Gene 93242.m00186 (T.vaginalis)
93242.m00186
Species: T.vaginalis
Alias: 93242.m00186, TvagK0231
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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93242.m00186.AA | Protein | None | 315 | None | Fasta, JSON |
93242.m00186.kin_dom | Protein Kinase Domain | None | 241 | None | Fasta, JSON |
Protein domains of 93242.m00186.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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S_TKc | 93242.m00186.AA | S_TKc | 20-263 | 26 | 3.1e-53 | 184.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 20-263 Range on HMM: 1-231/231 Sequence Identity: 26% (69 aa) LQYQDVITQLGDGVIYMVFSRQYKISFALKSIPQTKFNTSEIDCFQLLDDPNIVNLYQYFSFNGKVYLLMEYCTN---DLDRYLRNKPR------LSSED . ..| . . |. | . . . .|.| |. . .||.. . . ||||.|| .| ...|. |||| . || .|.....| .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H QLTLVFSVARAVKACHDKGIAHSDIKPSNFLIDQHGRLKINDFGNAQIVSPDQRSNYFNGTKNFQAPEIWKHEFYDPYKADIWSLGVTFYIIATGNHPFS .. ...|.. ||..|| | |.||.| |.|. ..|| ||| | .. . | || .. |||. |.. |.|.||.|...|. ..| ||. ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP LFDNEQMKGQILAGSFNESRIGDPCMRQLIKLCLDINPDNRPDIDTIIN-------LPMF . ..| .|. .| ....|. ||. .|..|| . . . | | --QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 93242.m00186.AA | CAMK | 28-263 | 17 | 2.1e-49 | 156.98 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 28-263 Range on HMM: 1-425/425 Sequence Identity: 17% (74 aa) QLGDGV---IYMVFSRQYK------------ISFALKSIP---------------------------------QTKFNTSEIDCFQL-------LDDPNI .|| | . .. .. . .| | |. |. .||.. .. || ||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLYQYFS------------FNGK--------VYLLM---EYCTN-----DLDRYLRNKPR---------------LSSEDQLTLVFSVARAVKACHDKG ..||... . | .|. | |||.. || |.. ... .. .. ... .. ||. ||... IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IAHSDIKPSNFLIDQH-----------------GRLKINDFGNAQIVSP------------------------DQRSNYFNGTKNFQA-PEIWKH----- |.| |.|| | |.|.. . .|| ||| |... | .| . | || . | ||. . IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN --------EFYDPYKADIWSLGVTFYIIATGNHPFSLF-------------DNEQMKGQILAGSFN-ESRIGDP-----------------------CMR . |...|.|.||.|| || .| || . .... .|..| .. .. .| . MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK QLIKLCLDINPDNRPDIDTIINLPMF .||. .| .|..|. |. . | | . DLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 93242.m00186.AA | Pkinase | 43-263 | 27 | 5e-48 | 170.67 | Pfam | 33-293 (293) | Show / Hide |
Range on Protein: 43-263 Range on HMM: 33-293/293 Sequence Identity: 27% (73 aa) KISFALKSIPQTKFNTSEIDCFQLLDDPNIVNLYQYFSFNGKVYLLMEYCTN-----DLDRYLR--NKPRL--SSEDQLTLVFSVARAVKACHDKGIAHS | . . .. .||....||| . |. |||| || .| ....|. |||| . || .|.. .. .. | .. . ..|... ||..|| | KKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR DIKPSNFLIDQHGRL----KINDFGNAQI--VSPDQRSNYFNGTKNFQAPEIWKHEFYDPYKADIWSLGVTFYIIATGNHPFSLF------DNEQMKGQI |.||.|.|||..| . || ||| | ... . | || .. |||. .. |...|.|.||.|...|. ..|. ||. | || .| DLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRI LAGSFNESRIGD---------------------PCMRQLIKLCLDINPDNRPDIDTIINLPMF . . . ... . . ....|| ||. .| || .. | . | | MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 93242.m00186.AA | Ciliate-E2 | 65-263 | 22 | 1.7e-45 | 154.12 | In-house | 87-365 (365) | Show / Hide |
Range on Protein: 65-263 Range on HMM: 87-365/365 Sequence Identity: 22% (65 aa) QLLDDPNIVNLYQYFS--FNGKVYLLMEYCTN-DLDRYLRNK-----------PRLSSEDQLTLVFSVAR---------------AVKACHDKG-IAHSD ..|. |||...| .| . ..|| |||| || |..|. ... . ... ... |.. .| |. | | | EQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRD IKPSNFLIDQHGRLKINDFGNAQIVSPDQRSNY--------------------------------FNGTKNFQAPEIWKHEFYDP--------YKADIWS |||.| |. .|| |||.......|. .. . || ...|||| . . || ||.|||| IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS LGVTFYIIATGNHPFSLFDNEQMKGQILAGSFN-------------ESRIGDPCMRQLIKL----CLDINPDNRPD-IDTIINLPMF |||..|. .|..|| .......| ... . .. . .||| .|. .|..|.. .. |.| | | LGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 93242.m00186.AA | CAMKL | 48-263 | 28 | 4e-43 | 135.37 | In-house | 38-297 (297) | Show / Hide |
Range on Protein: 48-263 Range on HMM: 38-297/297 Sequence Identity: 28% (75 aa) LKSIPQTKFN------------TSEIDCFQLLD---DPNIVNLYQYFSFNGK------VYLLMEYCTND---LDRYLRNKPR----LSSEDQLTLVFSVA .. .|..| | . || . ..|. |||. ||. . . .|| |||| . | |...... .. .. . . IWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIV RAVKACHDKGIAHSDIKPSNFLIDQHG--RLKINDFGNAQIVSP-----DQRSNYFNGTKNFQAPEIWKH--EFYDPYKADIWSLGVTFYIIATGNHPFS ||. ||..||.| |||| | |.|..| .|| ||| . . | .| . | |. ...|||| . . || .|.||||.||. | . .|. || SAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFD LF--------DNEQMKGQILAGSFNES---RIGDPCMRQLIKLCLDINPDNRPDIDTIINLPMF .. .. .| | ... .. .| |.||. | ||. || |. | | | . DDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DC-RDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 93242.m00186.AA | Ciliate-E2-Unclassified | 67-263 | 24 | 6.9e-43 | 146.59 | In-house | 78-352 (352) | Show / Hide |
Range on Protein: 67-263 Range on HMM: 78-352/352 Sequence Identity: 24% (67 aa) LDDPNIVNLYQYFSFNGKVYLLMEYCTN-DLDRYLRNKP----------------RLSSEDQL------TLVFSVARAVKACHDKG-IAHSDIKPSNFLI ...|.||... .| ..|. |||| . || |..... . .| | .. . . . .| |. | | ||||.| |. HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF DQHG---RLKINDFGNAQIVS----------------PDQRSNYFNGTKNFQ----APEIWKHEFYDP---YKADIWSLGVTFYIIATGNHPFSLFDNEQ |. | ..|| |||.. ..|... | || |.. |||. . . || ||.||||||| .| . .|..||. . || DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQ ----------------MKGQILAGSFNESR--------IGDPCMRQLIK----LCLDINPDNRPDIDTIINLPMF .. .|... .. . . .|. .|. .|. ||..|.... |.| | | HQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 93242.m00186.AA | MARK | 121-263 | 40 | 8.8e-37 | 117.87 | In-house | 116-262 (262) | Show / Hide |
Range on Protein: 121-263 Range on HMM: 116-262/262 Sequence Identity: 40% (60 aa) AVKACHDKGIAHSDIKPSNFLIDQHG--RLKINDFGNAQIVSPDQRSNYFNGTKNFQAPEIWKHEFYDPYKADIWSLGVTFYIIATGNHPFSLFD--NEQ ||. ||.|.|.| |||| | |||..| || ||| . .. |.|. | | ||. . |||| . . || .|.||||||| |.. .|. || . ... AVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKE MKGQILAGSFN-ESRIGDPCMRQLIKLCLDINPDNRPDIDTIINLPMF .. .||.|.. ... . | |.||.. | .||. ||.|. | . | . LYKKILRGKYDIPCHVSKEC-RNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 93242.m00186.AA | TKL | 70-261 | 17 | 4.5e-33 | 116.21 | In-house | 85-364 (364) | Show / Hide |
Range on Protein: 70-261 Range on HMM: 85-364/364 Sequence Identity: 17% (51 aa) PNIVNLYQYFSFNGK-------------VYLLMEYC-TND-LDRYLRNKPRLSSEDQLTLVFSVARAVKACHD--------KGIAHSDIKPSNFLIDQHG |||| .. | ... .. |||| . |.... . . .. ..||.. | ..|.| |.|..| |.|... PNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENW R--------------LKINDFGNAQIVSPDQ--------------------RSNYFNGTKNFQAPEIWKHE-FYDPY--------------KADIWSLGV . .|| ||| .. .|... ... ||... |||. . . .|. . |.|..| |. TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI TFYIIATGNHPFSLFDNEQMKGQ-------ILAGS-FNESRIG------------DPC---MRQLIKLCLDINPDNRPDIDTIINLP .. |.|. .|.. .....|..| ..... .. | ..| |..|.. | | .|..|| ..|. VLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 93242.m00186.AA | CAMKK-Unclassified | 118-263 | 24 | 2.3e-29 | 92.58 | In-house | 187-392 (392) | Show / Hide |
Range on Protein: 118-263 Range on HMM: 187-392/392 Sequence Identity: 24% (51 aa) VARAVKACHDKG---------------------IAHSDIKPSNFLIDQHGR-----LKINDFGNAQIVSPDQRS--NYFNGTKNFQAPEIWKHE-FYDPY .. ... .|... | | |||| | |||. .. .|| ||| ..|.. .| . . .||. |.||| | | | .| CCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDY KA--------------------------DIWSLGVTFYIIATGNHPFSLFDNEQMKG-QILAGS-FNES---RIGDPCMRQLIKLCLDINPDNRPDIDTI .. ||||||||||..... || ...... .|... . . . . ||. ..| ||. | .|| . NDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCSHEFKDLIQKMCDKNPKKRITIDQM INLPMF .. | | LVHPWF |
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Kinase | 93242.m00186.AA | ULK | 46-263 | 25 | 3.1e-29 | 99.23 | In-house | 31-329 (329) | Show / Hide |
Range on Protein: 46-263 Range on HMM: 31-329/329 Sequence Identity: 25% (77 aa) FALKSIP---QTKFN------------TSEIDCFQLLD----DPN----IVNLYQYFSFN--GKVYLLMEYCTN-DLDRYLRNKPRL---------SSED .| | |. . ..| ..||. . |. .| || || .| .|. |||| ||. |. .. .| ||. VACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQ QLTLVFS-VARAVKACHDKGIAHSDIKPSNFLIDQH------------GRLKINDFGNAQIVSPD----QRSNYFN------GTKNFQAPEIWK----HE . .| . . |. |...| | ||||.| ||. . |.||| ||| |. |. | | .. || . ||.|.. .. EAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQK FYDPYKADIWSLGVTFYIIATGNHPFSLFDNEQMKGQILAGSFN--------------------ESRIGDPCMRQLIKLCLDINPDNRPDIDTIINLPMF |. ||.||||||. || . .| ||. ... . ||. .| .. . | ...||. .| .... | ... ..| | | PYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 93242.m00186.AA | STE | 23-263 | 18 | 2.1e-28 | 97.44 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 23-263 Range on HMM: 1-359/359 Sequence Identity: 18% (68 aa) QDVITQLGDGVIYMVFSRQYK----IS--------------FALKSIPQTKFNT----------------------SEIDCFQLLD--DPNIVNLYQYFS .. | ..| | |. .. | .| | .. . |. ||. . .. ||||. | .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF FNG-------KVYLLMEYCT-NDLDRYLRNKPRLSS-------------EDQL-TLVFSVARA-VKACHDKGIAHSDIKPSNFLIDQHGRLKINDFGNAQ .| .... |||. || ...| |.|. . .... .. . |...| | ||||.| |. |. ||| . KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG IVSP-----------------DQRSNYFNGTKNFQAPEIWKH-EFY--DPY--KADIWSLGVTFYIIATGNHPFSLFDNEQMKGQILAGS---------- .... .|..| | || . |||. . . ..| |.|||||| | |||..|.. . . .. .|. .. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC ---FNESRIGD----------------------PCMRQLIKLCLDINPDNRPDIDTIIN--LPMF .. .. | |.... |..||...|..||. . .. | . IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 93242.m00186.AA | ULK | 46-263 | 26 | 1.1e-26 | 91.73 | In-house | 31-324 (324) | Show / Hide |
Range on Protein: 46-263 Range on HMM: 31-324/324 Sequence Identity: 26% (78 aa) FALKSIP---QTKFNT------------SEIDCFQLLD---DPN--IVNLYQYFSFN--GKVYLLMEYCTN-DLDRYLRNKPRL--------SSEDQLTL .| | |. . |.. .|| . |. || || || .| .|. |||| ||. |. .. .| ||.. VACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQ VFS-VARAVKACHDKGIAHSDIKPSNFLIDQ------------HGRLKINDFGNAQIVSPDQRSNYFN----------GTKNFQAPEIWK----HEFYDP .| . . |. |...| | ||||.| || .|.||| ||| |..| .. . . || . ||.|.. .. |. FFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYD YKADIWSLGVTFYIIATGNHPFSL-FDNEQ----------------MKGQILAGSFN---ESRIGDPCMRQLIKLCLDINPDNRPDIDTIINLPMF ||.||||||. || . .| ||. | ... .| | . |. .. . | ...||. .| .... | ... |.| | | YKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQ--FPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 93242.m00186.AA | TyrKc | 23-263 | 23 | 5.8e-12 | -29.23 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 23-263 Range on HMM: 1-280/280 Sequence Identity: 23% (66 aa) QDVITQLGDGVIYMVFSRQYKISFALKSIPQTKFNT----SEIDCFQLL--DDPNIVNLYQYFSFN-------GKVYLLMEYCTN-DLDRYLRNKPR-LS . .|| | |. ..|| | |.. . .|. | . ||||.|| . . . ....|||. . ||. |||.. . |. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC SEDQLTLVFSVARAVKACHDKGIAHSDIKPSNFLIDQHGRLKINDFGNAQIVSPD----QRSNYFN-----GTK-----NFQAPEIWKHEFYDPYKADIW .| | . .|. |.|.. | |. | |.. .. || ||| . . | .. | |.| ||| ... . . | |.| MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVW SLGVTFY-IIATGNHPFSL-----FDNEQMKGQILAGSFNESRIG---------DPCMRQLIKLCLDINPDNRPDIDTIINLPMF | ||. . | | | . .|... .. .| . . | |..| | . .|..|| .| | SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 93242.m00186.AA | MARK | 42-92 | 24 | 1.2e-05 | 14.63 | In-house | 23-84 (262) | Show / Hide |
Range on Protein: 42-92 Range on HMM: 23-84/262 Sequence Identity: 24% (15 aa) YKISFALKSIP---QTKFNT-----SEIDCFQLLDDPNIVNLYQYFS--FNGK-VYLLMEYC ... .|.| .. ..... .||. ..|| |||. |.... ... .|| |||. TGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYA |
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Kinase | 93242.m00186.AA | CAMKK-Unclassified | 59-92 | 39 | 0.002176 | 6.55 | In-house | 67-104 (392) | Show / Hide |
Range on Protein: 59-92 Range on HMM: 67-104/392 Sequence Identity: 39% (15 aa) SEIDCFQLLDDPNIVNLYQYF--SFNGKVYL--LMEYC .|| .|. |||. ||.. . | | |. .|||| QEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQVMEYC |