Gene 89437.m00041 (T.vaginalis)

89437.m00041

Species: T.vaginalis
Alias: TvagK0078, 89437.m00041
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
89437.m00041.AA Protein None 384 None Fasta, JSON
89437.m00041.kin_dom Protein Kinase Domain None 238 None Fasta, JSON

Protein domain

Protein domains of 89437.m00041.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89437.m00041.AA Ciliate-E2 61-265 19 8.3e-23 75.11 In-house 82-365 (365) Show / Hide 
Range on Protein: 61-265
Range on HMM: 82-365/365
Sequence Identity: 19% (56 aa)

EKIVLKSINSPFIPQLFEIIE--TPAESFIVKEYIPYNPISKVVKES----GPVPY------IIAKKYFQEFVI----------------AVNHLHDHDF
|| .|...|.|.| ...|  .  .    ..| ||. ..   .  |..    .  .       .   ||. . ..                |...||    
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN

VIFDDFTTESVLVDENDHIRIVDYEFFKEGSLP-----------PYHINNKPESLPLS----------------GLNFIPPEVLAGDI---------PSK
.|  |   | .|.     | |.|  . |. . .            |   .  .|   .                 ... .||.| |            ..
IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KADTWCAGIFLYYIVVGDLPFKSTEQIYSAC-PEFP------------------QKIPQKLQDLINQ----MLRKDPMQRVS-LRDVLSNNWL
|.| |..|. ||. . | .||   .|.   |  .||                  .|..|. .|||..    || ||| .| .   ..| . |.
KCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 89437.m00041.AA Ciliate-E2-Unclassified 65-265 20 2.2e-21 70.96 In-house 75-352 (352) Show / Hide 
Range on Protein: 65-265
Range on HMM: 75-352/352
Sequence Identity: 20% (57 aa)

LKSINSPFIPQLFEIIETPAESFIVKEYIPYNPISKVVKESGP-----------------VPYIIAK-----KYFQEFVIAVNHLHDHDFVIFDDFTTES
|.....|||  .|.. ..    .|| ||....  ..  |...                  ..   ||     .|| . . . ..||    .|  | . | 
LLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPEN

VLVDEND---HIRIVDYEFFKEGSLPPYHINN---------KPESLPLSG--LNFI----PPEVLAGDIPS----KKADTWCAGIFLYYIVVGDLPFKST
.|.|.|    .|.| |. ..|.   ...   .         |.. .      .|..    .|||| |  ..    .|.| |. |. ||... | .||...
ILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN

E------------------QIYSAC-------PEFPQ-----KIPQKLQDLIN----QMLRKDPMQRVSLRDVLSNNWL
                   |.|. .       |.||.     ..... .|.||    .|| |.| .| .. ..|   |.
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 89437.m00041.AA MARK 196-265 24 1.3e-19 60.94 In-house 185-262 (262) Show / Hide 
Range on Protein: 196-265
Range on HMM: 185-262/262
Sequence Identity: 24% (19 aa)

KKADTWCAGIFLYYIVVGDLPFK-ST-------EQIYSACPEFPQKIPQKLQDLINQMLRKDPMQRVSLRDVLSNNWL
.|.|.|  |. ||..|.| .||. .|       ..|..  ...| ... ....||...|  .|..| .. ....  |.
PKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 89437.m00041.AA CAMKK 183-265 23 1.6e-19 58.2 In-house 276-396 (396) Show / Hide 
Range on Protein: 183-265
Range on HMM: 276-396/396
Sequence Identity: 23% (28 aa)

FIPPEVLAG-D---------------IPSKKADTWCAGIFLYYIVVGDLPFKSTE---------QIYSACPEFPQ-------------KIPQKLQDLINQ
|..||..   .               . .|.|| | .|. ||..| | .||...          .|    ..||              .|.  |.|||..
FMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKR

MLRKDPMQRVSLRDVLSNNWL
||.|.|..| .. ..... |.
MLEKNPTKRITIPQIKVHPWV
Kinase 89437.m00041.AA MELK 13-265 25 8.6e-19 60.56 In-house 1-254 (254) Show / Hide 
Range on Protein: 13-265
Range on HMM: 1-254/254
Sequence Identity: 25% (66 aa)

YILEEMVGTFKGFA-IWTAINAITKQKVTIRIFPRAVLKSEFHKNLFASEKIVLKSINSPFIPQLFEIIETPAESFIVKEYIPYNPISKVVKESGPVPYI
| . . .||  ||| .  |   .| |.| |.|  .  | ... .     |   ||..    | ||. .|||    |.| || |   .   . .   .   
YEVHDEIGT-GGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPR--VKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEE

IAKKYFQEFVIAVNHLHDHDFVIFDDFTTESVLVDENDHIRIVDYEFFKEGSLPPYHINNKPESLPLSGLNFIPPEVLAG-DIPSKKADTWCAGIFLYYI
 ....|.. | |. ..|   .    |.  | .|.||. |....|. .         ...          . .  ||.. | .     || |  || || .
ETRHFFRQIVSAIAYVHSQGYA-HRDLKPENLLFDEDHHLKLIDFGLCAKT---KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVL

VVGDLPFKSTE------QIYSACPEFPQKIPQKLQDLINQMLRKDPMQRVSLRDVLSNNWL
..| |||          .| | | | |. .  . ..|. .||  || .|.|....|  .|.
MCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase 89437.m00041.AA CAMKK-Unclassified 196-265 27 1.1e-18 57.27 In-house 312-392 (392) Show / Hide 
Range on Protein: 196-265
Range on HMM: 312-392/392
Sequence Identity: 27% (22 aa)

KKADTWCAGIFLYYIVVGDLPFKST------E-QIYSAC----PEFPQKIPQKLQDLINQMLRKDPMQRVSLRDVLSNNWL
|||| | .|. .|..| . |||...      . .|  .     | .. ...  ..|||. |..|.|. | .. ..| . |.
KKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 89437.m00041.AA CAMKL 181-265 23 8.6e-18 53.21 In-house 197-297 (297) Show / Hide 
Range on Protein: 181-265
Range on HMM: 197-297/297
Sequence Identity: 23% (24 aa)

LNFIPPEVLAG-DIPSK--KADTWCAGIFLYYIVVGDLPFK------------STEQIYSACPEFPQ---KIPQKLQDLINQMLRKDPMQRVSLRDVLSN
... .||...|   |    |.| | .|. || .|.| |||.              . .   . ..|    ...  ..||| .|| ..|..| .. .... 
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

NWL
 |.
PWM
S_TKc 89437.m00041.AA S_TKc 13-265 21 1.1e-16 62.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-265
Range on HMM: 1-231/231
Sequence Identity: 21% (57 aa)

YILEEMVGTFKGFAIWTAINAITKQKVTIRIFPRAVLKSEFHKNLFASEKIVLKSINSPFIPQLFEIIETPAESFIVKEYIPY--NPISKVVKESGP---
| . . .|       . ...  |...| | | .          . . .|  .||. . |.| .|......  . ..| ||..       .. |. |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VPYIIAKKYFQEFVIAVNHLHDHDFVIFDDFTTESVLVDENDHIRIVDYEFFKEGSLPPYHINNKPESLPLSGLNFIPPEVLAGDIPSK-KADTWCA
    |   |..|... . |....|.|  .|  |   | .|.||  || | |  . ..             .     .....||||     .| |.| |  
RFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GIFLYYIVVGDLPFKSTEQIYSACPEFPQKIPQKLQDLINQMLRKDPMQRVSLRDVLS-------NNWL
|. ||  ..|  ||  ..|            .. . |.|...|.||| .| .  ..|          |.
GCILYEMLCGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 89437.m00041.AA CAMK 183-265 20 5.8e-16 47.23 In-house 285-425 (425) Show / Hide 
Range on Protein: 183-265
Range on HMM: 285-425/425
Sequence Identity: 20% (29 aa)

FIP-PEVLAG-------------DIP-SKKADTWCAGIFLYYIVVGDLPFKST-------------------EQIYSACPEFPQK---------------
... |||| |               . ..|.| | .|. ||  ..| .|| .                    |.| ..  .|| .               
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD

---------IPQKLQDLINQMLRKDPMQRVSLRDVLSNNWL
         . |  .|||..||..|| .| .. ..|.  |.
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 89437.m00041.AA RSK 113-265 24 8.3e-15 50.86 In-house 106-278 (278) Show / Hide 
Range on Protein: 113-265
Range on HMM: 106-278/278
Sequence Identity: 24% (44 aa)

AKKYFQEFVIAVNHLHDHDFVIFDDFTTESVLVDE---NDHIRIVDYEFFKEGSLPPYHIN-NKPESLPLSGLNFIPPEVLA---GDI-PSKKADTWCAG
|. |. | | || |||... .|. |   | .| |.   . ||...|  | |..     ... |..   .   .....||.|.   ..   .| .| |  |
ACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-----RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

IFLYYIVVGDLPFKS---------TEQIYSAC--PEFP--QKIPQKLQDLINQMLRKDPMQRVS-----LRDVLSNNWL
. .|   .| .||..          ..| ..   ...|  |.. |  .|||..|| .|| .| .     . ..... |.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 89437.m00041.AA AMPK 34-155 30 1.9e-12 33.3 In-house 22-143 (254) Show / Hide 
Range on Protein: 34-155
Range on HMM: 22-143/254
Sequence Identity: 30% (38 aa)

ITKQKVTIRIFPRAVLKSEFHKNLFASEKIVLKSINSPFIPQLFEII-ETPAESFIVKEYIPYNPISKVVKESGPVPYIIAKKYFQEFVIAVNHLHDHDF
.|..||.| |  .  .|..  ..  ..|   ||... | | ||.|.| ||| . |.| ||.. .    ..   | ..   |...||  . .|  .|.|  
LTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHM-

VIFDDFTTESVLVDENDHIRIVD
.   |   | .| |.| .| |||
IVHRDLKPENLLLDHNKNIKIVD
Kinase 89437.m00041.AA AMPK 199-265 30 6.9e-12 31.64 In-house 182-254 (254) Show / Hide 
Range on Protein: 199-265
Range on HMM: 182-254/254
Sequence Identity: 30% (22 aa)

DTWCAGIFLYYIVVGDLPFKSTEQ------IYSACPEFPQKIPQKLQDLINQMLRKDPMQRVSLRDVLSNNWL
|.|  |. ||  . | |||   ..      | .  .. |. . .. .|||..||..|||.|..  |.    |.
DIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 89437.m00041.AA Pkinase 181-265 20 2.1e-09 34.36 Pfam 175-293 (293) Show / Hide 
Range on Protein: 181-265
Range on HMM: 175-293/293
Sequence Identity: 20% (24 aa)

LNFIPPEVLA-GDIPSKKADTWCAGIFLYYIVVGDLPFKST------------EQIYSACPEFPQKIP---------------------QKLQDLINQML
.....|||.  |   ..|.| | .|. ||. . | .||..             ..| .. ..|.   .                     . ..|.|. .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

RKDPMQRVSLRDVLSNNWL
.||| .| . ...|   |.
CKDPKKRPTAEQILQHPWF
Kinase 89437.m00041.AA Pkinase 28-133 17 2.9e-08 30.28 Pfam 16-130 (293) Show / Hide 
Range on Protein: 28-133
Range on HMM: 16-130/293
Sequence Identity: 17% (20 aa)

WTAINAITKQKVTIRIFPRAVLKSEFHKNLFA-SEKIVLKSINSPFIPQLFEIIETPAESFIVKEYIPYN----PISKVVK--ESGPV--PYIIAKKYFQ
. ...  | ..| . |...   ||.......  ||  ..|..|.|.| .|... |.. .  .| || .        . ...  ..|..  ..  .|.|. 
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY

EFVIAVNHLHDHDFV
. . .....|.. ..
QILRGLEYCHSMGII
Kinase 89437.m00041.AA CAMK 30-131 14 3e-06 15.2 In-house 13-199 (425) Show / Hide 
Range on Protein: 30-131
Range on HMM: 13-199/425
Sequence Identity: 14% (28 aa)

AINAITK------------QKVTIRIFPRAVLKS-------------------------EFHKNLFASEKIVLKS-------INSPFIPQLFEIIET---
.|.  |.            ||| | | ..  ||.                         .. .  . .|  ..|.       .. | | .|.|..|.   
CIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHY

----------------PAESFIVK---EYIPYN----PISKVVKESGP---------------VPYIIAKKYFQEFVIAVNHLHDHD
                . . ..|    ||..       .   ..| |.               ..   |..||.  . ||...|.|.
FKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
Kinase 89437.m00041.AA CAMKL 65-131 29 3e-06 15.73 In-house 66-147 (297) Show / Hide 
Range on Protein: 65-131
Range on HMM: 66-147/297
Sequence Identity: 29% (24 aa)

LKSIN---SPFIPQLFEIIETPAE------SFIVKEYIPYNP--ISKVVKES----GPVPYIIAKKYFQEFVIAVNHLHDHD
.|..|    | | .|.|.||||         ..| ||..         ...     |. |   |..||.  | |||..|.|.
MKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG