Gene 88599.m00198 (T.vaginalis)

88599.m00198

Species: T.vaginalis
Alias: 88599.m00198, TvagK0925
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
88599.m00198.AA Protein None 392 None Fasta, JSON
88599.m00198.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of 88599.m00198.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88599.m00198.AA AMPK 188-259 44 7e-36 104.06 In-house 183-254 (254) Show / Hide 
Range on Protein: 188-259
Range on HMM: 183-254/254
Sequence Identity: 44% (32 aa)

VWRCGIILYRMLTGTFPFEDDSKSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
.| ||.||| || |. ||.|.. ..|. .|.. .. ||. .|..||.|...||..|| .||| .|| .||.|
IWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 88599.m00198.AA CAMK 55-259 19 1.6e-35 111.37 In-house 81-425 (425) Show / Hide 
Range on Protein: 55-259
Range on HMM: 81-425/425
Sequence Identity: 19% (66 aa)

EIKIHSQ-------ANYPFIAKFYQYFEE-------------------DDMSFIVM---EYLSEE----NFEDYITNAKE---------------RDEEK
||.|...        . | | |.|...|                    |.. ..||   || |         |||.  .                 .|. 
EIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTERE

IRIWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSH-----------------NLKLFDFENCQYLDT------------------------SMRSLAK
 | .| |..  . .. |.  ..|  |   |  |....                 |.|. ||   ...|                                
ARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTF

HCHPFYLS-PEEIRN--------------ESNPFTTTVWRCGIILYRMLTGTFPFEDD-------------SKSELFTNILSMKPI-IPSQ---------
   | | . || ..               .  .. . .| ||.||| ||.|..||..|             . .||| .|.. |   .|..         
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

------ISND--------AKNLLSRMLTKDPFERITLEDIQEHPFF
      ||..        .|.|...||..|| .|.|.|.. .||..
PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 88599.m00198.AA SAK 11-259 27 1.7e-32 107.83 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-254/254
Sequence Identity: 27% (69 aa)

YEFIKMIKCTNYYELWKAKNIHLSPTVLIKVVSKSSVE----TEHYGEEIKIHSQANYPFIAKFYQYFEEDDMSFIVMEYLSEENFEDYITN-AKERDEE
|.  ...    .   ..|| ||    | ||.. |  .     ..   .|..||.|   | | . |.|||.    ..|.|      .. |. . ..   ||
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

KIRIWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDFENCQYLDTSMRSLAKHC-HPFYLSPEEIRNESNPFTTTVWRCGIILYRMLTGTFP
  |  . |..  . .| |   . |  |   |  |.   ..|. ||     |          |  | |.||| .   .    . ||  | .|| .|.|. |
EARHFMHQIVIGMLYLHS-HGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPP

FEDDSKSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
|. |.  .    ..    |.|. .| .|. |. .|| |.| |||||. .  ||| 
FDTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 88599.m00198.AA PLK1 11-259 26 9.1e-30 94.82 In-house 1-253 (253) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-253/253
Sequence Identity: 26% (67 aa)

YEFIKMIKCTNYYELWKAKNIHLSPTVLIKVVSKS----SVETEHYGEEIKIHSQANYPFIAKFYQYFEEDDMSFIVMEYLSEENFEDYITNAKERDEEK
||  . .    . . .  .. .    .  |||.||    . . .   .||.|| | . . | ||...||...  .||.|  .   . .     |   |  
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

IRIWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDFENCQYLDTS-MRSLAKHCHPFYLSPEEIRNESNPFTTTVWRCGIILYRMLTGTFPF
 | .  |....  .| .| .. |  |  ||  | .  ..|. ||     .. .  |       | |. || . ..   |   .|  | |.| .| |  ||
CRYYMYQIVEGCQYL-HNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPF

EDDSKSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
|  .  | .  |   .  |||.||. |..|. .|| .|| .| | | . .  ||
ETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 88599.m00198.AA CAMKL 188-259 30 8.1e-29 88.98 In-house 219-297 (297) Show / Hide 
Range on Protein: 188-259
Range on HMM: 219-297/297
Sequence Identity: 30% (25 aa)

VWRCGIILYRMLTGTFPFEDDS---------KSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
.| ||.||| |..|..||.||.         . .. ....  .| |....| |...|...||...| .|.|...| .||..
IWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 88599.m00198.AA Ciliate-E2-Unclassified 65-259 22 1.1e-28 96.59 In-house 81-352 (352) Show / Hide 
Range on Protein: 65-259
Range on HMM: 81-352/352
Sequence Identity: 22% (60 aa)

PFIAKFYQYFEEDDMSFIVMEYLSEENFEDYITN-----------------AKERDEEKIR-----IWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNS
||| |.. .|. ..  .|||||.   . ..||..                  |. .|....      .| | .. |..| ..  ..|  .   |  ..|.
PFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNN

H---NLKLFDFENCQYLDT----------------SMRSLAKHCHPFYL----SPEEIRNESNP----FTTTVWRCGIILYRMLTGTFPFEDDSKSE---
.   ..|. || .. ....                ....  . . | |.    .|| .... .     .   .| .|.||| ||.|..||.| .. .   
GKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQ

-------------LFTNILSM------KPI--IPSQISNDAKNLLS----RMLTKDPFERITLEDIQEHPFF
             |. ||.         |   || ..|. ||....    .|| |.| .|||.|.| .||.|
LITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 88599.m00198.AA MELK 11-259 27 8.9e-28 91.76 In-house 1-254 (254) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-254/254
Sequence Identity: 27% (71 aa)

YEFIKMIKCTNYYELWKAKNIHLSPTVLIKVVSKSSVETE--HYGEEIKIHSQANYPFIAKFYQYFEEDDMSFIVMEYLSEENFEDYITNAKERDEEKIR
||  . |    .  .  |  |     | ||.. |  .  .      |.    .  .  | ..| | | .|  |.|||| .  .. |||   .  .||  |
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETR

IWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDFENCQYLDTSMRSL-AKHC--HPFYLSPEEIRNES-NPFTTTVWRCGIILYRMLTGTFP
  | |.. ..... |     |  |   |. . . |.||| ||  |      .     . |   | |  || |.  .       ||  ||.|| .. |  |
HFFRQIVSAIAYVHSQ-GYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLP

FEDDSKSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
|.||  . ..  |.| .   |  .|  .|.|| .||  ||  || . .. .||. 
FDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase 88599.m00198.AA S_TKc 11-259 25 9.4e-28 99.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-231/231
Sequence Identity: 25% (67 aa)

YEFIKMIKCTNYYELWKAKNIHLSPTVLIKVVSKSSVETEHYGEEIKIHSQANYPFIAKFYQYFEEDDMSFIVMEYLSE--ENFEDYITNAKE------R
||... |    . . .|.....    | ||...      ||   ||.|... . |.| |.| .|.. |  ..||||..    .  ||| . .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DEEKIRIWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDFENCQYLDTSMRSLAKHCHPFYLSPEEIRNESNPF-TTTVWRCGIILYRMLTG
.|  .| .. |... | .. |. ...|  |   |  |..  ..|. ||  .  |            |.|..|| .   .  .    .| ||.||| ||.|
PE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

TFPFEDDSKSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQE-------HPFF
  ||.     ..| .|.          | .||......|.||| .|.|  .. .       ||.|
YPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 88599.m00198.AA MARK 188-259 41 4.1e-27 85.81 In-house 189-262 (262) Show / Hide 
Range on Protein: 188-259
Range on HMM: 189-262/262
Sequence Identity: 41% (31 aa)

VWRCGIILYRMLTGTFPFEDDS--KSELFTNILSMKPIIPSQISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
.| .|..|| |..|.|||..|.    ||. .||. |. ||. .| ...||..|.|| .| ||.|.|.| .||..
IWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 88599.m00198.AA Ciliate-E2 57-259 21 1.7e-26 87.92 In-house 79-365 (365) Show / Hide 
Range on Protein: 57-259
Range on HMM: 79-365/365
Sequence Identity: 21% (64 aa)

KIHS------QANYPFIAKFYQYFE--EDDMSFIVMEYLSEENFEDYITNAKER-----------DEEKIRIWFSQMIL---------------SLSFLD
||        | | |.| |.| .|.   |.  ..||||..  . .||| | |             .|..|.  . | .                 | .| 
KI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH

SNYQVCHGSLEAGNFSLSNSHNLKLFDFENCQYLDTS--------MRSLAKHCH-------------------------PFYLSPEEIRNES--------
|.  ..|  .   |  .     .|. || .....|..        .. . .  .                         | |..|| .....        
SKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK

-NPFTTTVWRCGIILYRMLTGTFPFEDDSKSELFTNILSMKPIIP------------------SQISNDAKNLLSR----MLTKDPFERIT-LEDIQEHP
   .   .| .|.|||.||.| .||        . .|.  |  .|                   ..|...|.|...    || ||| .|||  |.| .||
GYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

FF
.|
WF
Kinase 88599.m00198.AA RSK 192-259 32 9.1e-25 87.65 In-house 199-278 (278) Show / Hide 
Range on Protein: 192-259
Range on HMM: 199-278/278
Sequence Identity: 32% (26 aa)

GIILYRMLTGTFPFED---DSKSELFTNILSMK--PIIP--SQISNDAKNLLSRMLTKDPFERIT-----LEDIQEHPFF
|...| ||||  ||     ....|....|.. |  . .|  . .|..||.|...||..||  |..     .|.|..||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 88599.m00198.AA Pkinase 169-259 25 4.6e-22 79.08 Pfam 175-293 (293) Show / Hide 
Range on Protein: 169-259
Range on HMM: 175-293/293
Sequence Identity: 25% (31 aa)

PFYLSPEEIRNESNPFTTTV--WRCGIILYRMLTGTFPFEDD------SKSELFTNILSMKPIIPSQIS---------------------NDAKNLLSRM
|.|..|| || .... .. |  | ||.||| ||.| .|| ..      .. ... .|.. ..  ... .                      ..| .....
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LTKDPFERITLEDIQEHPFF
|.||| .|.| |.| .||.|
LCKDPKKRPTAEQILQHPWF
Kinase 88599.m00198.AA CAMKL 39-121 21 6.3e-11 30.95 In-house 30-143 (297) Show / Hide 
Range on Protein: 39-121
Range on HMM: 30-143/297
Sequence Identity: 21% (24 aa)

IKVVSKSSVETEHYGE----------------EIKIHSQAN---YPFIAKFYQYFEEDDM------SFIVMEYLSEEN--FEDYITNAKE----RDEEKI
||.. |.    . . .                ||.|... |    | | |.|. .| ...       ..|||| |  .    ||| . ..     .|.  
IKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEA

RIWFSQMILSLSFL
|  | |..  ....
RRYFRQIVSAVNYC
Kinase 88599.m00198.AA MARK 55-96 33 1.5e-07 20.96 In-house 49-93 (262) Show / Hide 
Range on Protein: 55-96
Range on HMM: 49-93/262
Sequence Identity: 33% (15 aa)

EIKIHSQANYPFIAKFYQYFEEDDMSF---IVMEYLSEENFEDYI
||.|... . | | |.....|.|. .    ..||| |. .  |||
EIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYI
Kinase 88599.m00198.AA TyrKc 11-259 19 4e-06 -123.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 11-259
Range on HMM: 1-280/280
Sequence Identity: 19% (56 aa)

YEFIKMIKCTNYYELWKAKNIHLSPTVLIKVVSKSSVETEHYGEEIKIHSQA--NYPFIAKFYQYFEED-------DMSFIVMEYLSEENFEDYITNAKE
 ...|.. . .. | .|.. .    .| .|.. ...   |   .|..| ..   . | | ..| .  ..       .  .||||| .  .  ||. . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RDEEKIRIWFSQMILS-LSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDF------ENC-------QYLDTSMRSLAKHCHP-FYLSPEEIRNESNPFTT
.   |  . |.  | .  ..| |. .. |  | | |  ... |  |  ||      ..        .| ... .. .|   |   ..|| |    . |||
KLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT

T--VWRCGIILYRMLT-GTFPFED-----DSKSELFTNILSM-KPIIPSQ--------ISNDAKNLLSRMLTKDPFERITLEDIQEHPFF
   ||  |. .. ..| |  | ..      | .|.. .. .   . .|           . .  .. ..    || .| | ..|  | .|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 88599.m00198.AA Pkinase 26-121 22 0.000601 15.04 Pfam 16-124 (293) Show / Hide 
Range on Protein: 26-121
Range on HMM: 16-124/293
Sequence Identity: 22% (25 aa)

WKAKNIHLSPTVLIKVVSKSSVET-EHYGE----EIKIHSQANYPFIAKFYQYFEEDDMSFIVMEYLSE-----ENFEDYIT--NAKER--DEEKIRIWF
.|....  . .| .|...|.. .  ...      ||.|.   | |.| ..| .||..|   .||||.       . | |||.  . .    .|. .. ..
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYM

SQMILSLSFL
 |..  | ..
YQILRGLEYC
Kinase 88599.m00198.AA RSK 40-88 23 0.026671 4.66 In-house 30-84 (278) Show / Hide 
Range on Protein: 40-88
Range on HMM: 30-84/278
Sequence Identity: 23% (13 aa)

KVVSKSSVETE-----HYGEEIKIHSQAN-YPFIAKFYQYFEEDDMSFIVMEYLS
||..|. . .      |  .|..| .  .  ||| . .  |....  ...|||..
KVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCR
Kinase 88599.m00198.AA AMPK 55-150 28 0.073169 1.38 In-house 49-144 (254) Show / Hide 
Range on Protein: 55-150
Range on HMM: 49-144/254
Sequence Identity: 28% (28 aa)

EIKIHSQANYPFIAKFYQYF-EEDDMSFIVMEYLSEENFEDYITNAKERDEEKIRIWFSQMILSLSFLDSNYQVCHGSLEAGNFSLSNSHNLKLFDF
||.|    . | | . |.   |  .  |.|||| |     |||.  .  .|.  .  | |.|  .. . ..  . |  |   |  |   .|.|. ||
EIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYC-HRHMIVHRDLKPENLLLDHNKNIKIVDF
UBA_CAMKL 88599.m00198.AA UBA_CAMKL 277-312 20 2.7e-05 17.38 In-house 3-41 (41) Show / Hide 
Range on Protein: 277-312
Range on HMM: 3-41/41
Sequence Identity: 20% (8 aa)

DILKQLEEA--GYNKAAVIADLKSKLF-TEKSAAYNILL
.|......   |... ..|  |..  .  . .|.| .||
EIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL