Gene 81529.m00448 (T.vaginalis)
81529.m00448
Species: T.vaginalis
Alias: 81529.m00448, TvagK0907
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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81529.m00448.AA | Protein | None | 299 | None | Fasta, JSON |
81529.m00448.kin_dom | Protein Kinase Domain | None | 242 | None | Fasta, JSON |
Protein domains of 81529.m00448.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 81529.m00448.AA | CAMK | 27-277 | 20 | 2.7e-81 | 261.6 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 27-277 Range on HMM: 1-425/425 Sequence Identity: 20% (87 aa) ILDNTKNSIVFLAKNIKDN------------EKVAIKFIKYRKAA-----------------------------ISRVDAEIELMSNCK-------CPFI .| ..|.|....... .|||||.|. .|. .| |||.|.... | | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IQAREIFD------------YLPY--------KCLVM---PLAMSD------MNNIL-H------------CAENHRLDEDLVKEVIRSALLALKYLHDN |. |... . ..|| .. . | | . |..|..|. .. ..| . |..|.|.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH QICHRDIKPDNLLYLGEEEEE-------------A-VQLTDLGFATKVES------------------------NQLCNEYVGTLNYAA-PEIISG---- |.|||.||.|.|. .... . . ..| |||.|... .|......||. |.| ||...| NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ----------KPYDKSIDIWSLGVSMYTLLSGSNPFPSNPE-------------STLRRCIQNGAYLFPASK------------WKGISRE--------A ..|....|.||.|| .|..|.| || . . . | . |..| | || .. |..|| | . NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC KDLISHMIKVDPLERYTVNQCLDHKWF ||||..| .||| .|.|. |||.|.|. KDLIRKMLQVDPEKRMTIEQCLNHPWM |
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S_TKc | 81529.m00448.AA | S_TKc | 22-277 | 24 | 1.2e-74 | 255.19 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-277 Range on HMM: 1-231/231 Sequence Identity: 24% (66 aa) YSLEKILDNTKNSIVFLAKNIKDNEKVAIKFIKYRKAAISRVDAEIELMSNCKCPFIIQAREIFDYLPYKCLVMPLAMS---DMNNILHCAENHR----L | . ... . |......|....|||| || .. ||..... ..|.|.. ..|. . ..|| .. |. ... |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF DEDLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATKVESNQLCNEYVGTLNYAAPEIISGKPYDK-SIDIWSLGVSMYTLL .| .. ... ..||.|.|...|.|||.||.|.| . ..| |.|... . ..||..| |||.. .|.| ..|.||.|. .| .| PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML SGSNPFPSNPESTLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYTVNQCLD-------HKWF .| ||| ... ..... |.||||.|... ..|| .|.|. ..| | || CGYPPFP-QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 81529.m00448.AA | CAMK1 | 121-277 | 39 | 1.4e-66 | 192.52 | In-house | 112-276 (276) | Show / Hide |
Range on Protein: 121-277 Range on HMM: 112-276/276 Sequence Identity: 39% (65 aa) EVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQ--LTDLGFATKVESNQ-LCNEYVGTLNYAAPEIISG---KPYDKSIDIWSLGVSMYTLLS .... | |..|.|.. |.|||.|| |||| ...|. . . | | ....... | .||. | |||.. . |||||..|.|| || |.|| HIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLC GSNPFPSNP-ESTLRRCIQNGAYLFPASKWKGISRE-AKDLISHMIKVDPLERYTVNQCLDHKWF | || .. ...| ..| .. | || | || . |||.|.||..||| .|||. |||.|.|. GYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | 81529.m00448.AA | Pkinase | 34-277 | 24 | 2.9e-65 | 227.95 | Pfam | 13-293 (293) | Show / Hide |
Range on Protein: 34-277 Range on HMM: 13-293/293 Sequence Identity: 24% (69 aa) SIVFLAKNIKDNEKVAIKFIKYRKAAISRVDA-----EIELMSNCKCPFIIQAREIFDYLPYKCLVMPLAMS-----DMNNILHCAENHRL--DEDLVKE . |...........||.| ||.|.. . . ||..| ....|.|.. ...| . .. ..||.... | ... .. .. .|. .| GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF VIRSALLALKYLHDNQICHRDIKPDNLLYL-GEEEEEAVQLTDLGFATK--VESNQLCNEYVGTLNYAAPEIIS-GKPYDKSIDIWSLGVSMYTLLSGSN ... | .|.|.|.. |.|||.||.|.|. . .. | ..| |.| . .|. .. ..||..|.|||.| |..|....|.||.|. .| .|.| YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP PFPSN----PESTLRRCIQNGAY-LFPASKWKGIS-------------------REAKDLISHMIKVDPLERYTVNQCLDHKWF |||. . . . .|.. . .. . .. .| .|.||.|. ....|| .|.| |.| |.|| PFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 81529.m00448.AA | CAMKL | 36-277 | 27 | 2e-63 | 201.21 | In-house | 15-297 (297) | Show / Hide |
Range on Protein: 36-277 Range on HMM: 15-297/297 Sequence Identity: 27% (80 aa) VFLAKNIKD-NEKVAIKFIKYRKAA-ISRVDA---------------EIELMSNCK---CPFIIQAREIFDYLPY------KCLVMPLAMSD---MNNIL | ||..|. .||||||.|. .|. . ... ||..|. . | ||. |... . .||| .. . . . . VKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYI HCAENHR--LDEDLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATKVES-----NQLCNEYVGTLNYAAPEIISG--KPYD ...| ..|. . | . |..|.|.. |.||||||.|.| . . ..| ||... . .|.... |...|.||||..| |||| VKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYD -KSIDIWSLGVSMYTLLSGSNPFPSNPES-------TLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYTVNQCLDHKWF . .||||.|| .|... | || . . .|.. | | | .| .|. .| ...|||..| .|.| .|.|. | . |.|. GPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 81529.m00448.AA | Ciliate-E2 | 22-277 | 22 | 5.3e-60 | 204.65 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 22-277 Range on HMM: 1-365/365 Sequence Identity: 22% (87 aa) YSLEKILDNTKNSIVFLAKNIKDNEKVAIK---------------------FIKYRKAAISRVDAEIELM----------------SNCKCPFIIQAREI | . |.. . ..|...|..|.....||| ..| | . || .| .. ..|.||. | YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FD--YLPYKCLVMPLAMSD------------MNNILHCAENHRLDEDLVKEVIRSALL---------------ALKYLHDNQ-ICHRDIKPDNLLYLGEE | . ||| .. |.... . ....| .|.... | ||.||| . |.||||||.|.|. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- EEEAVQLTDLGFATKVESN--------------------------------QLCNEYVGTLNYAAPEIISGKP---------YDKSIDIWSLGVSMYTLL . ..|.|...|. . .. | ..||..| ||||..||. ||...||||||| .| .| ----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML SGSNPFPSNPESTLRRCIQNGAYLFPAS--------------KWKGISREAKDLISH----MIKVDPLERYT-VNQCLDHKWF .| || . |... . || .|| .| |.||||. |...|| .|.| .|.|.|.|| FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 81529.m00448.AA | Ciliate-E2-Unclassified | 22-277 | 23 | 1.2e-58 | 201.11 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 22-277 Range on HMM: 1-352/352 Sequence Identity: 23% (83 aa) YSLEKILDNTKNSIVFLAKNIKDNEKV-----AIKFIKYRKAAISRVDAEIELM-----------------------SNCKCPFIIQAREIFDYLPYKCL | . |.. . ...|......|.. .. ..|...| . | ..| || . .|...|||. ..| . .. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI VMPLA--------MSDMNN--------ILHCAENHRLDEDLVK-----EVIRSALLALKYLHDNQ-ICHRDIKPDNLLYLGEEEEE--AVQLTDLGFATK || .. ...... .. ......| .| .. |..|.||| .. |.||||||.|.|. .. . . ..|.|.. | VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF--DNNGKNYYIKIIDFGISKK VESN----------------QLCNEYVGTLNYA----APEIISGKPYD----KSIDIWSLGVSMYTLLSGSNPFPSNPEST----------------LRR ..| |... .||.|| |||.. |. || ...||||||| .| .| | ||..| . |.. YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ CIQNGAYLFPASKW----KGISREAKDLIS----HMIKVDPLERYTVNQCLDHKWF |... . || ..| |..| ||||.|. |.|..| .|.| .| | | || NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 81529.m00448.AA | CAMK-Unique | 111-277 | 27 | 7.4e-57 | 186.13 | In-house | 149-363 (363) | Show / Hide |
Range on Protein: 111-277 Range on HMM: 149-363/363 Sequence Identity: 27% (59 aa) NHRLDE--DLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEE-------------EEAVQLTDLGFATKVESNQLCN---EYVGTLNYAAP---- . .. | .. .... | |..|.|...| |||.|..|... .. . |.| | ......|. | ...||. |.|| QGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVF ----------EIISGKPYDKSI----DIWSLGVSMYTLLSGSNPFPSNPES--------TLRRCIQNGAY-LFPASKWKG---ISREAKDLISHMIKVDP |.| . .|| ||||||| ||..|.|. || ...| ...|| | | |. ..| | || ||||.. .||| CKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDP LERYTVNQCLDHKWF | . .. |.| |. DHRWSAKELLEHQWI |
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Kinase | 81529.m00448.AA | MAPKAPK | 121-277 | 34 | 3.7e-55 | 169.01 | In-house | 107-292 (292) | Show / Hide |
Range on Protein: 121-277 Range on HMM: 107-292/292 Sequence Identity: 34% (64 aa) EVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATKVESNQLCNEY---------VGTLNYAAPEIISGKP----YDKSIDIWSLGV .... .|...||. | |||.|| |.|. .. .| |.|.||| .. |. |.. ..| |.|||.. |||| |.||||| QIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCDMWSLGV SMYTLLSGSNPFPSNPE------S----------TLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYTVNQCLDHKWF || .|.| || || . ....||.| | || |. || ||||||... ..|| .|.|. | ..|.| IMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
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Kinase | 81529.m00448.AA | MARK | 36-277 | 31 | 2.2e-54 | 176.26 | In-house | 15-262 (262) | Show / Hide |
Range on Protein: 36-277 Range on HMM: 15-262/262 Sequence Identity: 31% (80 aa) VFLAKNIKDNEKVAIKFIK---YRK-AAISRVDAEIELMSNCKCPFIIQAREIFD-YLPYK--CLVMPLAMS-DMNNILHCAENHRLDEDLVKEVIRSAL | || ... ..|||||... . ... | |||.|. . | ||. .... . . .|.| .| . .. . . ..|.|| |.. . | . VKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIV LALKYLHDNQICHRDIKPDNLLYLGEEEEE--AVQLTDLGFATKVESNQLCNEYVGTLNYAAPEIISGKPYD-KSIDIWSLGVSMYTLLSGSNPFP--SN |..|.|.. |.||||||.|.| |. . ..| ||.......|. |. ||. |.||||...|||| . .||||||| .|....|. || .. SAVNYCHSKNIVHRDIKPENILI---DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQ PESTLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYTVNQCLDHKWF . .|.. |..| | .| .|.|...||. ...|.| || |. ... |.|. DYKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 81529.m00448.AA | RSK | 114-277 | 35 | 5.5e-53 | 182.36 | In-house | 101-278 (278) | Show / Hide |
Range on Protein: 114-277 Range on HMM: 101-278/278 Sequence Identity: 35% (63 aa) LDEDLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATK--VESNQLCNEYVGTLNYAAPEIIS---GKP-YDKSIDIWSLGV ..|| ...... ||...||. .| |||.||.| || |..|. . ||| ||. . . ||. . ...|..|.|||.. .. .||. |.||||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV SMYTLLSGSNPFPS----NPESTLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYT-----VNQCLDHKWF ||..|.| || . |.. ...| ||.| . .. |. .|.||||||..| ..|| |.. ... ..|.|| LMYEMLTGCPPFQGPNDNNRKEIMKR-IQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 81529.m00448.AA | MSK | 113-277 | 32 | 5.1e-49 | 163.84 | In-house | 97-277 (277) | Show / Hide |
Range on Protein: 113-277 Range on HMM: 97-277/277 Sequence Identity: 32% (59 aa) RLDEDLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATKVESN--QLCNEYVGTLNYAAPEIIS----GKP-YDKSIDIWSL . ||. . ...|. .|....|. | |||.|| |.|. .||.. | |.| ||| .. . . . .|| |.|||.. ... ||...|.||| HFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSL GVSMYTLLSGSNPFP------S---NPESTLRRCIQNGAYLFPASKWKGISREAKDLISHMIKVDPLERYTVNQCLDHKWF || .||.|.| || . | . ... |. | || .|...| .|||||. . .|| | ..| ..| | GVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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Kinase | 81529.m00448.AA | TyrKc | 22-277 | 17 | 3.3e-10 | -57.55 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-277 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) YSLEKILDNTKNSIVFLAKNIKDNEKVAIKFIKYRKAAISRVDAEIELMSNC--KCPFIIQ----AREI---FDYLPYKCLVMPLAMS-DMNNILHCAEN .|.|.| . .|.... . ..||.| .| . . |...|.. . | |.. ... | | . ..|| .. | .. |. .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP HRLDEDLVKEVIRSALLALKYLHDNQICHRDIKPDNLLYLGEEEEEAVQLTDLGFATKVESN--------QL------CNEYVGTLNYAAPEIISGKPYD . | . . . |||.... |||. | |. . | .| | . .... . .. . ||| | . . K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT KSIDIWSLGVSMYTLLS-GSNPFPS-----NPESTLRRCIQNGAYLFPASK-----WKGISREAKDLISHMIKVDPLERYTVNQCLDHKWF |.|| || |. ... | | | . . .......| .. . . . | .... . || .| | ... |. | TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 81529.m00448.AA | CAMK1 | 34-86 | 22 | 5.5e-10 | 25.16 | In-house | 13-78 (276) | Show / Hide |
Range on Protein: 34-86 Range on HMM: 13-78/276 Sequence Identity: 22% (15 aa) SIVFLAKNIK---DNEKVAIKFIK-YRKAAI------SRVDAEIELMSNC---KCPFIIQAREIFD |.|.|..... .....||| |. . . ... ||| | .. ..|.||. |... SEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYE |
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Kinase | 81529.m00448.AA | CAMK-Unique | 22-68 | 14 | 0.017181 | 3.81 | In-house | 1-47 (363) | Show / Hide |
Range on Protein: 22-68 Range on HMM: 1-47/363 Sequence Identity: 14% (7 aa) YSLEKILDNTKNSIVFLAKNIKDNEKVAIKFIKYRKAAISRVDAEIE | . .|. . ..|. ..... | |.| .| .. ... .. .. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRN |
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Kinase | 81529.m00448.AA | RSK | 49-80 | 26 | 0.13233 | 2.09 | In-house | 28-65 (278) | Show / Hide |
Range on Protein: 49-80 Range on HMM: 28-65/278 Sequence Identity: 26% (10 aa) AIKFIKYRKAAISRVD-----AEIELMSNCK-CPFIIQ | | .| .|.. . .| .|.. .. |. .|||.. AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVT |