Gene 86233.m00024 (T.vaginalis)

86233.m00024

Species: T.vaginalis
Alias: TvagK0909, 86233.m00024
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMK1

Sequence

Name Sequence Type Origin Length Description Download
86233.m00024.AA Protein None 227 None Fasta, JSON
86233.m00024.kin_dom Protein Kinase Domain None 182 None Fasta, JSON

Protein domain

Protein domains of 86233.m00024.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86233.m00024.AA CAMK 27-217 16 3.8e-54 172.49 In-house 1-332 (425) Show / Hide 
Range on Protein: 27-217
Range on HMM: 1-332/425
Sequence Identity: 16% (55 aa)

VLDNTKNSVVYIAKNKKTN------------EQFALKLIKHR-----------------------------ERITDRVNTEADLMSNCK-------CPFI
.|     ..|. ...|.|.            ...| | |. .                             ..  ..|  | ..|....        | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQAKEIFD--------YPPY------------KCLVM---PLAMAD------MKNILNNSQN------------HQLDEDLVKEVIRSALLALKYLHENQ
|.  |...         . |             ..||    ..            |  ....            . ..|. .. ..|  . |..|.|.. 
IKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ICHRDIKPENILFLGKSENE-------------F-LQLTDFGFATKVQE------------------------NELCNEYVGTLNYAA-PEIISG-----
|.|||.||||||.  .....             . . ..|||||.|...                        ........||. |.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------IPYNKSIDIWSLGVSMYMLLSGSS
          .|....|.||.|| .|..|.| .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
Kinase 86233.m00024.AA AGC 22-219 19 2.2e-51 129.98 In-house 1-305 (395) Show / Hide 
Range on Protein: 22-219
Range on HMM: 1-305/395
Sequence Identity: 19% (62 aa)

YQLEKVLDNTKNSVVYIAKNK------KTNEQFALKLIKHRE-----R--ITDRVNTE------------ADLMSNCK----------CPFIIQ-AKEIF
... ||.     . || .. |       |....|.| .| ..     .    ....||             . ...|.          .|||..  .  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DYPPY--KCLVMPL---AMA------DMKNILNNS---QNHQLDEDLVKEVIRS-------ALLALKYLHE-NQICHRD-IKPENILFLGKSENEFLQLT
  . .   ..|| .    .       ..   | .    ..  .||. ..  .          .||| |||. . | ||| .||||||.    |.  . ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL---DEDGHIKLT

DFGFATKVQ---------------------------------------------------ENELCNEYVG--TLNYAAPEIISGIPYNKSIDIWS--LGV
|||.....                                                    ......  .|  | .| ||||.    |.|. |.||  ||.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

SMYMLLSGSSHF
 || .|.| . |
LMYEMLTGYPPF
Pkinase 86233.m00024.AA Pkinase 22-220 26 1e-50 179.61 Pfam 1-213 (293) Show / Hide 
Range on Protein: 22-220
Range on HMM: 1-213/293
Sequence Identity: 26% (58 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFALKLIKHRERITDRVNT-----EADLMSNCKCPFIIQAKEIFDYPPYKCLVMPLAMA-----DMKNILNNSQN
|......     ..||....|.|....|.| || |..  .   |     |. .| ....|.|.. ...| .... ..||....      | . ..  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

HQL--DEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSEN-EFLQLTDFGFATK--VQENELCNEYVGTLNYAAPEIIS-GIPYNKSIDIWSL
  .  .|. .| ...  | .|.|.|.. |.|||.||||||.  . .. ... ..|||.| .     |. .. ..||..|.|||.|  | .| ...|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVSMYMLLSGSSHFP
|. .| .|.|   ||
GCILYEMLCGRPPFP
Kinase 86233.m00024.AA CMGC 22-206 18 1.6e-44 143.63 In-house 1-322 (513) Show / Hide 
Range on Protein: 22-206
Range on HMM: 1-322/513
Sequence Identity: 18% (61 aa)

YQLEKVLDNTKNSVVYIAKN--------------KKTNEQFALKLIKHRERITD-------------RVNTEADLMSNCK-----------------CPF
|.  |..     .||| ...              ..|||. |.| || ..  ..             | . |  .. . .                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIQAKEIFDYPP-----------------YKCLVMPLAMADMKNILNNSQ-------NHQLDEDL------------VKEVI------RSALLALK--YL
|.. ..|| ..                  . .||. .   | .... | |       .. |.|              .|  .      .  | .||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HENQ--ICHRDIKPENILFLGKSEN-----------------EFLQLTDFGFATKVQEN----------------------ELCNEYVGTLNYAAPEIIS
| .   |.|||.||||||.  . |.                   | . |||.|... ..                      .   .|| |. | ||||. 
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GIP----------YNKSIDIWSLG
| .          |...||.||.|
GWKHYTNHNYSMHYTTPIDMWSVG
Kinase 86233.m00024.AA Ciliate-E2 22-215 21 3.9e-43 145.91 In-house 1-292 (365) Show / Hide 
Range on Protein: 22-215
Range on HMM: 1-292/365
Sequence Identity: 21% (65 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFA-----------------------LKLIKHRE-RITDRVNTEAD-------------LMSNCKCPFIIQAKEI
| . |.. .   ..|| .|..|...|||                       .| .|... ... ... .               .... ..|.||. .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--YPPYKCLVMPLAMA-DMKNILNNS----------QNHQLDEDLVKEVIRSALL---------------ALKYLHENQ-ICHRDIKPENILFLGKSE
|      .  ||| ..   |.. ...|.          . ....|  .|....  |                ||.|||..  |.|||||||||||     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

NEFLQLTDFGFATKVQEN--------------------------------ELCNEYVGTLNYAAPEIISGIP---------YNKSIDIWSLGVSMYMLLS
   . ..|||...|....                                .. | ..||..| ||||..| .         |....||||||| .|..|.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

G
|
G
Kinase 86233.m00024.AA CAMKL 22-215 25 1.5e-42 133.47 In-house 1-232 (297) Show / Hide 
Range on Protein: 22-215
Range on HMM: 1-232/297
Sequence Identity: 25% (59 aa)

YQLEKVLDNTKNSVVYIAKN-KKTNEQFALKLIKHRERITDRVNT----------------EADLMSNCK---CPFIIQAKEIFDYPPY------KCLVM
|...|.|     ..|  |.. . |.|. | | |. .    | ...                |. .|.  .    | ||.  |... | .       .|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

PLAMAD---MKNILNNSQNHQ--LDEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSENEFLQLTDFGFATKVQE-----NELCNEYVGTLNY
 ..      . . . .  ..   ..|.  .   |  . |..|.|.. |.||||||||||.  .  |  . ..||||... ..     ......  |...|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPEIISG--IPYN-KSIDIWSLGVSMYMLLSG
.||||..|   ||. . .||||.|| .|... |
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCG
Kinase 86233.m00024.AA S_TKc 22-227 21 7.8e-40 139.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-227
Range on HMM: 1-231/231
Sequence Identity: 21% (55 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFALKLIKHRERITDRVNTEADLMSNCKCPFIIQAKEIFDYPPYKCLVMPLAMA---DMKNILNNSQN----HQL
|.. ...     ..|| ...|||....|.| ||      ...  | ..... ..|.|.. ...|.   . ..|| ..     |.. .. . .     ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSENEFLQLTDFGFATKVQENELCNEYVGTLNYAAPEIISGIPYNK-SIDIWSLGVSMYMLL
.|  .. ...  ..||.|.|...|.|||.||||||.        . ..|||.|...      . ..||..| |||..   .|.| ..|.||.|. .| .|
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

SGSSHFP-----------------------INPE-------ST----------L
.|   ||                        .||        .          .
CGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 86233.m00024.AA Ciliate-E2-Unclassified 22-215 22 3.9e-39 133.39 In-house 1-266 (352) Show / Hide 
Range on Protein: 22-215
Range on HMM: 1-266/352
Sequence Identity: 22% (60 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFALKLIKHRERITDRVNTEAD---------------------------LMSNCKCPFIIQAKEIFDYPPYKCLV
| . |.. .  ...|| ...||.. |.. . ...  .| .. . .                             ...|...|||.   ..|    . ..|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MPLA-MADMKNILNNSQN---------------HQLDEDLVK-----EVIRSALLALKYLHENQ-ICHRDIKPENILFLGKSENE--FLQLTDFGFATKV
| ..   |........ .               ....|  .|       ..  |..|.|||... |.|||||||||||  .....   . ..|||.. | 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF--DNNGKNYYIKIIDFGISKKY

QEN----------------ELCNEYVGTLNYA----APEIISGIPYN----KSIDIWSLGVSMYMLLSG
|.|                ....  .||.||     |||.. |  |.    ...||||||| .| .| |
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase 86233.m00024.AA CAMK1 121-215 37 3.8e-37 105.47 In-house 112-212 (276) Show / Hide 
Range on Protein: 121-215
Range on HMM: 112-212/276
Sequence Identity: 37% (38 aa)

EVIRSALLALKYLHENQICHRDIKPENILFLGKSENEFLQ--LTDFGFATKVQENE-LCNEYVGTLNYAAPEIISG---IPYNKSIDIWSLGVSMYMLLS
....  | |..|.|.. |.|||.||||.|. .|.|.  .   . ||| .... ..| |    .||. | |||.. .    || |..|.|| ||  | || 
HIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLC

G
|
G
Kinase 86233.m00024.AA CAMK-Unique 111-217 27 1.1e-36 118.5 In-house 149-291 (363) Show / Hide 
Range on Protein: 111-217
Range on HMM: 149-291/363
Sequence Identity: 27% (39 aa)

NHQLDE--DLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSE-------------NEFLQLTDFGFATKVQENELCN---EYVGTLNYAAP----
. .. |   ..  .... | |..|.|...| |||.|.|||..                  | .. |.||| ......|. |    ...||. |.||    
QGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVF

----------EIISGIPYNKSI----DIWSLGVSMYMLLSGSS
          |.| . .|        ||||||| ||..|.|..
CKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCP
Kinase 86233.m00024.AA MSK 110-217 33 2.9e-35 116.63 In-house 94-208 (277) Show / Hide 
Range on Protein: 110-217
Range on HMM: 94-208/277
Sequence Identity: 33% (39 aa)

QNHQLDEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSENEFLQLTDFGFATKVQEN--ELCNEYVGTLNYAAPEIIS----GIP-YNKSIDI
.    ||. . ...|.  .|....|.  | |||.||||||| ....|  . |.|||||    ..  .  . . .|| |.|||..     . . |....|.
KREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDW

WSLGVSMYMLLSGSS
||||| .|..|.| .
WSLGVILYTMLTGQV
Kinase 86233.m00024.AA RSK 114-217 36 1.4e-33 117.86 In-house 101-210 (278) Show / Hide 
Range on Protein: 114-217
Range on HMM: 101-210/278
Sequence Identity: 36% (41 aa)

LDEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSEN-EFLQLTDFGFATK-VQE-NELCNEYVGTLNYAAPEIIS---GIP-YNKSIDIWSLG
..|| ......   ||...||. .| |||.||||||.  .| | . . ||||||. . . . |.. . ...|..|.|||..    .   ..|. |.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VSMYMLLSGSS
| ||..|.| .
VLMYEMLTGCP
Kinase 86233.m00024.AA CAMK1 22-95 22 1.9e-11 29.47 In-house 1-87 (276) Show / Hide 
Range on Protein: 22-95
Range on HMM: 1-87/276
Sequence Identity: 22% (20 aa)

YQLEKVLDNTKNSVVYIAKNKKT---NEQFALKLIK-HRERIT------DRVNTEADLMSNC---KCPFIIQAKEIFDYPPYKCLVM
|.. |.. .   |.|| ...|.|   ..|.|.| |.  .   .      ... .| . | ..   ..|.||. .|... . . .|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVM
Kinase 86233.m00024.AA TyrKc 22-227 16 9e-06 -129.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-227
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFALKLIKHRERITDRVNTEADLMSNC--KCPFIIQAKEIFDYP-------PYKCLVMPLAMA-DMKNILNNSQN
 .|.|.| .    .|| .. |   .| | | .|.          || .|..   . | |..   .   .       .  ..|| ..   | |. | ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

HQLDEDLVKEVIRSALLALKYLHENQICHRDIKPENILFLGKSENEFLQLTDFGFATKVQEN--------EL------CNEYVGTLNYAAPEII-SGIPY
. |  .   .    .     |||.... |||.   |.| .|.        .||| . .. .                 .  ..  .   ||| |  |.  
K-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

NKSIDIWSLGVSMYMLLSGSSHFPIN-----------------------PES------------------------------------TL
 || |.|| || |. ...     . .                       |..                                     .
TKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 86233.m00024.AA RSK 41-80 21 0.009839 6.26 In-house 20-65 (278) Show / Hide 
Range on Protein: 41-80
Range on HMM: 20-65/278
Sequence Identity: 21% (10 aa)

NKKTNEQFALKLIKHRERITDRVN-----TEADLMSNCK-CPFIIQ
...|. ..| | .| .....  .      || . .. |. .|||..
HHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVT
Kinase 86233.m00024.AA CAMK-Unique 22-54 21 0.011072 4.45 In-house 1-33 (363) Show / Hide 
Range on Protein: 22-54
Range on HMM: 1-33/363
Sequence Identity: 21% (7 aa)

YQLEKVLDNTKNSVVYIAKNKKTNEQFALKLIK
| . ... .   ..||......|   .| |..|
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVK
Kinase 86233.m00024.AA MSK 34-85 15 0.068949 2.16 In-house 13-70 (277) Show / Hide 
Range on Protein: 34-85
Range on HMM: 13-70/277
Sequence Identity: 15% (9 aa)

SVVYIAKNKKTNEQFALKLIK-----HRERITDRVNTEADLMSNC-KCPFIIQAKEIF
...    ...|. ..| | ..      . . .  . ||.     | ..|.| . .. |
FICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAF