Gene 90098.m00019 (T.vaginalis)

90098.m00019

Species: T.vaginalis
Alias: TvagK0629, 90098.m00019
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
90098.m00019.AA Protein None 2250 None Fasta, JSON
90098.m00019.kin_dom Protein Kinase Domain None 106 None Fasta, JSON

Protein domain

Protein domains of 90098.m00019.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 90098.m00019.AA FAT 1368-1442 16 3.696747 0.76 Pfam 98-201 (408) Show / Hide 
Range on Protein: 1368-1442
Range on HMM: 98-201/408
Sequence Identity: 16% (17 aa)

AHKYLIASQHFVELYECILFKEKK-----------SQKVPKI---WSNRLENY-TEDSDAWKKLIDIRLLVLR--------------PEDNVESCRKMIS
.. ..   |  .|| | | .|..            ..|   .   | .|| .    . ..|  ..  | .|.               | .. .   |. .
HYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFAN

VLRK
. ||
LCRK
FAT 90098.m00019.AA FAT 1584-1671 14 9.2e-07 22.87 Pfam 306-408 (408) Show / Hide 
Range on Protein: 1584-1671
Range on HMM: 306-408/408
Sequence Identity: 14% (15 aa)

ANWRYNL---YKSNSNEINLKEVIDLFEKCVSLNEKDYL-SWAGLAYSCSRFLSHET---------N-EIRQNYAIIAIKGFLKASKLNPS-SSLQYLCQ
. |  .|    ..|.|. . .|... . . . .. . |   |. .|.   . ..|..         . ........ |.|.|... .|. . .|.|..  
GMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLR

VFS
. .
LLW
Kinase 90098.m00019.AA PIKK 1909-2179 31 3.1e-79 269.55 In-house 1-290 (290) Show / Hide 
Range on Protein: 1909-2179
Range on HMM: 1-290/290
Sequence Identity: 31% (93 aa)

YLYHIEERLELFNTLTHPRLLIVVDNQGNRHKFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGADTVLQIVN
.   . ....   ... |. ..     |  . .|.|| ||||.|||.||||.|.| .  ..  ..  . .|. | |.|  ...||| ||....|   | .
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DFRTLKN---RQNSIE-----------------KTVFHEYTSLRNNTLNGLQLLEIHDEICRKTNADELRESFWVWSDFPSTWVQITRNFTLSTALMSVE
. .  |.   .|..                   |..  ..   ..  ..  . .|.  |.. .| .| ... ||  .  | .|   . |.| |.|.|.. 
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQH-WPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV

GYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRILFPEKVPFRMTRLFQNALEGGNVDGIFRIACEDYMYLMRENVSPVIAMLEVF
|||.||||||. |||... || ..||||| |||||  |  .|||||||.|| . ||..   |.|.|| .||. | .||..  .... .|||
GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 90098.m00019.AA FRAP 1939-2189 41 2.8e-78 266.36 In-house 2-251 (251) Show / Hide 
Range on Protein: 1939-2189
Range on HMM: 2-251/251
Sequence Identity: 41% (103 aa)

HKFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGADTVLQIVNDFRTLKNRQNSIEKTVFHEYTSLRNNTLNG
. ||||| ||.| | |.|||| |.| |.. |  |.  | .|  | ..|   ||||| ||.  ||   .. |.|  .. .  ||  .. .  .   . |  
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCN-DYDHLPL

LQLLEIHDEICRKTNADELRESFWVWSDFPSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRILFPEKVPFRMT
..  ||   |   |  ..|.   |  |     | .   |.| | | ||. |||.||||||. ||| |  || ..||||| ||| |  |  ||||.|||.|
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RLFQNALEGGNVDGIFRIACEDYMYLMRENVSPVIAMLEVFVHEPIFSSKS
|.  ||.|   ..| .|..||  |  .||.   |.| || ||  |.|  . 
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 90098.m00019.AA PI3_PI4_kinase 1938-2189 24 3.4e-48 171.23 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1938-2189
Range on HMM: 1-300/300
Sequence Identity: 24% (77 aa)

RHKFLLKGNEDLR--LDQRIMQLF-----------------------SLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGADTVLQIVNDFR-
 ..|..||..|||   |.|.||..                       .|.| . | .. .| .| ..  | ..| .|. |.| ||. ..|  .|   .. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

-------------TLKNRQNSIEKTVFHEYTSLRNNTLNGLQLLEIHDEICRKTNADELRESFWVWSDFP-STWVQITRNFTLSTALMSVEGYIIGLGDR
              .| ... ....               .| .|. ..   ||  . |.. ||  .  .  .| .  .||..| | |.| .||.|.|||
KCKHKHFNKEHKMWMKMWPDWWHLM--------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDR

HLRNIMV--QQHTGTVIHIDFGECFE-SASNRILFPEKVPFRMTR------LFQNAL------EGGNVDGIFRIACEDYMYLMRENVSPVIAML------
|. ||||     || ..||||| ||. .....  .||.|||| |.       ...|.      .    .| ||  |.. . ..|..   ....|      
HNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMR

-EVFVHEPIFSSKS
 | .|| .... .|
GECMVHDGLPMWRS
Kinase 90098.m00019.AA PI3Kc 1940-2229 20 6.7e-48 166.37 SMART 1-336 (336) Show / Hide 
Range on Protein: 1940-2229
Range on HMM: 1-336/336
Sequence Identity: 20% (71 aa)

KFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGADTVLQIVNDFRTLKNRQNSIE------------------
 ...|...||| |.|.||.|.|.| . .... .|  .. .  | ..|  |..|.| ||. ..|. || . ... |.   ...                  
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------KTVFHEYTSLRNNTLNGLQLLEIHDEI----CRKTNADELRESFWVWSDFPSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQH
          ..   . |.... .... ..  .....    ..... |.              |..  .|||.|.| ... .|| |.||||. |||.   
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-----------EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMK

TGTVIHIDFGECFESASNRILFP----EKVPFRMTRLFQNALEGG----NVDGIFRIACEDYMYLMRENVSPVIAMLEVFVHEPI-FSSKSQ----FKNH
|| ..||||| .|...  ...|.    |.|||| |. .... .||     ..| ||  |.  . .||..   .....|..|. || .. ...     . .
TGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLR

HSILTR------VSQKI------LGTDSEYGGDETKEMEVPQHVANL
...         ..|..      .   .. ..  |. ... ...|..
QRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 90098.m00019.AA ATR 2068-2179 34 8.6e-30 98.37 In-house 157-267 (267) Show / Hide 
Range on Protein: 2068-2179
Range on HMM: 157-267/267
Sequence Identity: 34% (39 aa)

PSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRILFPEKVPFRMTRLFQNALEGGNVDGIFRIACEDYMYLMRE
|  |     |.  |.| ... ||||||||||  ||.... .| ..|.|.   | |  ...  || ||||.|.  ....     .|.|| |||. | .||.
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSG-EQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD

NVSPVIAMLEVF
.  ....... |
HRDDIMSVWDCF
Kinase 90098.m00019.AA ATM 2068-2185 38 1.5e-24 75.0 In-house 130-246 (304) Show / Hide 
Range on Protein: 2068-2185
Range on HMM: 130-246/304
Sequence Identity: 38% (46 aa)

PSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRIL-FPEKVPFRMTRLFQNALEGGNVDGIFRIACEDYMYLMR
|  |      .| | |  |. |||.||||||  ||..      ..||| |  ||    .||  || ||||.||     .    |.|.||  ||  |  ||
PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG--KILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMR

ENVSPVIAMLEVFVHEPIF
     .. . || . .|.|
NSQETLLTIVEVLLYDPLF
Kinase 90098.m00019.AA DNAPK 2054-2189 32 3.6e-20 69.96 In-house 166-301 (301) Show / Hide 
Range on Protein: 2054-2189
Range on HMM: 166-301/301
Sequence Identity: 32% (44 aa)

ADELRESFWVWSDFPSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRILFPEKVPFRMTRLFQNALEGGNVDGI
.| .|  |   |  . |.      |  . |.  . ..| | ||||| | ||   .| .| ||||  | ||      ||  |||.|| | | .    . ||
RDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGI

FRIACEDYMYLMRENVSPVIAMLEVFVHEPIFSSKS
..      |  .|      .   .||. .| |  | 
MYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN
Kinase 90098.m00019.AA SMG1 2068-2131 48 8.2e-19 58.82 In-house 180-242 (242) Show / Hide 
Range on Protein: 2068-2131
Range on HMM: 180-242/242
Sequence Identity: 48% (31 aa)

PSTWVQITRNFTLSTALMSVEGYIIGLGDRHLRNIMVQQHTGTVIHIDFGECFESASNRILFPE
|  |  .|  .  ||| ||. ||||||||||| |...   || |.|||.  |||     .  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKG-KKLNVPE
Kinase 90098.m00019.AA SMG1 1917-2000 36 5.9e-15 45.84 In-house 1-84 (242) Show / Hide 
Range on Protein: 1917-2000
Range on HMM: 1-84/242
Sequence Identity: 36% (31 aa)

LELFNTLTHPRLLIVVDNQGNRHKFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGA
. .  | | |. |. .   |    .| || ||| || ||||  |.|| .  |             | | |     ||| || ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA
Kinase 90098.m00019.AA FATC 2218-2250 39 3.6e-14 48.44 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2218-2250
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

KEMEVPQHVANLIKAATDRSRYCRHYQGWQPYL
... |.|.|  ||. ||| ...|..|.||.|..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 90098.m00019.AA DNAPK 1908-1998 30 6.8e-14 46.77 In-house 2-92 (301) Show / Hide 
Range on Protein: 1908-1998
Range on HMM: 2-92/301
Sequence Identity: 30% (28 aa)

LYLYHIEERLELFNTLTHPRLLIVVDNQGNRHKFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVN
  .   .||      |  |. .|.       | |. || ||||.|||| |||   |  .           . . | ..|     ||| ||.
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase 90098.m00019.AA ATM 1940-1999 36 5.2e-11 31.0 In-house 1-60 (304) Show / Hide 
Range on Protein: 1940-1999
Range on HMM: 1-60/304
Sequence Identity: 36% (22 aa)

KFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNG
. | || .||| |  . | | . | |.. |  ||   . |  | ||| .   | . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 90098.m00019.AA ATR 1909-2008 24 2.5e-10 30.94 In-house 2-101 (267) Show / Hide 
Range on Protein: 1909-2008
Range on HMM: 2-101/267
Sequence Identity: 24% (24 aa)

YLYHIEERLELFNTLTHPRLLIVVDNQGNRHKFLLKGNEDLRLDQRIMQLFSLVNSLIKTNRSTRAHNVNISMYDVVPFAPNTGLISWVNGADTVLQIVN
|.  ... .|.. .| .|. . .   .|  .  . |  .||| | | |.  .|.| . .     |    ..  | |.|   . ..| |||   |.  |..
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD