Gene 97340.m00050 (T.vaginalis)

97340.m00050

Species: T.vaginalis
Alias: TvagK0355, 97340.m00050
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
97340.m00050.AA Protein None 128 None Fasta, JSON
97340.m00050.kin_dom Protein Kinase Domain None 123 None Fasta, JSON

Protein domain

Protein domains of 97340.m00050.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 97340.m00050.AA MLK 2-128 34 1.2e-33 114.13 In-house 67-221 (291) Show / Hide 
Range on Protein: 2-128
Range on HMM: 67-221/291
Sequence Identity: 34% (53 aa)

NHFAVIGLIGV-TQEPP-YYIVSEFMPKENLFKCLHSN--------------IPPTPTQRTIIALGVAIGLSYMHRNN---YIYRDIKSLNILLDA----
||  .| . || .|.|. ..||.|....  |.  ||..              .  .. .   .|| .| |..| | .    .| ||.|| |||.|.    
NHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHD

--DEYPKICDFGISRFVPQSRDLMTGGVGTAQWEAPEVI---NNEPYTEKADVYS
  ..  ||||||.||.. |. . |..  ||. | |||||    .|.|.||.||.|
MHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWS
Kinase 97340.m00050.AA TKL 6-128 27 1.9e-33 117.43 In-house 87-274 (364) Show / Hide 
Range on Protein: 6-128
Range on HMM: 87-274/364
Sequence Identity: 27% (53 aa)

VIGLIGVTQEPP--------------YYIVSEFMPKENLFKCLHSNIPPTPTQRTIIALGVAIGLSYMHRNN--------YIYRDIKSLNILLDADEY--
.. ..|. ..||              ..|| |..|. .|.  ||      . ||  .||..| |..|.| .|         |.||.|| |||.| .    
IVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

------------PKICDFGISRFVPQSRD-------------------LMTGGVGTAQWEAPEVINNE----------------PYTEKADVYS
            .||||||.|||. || .                        .|| .| ||||....                .|.||.||||
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS
Kinase 97340.m00050.AA Dicty4 20-128 37 2.5e-30 98.5 In-house 79-202 (277) Show / Hide 
Range on Protein: 20-128
Range on HMM: 79-202/277
Sequence Identity: 37% (47 aa)

IVSEFMPKENLFKCLHS-------NIPPTPTQRTI---IALGVAIGLSYMHR-N-NYIYRDIKSLNILLDADEYPKICDFGISR---FVPQSRDLMTGGV
||.|.||| ||.. ||.       .|..  . ..    .|. .| |. . |  | . | ||.|| |.| |..   |.||||.|.    . .  | ... .
IVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTAC

GTAQWEAPEVINNEPYTEKADVYS
||. |.||||  ..||.|||||||
GTPCWMAPEVMMHQPYNEKADVYS
Kinase 97340.m00050.AA Dicty4-Unclassified 20-128 44 5.9e-27 89.32 In-house 79-193 (263) Show / Hide 
Range on Protein: 20-128
Range on HMM: 79-193/263
Sequence Identity: 44% (52 aa)

IVSEFMPKENLFKCLHSNIPPTPTQRTI---------IALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFVPQSRDLMTGGVGTAQWE
|| |||.| |||   ||   |   |. |         .|. .| |. ..|  | | ||||| |||.| .   || |||||| .      ||   ||  ||
IVMEFMHKGNLFEVIHSK--PSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFN-MTTIAGTPKWE

APEVINNEPYTEKADVYS
.||.   | |. |.||||
SPECLMHESYNQKSDVYS
Kinase 97340.m00050.AA Pkinase 18-128 28 6.9e-27 96.15 Pfam 75-197 (293) Show / Hide 
Range on Protein: 18-128
Range on HMM: 75-197/293
Sequence Identity: 28% (36 aa)

YYIVSEFMPKE----NLFKCLH--SNIPP--TPTQRTIIALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYP----KICDFGISRFV-PQSRDLMTGGV
.|.| |....      ||  ..  .. .   .. .   ... .. || |.|... |.||.|. |||.| . ..    ||||||.....   .   ||. .
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC

GTAQWEAPEVIN-NEPYTEKADVYS
||  . |||||. ...|. |.|..|
GTPWYMAPEVIRGGQYYGPKVDMWS
Kinase 97340.m00050.AA LZK 1-128 37 2e-24 79.23 In-house 44-172 (241) Show / Hide 
Range on Protein: 1-128
Range on HMM: 44-172/241
Sequence Identity: 37% (49 aa)

MNHFAVIGLIGV-TQEPPYYIVSEFMPKENLFKCLHSNIPPTPTQRTIIALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFVPQSRDL
..|  .| . || || | | |. |. |.  | . | .  . ||        ..| |. |.| .  | || || |||  ...  |||||| |.   .    
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDST

MTGGVGTAQWEAPEVINNEPYTEKADVYS
.    ||  | ||||| |||  || |..|
KMSFCGTVAWMAPEVIRNEPCSEKVDIWS
Kinase 97340.m00050.AA TKL-Unique 9-128 30 2.4e-24 82.89 In-house 61-213 (290) Show / Hide 
Range on Protein: 9-128
Range on HMM: 61-213/290
Sequence Identity: 30% (47 aa)

LIGVTQ----EPP-YYIVSEFMPKENLFKCLH----------SNIPPTPTQRTIIALGVAIGLSYMHRNN--YIYRDIKSLNILLDAD-----EYPKICD
..|..      || ..||.|..|  .| . ||          .|..... ||  .|. .| |. | |...   | ||.||.|.|.| .        ||||
YMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICD

FGISRFVPQSRDLMTGG---------VGTAQWEAPEVINN--EPYTEKADVYS
||.|.|  .. .  ...         .|...| ||||...  . |.||.||||
FGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYS
Kinase 97340.m00050.AA Dicty5 48-128 45 7.8e-24 78.91 In-house 109-188 (260) Show / Hide 
Range on Protein: 48-128
Range on HMM: 109-188/260
Sequence Identity: 45% (37 aa)

IALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFVPQSRDLMTGGVGTAQWEAPEVINNEPYTEKADVYS
.|...| .. ..|  | | ||.||.|.|.  .   || |||.||||   |  ||  |||  | |.|. |  ||..|.||||
MAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFV-DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYS
Kinase 97340.m00050.AA LRRK 1-128 33 8.6e-23 77.45 In-house 114-267 (351) Show / Hide 
Range on Protein: 1-128
Range on HMM: 114-267/351
Sequence Identity: 33% (52 aa)

MNHFAVIGLIGVTQEPPYYIVSEFMPKENLFKCLHSNI--------PP-TPTQRTIIALGVAIGLSYMHRNN--YIYRDIKSLNILLDADEYP-------
.||  .. |.|.. . |. .| |..|  .| . ||..         .  ... .  ||| .| |. |.|..|   |.|| || ||||     .       
LNHPNIVSLKGFCIH-PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPN

-----KICDFGISR-FVPQSRDLMTGGVGTAQWEAPEVIN---NEPYTEKADVYS
     ||.|||||| | .    .  | ||. .| |||...   .| ||||.|.||
AHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYS
Kinase 97340.m00050.AA Ciliate-E2 53-128 22 4.6e-21 69.03 In-house 157-281 (365) Show / Hide 
Range on Protein: 53-128
Range on HMM: 157-281/365
Sequence Identity: 22% (29 aa)

AI-------------GLSYMHRNN-YIYRDIKSLNILLDADEYPKICDFGISRFVPQS----------RDLMTGG----------------------VGT
..             .| |.| .|  |.||||  |||.     .||.|||.|... ..            .|  .                      .||
GFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGT

AQWEAPEVINNEP---------YTEKADVYS
.   |||..|...         |..|.|..|
PGYMAPEILNGKKYDNQQKQKGYDYKCDIWS
Kinase 97340.m00050.AA TKL-ciliate1 52-128 33 1.1e-20 67.52 In-house 112-204 (279) Show / Hide 
Range on Protein: 52-128
Range on HMM: 112-204/279
Sequence Identity: 33% (31 aa)

VAIGLSYMHRNN--YIYRDIKSLNILLDADEYPKICDF---GI---SRFVPQSRDLM---TGGVGTAQWEAPEVIN-----NEPYTEKADVYS
.| |..|.| ..   | ||.|..|||.| .  .|||.|    |    |    | . |   ..  .|  | |||..      | |..||.|.|.
IAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYA
Kinase 97340.m00050.AA Pkinase_Tyr 12-128 33 9.5e-13 43.8 Pfam 73-199 (270) Show / Hide 
Range on Protein: 12-128
Range on HMM: 73-199/270
Sequence Identity: 33% (42 aa)

VT-QEPP--YYIVSEFMPKENLFKCLHS----NIPPTPTQRTIIALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFV-PQSRD--LMT
.| |. |  .||| |.||. .| . |..    . |.|. .   ... .| |..| ...|.| ||.   |.|.. .   |||||| .| . . .      .
CTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG

GGVGTAQWEAPEVINNEPYTEKADVYS
||     | |||.||.  .|.| ||.|
GGKLPIKWMAPECINYGKFTTKSDVWS
Kinase 97340.m00050.AA S_TKc 1-128 14 1e-06 -78.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-128
Range on HMM: 1-231/231
Sequence Identity: 14% (36 aa)

M--------------------------------------------NHFAVIGLIGVTQEPPYYIVSEFMPK--ENLFKCLHSNIPP------TPTQRTII
                                             .|  .. |..| |.  .|.| |...    .||. .... ..      .. .   .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

ALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFVPQSRDLMTGGVGTAQWEAPEVINNEPYTE--------------------------
.  .. .| |.|... |.||.|  |||||     ||||||..|..       |  .||  . ||||.   .|.                           
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQ

-------------------------------KA-------DVYS
                                .       . . 
MMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 97340.m00050.AA TyrKc 1-126 14 1.3e-05 -131.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-126
Range on HMM: 1-280/280
Sequence Identity: 14% (40 aa)

M------------------------------------------------NHFAVIGLIGVTQE--------PPYYIVSEFMPKENLFKCLHSNIP-PTPT
                                                 .|  .. |.||  .        .|..|| |.||. .| . |... |  .. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QRTIIALGVAIGLSYMHRNNYIYRDIKSLNILLDADEYPKICDFGISRFVPQS-------RDLMT----GGV--GTAQWEAPEVINNE------------
.   ... .| | .| |..|.| ||.   |.|....   ||.||| ||..             ..    ||       | |||.||              
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFG

------------PYTE-----------------------KAD-------------------------------------V
            || .                        ..                                      
VCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF