Gene 81616.m00138 (T.vaginalis)
81616.m00138
Species: T.vaginalis
Alias: TvagK0727, 81616.m00138
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 81616.m00138.AA | Protein | None | 1048 | None | Fasta, JSON |
| 81616.m00138.kin_dom | Protein Kinase Domain | None | 232 | None | Fasta, JSON |
Protein domains of 81616.m00138.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 81616.m00138.AA | STE | 22-255 | 23 | 6.4e-60 | 205.38 | In-house | 15-359 (359) | Show / Hide |
Range on Protein: 22-255
Range on HMM: 15-359/359
Sequence Identity: 23% (81 aa)
VVKALSKT---------------SGKFFAMKYFPAES------------LKNI---EKKTIYRLINVLSSLY--HPHITYINEIMYKANP-----DEAFI
|.||. . .|...|.| . |. |.|. |.. | . |.... . ||.| .| .. || .|
VYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWI
ALEWCDGSSVKNTLD-RFST-------------LPEKLVGRYTYEIIKG-LEFLHSQGQVHKNLKAANLLLASGVLKLSDFGLSAEVST-----------
..|..|| |. .. .... .||.........|.|| |..|||.. .| .|.|| || ||.|||... ..
CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNII
---CSISEH-------PYWAAPEVIES------RTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKIL----------------NETPPIP-----
..... | | |||||. . |.|||| | ||||..|||||.....| .| |. .. ||.|
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQ
--------------AKASAHLQDFLCACFAKNPDERPSTEECYN--FFFV
| | ...||. |. |.|..||.... . |.
NEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | 81616.m00138.AA | S_TKc | 22-255 | 26 | 1.5e-47 | 165.19 | SMART | 15-231 (231) | Show / Hide |
Range on Protein: 22-255 Range on HMM: 15-231/231 Sequence Identity: 26% (65 aa) VVKALSKTSGKFFAMKYFPAESLKNIEKKTIYRLINVLSSLYHPHITYINEIMYKANPDEAFIALEWCDG--SSVKNTLDRFST------LPEKLVGRYT | |. | .|. .|.| . ..|.| |..|.. ||.| . .... |. .. .| ||| ... ... . .|| . .|. VYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYM YEIIKGLEFLHSQGQVHKNLKAANLLLASGVLKLSDFGLSAEVSTCSISEHPYWAAPEVIESRTFSN-KSDIWSMGATIIELLTGKPPFAELPPEEARIK |.|...||..||.| .| || .|.|| . ..|..||||.... .. |.. ||||. .. |.|.|| | ...|.|.|.||| ... .| YQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFK ILNETPPIPAKASAHLQDFLCACFAKNPDERPSTEECYN-------FFFV .. | . ||.. |. |.|..||. |. . .. KIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 81616.m00138.AA | STE11 | 86-248 | 32 | 6.3e-46 | 158.9 | In-house | 92-296 (303) | Show / Hide |
Range on Protein: 86-248 Range on HMM: 92-296/303 Sequence Identity: 32% (67 aa) LEWCDGSSVKNTLD-RFST--LPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLAS-GV-LKLSDFGLSAEVS-TCSISEH--------------P .|.| | |.. |. .. . ..|... .|| | .|| .|||.| .|. .|.||.|| | |. .||.||| . .. |. ... | MEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTP Y--------WAAPEVIESRT---FSNKSDIWSMGATIIELLTGKPPFAELP--PEEARIKIL---NETPPIPAKAS------AHLQDFLCACFAKNPDER | | ||||| . . |.|||| |.|.|| .|||||.... . | || . .|||| . | ....||| || ..| .| YNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKR PSTEE |. . PTANQ |
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| Kinase | 81616.m00138.AA | STE20 | 56-255 | 28 | 5.6e-42 | 145.78 | In-house | 55-288 (288) | Show / Hide |
Range on Protein: 56-255 Range on HMM: 55-288/288 Sequence Identity: 28% (67 aa) INVLSSLYHPHITYINEIMYKANP--DEAFIALEWCDGSSVKNTLDRFS---------TLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLASG- |.... . ||.|. . .| .. || .|. | |.| |. .... .. |. . ..|. .||..|||....| .||.| || . ISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDG VLKLSDFGLSAEVST------C----SISEHPYWAAPEVIES-----RTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKIL--NETPP---I--P ||.|||..| ... .. ||| |||||. .|.|||| | |.||...|.||.....| | .|. .. || | EVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKP AKASAHLQDFLCACFAKNPDERPSTEECYNFFFV | | ...||. | |.|..||.... . |. HKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | 81616.m00138.AA | Dicty2 | 22-245 | 35 | 1.3e-40 | 139.2 | In-house | 16-254 (264) | Show / Hide |
Range on Protein: 22-245 Range on HMM: 16-254/264 Sequence Identity: 35% (85 aa) VVKALSKTSGKFFAMKYFP-AESLKNIEKKTI---YRLINVLSSLYHPHI-TYINEIMYKANPDEAFIALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEI | |.| ...| | | | . ...| .. . |. | | |. | .|| | ... |.|| . | . .| ..|| |. .| | . VYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENH---LYIILEYIENGSLSKIIKKFGCFPESLCCIYIYQV IKGLEFLHSQGQVHKNLKAANLLLA----SGVLKLSDFGLSAEVS------TCSISEHPYWAAPEVIESRT--FSNKSDIWSMGATIIELLTGKPPFAEL |||. ||.|| .| ||||.| ||| ||.||| ... .. ||| |||||. . ..|||| | |||||||| || | LKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRYTVVGTPYWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDL PPEEARIKILNE-TPPIPAKASAHLQDFLCACFAKNPDERPS | | .. .. ||.| |. . ||| .|| | | .|.. NPMHAMFRMVQDDHPPLPNDISPECKDFLMQCFCKDPNQRMT |
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| Kinase | 81616.m00138.AA | Pkinase | 22-253 | 24 | 2.2e-40 | 143.87 | Pfam | 15-293 (293) | Show / Hide |
Range on Protein: 22-253 Range on HMM: 15-293/293 Sequence Identity: 24% (69 aa) VVKALSKTSGKFFAMKYFPAESLKNIEKKTIYR--LINVLSSLYHPHITYINEIMYKANPDEAFIALEWCDGS----SVKNTLD-----RFSTLPEKLVG | |. | .|| .|.| .. .. | ...| | | .. .| ||.| . .... .|. . .|.|.| . . . .|. ..|. . VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECK RYTYEIIKGLEFLHSQGQVHKNLKAANLLLA-SGVL----KLSDFGLSAEVSTCSISEH------PYWAAPEVIE-SRTFSNKSDIWSMGATIIELLTGK .| |.|..|||..||.| .| || .|.|. |.. |..||||.. ... . | |...||||| .. . |.|.||.| ...|.|.|. FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR PPFAEL---PPEEARIKILNETPPIPAKAS-------------------------AHLQDFLCACFAKNPDERPSTEECYNF--F ||| . .. ....... . | . . ..||.. |..|.| .||. |.. . | PPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 81616.m00138.AA | STE-Unique | 84-255 | 22 | 5.4e-40 | 139.18 | In-house | 371-616 (616) | Show / Hide |
Range on Protein: 84-255
Range on HMM: 371-616/616
Sequence Identity: 22% (56 aa)
IALEWCDGSSVKNTLDRFST---------LPEKLVGRYTYEIIKGLEFLHSQG--QVHKNLKAANLLLAS-G-----VLKLSDFGLSAEVSTC-------
| .| |...... ..| .. .|| .| .|||.| .|||.||||. .| .||..| .... | |..|||.. . .
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNN
------------------------------------SISEHPYWAAPEVIESR-----TFSNKSDIWSMGATIIELLTGKPPFAELPPEEA--RIKILNE
.. | . .||||. | .. |.|||| |........| ||. .. . .| . |..
SKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHIH
TPPI-------PAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV
..| | | . .|.|. .|. .|| |||... |.
CQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
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| Kinase | 81616.m00138.AA | CAMK | 22-255 | 14 | 4.7e-38 | 119.7 | In-house | 10-425 (425) | Show / Hide |
Range on Protein: 22-255 Range on HMM: 10-425/425 Sequence Identity: 14% (62 aa) VVKALSK-TSG-----------KFFAMKYFPAESLKNIE--------------------------KKTIYRLINVLSS-------LYHPHITYINEIMYK | .. | | | . .|.| . . ||. . .| ..| |..... | ||.| . |.. VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED AN-----------------PDEAFIAL---EWCDGS----SVKNTLDRF---------------STLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAAN .. ... .. . | |.| . . . . ..|. . || |. .....||.. || || | PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPEN LLLAS------------------GVLKLSDFGLSAEVS----------------------------TCSISEHPYWAA-PEVIES-------------RT .|| . . .|..|||..... |. .| |||... .. ILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKP F-SNKSDIWSMGATIIELLTGKPPFAELPPEEARI-------------KILNETPP-IPAK-----------------------ASAHLQDFLCACFAKN . |.|.||.| .|.|.||| . .| . ||.. .| . |. .|... . .. YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVD PDERPSTEECYNFFFV |..|.. |.| | .. PEKRMTIEQCLNHPWM |
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| Kinase | 81616.m00138.AA | TKL | 27-253 | 18 | 1.9e-36 | 127.42 | In-house | 23-364 (364) | Show / Hide |
Range on Protein: 27-253
Range on HMM: 23-364/364
Sequence Identity: 18% (64 aa)
SKTSGKFFAMKYFPAESLKNIEK-------------------------KTIYRLINVLSSLYHPHITYINE---------IMYK--ANPDEAFIALEWCD
| .|| |.| |. .. .. .| ... . |...|.| ||.| . .... .. . .| |.|.
S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCP
GSS-VKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQG--------QVHKNLKAANLLLAS-GV--------------LKLSDFGLSAEVS---------
| | . . . | ..| .|...|||.. .| .|| .|.|. . . .|..||||| ..|
GGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM
---------------TCSISEHPYWAAPEVIESR----------------TFSNKSDIWSMGATIIELLTGKPPFAELPPE---------EARIKIL--N
|... .|.| ||||.. ..| |.|..|.| . |.||...|....|.. | ... .
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKG
ETPPIP------------AKASAHLQDFLCACFAKNPDERPSTEECYNFF
. |||| . .. . . | . .|..||| .|. .
LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 81616.m00138.AA | MEKK2 | 84-255 | 38 | 5.6e-36 | 125.86 | In-house | 80-262 (262) | Show / Hide |
Range on Protein: 84-255 Range on HMM: 80-262/262 Sequence Identity: 38% (71 aa) IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLL-ASGVLKLSDFGLSAEVSTC--------SISEHPYWAAPEVIE | .|. | ||| | . | |. .|| |. |...||.. ||. .| ||.| .|| .||.||| | . | |. ||| .||||. IFMEYMPGGSVKDQLKAYGALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVIN SRTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKILNET--PPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV . | |.||.| |..|.|| |||.|| | || . | .| . | | ||| || . .||| || || GEGYGRKADVWSIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV |
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| Kinase | 81616.m00138.AA | MEKK15 | 84-255 | 31 | 5.7e-36 | 125.82 | In-house | 78-264 (264) | Show / Hide |
Range on Protein: 84-255 Range on HMM: 78-264/264 Sequence Identity: 31% (59 aa) IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLAS-GVLKLSDFGLSAEVSTC-----------SISEHPYWAAPE | ... | |. . || |.| .|| |..| ..|| ||. .| .|..| . |..|| ||| .. |. ||| ||| IFMQFVPGGSISSIINRFGPLDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPE VIESRTFSNKSDIWSMGATIIELLTGKPPFAELPPEEARIKILNE---TPPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFFFV || . ||||||.| |. |. |.|||.|.... | | . |..|.| | ..| .| . .|||. . |. VIMETGYGRKSDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI |
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| Kinase | 81616.m00138.AA | STE11-Unclassified | 84-248 | 28 | 4.6e-35 | 121.72 | In-house | 84-301 (308) | Show / Hide |
Range on Protein: 84-248
Range on HMM: 84-301/308
Sequence Identity: 28% (63 aa)
IALEWCDGSSVKNTLDRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLL-ASGVLKLSDFGLSAEVS----------------TCSIS-EH-
| .| . | |. |... . |.. || .|..||..|||.| .|. .|.||.|. . |. ||.|||.. .. .|. .
IFMEYMPGGSIWSMLNKYGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHIN
------------PY---WAAPEVIE---SRTFSNKSDIWSMGATIIELLTGKPPFAEL----PPEEAR-IKILNETPPIPAKAS-----------AHLQD
|| | |||||. . . |||||| | |.|| |||.|.. . .. ... | . |..|.|| . | . ..|
SQQNHCKSMQGTPYQPFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKD
FLCACFAKNPDERPSTEE
|| .|| .| .||.. .
FLRKCFQIDPKKRPTANQ
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| Kinase | 81616.m00138.AA | Pkinase_Tyr | 118-253 | 29 | 1.8e-23 | 80.14 | Pfam | 122-270 (270) | Show / Hide |
Range on Protein: 118-253 Range on HMM: 122-270/270 Sequence Identity: 29% (44 aa) KGLEFLHSQGQVHKNLKAANLLLA-SGVLKLSDFGLSAEV-------STCSISEHPY-WAAPEVIESRTFSNKSDIWSMGATIIELLT-GKPP-FAELPP ||.|.|.|.. .| | | | |.. ..| | .||||. . . . . | | |||.| . |. |||.|| | .. |..| |. | ...... KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN EEARIKIL--NETPPIPAKASAHLQDFLCACFAKNPDERPSTEECYNFF || .| .. |.| .... . | .. | ...|..||. .|..... EEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| TyrKc | 81616.m00138.AA | TyrKc | 7-253 | 20 | 3.2e-15 | 23.38 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-253 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) YVFSEKIPEDCNRPMVVKALSKTSGKFFAMKYFPAESLKNIEKKTIYRLINVLSSL--YHPHITYINEIMYKANP-------DEAFIALEWCDGSSVKNT .. .|. .. |.|. | | | ... .. ..| ......| ||.| .. . . . . .| .| ... . |. ITLGKKL-GEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY L-DRFSTLPEKLVGRYTYEIIKGLEFLHSQGQVHKNLKAANLLLASGV-LKLSDFGLSAEVSTC--------SISE-----HP-----YWAAPEVIESRT | .. .|. | . . | .| |.|||.. .| | | | |.... | |||||| .. .. | |||.| .. LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK FSNKSDIWSMGATIIELLT-GKPPFAE-----LPPEEARIKILNE-TPPIPAK--------ASAHLQDFLCACFAKNPDERPSTEECYNFF |. |||.|| | .. |..| |..| . ....|.. .. . .|.|. ... . . | . .|..||. .|.. .| FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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