVHSV
 .   |.| ||.|.|.|.. |   ..|| |..  .|       .   ||.  ...|   ||.|| |..|  ..           |..|.|. .  | .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IRANI--LMDVHKRFIVWQVLVALKYLHSRRLIHRDLKPSNLLINSDSKVKLCDFGLARTFSEG--------DICQS---VMTYYVSTRWYRSPELIIGS
.|..   |   ..  . ||.     ||||...|||||   | |....  || .||||.|   ..         . ..      . .  ||. .|| |   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NY

NHYNEGVDMWAVGCIVAELYA-GRPLFPG-----TSTLDQMERVVSLTGPPSAAD---IASMHSEFAETMIANLSYSQPRMTLPQKLPMADADTIDFISK
. ...  | |. |    |..  | .  ||      |  . .|.| .   .|  ..   ..                           . . ..  . ...
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQ

LLVFNPTQRMNVEQCLNHPYVAQF
   ..| .| . ...     . .|
CWHEDPEDRPTFSEI-----HECF