Gene 96955.m00161 (T.vaginalis)
96955.m00161
Species: T.vaginalis
Alias: 96955.m00161, TvagK0351
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
96955.m00161.AA | Protein | None | 968 | None | Fasta, JSON |
96955.m00161.kin_dom | Protein Kinase Domain | None | 271 | None | Fasta, JSON |
Protein domains of 96955.m00161.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 96955.m00161.AA | TKL | 201-445 | 23 | 3.2e-80 | 272.81 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 201-445 Range on HMM: 1-364/364 Sequence Identity: 23% (88 aa) IAQGGYAIVHLAKLRATN--------EELAIKELKPANLKPRTV-------------------------GYLKREIDSMLALDHPNLLKLAGVTITAP-- | .||...|. .|.| .. .. |.| .| | . .| ...|| .|. |.|||.... |. . | IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------FCIATGFLPNGDLYEILHGKNQKMKKPMLLSQISIDVARGLEYVHANH--------MVHRDLKPPNILMDKNWR-------------- .|| . . |.|.|...|| . .. ....|.|||..| |... ..|||||..||| |.||. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC AVICDFGLARYIGP--NMTC--------------------ELGTAQWMAPELFSGD---------------GSYDTCVDVYAYGILLWELFTQQMPYTQM . ||||||.| . . ||.. . || .|||||.. |. ..|.. .|||..||.|||..| . || .. CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY RLLQIA---------VGVLKEKMRPQFP------------PNSDPIYKNLIQSCWAHKKSARPTMKDVRTLL .. ..| ....|| | |. .| .|.|.| ||.|. ..||..... | PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 96955.m00161.AA | Dicty4 | 239-447 | 35 | 8.3e-58 | 191.43 | In-house | 45-277 (277) | Show / Hide |
Range on Protein: 239-447 Range on HMM: 45-277/277 Sequence Identity: 35% (82 aa) LKREIDSMLALDHPNLLKLAGVTIT---AP--FCIATGFLPNGDLYEILHG----KNQKMKKP-MLLSQ---ISIDVARGLEYVHA-N-HMVHRDLKPPN ...|.. | . |||.... | . .| .|| | ..| |.||..|| . |. |.. | . . .|.|||. . |. | .|||||. | FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHN ILMDKNWRAVICDFGLAR----YI--GPNMTCELGTAQWMAPELFSGDGSYDTCVDVYAYGILLWELFTQQMPYT--QMRLLQIAVGVLKEKMRPQFPPN .|.|||||. .|||||.. . . |.. ||. ||||| .. .|. .||| .||.|||..| | || | . |.. .| .|.|| |.. LLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ-PYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDW SDPIYKNLIQSCWAHKKSARPTMKDVRTL--LET .| .| ||| || | . ||... . ||. CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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Kinase | 96955.m00161.AA | TKL-Unique | 199-445 | 31 | 8.4e-57 | 195.02 | In-house | 3-290 (290) | Show / Hide |
Range on Protein: 199-445 Range on HMM: 3-290/290 Sequence Identity: 31% (90 aa) ENIAQGGYAIVHLAKLRATNEELAIKELKP-ANLKPRTVGYLKREIDSMLALD-HPNLLKLAGVTI----TAP-FCIATGFLPNGDLYEILH-------G . | .|||. | .| | . . ||| ..| . . .. . ...|. | |. |||.... |... ..| .|| . ..| | ||. || NKIGEGGYGQVYKGKWRGY--PVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN KNQKMKKPMLL-SQISIDVARGLEYVHANH--MVHRDLKPPNILMDKN-----WRAVICDFGLARYIG--PNMTCE----------LGTAQWMAPELFSG |...| .|.. .. ||.|.|..| | . . |||||..|.| | | |.. ||||||.. .|| .|...|||||.... NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM D-GSYDTCVDVYAYGILLWELFTQQM------PYTQMRLLQIA--VGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLL |.. .|||..|| |||..| . || | |.. | . .|. || |.. ..|..||| ||.| | ||. .... | NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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Kinase | 96955.m00161.AA | Dicty4-Unclassified | 249-445 | 36 | 2.2e-54 | 184.63 | In-house | 55-263 (263) | Show / Hide |
Range on Protein: 249-445 Range on HMM: 55-263/263 Sequence Identity: 36% (76 aa) LDHPNLLKLAGVTITAP------FCIATGFLPNGDLYEILHGKNQKMKKPMLLSQ-----ISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRAVICDF . ||||.|. | | .| .|| . |.. | | |. | | ..|. | . .|.|.|. . | ..|||.| ||||||. . | || IQHPNLVKCYGYCI-NPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADF GLARYI--GPNMTCELGTAQWMAPELFSGDGSYDTCVDVYAYGILLWELFTQQMPYTQMR-LLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSA |..| | ||| || | .|| . || ||| |...|.|| | || . .| | |.||. | | |. .| || || GISRVIDFNFNMTTIAGTPKWESPECLMHE-SYNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNK RPTMKDVRTLL |||| .. | RPTMNQIIQYL |
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Kinase | 96955.m00161.AA | MLK | 195-445 | 26 | 3.5e-53 | 182.81 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 195-445 Range on HMM: 1-291/291 Sequence Identity: 26% (76 aa) EITDENIAQGGYAIVHLAKLRATN---EELAIKELKPANLKPRTVGY-----LKREIDSMLALDHPN----LLKLAGVTITA-P-FCIATGFLPNGDLYE . | | |.. |.... |... ..|.|. . . | ...|. |.||| .. || . . ||| . ....| ||. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN ILHG-KNQKM-----------KKPMLLSQISIDVARGLEYVHANH---MVHRDLKPPNILMD------KNWRAVICDFGLARYIGPN---MTCELGTAQW .||| ... | .. .. ... ..|||..| |.. .|||||..||| | .. ..|||||..| . . |.. ||. | VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW MAPELF--SGDGSYDTCVDVYAYGILLWELFTQQMPYT-QMRLLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLL |||| . . . |. .||. .|..|||..| ..|| . ..|| .| .. || |.. ... |.|.. || . . ||... . . | MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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Kinase | 96955.m00161.AA | LRRK | 195-447 | 25 | 4.5e-53 | 182.65 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 195-447 Range on HMM: 1-351/351 Sequence Identity: 25% (89 aa) EITDENIAQGGYA-IVHLAKLR--------------------------ATNEELAIKELKP--------------------------------ANLKPRT . | | .||.. .|. ||.| . .. ||| .. . ..| LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA VGYLKREIDSMLALDHPNLLKLAGVTITAPFCIATGFLPNGDLYEILHGKNQKM------K-KPMLLSQISIDVARGLEYVHANH--MVHRDLKPPNILM . .|. | |.|||...| |..| |.|... ..|.||||. || | | . ..||. .|....|.|.|| | .. .|||||.||||. FREFRHEVWIMSHLNHPNIVSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL ---D---------KNWRAVICDFGLAR--YIGPN--MTCELGTAQWMAPELFS--GDGSYDTCVDVYAYGILLWELFTQQ-MPYTQMR------LLQIAV . . | |.|||. | .. .. .|. .||||| |. .|.. ||.|..|..|||| | | |. .. . . WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE GVLKEKMRPQFPPN-SDP-----IYKNLIQSCWAHKKSARPTMKDVRTLLET .|. || .|.. | |..|||.||.|. ||.. .. |.. DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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Kinase | 96955.m00161.AA | S_TKc | 195-451 | 23 | 4.5e-50 | 173.59 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 195-451 Range on HMM: 1-231/231 Sequence Identity: 23% (62 aa) EITDENIAQGGYAIVHLAKLRATNEELAIKELKPANLKPRTVGYLKREIDSMLALDHPNLLKLAGVTITAPFCIATGFLPN--GDLYEILHGKNQ----K . | .|... |.... . |... |||..| ..|||. . .|||. || .| . ... . .... |||..... .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF MKKPMLLSQISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRAVICDFGLARYIGPNMTCELGTAQWMAPELFSGDGSYDT-CVDVYAYGILLWELFTQ . . ....||| | .. .|||||| |||.|. . |||||||| . | || .||||.. .|.. .|... |..|.|... PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG QMPYTQMRLLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRT---LLETGEYV . |. . .. .. .| |..|. |. . ||| .. . . ... YPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 96955.m00161.AA | TK | 209-445 | 16 | 8.3e-47 | 154.49 | In-house | 18-486 (486) | Show / Hide |
Range on Protein: 209-445 Range on HMM: 18-486/486 Sequence Identity: 16% (77 aa) VHLAKLRATN-------------------------EELAIKELKP-ANLKPRTVGY--------------LKREIDSML--ALDHPNLLKLAGVTITA-- |.....| | .. |.| ||. .. .. . .|. |. ...|||...| || VYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEP -----------PFCIATGFLPNGD----LYEILHGKNQKMKKPMLLSQ---------------------------------------------------- |..| . . |.|| | . |. . |.... .. KPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDL ---------------------ISIDVARGLEYVHAN------HMVHRDLKPPNILMDKNWR-----------AVICDFG--------LARYIGPNMTCEL .. ..|.|.|| |.. ..||||| |.| ..| . . |.||| |||.|... LQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYR GTAQ-----------------------------WMAPELFSG--------DGSYDTCVDVYAYGILLWELFT--QQMPYTQMRL--------LQIAVGVL . . ||||| . . .| . | ||...|.|.||.|| |...| .| .| . | KSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYL KE--------------KMRPQFPPNSD--------------PIYKNLIQSCWAHKKSARPTMKDVRTLL .. .||. ||. ..| |.|.||... . |||..... | RRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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Kinase | 96955.m00161.AA | Dicty5 | 298-449 | 38 | 9.7e-45 | 151.91 | In-house | 109-260 (260) | Show / Hide |
Range on Protein: 298-449 Range on HMM: 109-260/260 Sequence Identity: 38% (59 aa) ISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRAVICDFGLAR--YIGPNMTCELGTAQWMAPELFSGDGSYDTCVDVYAYGILLWELFTQQMPYTQMR . ||.|......| .||||| |.| .|| . | ||| | .|| ..|| |||.||| | . |. .|||..|| |||.||. || . MAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQP-YHQKCDVYSFGIVLWEMFTRKEPYDNIN LLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLLETGE |.| | | || |. . ||| .|| | . ||. | . .| NWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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Kinase | 96955.m00161.AA | DRK | 220-447 | 33 | 1.9e-43 | 145.03 | In-house | 24-258 (258) | Show / Hide |
Range on Protein: 220-447 Range on HMM: 24-258/258 Sequence Identity: 33% (80 aa) ELAIKELKPANLK-PRTVGYLKREIDSMLALDHPNLLKLAGV-TITAPFCIATGFLPNGDLYEILHGKNQKMKKPMLLSQISIDVARGLEYVHANH--MV . |.| |. | . ..|||. | | ||| | .. || . ..| | || ||| .| | .. |. .|.|.|. | | . QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK-QMMFDCAKGMIYLHCCNPIII HRDLKPPNILMDKNWRAVICDFGLAR------YIGPNMTCELGTAQWMAPELFSGDGSYDTCVDVYAYGILLWELFTQQMPYTQMRLLQIAVGVLKEKMR ||||| | | | .|. . ||||. . || || | ||| .. | ||| ..| |||. | | || | .|. | ...|| HRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQR-YTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMR PQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLLET | |.. | | |.. || . ||.| .. || PPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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Kinase | 96955.m00161.AA | TyrKc | 195-445 | 26 | 5.1e-42 | 146.84 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 195-445 Range on HMM: 1-280/280 Sequence Identity: 26% (77 aa) EITDENIAQGGYAIVHLAKLRATNEELAIKELKPANLKPRTVGYLKREIDSMLAL--DHPNLLKLAGVTIT--------APFCIATGFLPNGDLYEILHG .. . | . .|...... .. |.| ||. . . ||. | | .|||...| || .. | .| . . |.||| . |. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK KNQKMKKPMLLSQISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRAVICDFGLARYIGPN--------MTCELG--TAQ------WMAPELFSGDGSY . | . . ||| .....|.| || | .. .|||| |.| ..| .. |.||||.|.|. . . . ||||| . .| . HRPKLCMKDLLS-FCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF DTCVDVYAYGILLWELFTQ-QMPYTQM----RLLQIAVGVLKEKMRPQFPPN---------SDPIYKNLIQSCWAHKKSARPTMKDVRTLL | ||...|...||.|| |.|| | | .. .|. .|. ||| .| .|. ....||... . |||..... .. TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 96955.m00161.AA | Pkinase | 195-445 | 23 | 4e-40 | 142.95 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 195-445 Range on HMM: 1-293/293 Sequence Identity: 23% (69 aa) EITDENIAQGGYAIVHLAKLRATNEELAIKELKPANLKPRTVGYLKR--EIDSMLALDHPNLLKLAGVTI-TAPFCIATGFLPNG----DLYEILH-GKN . . | .|... | ... . |... |.|..| . |. .. | || |. |.||| ..| .. .. . ....| ||..... .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH QKM-KKPMLLSQISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRA----VICDFGLAR---YIGPNMTCELGTAQWMAPELFSGDGSYDTCVDVYAYG .. . . . ..||||| |.. .|||||| |||.|.| |||||||. | .. || || .||||. |. |.. ||....| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG ILLWELFTQQMPYTQM------RLLQIAVGVLKEKMRPQFPPNSD-------------------PIYKNLIQSCWAHKKSARPTMKDVRTL--L ..|.|... . |. . . .|. . ... . . ..| .. . | .| .|.. . . ||| ... . CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 96955.m00161.AA | TKL-ciliate2 | 196-446 | 29 | 4.8e-39 | 127.61 | In-house | 2-273 (273) | Show / Hide |
Range on Protein: 196-446 Range on HMM: 2-273/273 Sequence Identity: 29% (82 aa) ITDENIAQGGYAIVHLAKLRATNEELAIKELKPANLKPRTVGYLKREIDSMLALDHPNLLKLAGVTITAP-FCIATGFLPNGDLYEILHGKNQKMKKPML ... |. ||| |. || | . |.| | . ... | . | || |||. | | ||| . | |. .| .. .. EIQNKITEGGYGIIYKAKWREI--VVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTW-ED LSQISIDVARGLEYVHANH--MVHRDLK--------------------PPNILMDKNWRAVICDFGLARYI--GPNMTCELGTAQWMAPELFSGDGSYDT .| .|.||| |.|. . ..||||| |.|.| | | . ||| | || .|| |||||| . | RRRIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNKIGTYQWMAPEVIKAF-YYTE CVDVYAYGILLWELFTQQMPYTQMRLLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLLE ||..|.|.|||. || .. .|. |... .|| | | | . .|.| || . ||.. .. || KADVFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE |
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Kinase | 96955.m00161.AA | Pkinase_Tyr | 196-445 | 27 | 6.9e-39 | 132.33 | Pfam | 2-270 (270) | Show / Hide |
Range on Protein: 196-445 Range on HMM: 2-270/270 Sequence Identity: 27% (74 aa) ITDENIAQGGYAIVHLAKLR----ATNEELAIKELKPANLKPRT--VGYLKREIDSMLAL-DHPNLLKLAGVTI--TAP--FCIATGFLPNGDLYEILHG . .. . .| . |...... |. . |.| ||. . .. . ||. | | .|||...| || . | .| . . |.|||.. |. TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK K---NQKMKKPMLLSQISIDVARGLEYVHANHMVHRDLKPPNILMDKNWRAVICDFGLARYI-----G-PNMTCELGTAQWMAPELFSGDGSYDTCVDVY . .|. . .. | |.....|.|.|| ......|||| |.| ..| . ||||||||.| . ||||| .. . | ||. HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVW AYGILLWELFT-QQMP-YTQMRLLQIAVGVLKEKMRPQFPPNSDPIYKNLIQSCWAHKKSARPTMKDVRTLL ..|.|.||.|| ..| | | .. . .. | |.| . .|...||... . |||..... | SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |