Gene 86669.m00117 (T.vaginalis)

86669.m00117

Species: T.vaginalis
Alias: TvagK0390, 86669.m00117
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
86669.m00117.AA Protein None 411 None Fasta, JSON
86669.m00117.kin_dom Protein Kinase Domain None 186 None Fasta, JSON

Protein domain

Protein domains of 86669.m00117.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86669.m00117.AA Ciliate-E2-Unclassified 102-342 18 1.2e-45 156.27 In-house 1-352 (352) Show / Hide 
Range on Protein: 102-342
Range on HMM: 1-352/352
Sequence Identity: 18% (67 aa)

FRKITKLGSSPYGDITLCEYNDT--------LNVIIEIGKKK----LVEFSHVESYIPERNLIFSLP-------------QNQFLLNLLYTFQDANNYYL
...| ..|.  .|.. .|. ...        ...|... .|.      |..  .  . ...  ..               .. |.....|.||| .| |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

SLEYPPS-ELLPFLSGLPM-----------------IPEDVLR-----FYASELVVTLDFLHNHF-IVYRGLTSSNIFLAKDG---HVKLGGYGT-----
 .|| .  .|. ...  .                  ..|   .     ||. .... |..||    |..| .. .||.. ..|   ..|. ..|      
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------------DISSHR--ELEYL----APEIIQGQPYG----KAVDWWSLGIILYEILYEETPFFADSPEK----------------IKKNI
                  ......   ..|.    |||..||| |.    ...|.||||.||||.|. . ||.. . |.                ...||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LENSIKFVRFRG----SPIS----ELIL----QLLEKDPKKRITIAGIKKSKFF
... |.|  |        .|    ..|     ..|.|.|.||||.  |..  .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 86669.m00117.AA AGC 253-342 30 7.5e-44 110.08 In-house 272-395 (395) Show / Hide 
Range on Protein: 253-342
Range on HMM: 272-395/395
Sequence Identity: 30% (39 aa)

EYLAPEIIQGQPYGKAVDWWS--LGIILYEILYEETPFFADSPE----------KIKKNIL------ENSIKFV----------RFRGSPISELILQLLE
||.||||.    ||||.||||  ||...|| |.  .||..|.|.          .. ..|.      .. .||           |.  .    || .||.
EYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLC

KDPKKRIT----------IAGIKKSKFF
|||.||..          .  ||. ..|
KDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 86669.m00117.AA Ciliate-E2 102-342 17 8.3e-40 134.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 102-342
Range on HMM: 1-365/365
Sequence Identity: 17% (66 aa)

FRKITKLGSSPYGDITLCEYNDT-------------------------LNVIIEIGKKKLVEFSHVESYI----------PERNLIFSLPQNQFLLNLLY
. .| |.|.  .|.. .|.   .                         .  .  . |... ... ... .           |.|. ..| .. ..... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

TFQ--DANNYYLSLEYPPS-ELLPFLS------------GLPMIPEDVLR---------------FYASELVVTLDFLHNHF-IVYRGLTSSNIFLAKDG
.||  | ||.|| .||    .|. ..             .   . |   .               ||. .... | .||.   |..| .  .||..    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

HVKLGGYGT------------------DISSHR------------------------ELEYLAPEIIQGQP---------YGKAVDWWSLGIILYEILYE
 .|.   |.                   .   .                         ..|.||||..|..         |....|.||||.|||| |. 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

ETPFFADSPEKIKKNILENSIKFV-----------------RFRGSPI-SELILQ----LLEKDPKKRIT-IAGIKKSKFF
..||         ..|... |.|                   .  |.    || .    .|.|||.|||| .  |.. ..|
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86669.m00117.AA Ciliate-E2b 160-342 26 4e-38 113.56 In-house 61-272 (272) Show / Hide 
Range on Protein: 160-342
Range on HMM: 61-272/272
Sequence Identity: 26% (57 aa)

FLLNLLYTFQDANNYYLSLEY-PPSELLPFLSGLP--MIPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKLGGYGT--DISSHRE---
|. .....|.| .. |. .|.    ||.  .. .    . . . .||  ... .|  |||  |.|| .  .|| . ..|..||   ||   ...  |   
FIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMT

--------LEYLAPEIIQ-----GQPYGKAVDWWSLGIILYEILYEETPFF--ADSPEKIKKNILEN--SIKFVRFRGSPIS--ELILQLLEKDPKKRI-
        ..|.||||||     |..|. .|| ||.||.|||..    |.   .. |. | . |...   |.|  .    ..  .|.||.|.| |  |  
RTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLG

-TIAGIKKSKFF
 ...  |  ..|
GSYSWLKSHPWF
Kinase 86669.m00117.AA S_TKc 102-342 24 1.4e-33 118.82 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-342
Range on HMM: 1-231/231
Sequence Identity: 24% (64 aa)

FRKITKLGSSPYGDITLCEYNDTLNV----IIEIGKKKLVEFSHVESYIPERNLIFSLPQNQFLLNLLYTFQDANNYYLSLEYPPS---ELLPFLSGLPM
.... |.|.  .|   .|  ..|  .    ||             |. . |...  .  .  .. .|...||| ...|. .|| .    .|. ..   . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------IPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKLGGYGTDISSHRE----LEYLAPEIIQGQPYGK-AVDWWSLGIILYEILY
      .|| . |||. ...  |...|.| |..| |  .||.| .  |.|..  |      .     ..|.|||..   .||| ..||||.|.|||| |.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

EETPFFADSPEKIKKNILENSIKFVRFRGSPISELILQLLEKDPKKRITIAGIKK-------SKFF
 ..||    .... |.|.           ..  ..| ..|.|||.||.|.  . .         .|
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86669.m00117.AA Delta 102-342 29 5.2e-33 115.98 In-house 1-259 (259) Show / Hide 
Range on Protein: 102-342
Range on HMM: 1-259/259
Sequence Identity: 29% (76 aa)

FRKITKLGSSPYGDITLCEYNDTLNVI-IEIGKKKLV-EFSHVESYIPERNLIFSLPQNQFLLNLLYTFQDANNYYLSLEY-PPSELLPFLSGLPMIPED
|     ||   .| . | |  .. .   |   ||  | |   ||. . ||  .    .. ||  |. |||  .. .  .||    .|.  .       | 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

VLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKLGGYG---TDISSHRELE-------YLAPEIIQGQPYGKAVDWWSLGIILYEILYEETPF
  ||||.|... | |||.. |.|| |   |..| .|||.|.  .|   ...    . .       |.|||||.|| | ..||||| |...||.|    ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

FADSPEKIKKNILENSIKFVRFRGSPISELILQLLEKDPKKRITI-----AGIKKSKFF
  .  ... . |...   . |.      ... .|.|.||.||. .       |..  ||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase 86669.m00117.AA SGK 252-342 37 3.1e-32 96.48 In-house 189-283 (283) Show / Hide 
Range on Protein: 252-342
Range on HMM: 189-283/283
Sequence Identity: 37% (36 aa)

LEYLAPEIIQGQPYGKAVDWWSLGIILYEILYEETPFFADSPEKIKKNILENSIKFVRFRGSPISELILQLLEKDPKKRITIA----GIKKSKFF
.||||||....||....||||.||..||| .|   ||.    .    ||.   ... ... .. ..|| .||.||||||   .     ||.  ||
PEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 86669.m00117.AA MAST 252-342 38 2e-29 91.74 In-house 228-334 (334) Show / Hide 
Range on Protein: 252-342
Range on HMM: 228-334/334
Sequence Identity: 38% (41 aa)

LEYLAPEIIQGQP-YGKAVDWWSLGIILYEILYEETPFFADSPEKIKKNILENS---IKF--V------RFRGSPISELILQLLEKDPKKRITIA----G
..|.|||.| ||. .||.|||||.|||.||.|   .||. |.||.|  |||  .   |..  .          ..  .|| .||. ||.||..       
PDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNGADE

IKKSKFF
.|. .||
VKQHPFF
Kinase 86669.m00117.AA AGC 152-239 28 2e-27 66.6 In-house 73-196 (395) Show / Hide 
Range on Protein: 152-239
Range on HMM: 73-196/395
Sequence Identity: 28% (35 aa)

IFSLPQ----------NQFLLN-LLYTFQDANN--YYLSLEYPP----------S-ELLPFLS---GLPMIPEDVLRFYASE-------LVVTLDFLHN-
|... .          ..|. . | |.||| ..   |. .|| |            ||.  |    .    .|.. ||||.|       .|  |..||. 
ILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSH

HFIVYRG-LTSSNIFLAKDGHVKL
. |..|  |   || | .|||.||
MGIIHRDYLKPENILLDEDGHIKL
Kinase 86669.m00117.AA RSK 252-342 29 9.5e-27 94.98 In-house 172-278 (278) Show / Hide 
Range on Protein: 252-342
Range on HMM: 172-278/278
Sequence Identity: 29% (32 aa)

LEYLAPEIIQ---GQP-YGKAVDWWSLGIILYEILYEETPFFA---DSPEKIKKNILENS--IKFV--RFRGSPISELILQLLEKDPKKRIT-----IAG
.||.|||..    .|  ..||.||||||...|| |   .|| .   .....| |.|...    ..    .   .  .|| ..|..||.||..     .. 
IEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE

IKKSKFF
||....|
IKQHPWF
Kinase 86669.m00117.AA PKA 253-342 41 2e-26 94.08 In-house 163-263 (263) Show / Hide 
Range on Protein: 253-342
Range on HMM: 163-263/263
Sequence Identity: 41% (42 aa)

EYLAPEIIQGQ-PYGKAVDWWSLGIILYEILYEETPFFAD--SPEKIKKNILENSIKFVRFRGSPI---SELILQLLEKDPKKRI-TIAG----IKKSKF
|||||||||.  ..||.||||.|||. || |   .||...  .| .| . |..  ||| |.  |       || .||..|..||. .  .    ||. |.
EYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKW

F
|
F
Kinase 86669.m00117.AA Pkinase 252-342 28 7.7e-25 88.92 Pfam 175-293 (293) Show / Hide 
Range on Protein: 252-342
Range on HMM: 175-293/293
Sequence Identity: 28% (34 aa)

LEYLAPEIIQ-GQPYGKAVDWWSLGIILYEILYEETPFFAD------SPEKIKKNILENSIKFVRFRG---------------------SPISELILQLL
..|.|||.|. ||.||..||.||.|.|||| |  ..||  .      .. .. ..|..  ..| ..                       ..  ..|  .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

EKDPKKRITIAGIKKSKFF
.||||||.|.. |.....|
CKDPKKRPTAEQILQHPWF
Kinase 86669.m00117.AA p70 253-342 32 6.2e-19 65.29 In-house 203-299 (299) Show / Hide 
Range on Protein: 253-342
Range on HMM: 203-299/299
Sequence Identity: 32% (32 aa)

EYLAPEIIQGQPYGKAVDWWSLGIILYEILYEETPFFADSPEKIKKNILENS--IKFVRFRGSPISELILQLLEKDPKKRIT-----IAGIKKSKFF
|| ||||. .  ...||||||||. .|  |    || .. . |. . || .   .|           || .|| ..|..|..     .| |.. .||
EYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 86669.m00117.AA p70 160-239 40 3.9e-16 55.03 In-house 89-169 (299) Show / Hide 
Range on Protein: 160-239
Range on HMM: 89-169/299
Sequence Identity: 40% (33 aa)

FLLNLLYTFQDANNYYLSLEY-PPSELLPFLSGLPMIPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKL
|.  |.| ||.    || ||| .  ||   |    . .||. .||.|| .. | .|| | |.|| |   |. | . |||.|
FICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVL
Kinase 86669.m00117.AA RSK 157-239 33 8.6e-14 47.11 In-house 59-148 (278) Show / Hide 
Range on Protein: 157-239
Range on HMM: 59-148/278
Sequence Identity: 33% (30 aa)

QNQFLLNLLYTFQDANNYYLSLEYPP-SELLPFLSGLPM---IPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAK---DGHVKL
| .|. .| |.||.    || .|| .  ||.  |.   .   . ||  .||..|.|.....|| . |..| |  .|| ..    .||.||
QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKL
Kinase 86669.m00117.AA SGK 196-239 50 5.7e-12 32.78 In-house 123-166 (283) Show / Hide 
Range on Protein: 196-239
Range on HMM: 123-166/283
Sequence Identity: 50% (22 aa)

PEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKL
|||. ||||.|.|  |. ||   |.|| |   || |  .||..|
PEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCL
Kinase 86669.m00117.AA TyrKc 102-342 15 1.3e-08 -83.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-342
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

FRKITKLGSSPYGDITLCEYNDTLNVIIEIGKKKLVEFSHVESYIPERNLIFSL-PQNQFLLNLLYTFQDA-------NNYYLSLEYPPS-ELLPFLSGL
 ... |||.  .| . .....  ..| .    |.| | . .|  . | ..  .| .... ...|.    .          ... .|| |   |. .|   
ITLGKKLGEGAFGEVYKGTWK--IQVAV----KMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PM-IPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKLG-------GYGT--------DISS----HRE----LEYLAPEIIQGQPYGKA
   .. . |  ..       ..|| . .. | |   |. ......|| .       .|           ...    ..     .  .||| |.   .  .
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDWWSLGIILYEIL-YEETPFFA-----DSPEKIKKNILENSIKFVRFR---------GSPISELILQLLEKDPKKRITIAGIKKSKFF
 | || |. ..||. | ..|         |.. . ... .                   . . ....|  . ||..| | . |   ..|
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 86669.m00117.AA Pkinase 160-240 22 1.6e-08 31.19 Pfam 61-154 (293) Show / Hide 
Range on Protein: 160-240
Range on HMM: 61-154/293
Sequence Identity: 22% (21 aa)

FLLNLLYTFQDANNYYLSLEYPPS-----ELLPFLS---GLPM-IPEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHV----KLG
. . |...|.| ...|. .|| .      .|  ..|   . ..  .|....||. ...  |...|.. |..| | ..||.. ..||.    |..
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC
Kinase 86669.m00117.AA MAST 196-239 38 7.2e-07 17.82 In-house 97-140 (334) Show / Hide 
Range on Protein: 196-239
Range on HMM: 97-140/334
Sequence Identity: 38% (17 aa)

PEDVLRFYASELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKL
.|.  ..| .|.|  |..||.| || | |   |. . ..||.||
DEWMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKL
Kinase 86669.m00117.AA PKA 196-240 36 2e-06 25.74 In-house 98-143 (263) Show / Hide 
Range on Protein: 196-240
Range on HMM: 98-143/263
Sequence Identity: 36% (17 aa)

PEDVLRFYAS-ELVVTLDFLHNHFIVYRGLTSSNIFLAKDGHVKLG
.... .|||  . | .|..||.. |.|| |   || . |.||.|..
SNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKIT
Kinase 86669.m00117.AA MAST 148-180 39 0.000372 8.93 In-house 49-80 (334) Show / Hide 
Range on Protein: 148-180
Range on HMM: 49-80/334
Sequence Identity: 39% (13 aa)

ERNLIFSLPQNQFLLNLLYTFQDANNYYLSLEY
||| |... ||.|  .. |.|| .|.... .||
ERN-ILAMYQNPFVVKMFYSFQTKNYLCMVMEY
Kinase 86669.m00117.AA PKA 160-180 36 0.12235 4.46 In-house 60-81 (263) Show / Hide 
Range on Protein: 160-180
Range on HMM: 60-81/263
Sequence Identity: 36% (8 aa)

FLLN-LLYTFQDANNYYLSLEY
|. . . .||||....|. .||
FIVKKMYWTFQDDRYLYMVMEY