Gene 87050.m00035 (T.vaginalis)
87050.m00035
Species: T.vaginalis
Alias: TvagK0195, 87050.m00035
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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87050.m00035.AA | Protein | None | 296 | None | Fasta, JSON |
87050.m00035.kin_dom | Protein Kinase Domain | None | 231 | None | Fasta, JSON |
Protein domains of 87050.m00035.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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S_TKc | 87050.m00035.AA | S_TKc | 27-257 | 26 | 1.1e-58 | 202.14 | SMART | 14-231 (231) | Show / Hide |
Range on Protein: 27-257 Range on HMM: 14-231/231 Sequence Identity: 26% (66 aa) VVYLVYDPHYETHFALKVIPENRFRQSEINLMNEIDDPSIVRMYNYEHYEGFIYILYEFCQA---SLYSIIKQKNY------LDGDNLIRYSCGILKAIQ .||.... . ..|.|.|. . ..||... . . | ||..| . . ...|. |.| .|...||.... .. .| . |..|.. KVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALE ACQNNKIAHLDIKPENILLDDYDRIKICDFGLSIKYENKDTELHYGGSIPFIAPEILDMKPYNPFKADIWSIGVTFFVMATGFFPWIGADETELCQNTLH | ...| | |.||||||||. .||||||||. .. .. |. ..|||.| .|...|.|.||.|.... |..| |. .. .. .. . YCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG- KKPQLELIRNHEFQKVIGCCLSKNPEERPTVDQLLN-------MAIF .|. | || |.||.|||. ..|. . | ---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 87050.m00035.AA | CAMK | 27-253 | 18 | 1.3e-48 | 154.36 | In-house | 9-421 (425) | Show / Hide |
Range on Protein: 27-253 Range on HMM: 9-421/425 Sequence Identity: 18% (75 aa) VVYLVYDPHYE------------THFALKVIP---------------------------------ENRFRQSEINLMNE-------IDDPSIVRMYN-YE .|.|... . ...| |.|. .. ..||..|. .| | |...| || KVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYE ----------------HYEG---FIYILY---EFCQA-----SLYSIIKQKNY---------------LDGDNLIRYSCGILKAIQACQNNKIAHLDIKP .. ..|. |.|. |.. |... . .. . || |. |.. | ...|.|.|.|| DPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKP ENILLDDYD-----------------RIKICDFGLSIKYENKDTEL------------------------HYGGSIPFIA-PEILDM------------- ||||||| . |||.|||...|.. .. .. . |. ...| ||.| ENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEE KPYNPFKADIWSIGVTFFVMATGFFPWIGADETELC---------QNTLHK--KPQLELIRNH--------------------------EFQKVIGCCLS ||| ..|.|.||.|| ..| .|..|. | .. | | .....| | . . . . | . | ..| KPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQ KNPEERPTVDQLLN ..||.|.|..| || VDPEKRMTIEQCLN |
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Kinase | 87050.m00035.AA | Ciliate-E2 | 40-257 | 24 | 4.1e-45 | 152.79 | In-house | 50-365 (365) | Show / Hide |
Range on Protein: 40-257 Range on HMM: 50-365/365 Sequence Identity: 24% (78 aa) FALKVIPEN--RFRQSEINLMNEID----------------DPSIVRMYNYEH--YEGFIYILYEFCQA-SLYSIIKQK-----------NYLDGDNLIR .|.|.. .| .. .||..|.||. | |..|| . . ||. |.|| .|...||.. .|.. .. YAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKY YSCGILK---------------AIQACQNNK-IAHLDIKPENILLDDYDRIKICDFGLSIKYENK-----------------DTELHYG----------- .. ||. |.. . ... | | ||||||||. |||.||||| || .. ||. ..| IMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMF ----GSIPFIAPEILDMKPY--------NPFKADIWSIGVTFFVMATGFFPWIGADETELCQNTLHKKPQL--------------ELIRNHEFQKVIGC- |. .. ||||| .|.| .|.||||.||... | .| .|. . . .|. . .. . | . | NTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF ---CLSKNPEERPT-VDQLLNMAIF .| |.||.|.| .|.|| .| GKRMLQKDPEKRITGWEQILNHPWF |
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Pkinase | 87050.m00035.AA | Pkinase | 27-257 | 25 | 1.2e-44 | 159.01 | Pfam | 14-293 (293) | Show / Hide |
Range on Protein: 27-257 Range on HMM: 14-293/293 Sequence Identity: 25% (71 aa) VVYLVYDPHYETHFALKVIPENRFRQ---------SEINLMNEIDDPSIVRMYNYEHYEGFIYILYEFCQA-----SLYSIIK--QKNYL--DGDNLIRY .||. .. .. .|.|.|. . . ||| .|.... | |||.| . .... ||. |.|. .|...|. ... . . . ...| CVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFY SCGILKAIQACQNNKIAHLDIKPENILLDDYDRI----KICDFGLSIK--YENKDTELHYGGSIPFIAPEILDMKPYNPFKADIWSIGVTFFVMATGFFP ||.... | ...| | |.||||||.|. . | |||||||. . | |. .. |.....|||.. .| . |.|.||.|.... |..| .| MYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP WIGA------DETELCQNTLHKKPQLELIRN---------------------HEFQKVIGCCLSKNPEERPTVDQLLNMAIF . |. |. .. ........ . |....| .|| |.|..||| .|.|. | FPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 87050.m00035.AA | CAMKL | 52-253 | 28 | 2.3e-42 | 132.93 | In-house | 60-293 (297) | Show / Hide |
Range on Protein: 52-253 Range on HMM: 60-293/297 Sequence Identity: 28% (68 aa) QSEINLMNEID---DPSIVRMYNYEHYEGF------IYILYEFCQAS---LYSIIKQKNY----LDGDNLIRYSCGILKAIQACQNNKIAHLDIKPENIL . ||..| .. | |...| . . ||. | |. |. |... . .. . || . |. |.. | ...|.| |||||||| RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENIL LDDYD--RIKICDFGLSIKYEN-----KDTELHYGGSIPFIAPEILDM--KPYNPFKADIWSIGVTFFVMATGFFPWIGAD---------ETELCQNTLH ||. . |||.|||.|..|.. .. || |. ||||. |||. .|.||||.||. ..| .| .|. ... . .. .... LDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG- KKPQLELIRNHEFQKVIGCCLSKNPEERPTVDQLLN ..| . . . | | .|||.|||..|..| YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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Kinase | 87050.m00035.AA | Ciliate-E2-Unclassified | 57-257 | 24 | 3.9e-41 | 140.45 | In-house | 70-352 (352) | Show / Hide |
Range on Protein: 57-257 Range on HMM: 70-352/352 Sequence Identity: 24% (70 aa) LMNE----IDDPSIVRMYNYEHYEGFIYILYEFC------------------QASLYSIIKQKNYLDGDNLI-----RYSCGILKAI-QACQNNKIAHLD .|.. ...| ||.|. .. . ||| .|.| . |. .||.. .. . . .| ||... . ...|.| | | IMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRD IKPENILLDDYD---RIKICDFGLSIKYEN----------------KDTELHYGGSIPFI----APEILDMKPYNP---FKADIWSIGVTFFVMATGFFP |||||||.|. .|||.|||.|.||.. .. . |.. .. |||.|. . |. .|.|||| || .. | .| .| IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP WIGADETE----------------LCQNTLHKKPQLEL--------IRNHEFQKVIG----CCLSKNPEERPTVDQLLNMAIF . .... | || . |..| . . | . | ..| |||..|.| .|.|| .| FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 87050.m00035.AA | STE | 40-257 | 22 | 5.7e-37 | 128.11 | In-house | 42-359 (359) | Show / Hide |
Range on Protein: 40-257 Range on HMM: 42-359/359 Sequence Identity: 22% (74 aa) FALKVIP----------------------ENRFRQSEINLMNEID--DPSIVRMYNYEHYEG-------FIYILYEFCQA-SLYSIIKQK-NYLDG---- .| |... | . ||..|.. . | ||. | .. .|| ..| |.. . || .|||.| ... MAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHN --------DNLI-RYSCGILKA-IQACQNNKIAHLDIKPENILLDDYDRIKICDFGLSIKYENK-------------DTEL----HYGGSIPFIAPEILD ..| .. . |||. . ...| | |||| |||| .|.||||.. . ... .| . |. . |||... RQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ M------KPYNPFKADIWSIGVTFFVMATGFFPWIG-ADETELCQNTLH---------------KKPQLELIRN-------------------HEFQKVI |.|. .|.||||.| | |||| || . . . . . |.|. ||. | QNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFI GCCLSKNPEERPTVDQLLN--MAIF || |.|..|||..|||. . NKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 87050.m00035.AA | ULK | 39-257 | 22 | 7.1e-36 | 124.8 | In-house | 30-324 (324) | Show / Hide |
Range on Protein: 39-257 Range on HMM: 30-324/324 Sequence Identity: 22% (67 aa) HFALKVIP-------ENR--------FRQSEINLMNEID---DPS--IVRMYNYEHYE--GFIYILYEFCQA-SLYSIIKQKNY---------LDGDNLI ..| |.|. .|. . ..||..| ... | ||..| . .||| .|.|. | ..||.... | . | YVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAI RYSCGILKAIQACQNNKIAHLDIKPENILLDDYD------------RIKICDFGLSIKYENKDTELHYG----------GSIPFIAPEILD----MKPYN . |. . .. ....| | ||||.|||. . . ..||.|||.. . .| . | |. . ||.|| |||. QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY PFKADIWSIGVTFFVMATGFFP---WIGADET----EL----------CQNTLHKKPQ--LELIRNHEFQKVIGCCLSKNPEERPTVDQLLNMAIF .|.||||.|. |. | .| | | |. .| .|. ..| . .. |.. | ..| .....| . ....|. .| DYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 87050.m00035.AA | ULK | 40-257 | 22 | 2.8e-35 | 120.65 | In-house | 31-329 (329) | Show / Hide |
Range on Protein: 40-257 Range on HMM: 31-329/329 Sequence Identity: 22% (67 aa) FALKVIP---ENRFR------------QSEINLMNEIDDPS--------IVRMYNYEHYEGF--IYILYEFCQA-SLYSIIKQKNY----------LDGD .| |.|. .|.. ..|| .| ....| ||..| . . ||| .|.|. | ..||.... | . VACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQ NLIRYSCGILKAIQACQNNKIAHLDIKPENILLDDYD------------RIKICDFGLSIKYE-N---KDTELHYG------GSIPFIAPEILD----MK | . . || . .. . ..| | ||||.|||... . ..||.|||.. . . . .. .. . |. . ||.|| | EAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQK PYNPFKADIWSIGVTFFVMATGFFP---WIGADET-ELCQNTLHK---------KPQLELI-------RNHEFQKVIGCCLSKNPEERPTVDQLLNMAIF ||. .|.||||.|. |. | .| | | |. .|. . . | .|. . |.. | ..| .....| . ..|.|. .| PYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 87050.m00035.AA | MARK | 112-253 | 39 | 2.2e-34 | 109.92 | In-house | 113-258 (262) | Show / Hide |
Range on Protein: 112-253 Range on HMM: 113-258/262 Sequence Identity: 39% (57 aa) ILKAIQACQNNKIAHLDIKPENILLDDYD--RIKICDFGLSIKYENKDTELHYGGSIPFIAPEILDMKPYNPFKADIWSIGVTFFVMATGFFPWIGAD-- |. |.. | .. |.| ||||||||.|. |||.|||.||. .. |. |. ||||. |||. .|.|||| || ..| .| ||. |.. IVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQD ETELCQNTLHKKPQLELIRNHEFQKVIGCCLSKNPEERPTVDQLLN . || .. |. |.. .| .. | | |||||||...... YKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMK |
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Kinase | 87050.m00035.AA | CMGC | 27-202 | 17 | 1.5e-26 | 83.5 | In-house | 14-344 (513) | Show / Hide |
Range on Protein: 27-202 Range on HMM: 14-344/513 Sequence Identity: 17% (59 aa) VVYLVYDPH--------------YETHFALKVIP---ENRFRQ-------------SEINLMNEI-----------------DDPSIVRMYNYEHYEG-- ||| .| . .. . |.| | . . . || .. .. ... ||..|.. .... VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSD ---------------FIYILYEFCQASLYSIIKQKN---------YLDGDN------------LIRYS------CGILKAIQ--ACQNNK--IAHLDIKP .|. |... .|| .||... .|. .. ||... | .. | | |.|| GNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKP ENILLDD--------------------YDRIKICDFGLSIKYENKDTE----------------------LHYGGSIPFIAPEILD-MKPYN-------- ||||... .|.|||||||. .|.. . . || . ||||| .| |. ENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHY PFKADIWSIGVTFFVMATG----------FFP . |.||.| |. | || .|| TTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFP |
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Kinase | 87050.m00035.AA | PLK1 | 54-257 | 28 | 9e-26 | 81.47 | In-house | 49-253 (253) | Show / Hide |
Range on Protein: 54-257 Range on HMM: 49-253/253 Sequence Identity: 28% (59 aa) EINLMNEIDDPSIVRMYNYEHYEGFIYILYEFCQ-ASLYSIIKQKNYLDGDNLIRYSCGILKAIQACQNNKIAHLDIKPENILLDDYDRIKICDFGLSIK ||.. ... . ||..... . ..||. | |. || . |.. . | |....| .|||| | |.| |. |.| ..|| |||| | EIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATK YENK-DTELHYGGSIPFIAPEILDMKPYNPFKADIWSIGVTFFVMATGFFPWIGADETELCQNTLHKKPQLELIRNHEFQKVIGCCLSKNPEERPTVDQL |.. . .| .||||.| | | |||||| .... | |. | . . . .. . .. ...| | ..|..|||..|. CEYDGERKKTLCGTPNYIAPEVLNKKGHS-FEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQV LNMAIF ||. | LNDEFF |
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TyrKc | 87050.m00035.AA | TyrKc | 14-255 | 19 | 2.2e-10 | -54.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-255 Range on HMM: 1-280/280 Sequence Identity: 19% (56 aa) IIIKDIVDADEHMVVYL-VYDPHYETHFALKVIPENRFRQ---SEINLMNEI--DDPSIVRMYNYEHYE-------GFIYILYEFCQA-SLYSIIKQKNY | ... . .||. ... . | |.. |. |. .|...| .. . | |||.| . . . ..|. |.. .| . .. . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP -LDGDNLIRYSCGILKAIQACQNNKIAHLDIKPENILLDDYDRIKICDFGLSIKYENKD-----TELHY-----GGS--IPF--IAPEILDMKPYNPFKA | . |. .. | . . ... | |. |.|... ..||.||||| . ...| .. || .| ||| .. . .. .| KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKS DIWSIGVTFF-VMATGFFPWIG-----ADETELCQNTLHK----KPQL--ELI----RNHEFQKVIGCCLSKNPEERPTVDQLLNMA |.|| ||. . .. | |. | . .|. .. . .|. . . | ... .| .||.||| .. DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 87050.m00035.AA | CMGC | 237-257 | 33 | 0.006425 | 4.39 | In-house | 493-513 (513) | Show / Hide |
Range on Protein: 237-257 Range on HMM: 493-513/513 Sequence Identity: 33% (7 aa) CLSKNPEERPTVDQLLNMAIF .| .|..|.|..| |.. | MLQYDPDKRITAEQALQHPYF |
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Kinase | 87050.m00035.AA | MARK | 27-70 | 21 | 0.024717 | 3.63 | In-house | 14-65 (262) | Show / Hide |
Range on Protein: 27-70 Range on HMM: 14-65/262 Sequence Identity: 21% (11 aa) VVYLVYDPHYETHFALKVIP-------EN-RFRQSEINLMNEIDDPSIVRMY .|.|. . |.....|.|... .. . ..||..| .| | |.... KVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLF |