Gene 87363.m00201 (T.vaginalis)

87363.m00201

Species: T.vaginalis
Alias: 87363.m00201, TvagK0625
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
87363.m00201.AA Protein None 2178 None Fasta, JSON
87363.m00201.kin_dom Protein Kinase Domain None 233 None Fasta, JSON

Protein domain

Protein domains of 87363.m00201.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 87363.m00201.AA FRAP 1871-2122 46 6e-99 335.04 In-house 1-251 (251) Show / Hide 
Range on Protein: 1871-2122
Range on HMM: 1-251/251
Sequence Identity: 46% (118 aa)

NYKFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDGCDTFYNLVAEYRISHNLKPNHEQDILFNLSVDDANKLT
 | ||||| ||.| | |||| | |||  .. .      | |.. |||.|||.. ||| ||  |||   |. .||  .... | |   ... .. | ..|.
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE-YNIMDRMCNDYDHLP

PMQRLEVHKEIRQIVDGGDLRKVFWLKSPSSEAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDFGDSFDVARNRVLFSEMIPFRL
 |.. |. . | .   | ||.|. |||||.|| |.||   | || | ||..||||||||||||| |..| .| ..|||||| |.||  |  | | |||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMVSSAFGLCGIEGEFYPVSVRVMMLIRENCNSLISVLEIFVQEPIEEGEA
|||   |   ||||| .  ..  ||  |||. .|.. ||| ||  |.     
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 87363.m00201.AA PIKK 1842-2112 36 9.9e-97 327.67 In-house 1-290 (290) Show / Hide 
Range on Protein: 1842-2112
Range on HMM: 1-290/290
Sequence Identity: 36% (107 aa)

RIHHFLPKLSVMGSKKRPRRVTIVGNNSQNYKFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDGCDTFYNLVA
||  . . . || .|..|.. .| | .   | .|.|| ||||.||||||.|.|.|   ..|   .  . . | ||..|.|.. |||.|||.|.|   .  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRISHNLKPNHE----------QDILFNLS---------VDDANKLTPMQRLEVHKEIRQIVDGGDLRKVFWLKSPSSEAWLERTSKYARSTALMSIVG
...   . . . |          .|.|  .|           . .... ....||  |. | . . ...| ||.|.|..|.|.||.. |.||.|.|..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNFMIDRNSGDVIHIDFGDSFDVARNRVLFSEMIPFRLTRMVSSAFGLCGIEGEFYPVSVRVMMLIRENCNSLISVLEIF
||||||||||.|.|||. .|...|||||..| .|  |  . | .||||||. . | | .|.|| |.   . |||..|.. ..|..|.| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 87363.m00201.AA PI3Kc 1873-2171 24 1.2e-62 215.32 SMART 1-336 (336) Show / Hide 
Range on Protein: 1873-2171
Range on HMM: 1-336/336
Sequence Identity: 24% (83 aa)

KFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDGCDTFYNLVAEYRISHNLKPNHEQDILFN-LSV--------
 ...|...||| |.|.||.|||.|   ..|.  .  .. .| |...|.. . |.|.||  |.|. ..  .|.   .. .. .|.. |. | |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

---------DDANKLTPMQRLEVHKEIRQIVD---GGDLRKVFWLKSPSS-EAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDFG
         ...   ..| ..|  | ..  ..   . .|.. || ..|.. |.| |. . ..||.| ...|.||||.||||..|.|.|...| ..|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DSFDVARNRVLFS----EMIPFRLTRMVSSAFG----LCGIEGEFYPVSVRVMMLIRENCNSLISVLEIFVQEPI-EEGEAKLHAPDVMKRIRSKIRGN-
. |. .. ...|     |  |||||..   . |      | .|.|.   .|.....|.. |......|..|  ||  .  ..   ..  | .|...| . 
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDH

DFEENVVLPV---------EKQVGRLINEALDEYNLAKLY
  .|..   .         |. .. ..... .. .. . |
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 87363.m00201.AA PI3_PI4_kinase 1871-2117 26 3.8e-62 217.58 Pfam 1-295 (300) Show / Hide 
Range on Protein: 1871-2117
Range on HMM: 1-295/300
Sequence Identity: 26% (77 aa)

NYKFLLKGNEDLR--LDQRVMQFF-----------------------RLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDGCDTFYNLVAEYRI
.|.|..||..|||   |.|.||..                       ||.|   . |  .   | ... |...|.... |.|.||. |.|| ..  .|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

SHNLKPNHEQDILFNLSVDDANKLTPMQRLEVHKEIRQIVDGGDLRKVFWLKSPSS-EAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMI--DRNSG
. . |... ... . ..  |.  |. ||..||  .    . ...|...|| ..|.  |.|.|. . ..|| | |..|.||||.||||..|.|.  |. .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

DVIHIDFGDSFD-VARNRVLFSEMIPFRLTR------MVSSAF------GLCGIEGEFYPVSVRVMMLIRENCNSLISVL-------EIFVQEPI
 ..|||||..|. .. ..  . | .|||.|.      . ..|.      .  | .|.|  . .... ..|.. |.....|       |..|. ..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGL
Kinase 87363.m00201.AA ATR 1999-2112 33 5.2e-29 95.66 In-house 155-267 (267) Show / Hide 
Range on Protein: 1999-2112
Range on HMM: 155-267/267
Sequence Identity: 33% (38 aa)

PSSEAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDFGDSFDVARNRVLFSEMIPFRLTRMVSSAFGLCGIEGEFYPVSVRVMMLI
| .. |    . | ||.| ...||||.||||||  | .||.  |...|.|.   |   . ..   |..|||||. .  ..|  . .| |    . .||..
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGE-QFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM

RENCNSLISVLEIF
|.. . ..||.. |
RDHRDDIMSVWDCF
Kinase 87363.m00201.AA ATM 2004-2117 38 1.8e-24 74.76 In-house 133-245 (304) Show / Hide 
Range on Protein: 2004-2117
Range on HMM: 133-245/304
Sequence Identity: 38% (44 aa)

WLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDFGDSFDVARNRVLFSEMIPFRLTRMVSSAFGLCGIEGEFYPVSVRVMMLIRENCN
| |.   | || |  |||||||||||||  | .|   | ...||| |  |.  .  .   | .|||||| .    |. |.|| |     . |  .|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGK-ILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SLISVLEIFVQEPI
 |. . |. . .|.
TLLTIVEVLLYDPL
Kinase 87363.m00201.AA DNAPK 1998-2116 36 1.5e-22 78.77 In-house 177-295 (301) Show / Hide 
Range on Protein: 1998-2116
Range on HMM: 177-295/301
Sequence Identity: 36% (43 aa)

SPSSEAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDFGDSFDVARNRVLFSEMIPFRLTRMVSSAFGLCGIEGEFYPVSVRVMML
| . |..|   ....|. |.  | ..||| ||||  |||.    ||.| |||| ||  |       |. ||||||         .| | .| . .  || 
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

IRENCNSLISVLEIFVQEP
.|   | |.   ..|...|
FRKDRNILTNFCDVFINDP
Kinase 87363.m00201.AA DNAPK 1841-1931 39 3.5e-21 73.7 In-house 2-92 (301) Show / Hide 
Range on Protein: 1841-1931
Range on HMM: 2-92/301
Sequence Identity: 39% (36 aa)

VRIHHFLPKLSVMGSKKRPRRVTIVGNNSQNYKFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVD
|||  |  .  || | .||.|. | |       |. || ||||.|||. | |   |  .  |   .      | |.|.|.    ||| |||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase 87363.m00201.AA SMG1 1990-2049 51 5.2e-18 56.11 In-house 169-228 (242) Show / Hide 
Range on Protein: 1990-2049
Range on HMM: 169-228/242
Sequence Identity: 51% (31 aa)

LRKVFWLKSPSSEAWLERTSKYARSTALMSIVGYILGLGDRHPSNFMIDRNSGDVIHIDF
| |  |      . |   |  |||||| ||.||||.||||||  | .||   |.|.|||.
LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 87363.m00201.AA SMG1 1850-1932 37 5.9e-18 55.94 In-house 1-83 (242) Show / Hide 
Range on Protein: 1850-1932
Range on HMM: 1-83/242
Sequence Identity: 37% (31 aa)

LSVMGSKKRPRRVTIVGNNSQNYKFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDG
. ..  | .|...  .|   . | .| || ||| || |.|||  ..|                | ||. || |  ||||||||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDG
Kinase 87363.m00201.AA FATC 2146-2178 54 1.1e-15 53.28 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2146-2178
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

VVLPVEKQVGRLINEALDEYNLAKLYSGWKPLW
. |.|| || |||.|| |..||...|.|| | |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 87363.m00201.AA ATR 1841-1931 28 2.3e-13 41.45 In-house 1-91 (267) Show / Hide 
Range on Protein: 1841-1931
Range on HMM: 1-91/267
Sequence Identity: 28% (26 aa)

VRIHHFLPKLSVMGSKKRPRRVTIVGNNSQNYKFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVD
  |  |   . .. | ..|..... | . . |  . |  .||| | | |.|  |||   |.|         .| |...||  . ..| ||.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVN
Kinase 87363.m00201.AA ATM 1873-1932 31 4.1e-07 18.35 In-house 1-60 (304) Show / Hide 
Range on Protein: 1873-1932
Range on HMM: 1-60/304
Sequence Identity: 31% (19 aa)

KFLLKGNEDLRLDQRVMQFFRLINAQIRRDISLSIDNVSVRCYSIVPLSTEVGLIQWVDG
. | || .||| |  . | | . |  . |        . .  | .||||   | . |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG