Gene 91714.m00087 (T.vaginalis)

91714.m00087

Species: T.vaginalis
Alias: TvagK0817, 91714.m00087
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI3K

Sequence

Name Sequence Type Origin Length Description Download
91714.m00087.AA Protein None 817 None Fasta, JSON
91714.m00087.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of 91714.m00087.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Ka 91714.m00087.AA PI3Ka 292-477 21 9.8e-28 99.38 SMART 1-232 (232) Show / Hide 
Range on Protein: 292-477
Range on HMM: 1-232/232
Sequence Identity: 21% (50 aa)

AKSSLLK-ESNITETLNKIKALPPLTELLTIQKTHLY-NNYYHCLTDPGLMP-----ALFRSVNWESDEESRDIVNALKTR--EPIDVEYALEFFTSRYN
.. .     ... . |  | ..||..|| . .| ...   .|.. . |  .|      ..|.|||.  .|  .    ..    .|||.| |||.. ....
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

I---SVVRSYAVRCIRSVPREELLLYLPQLIQAVK--A-------------------------PYTDG-LGDILIDHAKSDIIFASNFYW--IAQI---E
     .||.|||.|... . .|||.||.||.||.|  .                         || |. |.. |.. | ... ... |||   . .   .
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDHC

RDTDKSIGQLVDKLYKSLNEDI-RTQIDSQIS
.. |... |  . |. .. . .  ...   . 
QLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
PI3Ka 91714.m00087.AA PI3Ka 294-441 25 1.1e-20 72.69 Pfam 1-169 (211) Show / Hide 
Range on Protein: 294-441
Range on HMM: 1-169/211
Sequence Identity: 25% (43 aa)

SSLLK-ESNITETLNKIKALPPLTELLTIQKTHLYNNY-YHCL-TDPGLMP------ALFR-SVNWESDEESRDIVNALKT--REPIDVEYALEFFTSRY
 .| .  ... . |..| ...||..|   .|  ..    | |. . |  .|       ... .|.| . ... .   ...    .|||.. ||| . . .
KDLKPVNNKERKQLEQIIKYDPLSQLTAEEKCLIWKFRHY-CCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNF

NI--SVVRSYAVRCIRS-VPREELLLYLPQLIQAVK-A----PYTDG-LGDILIDHAKSDI-IFASNFYW
    . ||.|||.|..|  . .|||.||.|| ||.|      |. |. |  .|.. |.. . .... |.|
PDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFW
Kinase 91714.m00087.AA PI3Kc 563-807 20 1.4e-45 158.68 SMART 1-336 (336) Show / Hide 
Range on Protein: 563-807
Range on HMM: 1-336/336
Sequence Identity: 20% (68 aa)

RVIFKIGDDMRQDQLILQLFSVMDNIFKRA----SMQLNITAYKTLAFSPTFGCCQFIDNSKAILNIA--------------------------------
.|||| |||.|||....|.|..|..| ..      . | .. || .. .|  |  ... |.. . .|                                 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--------------------------------NEEKSIKKYLMADNKPIG----PKIELFTESLAAYSVMTYVLKIGDRHDNNILVT-RDGHLLHIDYGF
                                . . .......  ..  .      .. || |.|.|...||.| ||||| .||...  .||..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

ILGDVTKPFTP--------PLKLSREMVDTI-------DPENGLQKICDWACPAFNSLRKRARLILVLIELMFTAPL-ECFQQNPMRRLSQVENSLLLN-
|.|   |....        | .| ..||. .       . .   ...|   | |.. .|| . ||. |.|.|  .|.  |.. .   .. ...... |. 
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCC---CRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDH

CTEIEAINSLQA-----TFSESLSSKMQVLWDVVHSVAVS
 .. ||..  ..       ..|..|.   . .. | .|  
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 91714.m00087.AA PI3_PI4_kinase 561-756 18 1.7e-40 145.63 Pfam 1-300 (300) Show / Hide 
Range on Protein: 561-756
Range on HMM: 1-300/300
Sequence Identity: 18% (55 aa)

SYRVIFKIGDDMR--QDQLILQLF-----------------------SVMDNIFKRASMQLN----ITAYKTLAFSPTFGCCQFIDNSKAILNIANEE--
 |..||| |||.|  ||....|..                       ..|... |  .. ..    ...|. .. .|  |  ....|.  . .|  .   
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

------------------------------------------KSIKKYLMADNKPI----GPKIELFTESLAAYSVMTYVLKIGDRHDNNILV---TRDG
                                           .. ....  |.      .  .. |..|.| ..|..|.| .|||| .||.|   . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HLLHIDYGFILG-----DVTKPFTPPLKLSR------EMVDTI------DPENGLQKICDWACPAFNSLRKRARLILVLI-------ELMFTAPLECFQQ
|| |||.|....        ||...| .. .      .||. .      ||    .. .|  . |...||. ..|.. |.       |.|....| ..  
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase 91714.m00087.AA PIKK 531-611 28 4.8e-09 29.44 In-house 1-84 (290) Show / Hide 
Range on Protein: 531-611
Range on HMM: 1-84/290
Sequence Identity: 28% (24 aa)

VVNGVDPDDVKVFQSKLRPACICFKRADGGSYRVIFKIGDDMRQDQLILQLFSVMDNIFKRA----SMQLNITAYKTLAFSPTFG
 . . | . | |  .| .|  | ..  || .|.  .| ..| |||| ..|||..| ... .     .  |.|. |.  . |.  |
RIRFMD-RMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCG
Kinase 91714.m00087.AA PIKK 650-696 33 2.7e-08 26.7 In-house 189-236 (290) Show / Hide 
Range on Protein: 650-696
Range on HMM: 189-236/290
Sequence Identity: 33% (16 aa)

FTESLAAYSVMTYVLKIGDRHDNNILVTRD-GHLLHIDYGFILGDVTK
.| |.|  ..  |.| .|||| .||.. .. | ..|||.|.. .. ..
YTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQ
Kinase 91714.m00087.AA DNAPK 530-589 41 7.2e-08 24.52 In-house 2-60 (301) Show / Hide 
Range on Protein: 530-589
Range on HMM: 2-60/301
Sequence Identity: 41% (25 aa)

VVVNGVDPDDVKVFQSKLRPACICFKRADGGSYRVIFKIGDDMRQDQLILQLFSVMDNIF
| . | | . | |  |  ||  |  .  |      ..| . |.|||| | ||| || |||
VRIAGFD-ERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIF
Kinase 91714.m00087.AA ATR 653-714 31 8.1e-08 22.26 In-house 170-235 (267) Show / Hide 
Range on Protein: 653-714
Range on HMM: 170-235/267
Sequence Identity: 31% (21 aa)

SLAAYSVMTYVLKIGDRHDNNILVTR-DGHLLHIDYGFILGD---VTKPFTPPLKLSREMVDTIDP
| |..... |.. .|||| .|||. .  | . |.||  | .    .  | . | .| . || .. |
SYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGP
Kinase 91714.m00087.AA FRAP 650-688 47 8.4e-08 24.9 In-house 140-179 (251) Show / Hide 
Range on Protein: 650-688
Range on HMM: 140-179/251
Sequence Identity: 47% (19 aa)

FTESLAAYSVMTYVLKIGDRHDNNILVTRD-GHLLHIDYG
.| |||  |.  |.| .||||  ||.  |  | ..|||.|
YTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase 91714.m00087.AA ATM 650-710 41 4.3e-07 18.27 In-house 140-204 (304) Show / Hide 
Range on Protein: 650-710
Range on HMM: 140-204/304
Sequence Identity: 41% (27 aa)

FTESLAAYSVMTYVLKIGDRHDNNILVT-RDGHLLHIDYG--FILGDV-TKPFTPPLKLSREMVD
.| | |  |.. |.| .||||  |||.      | ||| |  |  | .   | | | .| |..||
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVD
Kinase 91714.m00087.AA SMG1 540-589 30 0.00013 11.03 In-house 1-50 (242) Show / Hide 
Range on Protein: 540-589
Range on HMM: 1-50/242
Sequence Identity: 30% (15 aa)

VKVFQSKLRPACICFKRADGGSYRVIFKIGDDMRQDQLILQLFSVMDNIF
. .   | .|  . |  .|| ||  .||  .|.  |  |.|  |... .|
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMF
Kinase 91714.m00087.AA ATR 530-575 34 0.001727 7.27 In-house 1-45 (267) Show / Hide 
Range on Protein: 530-575
Range on HMM: 1-45/267
Sequence Identity: 34% (16 aa)

VVVNGVDPDDVKVFQSKLRPACICFKRADGGSYRVIFKIGDDMRQD
  . | | | |... |  .|  | .| .||  | .. |  ||.|.|
AYIAGFD-DMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKD
Kinase 91714.m00087.AA SMG1 653-687 41 0.009946 4.69 In-house 193-228 (242) Show / Hide 
Range on Protein: 653-687
Range on HMM: 193-228/242
Sequence Identity: 41% (15 aa)

SLAAYSVMTYVLKIGDRHDNNILV-TRDGHLLHIDY
| |  |.. |.. .||||  |.|.    |   ||||
STAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 91714.m00087.AA DNAPK 662-692 43 0.036592 3.45 In-house 202-233 (301) Show / Hide 
Range on Protein: 662-692
Range on HMM: 202-233/301
Sequence Identity: 43% (14 aa)

YVLKIGDRHDNNILVT-RDGHLLHIDYGFILG
..| ||||| || .|    |    ||.|.  |
WILGIGDRHLNNFMVNMENGDIISIDFGHSFG
Kinase 91714.m00087.AA ATM 563-591 34 0.048235 1.86 In-house 1-29 (304) Show / Hide 
Range on Protein: 563-591
Range on HMM: 1-29/304
Sequence Identity: 34% (10 aa)

RVIFKIGDDMRQDQLILQLFSVMDNIFKR
| . |  ||.|||  . | | .   . .|
RQLVKGRDDLRQDAVMQQVFQMCNTLLQR
Kinase 91714.m00087.AA FRAP 562-582 42 0.148875 1.66 In-house 2-22 (251) Show / Hide 
Range on Protein: 562-582
Range on HMM: 2-22/251
Sequence Identity: 42% (9 aa)

YRVIFKIGDDMRQDQLILQLF
|  . |  .|.|||  ..|||
YHFLLKGHEDIRQDERVMQLF