Gene 81202.m00126 (T.vaginalis)

81202.m00126

Species: T.vaginalis
Alias: 81202.m00126, TvagK0674
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
81202.m00126.AA Protein None 533 None Fasta, JSON
81202.m00126.kin_dom Protein Kinase Domain None 202 None Fasta, JSON

Protein domain

Protein domains of 81202.m00126.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81202.m00126.AA NEK1 4-258 35 4.7e-67 229.07 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 35% (98 aa)

YVLQREISNDASGQFTLYLEKPTSHHVVIRKQSLAAMPREDWDSVLEEELSFCSLDHPNILKYHTAFIKDDS--LYTVMDFAQGGNLEQKIKKS--QGML
|. .. |   . |   |  .|  . | ||   ..  |....   ...|      ..|||| ||  .|.   .  || ||... || | |||..   .| |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFL--RNG---------------MLKVA--GIVNTKILVGTTNFTQTAQTMPYFFAPEICQGKQY
| ||||..||. |.|||...|||  ||  | ..||.    .||               ..|..  ||   ..|  |. . .|    ||   ||||| | |
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGI--ARMLNHTMEYACTCIGTPYYLSPEICQNKPY

TDKTEIWALGCLLYQLCAQKPPFEGKSIPALIRKILKGNITPIPYIFSSNLRNLVTACLQKFPSRRPNINKILNYDFI
. |. ||.||| || ||. | |||... ..|. ||..| ..|||  .|  |..||.  ... |. || .| ||   ||
NNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 81202.m00126.AA NEK8 58-258 33 2.6e-53 150.51 In-house 57-278 (278) Show / Hide 
Range on Protein: 58-258
Range on HMM: 57-278/278
Sequence Identity: 33% (76 aa)

LDHPNILKYHTAFIKDDSLYTVMDFAQGGNLEQKIKKSQG-MLFDED----------------QILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRN-
|.||||  |   |..| .|  .|  | ||.|.|.| . |.  ...|                 .||. |. ...|. .||. . ||  .   ||   |  
LQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHR

GMLKVA--GIVNTKILVGTTNFTQTAQTM---PYFFAPEICQGKQYTDKTEIWALGCLLYQLCAQKPPFEGKSIPALIRKILKG-NITPIPYIFSSNLRN
. .|.   ||   ||. .|    ||..|    || . ||.|.||.|  |  .||||| || .|  |  ||.   |||. ||  . . .||.   |. .| 
MVVKIGDFGI--SKIM-NTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRM

LVTACLQKFPSRRPNINKILNYDFI
||..|||. | .||    |. .  .
LVHNCLQQDPEQRPSASQIMAMPLC
Kinase 81202.m00126.AA NEK4 4-258 30 2.3e-49 170.33 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 30% (78 aa)

YVLQREISNDASGQFTLYLEKPTSHHVVIRKQSLA-AMPREDWDSVLEEELSFCSLDHPNILKYHTAFIKDDS--LYTVMDFAQGGNLEQKIKKSQGMLF
|   . . .   |  .|  ..      |..|  |  |  ||  .   | .|    | |||| .|   .  ..   || || |  || | .| |.  . . 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQL-LSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFL

DEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVAGIVNTKILVGTTNFTQTAQTMPYFFAPEICQGKQYTDKTEIWALGCLLYQLCAQK
.| |...||  | .|| |||..  ||      ||   .  ..|.  .   ..|    .. .|    ||.  ||.   . |  |  ||.||| .| .   |
EEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

PPFEGKSIPALIRKILKGNITPIPYIFSSNLRNLVTACLQKFPSRRPNINKILNYDFI
  |. | .. || .|..|   |.|  .| .| |||   |.| | .|| |  |.   .|
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 81202.m00126.AA NEK 167-258 45 3e-40 139.59 In-house 188-286 (286) Show / Hide 
Range on Protein: 167-258
Range on HMM: 188-286/286
Sequence Identity: 45% (45 aa)

PYFFAPEICQGKQYTDKTEIWALGCLLYQLCAQ--KPPFEGK--SIPALIRKILKG-NITPIP-YI-FSSNLRNLVTACLQKFPSRRPNINKILNYDFI
||. .||.||.| |. |  ||.|||.||..|..  |.|||..  ..|.|. || || .  ||| .. .|. |.||.. .||| |. ||..|.||.  ||
PYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 81202.m00126.AA Ciliate-E2 49-258 21 5.4e-38 128.0 In-house 63-365 (365) Show / Hide 
Range on Protein: 49-258
Range on HMM: 63-365/365
Sequence Identity: 21% (67 aa)

LEEELSFC-----------------SLDHPNILKYHTAFI--KDDSLYTVMDFAQGGNLEQKIKKSQGML---------FDEDQILDWFTKISL------
.. |.. .                 .|.||||.|.. .|.  .|...| ||...|||.|.. ||...            |.| .|.. ...|        
IKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA

---------ALKYMHDRG-FLHHSIQAKNIVFLRNGMLKVAGIVN----------------TKILVGTTNFTQTAQT----------------MPYFFAP
         ||.|.| ..  .|  |   ||.|     .|..   .                 |..    | | . ..                .|.. ||
EFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP

EICQGKQ---------YTDKTEIWALGCLLYQLCAQKPPFEGKSIPALIRKILKGNIT-P----------------IPYIFSSNLRNLVTA----CLQKF
|| .||.         |. |  ||.||..||...  ||||        ...|....|  |                ..   | .  .|       .||| 
EILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKD

PSRRPN-INKILNYDFI
|. |.. ...|||  ..
PEKRITGWEQILNHPWF
Kinase 81202.m00126.AA Ciliate-E2-Unclassified 54-258 21 1.7e-37 127.61 In-house 74-352 (352) Show / Hide 
Range on Protein: 54-258
Range on HMM: 74-352/352
Sequence Identity: 21% (60 aa)

SFCSLDHPNILKYHTAFIKDDSLYTVMDFAQGGNLEQKIKKSQG---------------MLFDEDQIL-----DWFTKISLALKYMHDRG-FLHHSIQAK
.. ...||.|.|.. .| ... .| ||....||.|.| |||. .                 |.| |..     ..|  | ..|.|.|  . ..|  |.  
ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPE

NIVFLRNG---MLKVAGIVNTKILV----------------GTTNFTQTAQTMPYF---FAPEICQGKQYTDK----TEIWALGCLLYQLCAQKPPFEGK
||.|  ||    .|...  . | .                    .......|  |     |||. ||..| ..      ||.||..||... ...||...
NILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN

SIPA----------------LIRKILKGNITPIP-------YIFSSNLRNLVT----ACLQKFPSRRPNINKILNYDFI
.                   |...|...||   .       .. | .  ....     .|.| |. |.....|||  ..
NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81202.m00126.AA NEK11 4-258 29 2.1e-35 123.97 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-259/259
Sequence Identity: 29% (79 aa)

YVLQREISNDASGQF-TLYL-----EKPTSHHVVIRKQSLAAM-PREDWDSVLEEELSFCSLDHPNILKYHTAFIKDDSLYTVMDFAQGGNLEQKIK--K
||||  .    || | | ||      |.     |..  |   . | |     .|  |    |.|| | ..| .|.  |    . ..  |  |...|.  |
YVLQQKL---GSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQL-LSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYK

SQGMLFDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVAGIVNTKILVGTTNFTQTAQTMPYFFAPEICQGKQYTDKTEIWALGCLLY
  | .| | ||..|| .. |   |||.|  ||  ...||| ||.| .||.      ..|.|  .   |    | . .||  . . |  | .||.| |.||
QAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNI-FLKNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILY

QLCAQKPPFEGKSIPALIRKILKGNITPIPYIFSSNLRNLVTACLQKFPSRRPNINKILNYDFI
 .|     | | .  ... .|  |.   .|  .   |  ..   | | || ||    ||   ..
EMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase 81202.m00126.AA S_TKc 4-258 24 2e-33 118.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

YVLQREISNDASGQFTLYLEKPTSHHVVIRKQSLAAMPREDWDSVLEEELSFCSLDHPNILKYHTAFIKDDSLYTVMDFAQG--GNLEQKIKKSQG----
| . |.|   | |.  .  .| | ..| | . .            .. |.. .. .|||| |.. .|   |.|| ||... |  |.| . ||| ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

MLFDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVA--GIVNTKILVGTTNFTQTAQTMPYFFAPEICQGKQYTD-KTEIWALGCLLY
  |.| ..  ..  | .||.|.|..|..|  .   || . .   .|..  |.            |    | |.. |||..   .|.  |  .|..||.||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGT-PWYMAPEVL---GYGKCKCDWWSCGCILY

QLCAQKPPFEGKSIPALIRKILKGNITPIPYIFSSNLRNLVTACLQKFPSRRPNINKILN-------YDFI
 ... .|||.   . ....||.           |. .....  |||| |..|| . ..|.         ..
EMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81202.m00126.AA NEK6 57-249 32 1.3e-32 104.51 In-house 55-252 (252) Show / Hide 
Range on Protein: 57-249
Range on HMM: 55-252/252
Sequence Identity: 32% (64 aa)

SLDHPNILKYHTAFIKDDSLYTVMDFAQGGNLEQKIK--KSQGMLFDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVAGIVNTKILV
.|.|||..||  .|| .  |  |.. |. | . . ||  | |. |  |  |  .| ... ||. || .  .|  |.  |.    ||. |.  .   .   
QLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFS

GTTNFTQTAQTMPYFFAPEICQGKQYTDKTEIWALGCLLYQLCAQKPPFEGKSIP--ALIRKILKGNITPIPY-IFSSNLRNLVTACLQKFPSRRPNI
  |         ||. .||  . . |  | .||.|||||| . | . || |  .   .| .|| . .  |.|  ..| .||.||. |..  | .||.|
SKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 81202.m00126.AA NEK-Unclassified 58-258 25 5.4e-32 102.99 In-house 50-258 (258) Show / Hide 
Range on Protein: 58-258
Range on HMM: 50-258/258
Sequence Identity: 25% (54 aa)

LDHPNILKYHTAFIKDDSLYTVMDFAQGGNLEQKIKKSQGM--LFDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVAGIVNTKILVG
| || |  || .|     |.   |.  |||| ..|.|  .    |||  |  |.  .  |. | | |  .|      ||      ..        .|.  
LRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDH

TTNFTQTAQTMPYFFAPEICQGKQYTDKTEIWALGCLLYQLCAQKPPFEGKSIPALIRKILKGNI------TPIPYIFSSNLRNLVTACLQKFPSRRPNI
|    .|    . . .||.|| . | ..  .|.|||..| .|.  | |  ...  .  || ..         |.   .|  | ....  |.. . .||  
TRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSA

NKILNYDFI
  |.  |.|
TEIVEQDYI
Kinase 81202.m00126.AA STE 4-258 19 7.9e-31 106.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-359/359
Sequence Identity: 19% (72 aa)

YVLQREISNDASG-QFTLYLEKPTSHH--------------VVIRKQSLAAMP---------------REDWDSVLEEELSFCSLD--HPNILKYHTAFI
. ....| . |.|  .. .  |..  |              . | . .|                    |.....|.|      ..  |||| ||. ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------DSLYTVMDFAQGGNLEQKIK---KSQGML---------FDEDQILDWFTKISLA-LKYMHDRGFLHHSIQAKNIVFLRNGMLKVAG-----
|.       |.|. .| .  || |.. ||   . ...|         |.|.||      |  . |.| |. .  |  | . || .      | .      
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-IVN--------------------TKILVGTTNFTQTAQTMPYFFAPEICQG------KQYTDKTEIWALGCLLYQLCAQKPPFEGKSIP-ALIRKILK-
 ...                    .. .|||            . |||. |.      |.|. |  || |||..  ..  |||.   . . |. ... . 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----------WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNY

-------------GNITPIPY-------------------IFSSNLRNLVTACLQKFPSRRPNINKILN--YDFI
             |.. |.|                     .|..... .  |||| |. ||. .. |.    ||
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 81202.m00126.AA NEK 57-126 46 3.5e-26 89.46 In-house 60-142 (286) Show / Hide 
Range on Protein: 57-126
Range on HMM: 60-142/286
Sequence Identity: 46% (39 aa)

SLDHPNILKYHTAFIKDD--SLYTVMDFAQ-GGNLEQK---IKKSQ--GMLFDEDQILDWFTKISLALKYMHDR-----GFLH
.|.|||| ||. .|| ..  .|. ||...  ||.|.||   ||| .  | .|.|.||.|||. ..|||||||||       ||
QLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILH
Kinase 81202.m00126.AA Pkinase 167-258 23 9.4e-20 70.92 Pfam 175-293 (293) Show / Hide 
Range on Protein: 167-258
Range on HMM: 175-293/293
Sequence Identity: 23% (28 aa)

PYFFAPEICQ-GKQYTDKTEIWALGCLLYQLCAQKPPFEGK------SIPALIRKILK-GNITPIPYIFS-------------------SNLRNLVTACL
|.. |||... |. |. |  .|..||.||...  .||| |.      .  ..|..|..  .  ..|.  |                   .... ... ||
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QKFPSRRPNINKILNYDFI
.| |..||..  ||. ...
CKDPKKRPTAEQILQHPWF
Kinase 81202.m00126.AA Pkinase 57-126 28 6e-15 53.94 Pfam 56-131 (293) Show / Hide 
Range on Protein: 57-126
Range on HMM: 56-131/293
Sequence Identity: 28% (22 aa)

SLDHPNILKYHTAFIKDDSLYTVMDFAQGG----NLEQKIK--KSQGMLFDEDQILDWFTKISLALKYMHDRGFLH
.|.||||.... .|  .|..| ||....||     |   |.  .. ...|.|... .... |  .|.|.|..|..|
RLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH
Kinase 81202.m00126.AA TyrKc 4-258 16 2.4e-10 -55.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

YVLQREISNDASGQF------TLYLEKPTSHHVVIRKQSLAAMPREDWDSVLEEELSFCSL--DHPNILKYHTAFIKD-------DSLYTVMDFAQGGNL
 .| ...    .|.|      |..         |  |   .          ..|    |.|  .||||.. . . ...       . |. || .. .|.|
ITLGKKL---GEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

EQKIKKSQGMLFDEDQILDWFTKISLALKYMHDRGFLHHSIQAKNIVFLRNGMLKVA--GIVNTKILVGT--------TNFTQT---AQT-MPYF-FAPE
 . ..|...  .  .. |.. . |.    | |.... |  . | |.   .|.  |..  |   .. .           .  ...   . | .|.   |||
KDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL--SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ICQGKQYTDKTEIWALGCLLYQLCAQ-KPPFEG-----KSIPALIRKILKGNITPIPYI--------FSSNLRNLVTACLQKFPSRRPNINKILNYDFI
  . . .| |. .|. | ... ..   ..| .|     .|   .|... .|.  |.|           .. . .. . | .  |. ||. . |  ....
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81202.m00126.AA Pkinase_Tyr 56-126 19 5.4e-07 24.32 Pfam 58-134 (270) Show / Hide 
Range on Protein: 56-126
Range on HMM: 58-134/270
Sequence Identity: 19% (15 aa)

CSL-DHPNILKYHTAFI-KDDS--LYTVMDFAQGGNLEQKIKKS--QGMLFDEDQILDWFTKISLALKYMHDRGFLH
..| .||||.... . . ....  .| || ....|.|    .|   ..  ..  ..|.. . |. .. | ..... |
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIH