Gene 97324.m00264 (T.vaginalis)

97324.m00264

Species: T.vaginalis
Alias: TvagK0900, 97324.m00264
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
97324.m00264.AA Protein None 2294 None Fasta, JSON
97324.m00264.kin_dom Protein Kinase Domain None 217 None Fasta, JSON

Protein domain

Protein domains of 97324.m00264.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 97324.m00264.AA FAT 1417-1473 23 0.447713 3.83 Pfam 39-102 (408) Show / Hide 
Range on Protein: 1417-1473
Range on HMM: 39-102/408
Sequence Identity: 23% (15 aa)

DDDMT--DIVDIGIANALSTL--DKRQFD--RFENIIEKMRIELANPLQQ-DSNLSFERMMPNL
|.|..  .  |  . .|.. |   ..|||  ...  |.|.|  |   . .  ...| .|  | .
DEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVM
FAT 97324.m00264.AA FAT 1547-1740 12 0.001047 12.64 Pfam 188-408 (408) Show / Hide 
Range on Protein: 1547-1740
Range on HMM: 188-408/408
Sequence Identity: 12% (31 aa)

LMEQWVKFASACRKSGELQRSQFACWRAFQ--LENNS-----ISTIET--AKITWSLHDKTRAVSLLNPDLR---QNK----------------------
.|. | |||. |||.| .|... .  .. .   ....     .. ..   .|. |.  ..  | . |.  .    |..                      
DMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNT

--IFNSDEEIG-KFTYLRAKWNQEL--------DHLLPDELMKQYQDASKLMKKNGK-CYYQMANLADERLESYLEYFEKIHYGTSMRRNAVSKFVGTNS
  .  . .  . ..  ....| ..|        ..  .|| .. |. | .. ..  | .....|   .|... |    .... .                
NLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN----------------

NPGSIL-EFLQKNTVLALECYMKCLSNSPE-LAPEVVPRVLQ
     . .  .   | |..|. .... | .  . .  .|.|.
-----YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase 97324.m00264.AA PIKK 1941-2213 34 1e-97 330.93 In-house 1-290 (290) Show / Hide 
Range on Protein: 1941-2213
Range on HMM: 1-290/290
Sequence Identity: 34% (100 aa)

KISQMQQEIVIFSSLQRPKKISLLGSDGNNYHYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILD
 |  | . . .  ..|.||||...|.||  |.||||  .|||.| |.|..  ..|. . .| .|. |.|.| |..|| .. .||.||| .|. . | |..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

KYMKQGKIGLSRS------------------QLLELCCDKEQQKEISEATKNKKRQNFVNKILPFYPPQLHKWFMHRFCQPQRWFQSRLHYARSTAVWSM
..... .|                        .  ..  ..|  . . ..  .| . |     .  |. ..|||...|  |. |. .| .|.||.||..|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQM--QQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

VGYIVGLGDRHTENILLNENTGGAVHVDFCCMFDKAKT-LPVPECVPFRLTQNVVDGFGVLGTDGPFTESSVCCLTAMRDKKQKLVSVLQTF
|||| ||||||.|||.... ||. ||.|| | | .|.. ||||| ||||||.| |.. |. |..|.|. . .  . .||... .| .|. .|
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 97324.m00264.AA ATR 1941-2213 44 1.5e-89 303.83 In-house 2-267 (267) Show / Hide 
Range on Protein: 1941-2213
Range on HMM: 2-267/267
Sequence Identity: 44% (122 aa)

KISQMQQEIVIFSSLQRPKKISLLGSDGNNYHYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILD
 |. ... . |..|||.|||||| ||||  |  .||  |||||| | |.|   ||.    | . | | . . |.||| ||..|.|||| .|| . ..|||
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

KYMKQGKIGLSRSQLLELCCDKEQQKEISEATKNKKRQNFVNKILPFYPPQLHKWFMHRFCQPQRWFQSRLHYARSTAVWSMVGYIVGLGDRHTENILLN
|  |  |.  .. . | .| ||  ..|       .| . | . .|| .||  | || .||  || |. ||  | ||.|||.|||||.|||||||.|||..
KLWKEKKQ-YMQFYQLRQCMDKKSREEW------EKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILID

ENTGGAVHVDFCCMFDKAKTLPVPECVPFRLTQNVVDGFGVLGTDGPFTESSVCCLTAMRDKKQKLVSVLQTF
. .|  ||||. |.| . ... ||| ||||||.|.| |.| ..|.| |    .  .  |||... ..||...|
KINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 97324.m00264.AA PI3Kc 1972-2287 25 9.6e-71 242.25 SMART 1-336 (336) Show / Hide 
Range on Protein: 1972-2287
Range on HMM: 1-336/336
Sequence Identity: 25% (90 aa)

HYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILDKYMKQGKIGLSRSQLLELCC-----------
. ..|..||||.|||||..   .|.  ..|. || |.| . ....|....|||.|||  |. .. .|..||.|. |. ..  |.  .             
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------DKEQQKEISEATKNKKRQNFVNKILPFYPPQLHKWFMHRFCQPQ-RWFQSRLHYARSTAVWSMVGYIVGLGDRHTENILLNENTGGAVHVDFCC
       .  ...  ..|. .. . |  .. || || |..||. .| .|  .|...| ...||.|...||.|| |.||||..||.| ..|| ..|.|| .
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

MFDKAKTLPVP-----ECVPFRLTQNVVDGFG----VLGTDGPFTESSVCCLTAMRDKKQKLVSVLQTFIHDPL-LEWKQKAMSDKSREFKQNKDSNEAK
.|......|..     | ||||||.. |.. |    . | .| | .  .  ..|||  . ...........||.  .|. .                | .
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----------------EKD

MVLYEVDCRLSGLTEDKSRPQ--------SPECVVKNLITQATDNDNLALMY
   ..   ||..|........          |. .  ..|.. . ... ..|
IKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 97324.m00264.AA PI3_PI4_kinase 1970-2223 24 1.9e-66 231.84 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1970-2223
Range on HMM: 1-300/300
Sequence Identity: 24% (77 aa)

NYHYLCKNDDDLR--KDMRMMEFA-----------------------TFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILDKYMK
.|....|..||||  .|||||..                        ...|.. ..|. .| ||... .. .| ....||.||| .|...|. |...||.
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QGKIGL----------SRSQLLELCCDKEQQKEISEATKNKKRQNFVNKILPFYPPQLHKWFMHRFCQP-QRWFQSRLHYARSTAVWSMVGYIVGLGDRH
..|.            ..   ..|              . .|.. | ..| ....| |..||.  ....   |...| ...|| |....|.|| |.||||
KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRH

TENILL--NENTGGAVHVDFCCMFD--KAKTLPVPECVPFRLTQ------NVVDGF------GVLGTDGPFTESSVCCLTAMRDKKQKLVSVL-------
 .||..  .. ||  .|.|| ..|.  | |....|| ||||.|.      . |...      ...| .| | .. .  . |.|  .  ....|       
NDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRG

QTFIHDPLLEWKQ
....||.|..|. 
ECMVHDGLPMWRS
Kinase 97324.m00264.AA ATM 2097-2221 44 4.2e-41 128.84 In-house 124-248 (304) Show / Hide 
Range on Protein: 2097-2221
Range on HMM: 124-248/304
Sequence Identity: 44% (56 aa)

MHRFCQPQRWFQSRLHYARSTAVWSMVGYIVGLGDRHTENILLNENTGGAVHVDFCCMFDKAKTLPVPECVPFRLTQNVVDGFGVLGTDGPFTESSVCCL
| .|  |  ||  || | || |  |.||||.||||||  |||.||     ||.|    |.. | || || ||||||  .||| |. | .| |       .
MEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTM

TAMRDKKQKLVSVLQTFIHDPLLEW
  ||  .  |. .    . ||| .|
EVMRNSQETLLTIVEVLLYDPLFDW
Kinase 97324.m00264.AA FRAP 2106-2223 40 4.4e-30 106.28 In-house 133-251 (251) Show / Hide 
Range on Protein: 2106-2223
Range on HMM: 133-251/251
Sequence Identity: 40% (48 aa)

WFQSRLHYARSTAVWSMVGYIVGLGDRHTENILLNENTGGAVHVDFCCMFDKAKTL-PVPECVPFRLTQNVVDGFGVLGTDGPFTESSVCCLTAMRDKKQ
||. |  | || |. ||.||| ||||||  ||.|.  ||  ||.||   |. | .    || .|||||   |    . | .| .   .   .  .|..|.
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

KLVSVLQTFIHDPLLEWKQ
 .. ||  |. |||. |. 
SVMAVLEAFVYDPLFYWRL
Kinase 97324.m00264.AA SMG1 2103-2165 55 1.5e-23 74.75 In-house 180-242 (242) Show / Hide 
Range on Protein: 2103-2165
Range on HMM: 180-242/242
Sequence Identity: 55% (35 aa)

PQRWFQSRLHYARSTAVWSMVGYIVGLGDRHTENILLNENTGGAVHVDFCCMFDKAKTLPVPE
|  |.     ||||||| ||||||.|||||| .|.|.   ||  ||.|.   |.| | | |||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase 97324.m00264.AA DNAPK 2110-2223 32 2.7e-21 74.14 In-house 187-301 (301) Show / Hide 
Range on Protein: 2110-2223
Range on HMM: 187-301/301
Sequence Identity: 32% (37 aa)

RLHYARSTAVWSMVGYIVGLGDRHTENILLNENTGGAVHVDFCCMFD-KAKTLPVPECVPFRLTQNVVDGFGVLGTDGPFTESSVCCLTAMRDKKQKLVS
| |..|. ||    ..| | |||| .| . |  .|. . .||   |      |||||  |||||   .     ..  | .  . .  . |.| ..  |. 
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN

VLQTFIHDPLLEWKQ
    || ||.. ||.
FCDVFINDPSFDWKN
Kinase 97324.m00264.AA DNAPK 1941-2045 32 1.4e-15 53.06 In-house 3-107 (301) Show / Hide 
Range on Protein: 1941-2045
Range on HMM: 3-107/301
Sequence Identity: 32% (34 aa)

KISQMQQEIVIFSSLQRPKKISLLGSDGNNYHYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILD
.|      . .  || |||.| . | |     .. |   ||| | |        |  |  |  |  | |   |. .| .    | ||| .||   | || 
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDILN

KYMKQ
. | |
NEMQQ
Kinase 97324.m00264.AA FATC 2262-2294 51 6.1e-14 47.68 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2262-2294
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

RPQSPECVVKNLITQATDNDNLALMYIGWTPYI
 | |.|  |  || .|||..||. ||||| |. 
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 97324.m00264.AA FRAP 1970-2048 31 6.1e-12 40.28 In-house 1-79 (251) Show / Hide 
Range on Protein: 1970-2048
Range on HMM: 1-79/251
Sequence Identity: 31% (25 aa)

NYHYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEWAENTCSFKSILDKYMKQGKI
 ||.| |  .|.| | | |     |||   |.   . .||||  ...| |  . |.| | ..    . ..  | |. .|
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHI
Kinase 97324.m00264.AA SMG1 1949-2028 35 2.3e-11 33.77 In-house 1-80 (242) Show / Hide 
Range on Protein: 1949-2028
Range on HMM: 1-80/242
Sequence Identity: 35% (28 aa)

IVIFSSLQRPKKISLLGSDGNNYHYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEW
| |     .|||.  |||||  | || |  .||  | |.| |   .|  |    |          ..|  |  . |.| |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQW
Kinase 97324.m00264.AA ATM 1972-2028 33 3.3e-07 18.63 In-house 1-57 (304) Show / Hide 
Range on Protein: 1972-2028
Range on HMM: 1-57/304
Sequence Identity: 33% (19 aa)

HYLCKNDDDLRKDMRMMEFATFINRTFSNDRRCRDRNLSIVTFAVICLNEKCGIIEW
  | |  ||||.|  |       |         | | | | |. |. |  . |..||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW