Gene 81732.m00007 (T.vaginalis)
81732.m00007
Species: T.vaginalis
Alias: TvagK0146, 81732.m00007
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 81732.m00007.AA | Protein | None | 269 | None | Fasta, JSON |
| 81732.m00007.kin_dom | Protein Kinase Domain | None | 206 | None | Fasta, JSON |
Protein domains of 81732.m00007.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 81732.m00007.AA | CAMK | 4-209 | 19 | 1.6e-50 | 160.66 | In-house | 79-425 (425) | Show / Hide |
Range on Protein: 4-209
Range on HMM: 79-425/425
Sequence Identity: 19% (67 aa)
QSEIECLKA-------IDDPRIVRLYQVYNFGGF-------------------IYLLM---ELCKND------LDKIYKHKK--------------MTTP
..|||..| .| | |..||.|| . . .|. | |.| . .|.| .|.. |
RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE
EELFKVVHDTVLAVKACHDRHIAHSDIKPANFLIDQYD-----------------RIKISDFGLSSCYEN------------------------ECKCCL
.| .... . ||. ||...|.| |.|| | |.|. . |||.|||.. .. |.
REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT
FKGTKLFMA-PEIFSK-------------TDYDPFSADIWSLGVTIYYIATHHYPFVDKDLDKIPD-------------LIIKGEYQ-DFRIKDP-----
| || .|| ||.... .|.....|.||.|| | . ..|| ... . |.. |.||.|. . .|
FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY
------------------DLREVVRCCLTKDVSMHCTVNELLELPYF
. . .|..|..| . |. . |. | .
GPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 81732.m00007.AA | Pkinase | 5-209 | 26 | 3.9e-44 | 157.14 | Pfam | 49-293 (293) | Show / Hide |
Range on Protein: 5-209
Range on HMM: 49-293/293
Sequence Identity: 26% (65 aa)
SEIECLKAIDDPRIVRLYQVYNFGGFIYLLMELCKN-----DLD-KIY--KHKKM-TTPEELFKVVHDTVLAVKACHDRHIAHSDIKPANFLIDQYDRI-
|||. .| .. | ||||| .. .. ||. ||.| . || | .|... ...|. ... .. ... ||.. | | |.||.|.|||. . |
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHID
---KISDFGLSSC--YENECKCCLFKGTKLFMAPEIFSKTDYDPFSADIWSLGVTIYYIATHHYPFVDK------DLDKIPDLIIKGEYQDFRIKD----
||.||||. . | | . | || .||||. . |.. ..|.||.|...|. .. . || .. | ... ..| .... . ..
ACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSIS
-----------------PDLREVVRCCLTKDVSMHCTVNELLELPYF
.........||.|| . .| ..|. |.|
YFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 81732.m00007.AA | CAMKL | 4-209 | 29 | 1.6e-39 | 123.68 | In-house | 60-297 (297) | Show / Hide |
Range on Protein: 4-209 Range on HMM: 60-297/297 Sequence Identity: 29% (71 aa) QSEIECLKAID---DPRIVRLYQVYNFGGF------IYLLMELCKND----LDKIYKH----KKMTTPEELFKVVHDTVLAVKACHDRHIAHSDIKPANF . ||...| .. | |..||.|. . ||| ||.| . .|.| || ..| ...| . | ||. ||...|.| |||| | RREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRM-PEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENI LIDQYD--RIKISDFGLSSCYEN-----ECKCCLFKGTKLFMAPEIFSK--TDYDPFSADIWSLGVTIYYIATHHYPFVDKDL------DKIPDLIIKGE |.|. . |||.|||.| |.. . |. | |. .||||||.. ..|| . .||||.||. | . . ..|| | .. .. ..|.. LLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG YQDFRIK---DPDLREVVRCCLTKDVSMHCTVNELLELPYF ..| . |.| | |... . |. .... | . -YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 81732.m00007.AA | MARK | 65-173 | 44 | 9.3e-35 | 111.16 | In-house | 114-226 (262) | Show / Hide |
Range on Protein: 65-173 Range on HMM: 114-226/262 Sequence Identity: 44% (50 aa) VLAVKACHDRHIAHSDIKPANFLIDQYD--RIKISDFGLSSCYENECKCCLFKGTKLFMAPEIFSKTDYDPFSADIWSLGVTIYYIATHHYPFV--DKDL | ||. ||...|.| |||| | |||. |||.|||.| | ....| | ||. .||||||.| .|| . .||||||| |.. . ..|| ..|. VSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDY DKIPDLIIKGEYQ .. | .|.|. KELYKKILRGKYD |
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| Kinase | 81732.m00007.AA | Ciliate-E2-Unclassified | 1-209 | 21 | 1e-34 | 117.87 | In-house | 50-352 (352) | Show / Hide |
Range on Protein: 1-209 Range on HMM: 50-352/352 Sequence Identity: 21% (65 aa) MFSQSEIECLK----------------AIDDPRIVRLYQVYNFGGFIYLLMELC------------------KNDLDKIYKHKKMTTPEELF-----KVV |... |....| ...| ||... . . ||. ||.| .|||.. |..|. | .. . MNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYF HDTVLAVKACHDRH-IAHSDIKPANFLIDQYD---RIKISDFGLSSCYEN----------------ECKCCLFKGTKLFM----APEIFSKTDYDP---F ... . .| . | | |||| | |.|. .|||.|||.|. |.. ..... | || .| |||.. . || . AQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY SADIWSLGVTIYYIATHHYPFVDKDLDK----------------IPDLIIKGEYQDFR--------IKDPDLREVVR----CCLTKDVSMHCTVNELLEL ..||||||| .|.. . ||| |.. .. . . |.....| . . .| . .. ..| |. . | ...|. KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH PYF |.| PWF |
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| Kinase | 81732.m00007.AA | S_TKc | 2-209 | 24 | 2.4e-33 | 118.03 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2-209 Range on HMM: 1-231/231 Sequence Identity: 24% (62 aa) FS----------------------------------QSEIECLKAIDDPRIVRLYQVYNFGGFIYLLMELCKN---DLDKIYKHKKM------TTPEELF . ..||..|| . | ||.|| |. ...|. ||.| . || .. |... .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR KVVHDTVLAVKACHDRHIAHSDIKPANFLIDQYDRIKISDFGLSSCYENECKCCLFKGTKLFMAPEIFSKTDYDPFSADIWSLGVTIYYIATHHYPFVDK .... ...|.. ||...| | |.||.| |.|. .|||.||||. . | || .||||.. |.....|.||.|...| .. || FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-- DLDKIPDLIIKGEYQDFRIKDPDLREVVRCCLTKDVSMHCTVNELLE-------LPYF ..... ..| .|.... .| ||.|| . |. |.|. |.| QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 81732.m00007.AA | Ciliate-E2 | 1-209 | 19 | 2.4e-30 | 101.36 | In-house | 54-365 (365) | Show / Hide |
Range on Protein: 1-209
Range on HMM: 54-365/365
Sequence Identity: 19% (66 aa)
MFSQSEIECLKAIDDPR-----------------------IVRLYQVYN--FGGFIYLLMELCKND--LDKIYKHKKMTTPE-------ELFKVV----H
......|| .| ... |...| .. ||| ||.|. .| |...|| . | .... .
IMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQ
DTV--------------LAVKACHDRH-IAHSDIKPANFLIDQYDRIKISDFGLSSCYENE---------CKCCLFKG----------------------
. ||.. .| .. | | |||| | |. |||.||||| | .. || ..| .
ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTI
--TKLFMAPEIFSKTDYDP--------FSADIWSLGVTIYYIATHHYPFVDKDLDKIPDLIIKGEYQDFRIKDPDLR-----------------------
| .|||||... .|| ...|||||||..|. . .|| .| .. |..
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQ
---EVVRC----CLTKDVSMHCT-VNELLELPYF
. .| || . | ...|. |.|
ECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 81732.m00007.AA | STE | 4-209 | 23 | 7e-29 | 99.17 | In-house | 76-359 (359) | Show / Hide |
Range on Protein: 4-209 Range on HMM: 76-359/359 Sequence Identity: 23% (67 aa) QSEIECLKAID--DPRIVRLYQVYNFGG-------FIYLLMELCK-NDLDKIYKHKKMT-TP------------EELF-KVVHDTVLA-VKACHDRHIAH . ||. .| . | ||. | | .| ... ||.. ||.|.|||... | |.. ....... . . |. || | LKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH SDIKPANFLIDQYDRIKISDFGLSSCYENECK----------------CC-LFKGTKLFMAPEIFSK------TDYDPFSADIWSLGVTIYYIATHHYPF |||||| |. .|..|||.... .... . | || .||||. .. .|| ...|||||| || || ..|. RDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPW VD-KDLD---KIPDLIIKGE---------YQDFRIKD----------------------PDLREVVRCCLTKDVSMHCTVNELLE--LPYF | ... ||. ..... . ...| |.... .. ||.|| . |...||. | . HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | 81732.m00007.AA | ULK | 4-193 | 25 | 3.9e-26 | 89.78 | In-house | 58-308 (324) | Show / Hide |
Range on Protein: 4-193 Range on HMM: 58-308/324 Sequence Identity: 25% (64 aa) QSEIECLKAID---DPR--IVRLYQVYNFG--GFIYLLMELCKN-DLDKIYKHK---------KMTTPEELFKVVHDTVLAVKACHDRHIAHSDIKPANF ..||. .| .. | ||.|| ... .||. ||.| ||... | . | . .| .. .. . . |. |.. | | ||||.| KNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNI LIDQYD------------RIKISDFGLSSCYENE----CKC--CL----FKGTKLFMAPEIFS----KTDYDPFSADIWSLGVTIYYIATHHYPFVDKDL || . ..||.|||.. .|. ..| |. ||| |.|||.|.. . .|. . .||||||. .|.. . |||. LIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-F DKIP----DLIIKG------EYQ---DFRIKD------PDLREVVRCCLTKD . .|| .| ... .|.... |.... |..|..| NDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYD |
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| Kinase | 81732.m00007.AA | ULK | 4-193 | 22 | 6.4e-26 | 87.53 | In-house | 58-313 (329) | Show / Hide |
Range on Protein: 4-193
Range on HMM: 58-313/329
Sequence Identity: 22% (59 aa)
QSEIECLKAIDDPR--------IVRLYQVYNFGGF--IYLLMELCKN-DLDKIYKHK----------KMTTPEELFKVVHDTVLAVKACHDRHIAHSDIK
..||. .| ...| ||.|| ... . ||. ||.| ||... | . | . .| .. .. . . |. |.. | | |||
KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIK
PANFLIDQYD------------RIKISDFGLSSCYENE-------CKCC---LFKGTKLFMAPEIFS----KTDYDPFSADIWSLGVTIYYIATHHYPFV
|.| ||. . ..||.|||.. .|. . | ...|| |.|||.|.. . .|. . .||||||. .|.. . .||.
PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY
DKDLDKIPDLIIKGEYQD------------FRIK--------DPDLREVVRCCLTKD
. ..||. .... .... |.... |..|..|
AW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYD
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| Kinase | 81732.m00007.AA | CAMKK-Unclassified | 63-171 | 29 | 9.3e-26 | 80.64 | In-house | 186-350 (392) | Show / Hide |
Range on Protein: 63-171 Range on HMM: 186-350/392 Sequence Identity: 29% (49 aa) DTVLAVKACHDRH---------------------IAHSDIKPANFLIDQYDR-----IKISDFGLSSCYENECKCCLF--KGTKLFMAPEIFSKT--DYD . .... .|.. | | |||| | |||. |. .||.|||.| | | . |. ||. ||||| .|| || QCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYD PFS-------------------------ADIWSLGVTIYYIATHHYPFVDKDLDKIPD-LIIKGE . |||||||||.|....| || |.| .. .|...| YNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKE |
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| Kinase | 81732.m00007.AA | QIK | 6-170 | 30 | 5.5e-25 | 89.33 | In-house | 48-233 (272) | Show / Hide |
Range on Protein: 6-170 Range on HMM: 48-233/272 Sequence Identity: 30% (56 aa) EIECLKAIDDPRIVRLYQVYNFGGFIYLLMELCKN-DL-DKIYKHKK----------------MTTP---EELFKVVHDTVLAVKACHDRHIAHSDIKPA |.. .| .. | |..|||| .|...| |.| .. | . || . | | .| .. ....||. ||.|.|.| |.| EVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAE NFLIDQYDRIKISDFGLSSCYENECKCCLFKGTKLFMAPEIFSKTDYDPFSADIWSLGVTIYYIATHHYPFVDKDLDKIPDLIIKG | |.|. ||| |||.| .... . |. . |||.| .|| .||||.|| | . || | | . . .. | NILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSG |
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| Kinase | 81732.m00007.AA | TyrKc | 2-207 | 17 | 3.8e-07 | -107.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-207 Range on HMM: 1-280/280 Sequence Identity: 17% (49 aa) FS-----------------------------------QSEIECLKAI--DDPRIVRLYQVYNFG-------GFIYLLMELCKN-DLDKIYKHKKM-TTPE . .|.. .. . . | ||||| | . . ....||.... ||.. . .. ... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK ELFKVVHDTVLAVKACHDRHIAHSDIKPANFLIDQYDRIKISDFGLSSCYENE--------CKCCLF-KGTK--L---FMAPEIFSKTDYDPFSADIWSL .| . .. |.... | |. | |.. ..|||||||| ... . ||.| | |||| . . . . | |.|| DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS-DVWSF GVTIYYIATH-HYPFVD-----KDLDKIPDLIIKGEYQDFRIK---------DPDLREVVRCCLTKDVSMHCTVNELLELP ||... | | | . .. . . .. .|.. . ... .. ..| | .. .| .|. |. GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 81732.m00007.AA | CAMKK-Unclassified | 4-24 | 42 | 0.011382 | 4.17 | In-house | 66-86 (392) | Show / Hide |
Range on Protein: 4-24 Range on HMM: 66-86/392 Sequence Identity: 42% (9 aa) QSEIECLKAIDDPRIVRLYQV |.||. | .. | |..||.| QQEIAIMKKLWHPNICKLYEV |
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