Gene 92287.m00044 (T.vaginalis)

92287.m00044

Species: T.vaginalis
Alias: TvagK0632, 92287.m00044
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
92287.m00044.AA Protein None 2159 None Fasta, JSON
92287.m00044.kin_dom Protein Kinase Domain None 268 None Fasta, JSON

Protein domain

Protein domains of 92287.m00044.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF3385 92287.m00044.AA DUF3385 706-766 29 5.1e-07 26.48 Pfam 33-116 (181) Show / Hide 
Range on Protein: 706-766
Range on HMM: 33-116/181
Sequence Identity: 29% (25 aa)

MKLLGLLGAVDPSLMKNNENTTNEN------------VFDDVEIDVNKQ----------SYYLTVTCNSLLN-VLNDQSLSSDH
.|..| |||.||.  | ||.. ...            . ..  .|.             .|| ||  |||.. .|.|.||||.|
IKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVINSLMRLILKDPSLSSHH
Kinase 92287.m00044.AA PIKK 1820-2090 35 1.4e-98 333.82 In-house 1-290 (290) Show / Hide 
Range on Protein: 1820-2090
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

TIESVDPLLEVIVSKQHPRIIVFHGSDGKPHRSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDTFNQLIT
 | . |. ..|. .|| |. |.. |.||| .. |.|||||||.||||||.|||||    . | .. |.| . |....| |.|.|.|.  |...|   ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

SYRKQR--RININLEK-----------------DIISNNFTSSVDEMTTVQRYEALLTAIQSTDDNDLEKAIWMRSPSSNEWIKRTTRFAQTSAVMSIIG
 ....   | ....                   . .      ...  . ....|..  . | |  ... |. | ..|.. .|  |..... . |||.. |
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNLMMHKSSGDVIHIDFSDCFEIAKTREQFPEGVPFRLTRMMVRAFGPARIEGNFRIAAEEMMKIVRSHRESIMTVLDIF
||||||||||.|.|  ...|...|||| .||| |..|. .|| |||||||.|| | ||  .||.|| . |  |.. |.|||..|||.. |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 92287.m00044.AA FRAP 1850-2090 44 2.5e-88 299.77 In-house 2-241 (251) Show / Hide 
Range on Protein: 1850-2090
Range on HMM: 2-241/251
Sequence Identity: 44% (107 aa)

HRSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDTFNQLITSYRKQRRININLEKDIISNNFTSSVDEMTT
.  |||||||.| | |||| | |.|  ..| |.|. .|| .  ..| |.| ..|.|  . . ||   ||  |||. .|  | |  |.   . .  |... 
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMC-NDYDHLPL

VQRYEALLTAIQSTDDNDLEKAIWMRSPSSNEWIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMMHKSSGDVIHIDFSDCFEIAKTREQFPEGVPFRLT
... |    ... |  .|| | .|..||.|  |. | | .    |.||..|||||||||||||.|. . .| ..|||| ||||.| .||.||| .|||||
MNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLT

RMMVRAFGPARIEGNFRIAAEEMMKIVRSHRESIMTVLDIF
||.| |   . ||||.|.. |  ||..| |.||.| ||. |
RMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAF
Kinase 92287.m00044.AA PI3Kc 1851-2148 22 1.7e-64 221.53 SMART 1-336 (336) Show / Hide 
Range on Protein: 1851-2148
Range on HMM: 1-336/336
Sequence Identity: 22% (77 aa)

RSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDTFNQLITSYRKQRRININLEKDIISNNFTS--------
. ..|...||| |.|.||.|.|||   ..   .| |.| . .... |.. ..|.|... ...|. |.   |.|.... .... ..  .            
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

-------------SVDEMTTVQRYEALLTAIQSTDDNDLEKAIWMRSPSSN-EWIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMMHKSSGDVIHIDFS
             ....||  .. .  . |. .. ...| .  | ..|..| .| .. ..|..  |......||||.||||..|.|... .| ..|||| 
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFEIAKTREQFP----EGVPFRLTRMMVRAFG----PARIEGNFRIAAEEMMKIVRSHRESIMTVLDIFLQVPI--ESEEESELSKLDIHAALDRI--T
..|. ..... |.    | ||||||..|| . |    |.  .|.||  ... ....|.|...||... ...  ||  .   . | ..  .....  .  .
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFRLDHLS

DKIVGRDFGS------QELSIEDQVRRLINDATNVYNL
|. . . |         | |.| .  |... . |. ..
DEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 92287.m00044.AA PI3_PI4_kinase 1849-2095 23 6.6e-59 206.81 Pfam 1-295 (300) Show / Hide 
Range on Protein: 1849-2095
Range on HMM: 1-295/300
Sequence Identity: 23% (70 aa)

PHRSLLKGHEDLR--LDQRVMQFF-----------------------QLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDTFNQLITSYRK
 .. ..||..|||   |.|.||..                       .|||   |.   .| ||. .... . | . ..|.|.......||....  |..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QRRININLEKDIISNNFTSSVDEMTTVQRYEALLTAIQSTDDNDLEKAIWMRSPSS-NEWIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMM--HKSSG
.... ..  ... .   . . .. . .|. |    .|  |  ..| .  |. .|.   || .. ..|.   |.|....||||.||||..|.|.  .|..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

DVIHIDFSDCFE-IAKTREQFPEGVPFRLTR------MMVRAF------GPARIEGNFRIAAEEMMKIVRSHRESIMTVL-------DIFLQVPI
 ..|||| .||.  .  .. .|| ||||.|.      .|| |.      .| . .| ||   .... ..|.| ...|..|       ..... ..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGL
Kinase 92287.m00044.AA ATR 1819-2090 30 5.7e-52 175.18 In-house 1-267 (267) Show / Hide 
Range on Protein: 1819-2090
Range on HMM: 1-267/267
Sequence Identity: 30% (84 aa)

VTIESVDPLLEVIVSKQHPRIIVFHGSDGKPHRSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDTFNQLI
  |   | ..|.. | |.|. | ..||||| .  . | ..||| | | |.| .|.|   .   . |.| . . |.|. |. ....|| ....| |   ..
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

TSYRKQRRININLEKDIISNNFTSSVDEMTTVQRY-EALLTAIQSTDDNDLEKAIWMRSPSSNEWIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMMHK
.   | ...     ...       | .|    . . | ||    .      .     | | . .|      .  . ||....|||.||||||  |... |
DKLWKEKKQYMQF-YQLRQCMDKKSREEWEKQKVFREFLLPRHPPI----FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDK

SSGDVIHIDFSDCFEIAKTREQFPEGVPFRLTRMMVRAFGPARIEGNFRIAAEEMMKIVRSHRESIMTVLDIF
  |...|.|.   |   .. |  || ||||||. || ..|| . .| || | |..|...| ||. || |.| |
INGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 92287.m00044.AA ATM 1982-2095 38 2.1e-24 74.55 In-house 133-245 (304) Show / Hide 
Range on Protein: 1982-2095
Range on HMM: 133-245/304
Sequence Identity: 38% (44 aa)

WIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMMHKSSGDVIHIDFSDCFEIAKTREQFPEGVPFRLTRMMVRAFGPARIEGNFRIAAEEMMKIVRSHRE
|  .   .    |  ||.||||||||||  |...   | ...|||    ||  |     || ||||||| .|   |   .|| ||   |  | ..|   |
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SIMTVLDIFLQVPI
 ..|. .. |  |.
TLLTIVEVLLYDPL
Kinase 92287.m00044.AA DNAPK 1819-1913 38 2.3e-19 67.02 In-house 2-96 (301) Show / Hide 
Range on Protein: 1819-1913
Range on HMM: 2-96/301
Sequence Identity: 38% (37 aa)

VTIESVDPLLEVIVSKQHPRIIVFHGSDGKPHRSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFIDDTDT
| |   |    |. |   |. |.  | | . |  . || ||||.|||. | || ||  .   |    | | | |. | |  || | |  .| | .
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVV
Kinase 92287.m00044.AA FATC 2127-2159 51 8e-18 60.14 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2127-2159
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

QELSIEDQVRRLINDATNVYNLATLYHGWTPLW
..||.|.||.|||..||...||. .|.|| | |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 92287.m00044.AA SMG1 1963-2042 42 3.1e-17 53.51 In-house 164-242 (242) Show / Hide 
Range on Protein: 1963-2042
Range on HMM: 164-242/242
Sequence Identity: 42% (34 aa)

TDDNDLEKAIWMRSPSSNEWIKRTTRFAQTSAVMSIIGYILGLGDRHPSNLMMHKSSGDVIHIDFSDCFEIAKTREQFPE
|  | | | .|       || . |  .|   ||||..|||.||||||  | ..    |.|.|||.  |||  |   . ||
TPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 92287.m00044.AA SMG1 1828-1909 35 7.5e-15 45.48 In-house 1-82 (242) Show / Hide 
Range on Protein: 1828-1909
Range on HMM: 1-82/242
Sequence Identity: 35% (29 aa)

LEVIVSKQHPRIIVFHGSDGKPHRSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGIIQFID
. ..  |  |. ..| |||||    | || ||| || |.|||  ..|                  ...||.  |||.||..|
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD
Kinase 92287.m00044.AA DNAPK 1988-2094 35 9.7e-15 49.91 In-house 189-295 (301) Show / Hide 
Range on Protein: 1988-2094
Range on HMM: 189-295/301
Sequence Identity: 35% (38 aa)

RFAQTSAVMSIIGYILGLGDRHPSNLMMHKSSGDVIHIDFSDCFEIAKTREQFPEGVPFRLTRMMVRAFGPARIEGNFRIAAEEMMKIVRSHRESIMTVL
.|. . ||  | ..||| ||||  | |   . ||.| |||   |  |      ||  ||||||  .    |  | | ..      |.  |. |   .   
HFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFC

DIFLQVP
|.| . |
DVFINDP
Kinase 92287.m00044.AA ATM 1851-1905 40 5.4e-12 34.21 In-house 1-55 (304) Show / Hide 
Range on Protein: 1851-1905
Range on HMM: 1-55/304
Sequence Identity: 40% (22 aa)

RSLLKGHEDLRLDQRVMQFFQLMNLHIKNGPNTRMRNLALHTFAITPISNRSGII
| | || .||| |  . | ||. |  ..    || | | . |. . |.| |||..
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL