Gene 95912.m00294 (T.vaginalis)
95912.m00294
Species: T.vaginalis
Alias: 95912.m00294, TvagK0963
External Links:
Annotation:
Group:
Other
Family:
Other-Tvag1
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 95912.m00294.AA | Protein | None | 317 | None | Fasta, JSON |
| 95912.m00294.kin_dom | Protein Kinase Domain | None | 214 | None | Fasta, JSON |
Protein domains of 95912.m00294.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 95912.m00294.AA | Ciliate-E2 | 66-274 | 14 | 1.4e-26 | 88.24 | In-house | 44-365 (365) | Show / Hide |
Range on Protein: 66-274
Range on HMM: 44-365/365
Sequence Identity: 14% (47 aa)
KNTKSKCVIKYLPSRSRFRKFKDEKIE--------------ILGILNHSNIVSIERIIM--QEDFNAIVMPFYKKGDLYE-----RIFDNKK------IT
|..... .|.. . . ... ..| || .||| ||. . ... .|| ... |||.. ... |.. .|
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFT
LENASKMMWGLVN---------------VVKHMHCLS-CIHGNISLSNILVESKTKVIITGFSMAT--------------MNKFIDSHGP----------
.. ....|. ... ....| .|| .| ..|||. . |. | ... ...... ..
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQ
------------MTLYTAPEVETTHK---------LTFATDVFALGTVFYYLLMNTY---EVNKD-----------------------PSKLPQDAQVLL
. | |||. | ... |...|| ..|..|.. . . .|. . |..|... |.
IIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLI
SG----MVNPNPKKRFT-IFHVASNKFF
. | . .|.||.| . . ...|
KKFGKRMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | 95912.m00294.AA | Ciliate-E2-Unclassified | 124-234 | 19 | 1.4e-16 | 54.04 | In-house | 122-268 (352) | Show / Hide |
Range on Protein: 124-234 Range on HMM: 122-268/352 Sequence Identity: 19% (29 aa) KGDLYERIFDNKKITLENAS-----KMMWGLVNVVKHMHCLS-CIHGNISLSNILVESKT---KVIITGFSMAT-----------------------MNK ..||.... .|..| ..|. .... ... ...| .|| .| ..|||. .. .. |..|. . |. GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWT FIDSHGPMTL--YTAPEVETTHKLT----FATDVFALGTVFYYLLMNTY |. . |... |||||| .. .. |...|| ..|..|...| FCGT--PNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY |
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| S_TKc | 95912.m00294.AA | S_TKc | 46-274 | 19 | 9.3e-16 | 54.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 46-274
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)
YEVFAKLTAKLHSACYEATNKNTKSKCVIKYLPSRSRFRKFKDEKIEILGILNHSNIVSIERIIMQEDFNAIVMPFYKK--GDLYERIFDNKK------I
||. |. . .| ...|.|. .. || .. .... | |.|| .| ||| . .. |. .|| . |||...| .... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRRE-IQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF
TLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTKVIITGFSMATMNKFIDSHGPMTL-----YTAPEVETTHKLTF-ATDVFALGTVFYYLLM
. | ..|. ... ....| . || . .|||. . . |. | .|. .|. | |||| . .. . |. ..| ..| .|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC
---------NTYEVNKDPSKLPQDAQVLLSGMVNPNPKKRFTIFHVAS-------NKFF
.... . ...| ..... . .|.|| |. . .|
GYPPFPQMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 95912.m00294.AA | TKL | 76-227 | 15 | 5.1e-15 | 50.54 | In-house | 61-280 (364) | Show / Hide |
Range on Protein: 76-227
Range on HMM: 61-280/364
Sequence Identity: 15% (35 aa)
YLPSRSRFRKFKDEKIEILGILNHSNIVSIERIIMQEDF-------------NAIVMPFYKKGDLYERIFDNKKITLENASKMMWGLVNVVKHMHCLS--
. | |.||.|. | | .. |.| |||.. . ..... .||| ....|.|.... .. ... . . ..|
NDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPK
------CIHGNISLSNILVESKTK--------------VIITGFSMATMNKFIDSHGPMT-----------------------LYTAPEV-----ETTH-
|| .. .|||| .. . . |. | ..... . . . |||| ..|.
WCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEK
----------KLTFATDVFALGTVFY
. . ..||.. | |..
VGIDEFCKGFEYSEKCDVYSFGIVLW
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| Kinase | 95912.m00294.AA | Pkinase | 58-163 | 20 | 1.2e-13 | 49.29 | Pfam | 13-131 (293) | Show / Hide |
Range on Protein: 58-163 Range on HMM: 13-131/293 Sequence Identity: 20% (24 aa) SACYEATNKNTKSKCVIKYLPSRSRFRKFKDE-----KIEILGILNHSNIVSIERIIMQEDFNAIVMPFYKKG----DLYERIF--DNKKI--TLENASK . .|....|.| . ..| .. |.. ... . |.|. ||| ||| . .. . .| .||.. .| ||...| ..... . . . . GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF MMWGLVNVVKHMHCLSCIH .|. .. ....| ..|| YMYQILRGLEYCHSMGIIH |
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| Kinase | 95912.m00294.AA | PLK1 | 46-231 | 25 | 1.6e-12 | 37.2 | In-house | 1-194 (253) | Show / Hide |
Range on Protein: 46-231 Range on HMM: 1-194/253 Sequence Identity: 25% (50 aa) YEVFAKLTAKLHSACYEATNKNTK----SKCVIKYLPSRSRFRKFKDEKIEILGILNHSNIVSIERIIMQEDFNAIVMPFYKKGDLYERIFDNKKITLEN || . | ||| ..|.|| | | | | .. | . |.| |.| .|| . ... ||. .. | | | || YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE ASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTKVIITGFSMATMNKFI----DSHGPMTLYTAPEVETTHKLTFATDVFALGTVFYYLLM . | .|. ....| . || . | |. .. . .| | | .|| . . | |||| . . .| |....| ..| ||. CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLF |
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| Kinase | 95912.m00294.AA | CAMK | 61-230 | 12 | 1.8e-11 | 32.53 | In-house | 11-328 (425) | Show / Hide |
Range on Protein: 61-230 Range on HMM: 11-328/425 Sequence Identity: 12% (41 aa) YEATNKNTK------------SKCVIKYLPSRSRF-----------------------------RKFKDEKIEILGI-------LNHSNIVSIERIIMQE .....|||. |. || .. . ||. |||. |.| ||... .. . KLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDP DFNA-------------------IVM---PFYKKG----DLYERIFDN---------------KKITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNI .... .|| . | ||...| .. ...| . |..... .. |...| . .| . . || HYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENI LVESKT-----------------KVIITGFSMATM---------------------------NKFIDSHGPMTLYTA-PEVETT--------------HK |. .. .. |. | .|.. .. | | ||| LLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPY LTFATDVFALGTVFYYLL ....|. ..| . | .| YGPKCDMWSCGVILYIML |
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| Kinase | 95912.m00294.AA | CAMKL | 63-180 | 19 | 8.6e-10 | 27.27 | In-house | 18-168 (297) | Show / Hide |
Range on Protein: 63-180 Range on HMM: 18-168/297 Sequence Identity: 19% (29 aa) ATN-KNTKSKCVIKYLP-SRSRFRKFKDEK---------------IEILGILN---HSNIVSIERIIMQEDF------NAIVMPFYKKGD--LYERI--F ||. ..|. | || . .. . . ... . |.|. || | ||... .| ... .|| |. |...| ATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKH DNKK--ITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTK-VI ... .. . | .. . .| |...| . .| | . |||. .. . .| GHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNI |
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| Kinase | 95912.m00294.AA | DCAMKL | 91-173 | 28 | 4.7e-09 | 23.73 | In-house | 66-148 (279) | Show / Hide |
Range on Protein: 91-173 Range on HMM: 66-148/279 Sequence Identity: 28% (24 aa) IEILGILNHSNIVSIERIIMQEDFNAIVMPFYKKGDLYERIFDNKKITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILV ..|. ..| .|... .|. .|| . . |||.. | | |.| |. || | . |..| .. .| | . | || VSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLV |
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| Kinase | 95912.m00294.AA | CAMKL | 240-274 | 25 | 5.4e-08 | 21.43 | In-house | 264-297 (297) | Show / Hide |
Range on Protein: 240-274 Range on HMM: 264-297/297 Sequence Identity: 25% (9 aa) PSKLPQDAQVLLSGMVNPNPKKRFTIFHVASNKFF ..... |.. |...| ..||.||.|| . . ... WYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 95912.m00294.AA | TyrKc | 50-273 | 17 | 5.7e-08 | -93.83 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 50-273 Range on HMM: 1-280/280 Sequence Identity: 17% (52 aa) AKLTAKL--------HSACYEATNKNTKSKCVIKYLPSRSRFRKFKDEKIEILGIL--NHSNIVSIERIIMQE-------DFNAIVMPFYKKGDLYERIF .| || . . . .. .| | . . . | .| ..|. | .| ||| . ...|. . ||| . ..||| ... ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-REDFMRE-ARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR DNKK-ITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTKVIITGFSMATMN----------KFIDS----HGP--MTL-YTAPEVETTHKLT .... .... ...| . . | ||| . |.|| .. | |. | .. . ... .| . . .|||. ..| | KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT FATDV----------FALGTVFYYLL----MNTYEVNKDPSKL-----PQD---------AQVLLSGMV---NPNPKKRFTIFHVASNKF ...|| | .| |. |. .|| .. . |.. . . . | . .|..| | | .| TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT-FSEIHECF |
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| Kinase | 95912.m00294.AA | Ciliate-E1 | 105-220 | 14 | 1.4e-07 | 21.18 | In-house | 61-202 (202) | Show / Hide |
Range on Protein: 105-220 Range on HMM: 61-202/202 Sequence Identity: 14% (21 aa) IERIIMQED-FNAIVMPFYKKGDLYERIF-------------DNKKITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTKVIITGFSMAT-- |. |.... . .|.. .... |.. .. .... | .. ... |. . .| . ||..| .|||.... . ... |. . IDYIKIDQNYICIIIFECCCC-SLKDYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFL MNKFIDSH---GPMTLYTAPEV--------ETTHKLTFATDVF .|. ... | . | ||. . . | .. .|.. KNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 95912.m00294.AA | Ciliate-E2a | 241-274 | 26 | 1.9e-07 | 18.01 | In-house | 242-275 (275) | Show / Hide |
Range on Protein: 241-274 Range on HMM: 242-275/275 Sequence Identity: 26% (9 aa) SKLPQDAQVLLSGMVNPNPKKRFTIFHVASNKFF .|...... |...|....||||.|. ...| EKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 95912.m00294.AA | Kin4 | 91-184 | 26 | 2.1e-07 | 18.12 | In-house | 61-154 (273) | Show / Hide |
Range on Protein: 91-184 Range on HMM: 61-154/273 Sequence Identity: 26% (25 aa) IEILGILNHSNIVSIERIIMQEDFNAIVMPFYKKGDLYERIFDNKKITLENASKMMWGLVNVVKHMHCLSCIHGNISLSNILVESKTKVIITGF | | | | ||. .| .. . ||. . |. | | ... || .. |. |. || .| . | |.|.. . ..|| | INALKHLTHPNIIYLEEVLQNSRYIGIVLEYVCGGEFYKYIQRKRRLKEMNACRLFAQLISGVHYMHYKGLVHRDLKLENLLLDKHENLVITDF |
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| Kinase | 95912.m00294.AA | Ciliate-E2a | 117-157 | 27 | 7.7e-07 | 16.2 | In-house | 76-119 (275) | Show / Hide |
Range on Protein: 117-157 Range on HMM: 76-119/275 Sequence Identity: 27% (12 aa) IVMPFYKKGDLYERIFDNKKITLE--NASKMMWGLV-NVVKHMH .|| ... |.||..| .|... | .....|. | . .|| LVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMH |
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| Kinase | 95912.m00294.AA | CAMK | 240-274 | 22 | 4.6e-05 | 11.49 | In-house | 392-425 (425) | Show / Hide |
Range on Protein: 240-274 Range on HMM: 392-425/425 Sequence Identity: 22% (8 aa) PSKLPQDAQVLLSGMVNPNPKKRFTIFHVASNKFF . .. |... |...| ...|.||.|| . . ... H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 95912.m00294.AA | PLK1 | 232-274 | 37 | 9.1e-05 | 11.31 | In-house | 214-253 (253) | Show / Hide |
Range on Protein: 232-274 Range on HMM: 214-253/253 Sequence Identity: 37% (16 aa) NTYEVNKDPSKLPQDAQVLLSGMVNPNPKKRFTIFHVASNKFF | | . ||.. | |. |. |..|.|..| || .| . .|| NEYRI---PSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 95912.m00294.AA | Ciliate-E2-Unclassified | 239-274 | 22 | 0.005442 | 6.24 | In-house | 313-352 (352) | Show / Hide |
Range on Protein: 239-274 Range on HMM: 313-352/352 Sequence Identity: 22% (9 aa) DPSKLPQDAQVLLS----GMVNPNPKKRFTIFHVASNKFF .| .... |. ... | . ||.|| |. . .| IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 95912.m00294.AA | Pkinase | 242-274 | 18 | 0.106458 | 7.09 | Pfam | 261-293 (293) | Show / Hide |
Range on Protein: 242-274 Range on HMM: 261-293/293 Sequence Identity: 18% (6 aa) KLPQDAQVLLSGMVNPNPKKRFTIFHVASNKFF ....... ..... ...|||| |. .. ..| NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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