Gene 82538.m00101 (T.vaginalis)

82538.m00101

Species: T.vaginalis
Alias: TvagK0618, 82538.m00101
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
82538.m00101.AA Protein None 2152 None Fasta, JSON
82538.m00101.kin_dom Protein Kinase Domain None 140 None Fasta, JSON

Protein domain

Protein domains of 82538.m00101.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 82538.m00101.AA HEAT 135-165 12 18.723209 1.97 Pfam 1-31 (31) Show / Hide 
Range on Protein: 135-165
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

FLDALTVGIFHKNLQVRIRSEKKICDFLDRS
.|..|  .. ... .||  . . ...... .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 82538.m00101.AA HEAT 215-245 16 11.298867 2.73 Pfam 1-31 (31) Show / Hide 
Range on Protein: 215-245
Range on HMM: 1-31/31
Sequence Identity: 16% (5 aa)

YMSKCRQLMKSEEEYVSIAALRLLIVLAPLD
 .. . ........ |  ||.. | .|..  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 82538.m00101.AA HEAT 403-433 25 0.189311 8.88 Pfam 1-31 (31) Show / Hide 
Range on Protein: 403-433
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LLPLIRPLLNSTDQNIRQYTPAALLSLSSDI
.||..  .||..| ..|. .  .| .|.. .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 82538.m00101.AA HEAT 478-508 29 0.033155 11.5 Pfam 1-31 (31) Show / Hide 
Range on Protein: 478-508
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ALSLFSVLVNDDSFRVRSRTLTILGELAESN
 |...  . ||.. .||. ..  ||.|.|  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 82538.m00101.AA HEAT 934-964 22 0.000286 18.65 Pfam 1-31 (31) Show / Hide 
Range on Protein: 934-964
Range on HMM: 1-31/31
Sequence Identity: 22% (7 aa)

LVRACFQCFRNNNEEIRLAAVKLLKSLSKTL
.. ....|.. ...|.|.||.. |..|.. .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase 82538.m00101.AA PIKK 1799-2063 34 4.7e-86 292.21 In-house 1-290 (290) Show / Hide 
Range on Protein: 1799-2063
Range on HMM: 1-290/290
Sequence Identity: 34% (101 aa)

TMKKFASSLDVFPSKQRPKRLAIIGSNGGEFWYLLKGHEDLRLDQRVVQVFHLINTFIPIE------MPKIVTNFIMPLLPTVGLIQWIPGSDTMFKLIR
  . .. .. | ..||.||.. | |..| |. ||.|||||||.|||| |.| |.||    .         | |  . |. .  |||.| ....| . ...
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DFRSARNIPVDYESRL-------------LS------QITTPKFDDLRPIQRLEALQQVSNETSDSVLSDILWLKAPDAENWIKRVTTFSRTSALMSVVG
. ... .|  ..|.               .|      |   .. ...   ...|..  ... |  ... ...|.|.||.| |  | . . |. |.|..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPSNIMIHNFTGSVIHVDFGDCFETTKERVLFPELIPFRLTRFMIRAFGPAGIDGSFRKTCLDIVKLIRRHREEVLSVLEIF
||||||||||.||||   || ..|.|||.|||  ..|  .||..|||||| |. | || |..| ||..| ......|.||| ...|.| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 82538.m00101.AA FRAP 1828-2073 43 1.1e-78 267.74 In-house 1-251 (251) Show / Hide 
Range on Protein: 1828-2073
Range on HMM: 1-251/251
Sequence Identity: 43% (110 aa)

EFWYLLKGHEDLRLDQRVVQVFHLINTFI---PIEMPK---IVTNFIMPLLPTVGLIQWIPGSDTMFKLIRDFRSARNIPVDYESRLLSQITTPKFDDLR
|. .|||||||.| | || | | |||. .   |    |   |    |.||    ||| |..  ||.  ||||.| . .|  . | ... .   . .| | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRM-CNDYDHLP

PIQRLEALQQVSNETSDSVLSDILWLKAPDAENWIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMIHNFTGSVIHVDFGDCFETTKERVLFPELIPFRL
 ... |  . . | |    |  .|||| |  | |. | | . |  | ||..|||||||||||||||.  .|| ..|.|||||||    |  |||.|||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRFMIRAFGPAGIDGSFRKTCLDIVKLIRRHREEVLSVLEIFAHAPLVRSFG
|| .. |   .||.| .| ||  ..| || |.| |. ||| |   ||     
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 82538.m00101.AA PI3_PI4_kinase 1830-2073 25 2.8e-54 191.43 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1830-2073
Range on HMM: 1-300/300
Sequence Identity: 25% (78 aa)

WY--LLKGHEDLR--LDQRVVQVF-----------------------HLINTFIPIEMPKIVTNF---------IMPLLPTVGLIQWIPGSDTMFKLIRD
||  ..||..|||   |.|..| .                        |.|..    . . ...          ..|. |  |.|.|.| ..|. ...| 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCW---KKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRT

FRSARNIPVDYESRLLSQITTPKFDDLRPIQRLEALQQVSNETSDSVLSDILWLKAPDA-ENWIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMI--HN
..  .... .. ..  .   .|. ..|  .|..|    ... |   .| . .| . ||| |.| .. ..| |  | |.||.||||.||||..|||.  . 
YMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK

FTGSVIHVDFGDCFE-TTKERVLFPELIPFRLTR------FMIRAF------GPAGIDGSFRKTCLDIVKLIRRHREEVLSVL-------EIFAHAPLVR
.|| ..|.|||.||. .  ..  .||..|||.|.       |. |.      .| | .| ||..| ..  ..||| . ....|       |...|..|..
TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPM

SFG
   
WRS
Kinase 82538.m00101.AA PI3Kc 1830-2135 20 2e-48 168.12 SMART 1-336 (336) Show / Hide 
Range on Protein: 1830-2135
Range on HMM: 1-336/336
Sequence Identity: 20% (72 aa)

WYLLKGHEDLRLDQRVVQVFHLINTFIPIE-----MP-KIVTNFIMPLLPTVGLIQWIPGSDTMFKLIRDFRSARNIPVDYESRL-LSQITT--------
  ..|...||| |.|. |.| |.|.    .     .. .. .  ..|. |  |.|.|.| ..|. .. . ..  ...| ||. .  .    .        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

------------PKFDDLRPIQRLEALQQVSNETSDSVLSDILWLKAPDA-ENWIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMIHNFTGSVIHVDFG
            .  .... ...|.    . . . . || | .| . ||. |.| .....| |  | ...|.||||.||||..|||..  || ..|.|||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFETTKERVLFP----ELIPFRLTRFMIRAFG----PAGIDGSFRKTCLDIVKLIRRHREEVLSVLEIFAHAPL-VRSFGTTGIKPNRNSQFSASLPSN
..|.  . ...|.    |. |||||. |. . |    |.| .| ||..|  . ...|.|........|.....|.     .     ...  .  .... .
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----EKDIKYLRQRFRLD

AGSDENDIDRAINRISD--KINGRDFDLKHRLTQQEQVTKLICSA
.       . |.... .  ..     .. . .|.  ..  ..  .
H----LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 82538.m00101.AA ATR 1799-2063 26 2.8e-42 141.64 In-house 2-267 (267) Show / Hide 
Range on Protein: 1799-2063
Range on HMM: 2-267/267
Sequence Identity: 26% (71 aa)

TMKKFASSLDVFPSKQRPKRLAIIGSNGGEFWYLLKGHEDLRLDQRVVQVFHLINTFIPIEMPKIVTNFIMPLL---PT---VGLIQWIPGSDTMFKLIR
 .  |   .... | |.||.... ||.|  .  . | ..||| | |  ..  |||    ... .    . |.     |     ..| |.    |.  .. 
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

DFRSARNIPVDYESRLLSQITTPKFDDLRPIQRLEALQQVSNETSDSVLSDILWLKAPDAENWIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMIHNFT
     .   .  . . | |   .|  ..   ... ....       ..  |    . ||...|      . |. | ...||||.||||||  ||.|   .
KLWKEKK--QYMQFYQLRQCMDKKSREE--WEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

GSVIHVDFGDCFETTKERVLFPELIPFRLTRFMIRAFGPAGIDGSFRKTCLDIVKLIRRHREEVLSVLEIF
| ..|||.  |     |..  ||..|||||. |. ..|| . .| ||. | .|....| ||....||.. |
GECVHVDY-NCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 82538.m00101.AA ATM 1955-2068 38 3.7e-25 76.98 In-house 133-245 (304) Show / Hide 
Range on Protein: 1955-2068
Range on HMM: 133-245/304
Sequence Identity: 38% (44 aa)

WIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMIHNFTGSVIHVDFGDCFETTKERVLFPELIPFRLTRFMIRAFGPAGIDGSFRKTCLDIVKLIRRHRE
|  .   . |  |  |.|||||||||||  ||.|      ..|.| |  ||  |  .  || .|||||| ..   |  |..| ||. |   .  .|   |
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGK-ILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

EVLSVLEIFAHAPL
 .| . |.    ||
TLLTIVEVLLYDPL
Kinase 82538.m00101.AA DNAPK 1962-2069 32 1.4e-16 56.68 In-house 190-297 (301) Show / Hide 
Range on Protein: 1962-2069
Range on HMM: 190-297/301
Sequence Identity: 32% (35 aa)

FSRTSALMSVVGYILGLGDRHPSNIMIHNFTGSVIHVDFGDCFETTKERVLFPELIPFRLTRFMIRAFGPAGIDGSFRKTCLDIVKLIRRHREEVLSVLE
| |. |.  . ..||| ||||  | |.   .| .| .|||  |         ||| ||||||  |    | .| | ..       . .|. |   .   .
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCD

IFAHAPLV
.|   |..
VFINDPSF
Kinase 82538.m00101.AA SMG1 1945-2015 42 8.7e-16 48.63 In-house 173-242 (242) Show / Hide 
Range on Protein: 1945-2015
Range on HMM: 173-242/242
Sequence Identity: 42% (30 aa)

LWLKAPDAENWIKRVTTFSRTSALMSVVGYILGLGDRHPSNIMIHNFTGSVIHVDFGDCFETTKERVLFPE
||      . | .    . |  | ||.||||.||||||  |..|   || |.|.|.  |||  |  .  ||
LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 82538.m00101.AA SMG1 1807-1890 38 4.3e-14 42.93 In-house 1-90 (242) Show / Hide 
Range on Protein: 1807-1890
Range on HMM: 1-90/242
Sequence Identity: 38% (35 aa)

LDVFPSKQRPKRLAIIGSNGGEFWYLLKGHEDLRLDQRVVQVFHLINT-FIPI---EMPKIVTNF--IMPLLPTVGLIQWIPGSDTMFKL
. . | | .||.|  .|| |  . || || ||| || |..|   ..|| |  |   | |.       . ||    |||||. |   .| |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 82538.m00101.AA DNAPK 1798-1853 39 6.5e-11 35.76 In-house 2-57 (301) Show / Hide 
Range on Protein: 1798-1853
Range on HMM: 2-57/301
Sequence Identity: 39% (22 aa)

ITMKKFASSLDVFPSKQRPKRLAIIGSNGGEFWYLLKGHEDLRLDQRVVQVFHLIN
. .  |     |  |  ||||. | |    |  .. || ||||.|||. | |   |
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMN
Kinase 82538.m00101.AA FATC 2120-2152 42 7.7e-11 37.74 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2120-2152
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

HRLTQQEQVTKLICSATDMYNFAHLYHGWNPLW
. |. ..|| .|| .||| .| ...|.|| | |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 82538.m00101.AA ATM 1831-1856 46 0.000322 8.93 In-house 2-27 (304) Show / Hide 
Range on Protein: 1831-1856
Range on HMM: 2-27/304
Sequence Identity: 46% (12 aa)

YLLKGHEDLRLDQRVVQVFHLINTFI
 | || .||| |  . ||| . || .
QLVKGRDDLRQDAVMQQVFQMCNTLL