Gene 81528.m00051 (T.vaginalis)

81528.m00051

Species: T.vaginalis
Alias: 81528.m00051, TvagK0266
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
81528.m00051.AA Protein None 799 None Fasta, JSON
81528.m00051.kin_dom Protein Kinase Domain None 197 None Fasta, JSON

Protein domain

Protein domains of 81528.m00051.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81528.m00051.AA TKL 49-269 16 3.7e-32 113.11 In-house 32-364 (364) Show / Hide 
Range on Protein: 49-269
Range on HMM: 32-364/364
Sequence Identity: 16% (56 aa)

KAINTDD-----------------------------YMKNRSYMMNKLSKASIPYLLPIFGFINSEN--------------HATIYEYSNYKSLYLTLHC
| .....                             ... . . .. .|. . | .... |. ....              .. ..||    ||. .|| 
KKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-

DPSPIILSSTQKMKIIICILQSLIKLHENG--------IVHQNIRTESILLDTNLL--------------PKLIDC------CENFYPEANDT-------
          |...... | . .  || ..        |.| .. .. ||.| |.               .|. |       ....  ... |       
--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE

------QVDDFIGSPTWIAPEVFKTH----------------KYTEKSDIYSFGIFLFEILADQKPYSGYSYK---------YIQELALKSSLKLPKS--
      .    .|.| | ||||.. .                .|.||.|.||||| |.|||. ..||..| |           ..... . .|..|    
HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPI

----------DFISQDFMRIIEKCCNINPETRPSATDIYNDI
          . . ... .....|.. .|| |||...|   .
WQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 81528.m00051.AA TKL-Unique 112-269 26 1.5e-28 97.88 In-house 107-290 (290) Show / Hide 
Range on Protein: 112-269
Range on HMM: 107-290/290
Sequence Identity: 26% (49 aa)

LSSTQKMKIIICILQSLIKLHENG--IVHQNIRTESILLDTNL-------------LPKLID-CCENFYPEANDTQVDDFIGSPTWIAPEVFKT--HKYT
|.  |..|..|.| | .. || ..  | | .... ..|.| |.             |.|. .   .... | . |  ....||. |.||||..    .|.
LNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYS

EKSDIYSFGIFLFEILADQK------PYSGYSYKYIQELALK--SSLKLPKSDFISQDFMRIIEKCCNINPETRPSATDIYNDI
||||.||||| | ||.  .       ||.|.. . . |.. .   .. .| .. . ...  .|..|.. .|. ||| ..|.. .
EKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 81528.m00051.AA STE 119-270 20 2.1e-25 86.75 In-house 155-359 (359) Show / Hide 
Range on Protein: 119-270
Range on HMM: 155-359/359
Sequence Identity: 20% (44 aa)

KIIICILQS-LIKLHENGIVHQNIRTESILLDTNLLPKLID--CCENFYPE--------------ANDTQVDDFIGSPTWIAPEVFKT------HKYTEK
.|.  ||.  |  ||...|.|  |    |||      ||.|  .| .. ..               .. . . |.|.| | |||| .       ..|..|
YICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTK

SDIYSFGIFLFEILADQKPYSGYSYKYIQELAL----------------KSSLKLPK-----------------SDFISQDFMRIIEKCCNINPETRPSA
.||.|.|. . | .  . |.. ... .   ...                . . .||                  ..  |..|   |.||....|. ||.|
CDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

TDIYN---DII
..  .     |
SQLLKSEHPFI
Kinase 81528.m00051.AA Ciliate-E2-Unclassified 78-271 19 5.9e-21 69.45 In-house 87-352 (352) Show / Hide 
Range on Protein: 78-271
Range on HMM: 87-352/352
Sequence Identity: 19% (53 aa)

IFGFINSENHATIYEYSNYKSLYLTLHCDPSP---------------IILSSTQKM-----KIIICILQSLIKLHENG-IVHQNIRTESILLDTNL---L
.. | . .|   ..|| ....| .  ... .                 |..  |       ... .||| | .||... |.| .|  | ||.| |     
FYCFQDKQNIYIVMEYCEGGDL-WQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYY

PKLID--------CCENFYPEAN--------DTQVDDFIGSPTWI----APEVFKTHKYT----EKSDIYSFGIFLFEILADQKPYSGYSYKY-------
.|.||         ..|.. . .        .   ..|.|.|  .    ||||.. ..|     .|.||.|.|. |.|.|  . |.......        
IKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQ

---------IQELALKSSLKLPKSDF------IS---QDFMR-IIEKCCNINPETRPSATDIYNDIIN
         ...  ..  .. ||...      .|   .|| . .. |. . ||. |... .| |  . 
WINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81528.m00051.AA Ciliate-E2 120-275 20 8.7e-20 64.58 In-house 165-365 (365) Show / Hide 
Range on Protein: 120-275
Range on HMM: 165-365/365
Sequence Identity: 20% (45 aa)

IIICILQSLIKLHENG-IVHQNIRTESILLDTNLLPKLIDCCE-----------------NFYPEAN---------------DTQVDDFIGSPTWIAPEV
.| ||.. |  ||... |.| .|  | ||.     .|.||                    . |.. .               . ... ..|.|   |||.
YIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI

FKTHK---------YTEKSDIYSFGIFLFEILADQKPYSGYSYKYIQELALKSSLKLPKS------------DF--ISQDFMRIIEK----CCNINPETR
..  |         |..|.||.|.|. |.| |  . |.      ..| .  | ..  |..            ..  .||. . .| |    . . .|| |
LNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR

PSATDIYNDIINNKIF
..    ...|.|...|
IT---GWEQILNHPWF
Kinase 81528.m00051.AA MLK 175-269 27 1.7e-19 64.42 In-house 193-291 (291) Show / Hide 
Range on Protein: 175-269
Range on HMM: 193-291/291
Sequence Identity: 27% (28 aa)

FIGSPTWIAPEVF---KTHKYTEKSDIYSFGIFLFEILADQKPYS-GYS-YKYIQELALKS-SLKLPKSDFISQDFMRIIEKCCNINPETRPSATDIYND
..|.. | ||||.   .  ||.||.|..|.|. | |.|. . ||. .|.    . . |...  . .|..  ..  . . ...| | .|. |||   |   
NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST--CPEHWKKLMKQCWNQDPHKRPSFRQIVQH

I
 
L
Kinase 81528.m00051.AA Fer 181-270 26 1.7e-19 63.11 In-house 184-283 (283) Show / Hide 
Range on Protein: 181-270
Range on HMM: 184-283/283
Sequence Identity: 26% (26 aa)

WIAPEVFKTHKYTEKSDIYSFGIFLFEILAD-QKPYSG----YSYKYI----QELALKSSLKLPKSDFISQDFMRIIE-KCCNINPETRPSATDIYNDII
| |||...|  |..|.|..|||. ..|| .. ..|| |       . .    ..   |.   .|  .    ..|.|.. .|.. .|| ||....|.. . 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase 81528.m00051.AA TAK1 177-268 24 2.7e-19 61.77 In-house 165-284 (284) Show / Hide 
Range on Protein: 177-268
Range on HMM: 165-284/284
Sequence Identity: 24% (29 aa)

GSPTWIAPEV----------------------FKTHKYTEKSDIYSFGIFLFEILADQKPYSGYSY---KYIQELALKSSLKLPKSDF---ISQDFMRII
|.. | ||||                      |.  ||..|.||||.|| . |... ..||...      |    |  .  ..|       .        
GTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCEKYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRIEQFM

EKCCNINPETRPSATDIYND
..| ..||| |||  ..   
KCCWDDNPEKRPSMQECVKY
Kinase 81528.m00051.AA TK 181-269 17 6.6e-19 59.3 In-house 351-486 (486) Show / Hide 
Range on Protein: 181-269
Range on HMM: 351-486/486
Sequence Identity: 17% (24 aa)

WIAPEVFK---------THKYTEKSDIYSFGIFLFEILA--DQKPYSGYSY---------KYIQELALKS-------------SLKLPKSDFIS------
| |||...         ..|.|.|||..|||....||.   .. .| | |          . . |.  .               . .|. .  .      
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------QDFMRIIEKCCNINPETRPSATDIYNDI
        ....... .|.. .|| ||. ..... .
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 81528.m00051.AA UTK 181-269 27 8.2e-19 60.99 In-house 205-296 (296) Show / Hide 
Range on Protein: 181-269
Range on HMM: 205-296/296
Sequence Identity: 27% (25 aa)

WIAPEVFKTH-KYTEKSDIYSFGIFLFEILAD-QKPYSGYSYKYIQELALKSS-LKLPKSDFISQDFMRIIEKCCNINPETRPSATDIYNDI
| |||..  | ..|.|||..|||....||..  ..|| |.|   . .  .. . . .|. .  . .  |.  .|.. .|. ||.. |..  .
WMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase 81528.m00051.AA Pkinase 146-269 21 1.7e-18 66.45 Pfam 139-293 (293) Show / Hide 
Range on Protein: 146-269
Range on HMM: 139-293/293
Sequence Identity: 21% (34 aa)

ILLDTNLLP----KLID--CCENFYPEANDTQVDDFIGSPTWIAPEVFK-THKYTEKSDIYSFGIFLFEILADQKPYSGY------SYKYIQELALKSSL
||.| |  .    |..|  ... |. . |..  ..| |.| ..|||| .   .|. |.|..|.|. |.| |  . |..|       . ... .. ..  |
ILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPL

KLPKSDFIS-------------------QDFMRIIEKCCNINPETRPSATDIYND--I
. . .  .|                   ...  .|..|.. .|. ||.|..| ..  .
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc 81528.m00051.AA S_TKc 16-275 19 3.8e-15 45.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-275
Range on HMM: 1-231/231
Sequence Identity: 19% (52 aa)

FQKDYIILRYDDCEIFTAKFKENSQKFVIQTRKKAINTDDYMKNRSYMMNKLSKASIPYLLPIFGFINSENHATIYEYSNY--KSLYLTLHCDPSP---I
...  .| .    . . .. |.  ... |    | |. .. .. .. ...      |  |. .|     ..   . || .    .|.  ..  ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAI----KIIK-EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

ILSSTQKMKIIICILQSLIKLHENGIVHQNIRTESILLDTNLLPKLID---CCENFYPEANDTQVDDFIGSPTWIAPEVFKTHKYTE-KSDIYSFGIFLF
 ..  .  ...  |.. |  .|..||.|  .  | ||||.    |..|   ...           . |.|.| ..||||.   .|.  |.|..|.|. |.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EILADQKPYSGYSYKYIQELALKSSLKLPKSDFISQDFMRIIEKCCNINPETRPSATDIYN---DIINNKIF
| |. . |..   .. . .. .            |...  .|.||.. .|| ||.| .. .   || .   |
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81528.m00051.AA Pkinase_Tyr 181-269 28 3.8e-15 51.93 Pfam 180-270 (270) Show / Hide 
Range on Protein: 181-269
Range on HMM: 180-270/270
Sequence Identity: 28% (26 aa)

WIAPEVFKTHKYTEKSDIYSFGIFLFEILA-DQKP-YSGYSYKYIQELALKSSLKLPKSDFISQDFMRIIEKCCNINPETRPSATDIYNDI
| |||.... |.|.|||..|||. ..||.   ..| | | |   . |.  ..   .|. .  ...  ... .| . .|| ||. ..|....
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc 81528.m00051.AA TyrKc 23-269 19 6.2e-10 -62.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-269
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

LRYDD-------CEIFTAKFKENSQKFVIQTRKKAINTDDYMKNRSYM--MNKLSKA--SIPYLLPIFGFINS--------ENHATIYEYSNYKSL--YL
.. ..       .|.. .. |       ||   | .. |     .  |  .. ..|   . | .. ..| . .        | .  . ||  . .|  ||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

TLHCDPSPIILSSTQKMKIIICILQSLIKLHENGIVHQNIRTESILLDTNL--------LPKLIDCC-ENFYPEANDTQVDDF-IGSPT-----WIAPEV
  | .     |.  .. .. . | .    ||.....|  . .  .|.. |.        | . |.   ..   |. |. .     |. |     | |||.
RKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPEC

FKTHKYTEKSDIYSFGIFLFEILAD-QKPYSG------YSYKYIQELALKSSLKLPKSDF------ISQDFMRIIEKCCNINPETRPSATDIYNDI
....|.|.|||..|||. ..||. . |.||.|        .  |. .     .. |..|        ...  .|...|.. .|| ||. ..|. ..
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF