Gene 96098.m00089 (T.vaginalis)

96098.m00089

Species: T.vaginalis
Alias: TvagK0252, 96098.m00089
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
96098.m00089.AA Protein None 315 None Fasta, JSON
96098.m00089.kin_dom Protein Kinase Domain None 244 None Fasta, JSON

Protein domain

Protein domains of 96098.m00089.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 96098.m00089.AA S_TKc 15-258 26 3e-50 174.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-258
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

VMYQDLITHLSRGVIYQVYSPNYKMSFALKTIPEDMLSESELRCLEAIDDPNIVSLYQIYKFQGFSYLMMEYCPK---DLDTLLKEKRS------IRGEE
    ..| . . |. |...  . .  .|.| |.     ..|...|.  . |||| || ..   .. |. ||||.    || ...|....      .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

LCNMLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYNRVKINDFSKSVILTDPPLTSQREGTKLYQAPEIFSEKEYNPVKADIWSLGVLMFYMTTNTYPFQ
 . ..  . . .  ||..|| |.|.||.| |.|.  ..|| ||  . .|      .   ||  | |||..    |.. |.|.||.|.... | .   ||.
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

ADDPYTTIEKIQSGIYNENKISDPQLRFVIRKCLDIDPNSRPDALDLLQ-------MPYF
  .......||           .|...  |||||. ||. || | ..||       .|.|
--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96098.m00089.AA Pkinase 27-258 23 4.4e-46 164.04 Pfam 13-293 (293) Show / Hide 
Range on Protein: 27-258
Range on HMM: 13-293/293
Sequence Identity: 23% (67 aa)

GVIYQVYSPNYKMSFALKTIPEDMLSE---------SELRCLEAIDDPNIVSLYQIYKFQGFSYLMMEYCPK-----DLDTLLK--EKRSI--RGEELCN
|. |. .  ..   .|.|.|. .  ..         ||.. .  .. |||| || ..   .  |. ||||..     || ....  .....    .|...
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF

MLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYNRV----KINDFSKSVI--LTDPPLTSQREGTKLYQAPEIFSEKEYNPVKADIWSLGVLMFYMTTNTY
..  . | .  ||..|| |.|.||.|.|.|. . .    || ||  .    .   . .. . ||  | |||.  . .| . |.|.||.|.....| .   
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP

PFQAD------DPYTTIEKIQSGIYNENKISD---------------------PQLRFVIRKCLDIDPNSRPDALDLLQMPYF
||. .      |..  |..| .... ..   .                     . .. .|..||. ||..|| | ..|| |.|
PFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96098.m00089.AA CAMK 20-258 17 2.3e-44 140.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-258
Range on HMM: 1-425/425
Sequence Identity: 17% (73 aa)

LITHLSRGVIYQVYSPNYK------------MSFALKTIP---------------------------------EDMLSESELRCLEA-------IDDPNI
 . . | |. . ..  | .              .| | |.                                      ..|....         .| |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLYQIYKFQGF-------------------SYLMM---EYCPK-----DLDTLLKEK---------------RSIRGEELCNMLFNVTRCVRACHDNGI
..||..|    .                    |. |   |||.      ||   ..|.               . .  .| . .   .   |. ||...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHCDIKPSNFLVDKY-----------------NRVKINDFSKSVILTD------------------------PPLTSQREGTKLYQA-PEIFSE------
.|.|.|| | |.|.                  | .|| ||  . ....                         .. . . ||  | | ||...       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KEYNPVKADIWSLGVLMFYMTTNTYPFQAD-------------DPYTTIEKIQSGIY--NENKISD----------------------PQLRF
       |.| . |.|.||.||... | . ..||..|             ..| . |||..| |   . ..|.                      .. . 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VIRKCLDIDPNSRPDALDLLQMPYF
 |||.|  ||. |. . . |. | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 96098.m00089.AA Ciliate-E2 55-258 21 7.3e-40 134.51 In-house 82-365 (365) Show / Hide 
Range on Protein: 55-258
Range on HMM: 82-365/365
Sequence Identity: 21% (63 aa)

ELRCLEAIDDPNIVSLYQIYK--FQGFSYLMMEYCPK-DLDTLLKEKRSIRG-----------EELCNMLFNVTR---------------CVRACHDNG-
|.. || .. |||. .|  ..   .   || ||||   ||  ..|...  |.           .| ...   ...               ... .| .. 
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN

IAHCDIKPSNFLVDKYNRVKINDFSKSVILTDP-----------PLTSQRE----------------------GTKLYQAPEIFSEKEY--------NPV
| | ||||.| |.     .|| ||  | ...|.            ..  .                       ||  |.||||.. |.|           
IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

KADIWSLGVLMFYMTTNTYPFQADDPYTTIEKIQSGIYN-------------------ENKISDPQLRFVIR---KCLDIDPNSRPD-ALDLLQMPYF
|.|||||||....| .. .||        ...|. . ..                    .|.|.    .  .   ..|. ||. |.. . ..|. |.|
KCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96098.m00089.AA Ciliate-E2-Unclassified 36-258 19 3.1e-36 123.18 In-house 37-352 (352) Show / Hide 
Range on Protein: 36-258
Range on HMM: 37-352/352
Sequence Identity: 19% (62 aa)

NYKMSFALKTIPEDMLSESELRCLE----------------AIDDPNIVSLYQIYKFQGFSYLMMEYC------------------PKDLDTLLKEKRSI
.||.   .. . | |... |. ...                 ...|.|| .. . . .   |. ||||                   .||.  .|... .
IYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIF

RGEELC-----NMLFNVTRCVRACHDNG-IAHCDIKPSNFLVDKYN---RVKINDFSKSVILTD----------------PPLTSQREGTKLYQ----AP
  .. .     ...  .  .   .| .. | | ||||.| |.|. .   ..|| ||. |  . .                . ..... ||  |.    ||
TEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP

EIFSEKEYNP---VKADIWSLGVLMFYMTTNTYPFQADDPYT----------------TIEKIQSGIYNENK--------ISDPQLRFVIR----KCLDI
|.. ...|.     |.|||||||....| ...|||.. . .                  ...|. .... .|        ...|.    |.    |.|. 
EVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKK

DPNSRPDALDLLQMPYF
.||.|... ..|. |.|
NPNKRITFEQILNHPWF
Kinase 96098.m00089.AA CAMKL 120-258 29 1e-34 108.13 In-house 143-297 (297) Show / Hide 
Range on Protein: 120-258
Range on HMM: 143-297/297
Sequence Identity: 29% (46 aa)

CHDNGIAHCDIKPSNFLVDKYN--RVKINDFSKSVILTD-----PPLTSQREGTKLYQAPEIFSE--KEYNPVKADIWSLGVLMFYMTTNTYPFQADD--
||..||.| |||| | |.|. .   .|| ||  | . ..       . . . |.  |.|||||.   |.|.  |.||||.||... | . ..|| .|.  
CHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN

-------PYTTIEKIQSGIYNENKISDPQLRFVIRKCLDIDPNSRPDALDLLQMPYF
        .  ..... . ..  .  . ..|  ||| |  .|. || . .... | .
KQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 96098.m00089.AA ULK 41-258 23 5.6e-34 117.96 In-house 31-324 (324) Show / Hide 
Range on Protein: 41-258
Range on HMM: 31-324/324
Sequence Identity: 23% (69 aa)

FALKTIP-------EDM--------LSESELRCLEAID---DPN--IVSLYQIYKFQ--GFSYLMMEYCPK-DLDTLLK---------EKRSIRGEELCN
.| | |.       . .        | ..| . .  ..    ||  || || ... .   . |..||||.  ||....|         ||. .  .|  .
VACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQ

MLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYN------------RVKINDF--SKSVIL--TDPPLTSQRE------GTKLYQAPEIFS----EKEYNP
 .       .. |...| |.||||.| |. . .            ..|| ||  .|.|     .  .. .        || || ||.|..    .|.|. 
FFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYD

VKADIWSLGVLMFYMTTNTYPFQADDPYTTI----EKIQSG------IYNENKISD---------PQLRFVIRKCLDIDPNSRPDALDLLQMPYF
 |.||||||.....| .. |||... .....    . |. |      |.|..   .         |...  ||..| .|.. | .  .....| |
YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 96098.m00089.AA ULK 65-258 24 4.4e-32 109.32 In-house 78-329 (329) Show / Hide 
Range on Protein: 65-258
Range on HMM: 78-329/329
Sequence Identity: 24% (63 aa)

PNIVSLYQIYKFQGF--SYLMMEYCPK-DLDTLLK----------EKRSIRGEELCNMLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYN----------
|||| || ... . .   |..||||.  ||....|          ||. .  .|  . .       .. |...| |.||||.| |... .          
PNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP

--RVKINDF--SKSVILT--DPPLTSQRE------GTKLYQAPEIFS----EKEYNPVKADIWSLGVLMFYMTTNTYPFQADDPYTTI-----EKIQSG-
  ..|| ||  .|.|     .  ..          || || ||.|..    .|.|.  |.||||||.....| .. .||.|  .....     . |. . 
NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPP

-----IYNENKI---------SDPQLRFVIRKCLDIDPNSRPDALDLLQMPYF
     | ...             |...  ||..| .|.. | .  .|...| |
PWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 96098.m00089.AA GIN4 53-258 30 5.1e-30 92.73 In-house 82-293 (293) Show / Hide 
Range on Protein: 53-258
Range on HMM: 82-293/293
Sequence Identity: 30% (65 aa)

ESELRCLEAIDDPNIVSLYQIYKFQGFSYLMMEYCPK-DLDTLLKEKRSIRGEELCNMLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYNR-VKINDFSK
| |.  .  |. ||...||...  .   ||..||  | .|  .| ..  .   |  ..   .   |  ||  .| | |.|| | |.|. .. .|| ||  
EREIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGM

SVILTDPPLTSQREGTKLYQAPEIFSEKEYNPVKADIWSLGVLMFYMTTNTYPFQAD--DPYTTIEKIQSGIY---NENKISDPQLRFVIRKCLDIDPNS
  . ||  |     |   | |||| .   |.   .|.|| ||..| . |   ||. .     . . |.|.| |   ....||  . . .||| | .||. 
AALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISR-EAQDLIRKILVVDPEK

RPDALDLLQMPYF
|    |.|. |  
RIKTRDILKHPLI
Kinase 96098.m00089.AA MARK 165-258 35 1.2e-23 74.28 In-house 167-262 (262) Show / Hide 
Range on Protein: 165-258
Range on HMM: 167-262/262
Sequence Identity: 35% (34 aa)

GTKLYQAPEIFSEKEYNPVKADIWSLGVLMFYMTTNTYPFQADD--PYTTIEKIQSGIYN-ENKISDPQLRFVIRKCLDIDPNSRPDALDLLQMPYF
||. | |||||. |.|.  |.|||||||....|.. ..|| .|.    .  .||..| |    ..|. ..|  |.. | ..|. ||.. .... | .
GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSK-ECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 96098.m00089.AA CMGC 42-216 15 3.8e-22 68.76 In-house 42-366 (513) Show / Hide 
Range on Protein: 42-216
Range on HMM: 42-366/513
Sequence Identity: 15% (50 aa)

ALKTIP---EDMLSE-------------SELRCLEAI-----------------DDPNIVSLYQIYKFQGFS-----------------YLMMEYCPKDL
|.| |    ..                  |...|. .                 ...|||.|| |... .                   || .||...||
AIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDL

DTLLKEKRS-IRG-------------------EELCNML------FNVTRCVR--ACHDNG--IAHCDIKPSNFLVDKYNRV------------------
  ..|...   .|                   .  ....      . . |..    || ..  | |.|.||.| |... ...                  
YQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNG

--KINDFSKSVILTDPP----------------------LTSQREGTKLYQAPEIFS-EKEYN--------PVKADIWSLGVLMFYMTTN--------TY
  || ||  . .. ...                        ...  |  | ||||    |.|.          . |.||.|  .. | |.         .
RLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP

PFQADDP-----------YTTIEKI
 |. ..            .  ..||
LFPGHSEYPNDDKNGKSHIDQLFKI
Kinase 96098.m00089.AA NEK 165-258 33 1.3e-18 62.48 In-house 186-286 (286) Show / Hide 
Range on Protein: 165-258
Range on HMM: 186-286/286
Sequence Identity: 33% (35 aa)

GTKLYQAPEIFSEKEYNPVKADIWSLGVLMFYMTTN--TYPFQAD--DPYTTIEKIQSG-IYNENKISDP-----QLRFVIRKCLDIDPNSRPDALDLLQ
||  | .||....| ||  |.||||||.. . | |     ||.|.  . .  . ||. |  |  ..|..      .|. .|...|  || .||.. ..|.
GTPYYMSPEVCQNKPYN-NKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQY--PPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILE

MPYF
||. 
MPFI
Kinase 96098.m00089.AA TyrKc 22-256 21 1.8e-11 -37.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-256
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

THLSR-------GVIYQ-VYSPNYKMSFALKTIP----EDMLSESELRCLEAI--DDPNIVSLYQIYKFQ-------GFSYLMMEYCPK-DLDTLLKEKR
 .| .       |..|. ...    .  | |..     ||..  .|.| .  .  . |||| || .   |       .  .. |||.|. ||.  |...|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDAREDFM--REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

S-IRGEELCNMLFNVTRCVRACHDNGIAHCDIKPSNFLVDKYNRVKINDFSKSVILTDP-------PLTSQRE--GTK--L---YQAPEIFSEKEYNPVK
  .  ..|... . . .  .  |.... | |.   | ||.. ..||| ||  |  ..|           ...|  |.|  |     ||| . ...... |
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-K

ADIWSLGVLMFYMTTNTYPFQAD------DPYTTIEKIQSGIYNENKIS---------DPQLRFVIRKCLDIDPNSRPDALDLLQMP
 |.|| ||.|. . |.  .   .      ...  ||....| . .   .          . .  ....| . ||..||   .. .  
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 96098.m00089.AA MARK 120-148 48 6.2e-11 32.15 In-house 120-150 (262) Show / Hide 
Range on Protein: 120-148
Range on HMM: 120-150/262
Sequence Identity: 48% (15 aa)

CHDNGIAHCDIKPSNFLVDKYN--RVKINDF
||...|.|.|||| | |.|. .   .|| ||
CHSKNIVHRDIKPENILIDENGNHNIKIIDF
Kinase 96098.m00089.AA NEK 52-148 27 1e-09 30.78 In-house 50-167 (286) Show / Hide 
Range on Protein: 52-148
Range on HMM: 50-167/286
Sequence Identity: 27% (32 aa)

SE-SELRCLEAIDDPNIVSLYQIYKFQG--FSYLMMEYCPK--DLDTL---LKEKR----SIRGEELCNMLFNVTRCVRACHDN-----GIAHCDIKPSN
.  .| | |. .. ||||. |  .  ..  . .  ||||    ||. .   .|...     .  |.  ....     .. .||.      | | ||||.|
AQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQN

FLVDKYNR----VKINDF
   .| |.    ||| ||
IFLTKNNNDYHNVKIGDF
Kinase 96098.m00089.AA CMGC 224-258 42 9e-09 23.99 In-house 479-513 (513) Show / Hide 
Range on Protein: 224-258
Range on HMM: 479-513/513
Sequence Identity: 42% (15 aa)

NKISDPQLRFVIRKCLDIDPNSRPDALDLLQMPYF
.|  |||..  . |.| .||. |. | . ||.|||
RKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 96098.m00089.AA CAMKL 53-88 26 8.1e-07 17.62 In-house 60-104 (297) Show / Hide 
Range on Protein: 53-88
Range on HMM: 60-104/297
Sequence Identity: 26% (12 aa)

ESELRCLEAID---DPNIVSLYQIYKFQGF------SYLMMEYCP
. | .... ..    |||..||...  . .       || ||||.
RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCS