Gene 81174.m00100 (T.vaginalis)

81174.m00100

Species: T.vaginalis
Alias: TvagK0673, 81174.m00100
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81174.m00100.AA Protein None 307 None Fasta, JSON
81174.m00100.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of 81174.m00100.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81174.m00100.AA NEK 10-265 41 9.40000000001e-116 390.85 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-286/286
Sequence Identity: 41% (118 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKT-----VALKQINYGNMSTHEKEMLV-NECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCS-GGDLQKF---
|||   ||.||||..| . ||||.|      ...|.||.||||  ||.... ||..|||.|...|||.|||....    .|. .||||  ||||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQNSTS---PIGENQIWLSLSELALALNECHNG---KERIIHRDIKPGNIFIDSSGH----VKLGDFGLAKPIPDG--STKT-YLGTPLYMSPELVSHHS
|.. .    .. |.|||  .  ..|||...|.    . .|.|||||| |||.....     ||.||||..|   ..    .| . ||| |||||.... .
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDDKSDIWALGCVIYEMAAKSP--PFRAY--GQQQLNGKIKYA-EVRRIPSE--YSEELWKVISSMLDKDPSKRPSASDILQVRNV
|. |||||.||||.|||.. .|  ||.|    . .|  ||.   .  .|||   ||..| ..||.|| |||..|||...||.   .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 81174.m00100.AA NEK2 10-265 40 1.1e-112 380.67 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-319/319
Sequence Identity: 40% (129 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTVALKQINYGNMSTHEKEMLVNECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCSGGDLQKFIQNSTSP---
||.   ||.||||. .  .|||| |  . | |.||.|   |. |||.|||||..|.  ||| |||.|.|  . || ..||||.||||   |.  ..    
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IGENQIWLSLSELALALNECHN-------------------GKERIIHRDIKPGNIFIDSSGH-------------------------------------
. |  ||  .  | .|| ||||                   ||. |.||||||.||| |. .                                      
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDFGLAKPIP-DGS-TKTYLGTPLYMSPELVSHHSYDDKSDIWALGCVIYEMAAKSPPFRAYGQQQLNGKIKYAEVRRIPSEYSEELWKVISSML
  |||||||||.    | |  .|. ||| |||||...  .|..|||||..||.||||.| .|||.|  |.|| .|||  . ||||. ||..| ..|..|.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

DKDPSKRPSASDILQVRNV
. |...|||   |||   .
NVDHYHRPSIEEILQHPQI
Kinase 81174.m00100.AA S_TKc 10-268 35 1.7e-85 291.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTVALKQINYGNMSTHEKEMLVNECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCSG--GDLQKFIQNSTSP-
||| . ||||.||. | .. |.... ||.|.|.         |.. .| .|||| . .|||..|| ..|     |...||||.|  ||| ..|..  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IGENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFIDSSGHVKLGDFGLAKPIPDGSTKTYLGTPLYMSPELVSHHSYDD-KSDIWALGCVIY
    . | ...  . ....||. ||  . .|||||.|| ||..|.  |.|..|||||. .     .|. ||| ||.||..   .|.  |.|.|..||..|
LRFPFPE-HARFYMYQICCALEYCH--SHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMAAKSPPFRAYGQQQLNGKIKYAEVRRIPSEYSEELWKVISSMLDKDPSKRPSASDILQ----VRNVALT
||..  |||.   .|..  ||.           |.|..  |. .|.|||.|||.| ..||    ...    
EMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81174.m00100.AA Pkinase 10-261 32 2.7e-76 264.59 Pfam 1-289 (293) Show / Hide 
Range on Protein: 10-261
Range on HMM: 1-289/293
Sequence Identity: 32% (95 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTVALKQINYGNMSTHEKEMLVN--ECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCSGG----DLQKFIQ-N
|.|.  ||.||||. |....|...|.||.|.|.. . .  ... ...  |. |.|.|. .|||..||   |   . . ..|||| ||    ||  .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

STSPI--GENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFIDSSGHV----KLGDFGLAK---PIPDGSTKTYLGTPLYMSPELVS-HHSYDDKSD
.  ..   |...   . ... .|. ||.  ..|||||.|| ||.||. ||.    |..||||||     ... ..|. ||| ||.||..  .  |. |.|
RHGCFYFSEWECKFYMYQILRGLEYCHS--MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWALGCVIYEMAAKSPPFRAY------GQQQLNGKIKYAEVRRIPSEYS--------------------EELWKVISSMLDKDPSKRPSASDILQ
.|..||..|||. . |||.         |.|.  .|.......  .. .                    ||. ..|...|.|||.|||.| .|||
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase 81174.m00100.AA NEK1 10-265 36 8.8e-72 244.79 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-276/276
Sequence Identity: 36% (101 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTVALKQINYGNMSTHEKEMLVNECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCSGGDLQKFIQNS---TSP
|...  ||.|||| |. . .|.|... ..| ||  .|.  |.|  .|| .||.|..  |||.|..  .   .  |. .|||| |||| . |..      .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IGENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFID--SSG---------------HVKLGDFGLAKPI--PDGSTKTYLGTPLYMSPELVSHHSY
. | ||    . . ||||  |  ...|.|||||. |||    ..|                ||||||| |.    ..   .|..||| | |||.     |
FSEDQIMHWFCQICLALNHIH--DRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPY

DDKSDIWALGCVIYEMAAKSPPFRAYGQQQLNGKIKYAEVRRIPSEYSEELWKVISSMLDKDPSKRPSASDILQVRNV
. |||||.|||| ||  . . || |   ..|  ||  . .  ||. ||.||   .|.|. ..|. |||. .||.   .
NNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 81174.m00100.AA STE 10-265 24 3.2e-67 229.64 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-359/359
Sequence Identity: 24% (90 aa)

YEIKDFIGKGSFGQAYIAIRK------SDNKT---------VALKQINYGNMST---------------HEKEMLVNECNILKKLR--NDNIVTYYDRIV
.|. ..||||.||. | |...      . ...         .| ||.|. | ..                |.. . .| .|.||..   .|||.||.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

D----TSQRT-LFLIMEYCSGGDLQKFIQ-NSTSPIG------------ENQIWLSLSELALA-LNECHNGKERIIHRDIKPGNIFIDSSGHVKLGDFGL
.    ..... |...|||..|| | ..|. .   . .            |.||   . ..  . |.  |. .  ||||||||.||..     ||| |||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

AKPIPD------------------GSTKTYLGTPLYMSPELVSH------HSYDDKSDIWALGCVIYEMAAKSPPF---RAY--GQQQLNGKIKYA----
.. . |                  . ..|  ||| .|.|| ..       . || |.||| |||.| |||   ||.          . ........    
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

------EVRRIPS-------------------EYSEELWKVISSMLDKDPSKRPSASDILQ--VRNV
      .  ..|.                   ..|.|.   |.  |.|||.|||.||. |.     .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 81174.m00100.AA ULK 10-253 29 1.9e-66 227.04 In-house 1-312 (324) Show / Hide 
Range on Protein: 10-253
Range on HMM: 1-312/324
Sequence Identity: 29% (92 aa)

YEIKDFIGKGSFG-QAYIAI-RKSD--NKTVALKQIN--YGNMSTHE------KEMLVNECNILKKLR------NDNIVTYYDRIVDTSQ-RTLFLIMEY
|.... .|||||| . | ..  |..  |. || |.|.  . |.. .|      ...| || .|.|||       . .|| .|| .  ||.   ...||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYD-WFETSNHNNIYIIMEY

CSGGDLQKFIQNS-TSP-------IGENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFIDS------------SGHVKLGDFGLAKPIPDG-----
| ||||...|..  ..|       . |...   .  .. .. | |  |. |||||||| || |              .|..|..|||.|| . ..     
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELH--KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

STKTYL------GTPLYMSPELVS----HHSYDDK-SDIWALGCVIYEMAAKSPPFRAYGQQQLNGK--------------IKYAEVRRIP----SEYSE
 ..|..      ||||||.|....    .  |.|. .||| |||..|||   ..||...  .... .              ||.  ..  .       |.
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

ELWKVISSMLDKDPSKR
|.   |. || .|...|
ECKDLIRRMLQYDEKDR
Kinase 81174.m00100.AA CAMK 15-261 19 2.5e-66 212.45 In-house 1-421 (425) Show / Hide 
Range on Protein: 15-261
Range on HMM: 1-421/425
Sequence Identity: 19% (83 aa)

FIGKGSFGQAYIAIRKSDN------------KTVALKQINYGNMS--------------------------THEKEMLVNECNILKK-------LRNDNI
 .|.||||. . .|.|...            . || | |.   ..                           . .... .| .|.||       |.  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTYYDRIVD-----------TSQR-------TLFLIM---EYCSGG----DLQKFIQNSTS--------------PIGENQIWLSLSELALALNECHNGK
.  |. . |           | ..        ....|   ||||||    ||  .|.  ..               . | .       .. |.. ||. .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ERIIHRDIKPGNIFIDSS-----------------GHVKLGDFGLAKPIPDGS-------------------------TKTYLGTPLYMS-PELVSHHS-
  |.|||.|| || .|..                 . .|. |||.|. ...|.                          ||. ||| ||. ||...  . 
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YDDKSDIWALGCVIYEMAAKSPPFRAY-------------GQQQLNGKIKYAEVRRIPSE---------------YSEE--------
             |. |.|.|..|.. | |    |||..               ...|  ||. .. . .|..                |.|        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

LWKVISSMLDKDPSKRPSASDILQ
    |..|| .||.||......|.
CKDLIRKMLQVDPEKRMTIEQCLN
Kinase 81174.m00100.AA ULK 10-253 29 6e-66 225.41 In-house 1-317 (329) Show / Hide 
Range on Protein: 10-253
Range on HMM: 1-317/329
Sequence Identity: 29% (96 aa)

YEIKDFIGKGSFGQAYIAI-RKSD---NKTVALKQIN--YGNMSTHE------KEMLVNECNILKKLR--------NDNIVTYYDRIVDTSQ-RTLFLIM
|.... .||||||. | ..  |..   |. || |.|   . |.. .|      ...| ||. |.|||         . ||| .|| .  ||.   ...||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD-WFETSNHNNIYIIM

EYCSGGDLQKFIQ-NSTSP--------IGENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFIDSS------------GHVKLGDFGLAKPIPDG--
||| ||||...|. | ..|        . |...   .  .. .. | |  |..|||||||| || |.              |..|..|||.|| . ..  
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELH--KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNM

---STKTYL------GTPLYMSPELVS----HHSYDDK-SDIWALGCVIYEMAAKSPPFRAYGQQQLNGKIKYAEVR----------RIPSE--------
    ..|..      ||||||.|....    .  |.|. .||| |||..|||    |||.|.  .... .|.. ...           .| .        
EQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDP

-YSEELWKVISSMLDKDPSKR
  |.|.   |. || .|...|
QISPECKDLIRRMLQYDEKDR
Kinase 81174.m00100.AA Ciliate-E2-Unclassified 10-261 22 3.2e-63 216.35 In-house 1-348 (352) Show / Hide 
Range on Protein: 10-261
Range on HMM: 1-348/352
Sequence Identity: 22% (78 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTV-----ALKQINYG-NMSTHEKEMLVNECNILKKLR-----------------NDNIVTYYDRIVDTSQRTLFL
|.|   ||.|.||. | ...|...  .     . |...|  .   ...  ..|| ......                  ..... ...  ..... ....
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYCSGGDLQKFIQNSTS----------------PIGENQIW-----LSLSELALALNECHNGKERIIHRDIKPGNIFIDSSG---HVKLGDFGLAK--
.|||| ||||...|... .                 . |.|.        . .. ..|. .|  .  |||||||| ||..|..|   ..|. |||..|  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------PIPDGSTKTYLGTPLYM----SPELVSHHSYDDK----SDIWALGCVIYEMAAKSPPFR---------------------AYGQQ
                ...  ..|  ||| ||    .||.   . ||..    .|||.||...|||    .||                       . |.
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

QLNGKIKYAEVRR--IPSEYSEELWKVIS----SMLDKDPSKRPSASDILQ
.....|.. .     ||   |.| .  |.    .||.|.|.||.....||.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 81174.m00100.AA Ciliate-E2 10-261 24 6.9e-62 211.23 In-house 1-361 (365) Show / Hide 
Range on Protein: 10-261
Range on HMM: 1-361/365
Sequence Identity: 24% (90 aa)

YEIKDFIGKGSFGQAYIAIR-----------------------KSDNKTVALKQIN-YGNMSTHEKEMLV----------NECNILKKLRNDNIVTYYDR
|..   ||.|.||. | . .                       | ..| .|.|... ..  ..  .. .           || |||..| ..||. .|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IVDTSQRTLFLIMEYCSGGDLQKFIQNSTSPIG----------ENQIWLSLSELAL---------------ALNECHNGKERIIHRDIKPGNIFIDSSGH
  .... ...|.||||.||||...|.|.    .          |..|     ...                ||...|. .  |||||||| ||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

VKLGDFGLAK----------------PIPDGS------------------TKTYLGTPLYMSPELVSHHS---------YDDKSDIWALGCVIYEMAAKS
.|. ||||.|                 ... .                  ..|..||| ||.|| ..  .         || |.|||.||...|||  . 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFRAYGQQQLNGKIKYAEVRR------------IPSEYSEELWKVISS----MLDKDPSKRPS-ASDILQ
|||    ||....||.. .               .. . |.|    |.     ||.|||.||.. ...||.
PPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 81174.m00100.AA NEK8 130-260 41 3.1e-51 144.44 In-house 137-273 (278) Show / Hide 
Range on Protein: 130-260
Range on HMM: 137-273/278
Sequence Identity: 41% (57 aa)

KERIIHRDIKPGNIFIDSS-GHVKLGDFGLAKPIPDG---ST-KTYLGTPLYMSPELVSHHSYDDKSDIWALGCVIYEMAAKSPPFRAYGQQQLNGKIKY
.. | |||.|. ||| . . . ||.||||..|   .    .| || .|||.|||||...  .|. |||.||||||.|||.     | |  .  |  ||  
QHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQ

A-EVRRIPSEYSEELWKVISSMLDKDPSKRPSASDIL
  .   |.. || |.  .... |..|| .||||| |.
CRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIM
Kinase 81174.m00100.AA Pkinase_Tyr 10-203 25 3.3e-24 82.59 Pfam 1-207 (270) Show / Hide 
Range on Protein: 10-203
Range on HMM: 1-207/270
Sequence Identity: 25% (54 aa)

YEIKDFIGKGSFGQAYIAIRK----SDNKTVALKQINYGNMSTH-EKEMLVNECNILKKL-RNDNIVTYYDRIVDTSQR-TLFLIMEYCSGGDLQKFIQN
 ..   .|.|.||. | .. |    ... .|| | .. | |. .  .|.. .| .|.|.| ...||| .|  ..| ..   ....|||. .||| .. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---TSPIGENQIWLSLSELALALNECHNGKERIIHRDIKPGNIFIDSSGHVKLGDFGLAKPI-PDGST-KTYLGTPL---YMSPELVSHHSYDDKSDIW
      |.   ..     . | ...  .. .  .||||.   |. ......|| .|||||. | .|.   ..  |..|    |.||  ..  .  |||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

ALGCVIYEM
. | ...|.
SFGVLMWEI
Kinase 81174.m00100.AA NEK8 16-101 39 7.4e-23 61.98 In-house 7-92 (278) Show / Hide 
Range on Protein: 16-101
Range on HMM: 7-92/278
Sequence Identity: 39% (35 aa)

IGKGSFGQAYIAIRKSDN--KTVALKQINYGNMSTHEKEMLVNECNILKKLRNDNIVTYYDRIVDTSQRTLFLIMEYCSGGDLQKFIQ
.|.|.|| .    ||.|.  . | .||||   ||  |  |  ||...|..|  .||. |||   .    ||.  |||. || |  .||
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFME--DNTLMIEMEYADGGTLYQMIQ
Kinase 81174.m00100.AA TyrKc 10-265 21 2.4e-20 74.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-265
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YEIKDFIGKGSFGQAYIAIRKSDNKTVALKQINYGNMSTHEKEMLVNECNILKKL--RNDNIVTYYDRIVDT-----SQRTLFLIMEYCSGGDLQKFIQN
 . .. .| | ||. | .. |    .|| | .. .      .|.. .| .|..||  ...|||  |  ...      .   |...|||...|||......
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

STSPIGENQIWLSLSELALALNECHNG-----KERIIHRDIKPGNIFIDSSGHVKLGDFGLAKPIPDG-----STKTYL-----GTP--L---YMSPELV
.          |....|        .|     . ..||||.   |. ... ..|| .||||.. | |.     |...|      |.   |    |.||  
HRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

SHHSYDDKSDIWALGCVIYEMA--AKSPPFRA----YGQQQLNGKIKYAEVRRIPSE--------YSEELWKVISSMLDKDPSKRPSASDILQVRNV
 .. .  |||.|. | ...|.    ..|.          |..  ..|  . ...| .         ..|. .....  . ||..||. |.|  ..  
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF