Gene 93835.m00194 (T.vaginalis)
93835.m00194
Species: T.vaginalis
Alias: 93835.m00194, TvagK0980
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93835.m00194.AA | Protein | None | 273 | None | Fasta, JSON |
| 93835.m00194.kin_dom | Protein Kinase Domain | None | 124 | None | Fasta, JSON |
Protein domains of 93835.m00194.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 93835.m00194.AA | Ciliate-E2 | 75-178 | 19 | 4.1e-18 | 58.76 | In-house | 114-286 (365) | Show / Hide |
Range on Protein: 75-178
Range on HMM: 114-286/365
Sequence Identity: 19% (35 aa)
EFFPNGDLKNFTKNN------------CIVTEDIARFFYQCAR---------------GLQYLHKNG-YIHRDISPRNIFIDINRNASLGDLEYSTNNPD
|.. |||. . ||| ... . |.....| .. .|.|||... ||||| | ||.. . |. .|... |
EYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDD
----------ASSRIISK---------------------------YSAPEIKEVPN----------TKKSDIYSIGATF
. . | | |||| . . ..|.||.|.| ..
DNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
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| Kinase | 93835.m00194.AA | Ciliate-E2-Unclassified | 35-175 | 18 | 1.6e-16 | 53.87 | In-house | 42-257 (352) | Show / Hide |
Range on Protein: 35-175 Range on HMM: 42-257/352 Sequence Identity: 18% (41 aa) KKRVVISDLPYQTNRMNLRF--------------------PSIIQLYYVENIDNELEFYQEFFPNGDLKNFTKNN-----------------CIVTEDIA ... .. .. . ..|| . | |. ..|... .. . . |....|||... |.. .|.|| | QIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQA R------FFYQCARGLQYLHKNG-YIHRDISPRNIFIDINR---NASLGDLEYSTNNPD-------------------ASSRIISKY--S---APEIKEV . .|.| ||.|||... ||||| | ||..| | . . |. | .. . ..... . . . |||. . KYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG -PNT----KKSDIYSIG . .|.||.| | QNYDHSKAYKCDIWSLG |
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| Kinase | 93835.m00194.AA | TKL | 75-175 | 18 | 2.8e-13 | 44.19 | In-house | 118-276 (364) | Show / Hide |
Range on Protein: 75-175 Range on HMM: 118-276/364 Sequence Identity: 18% (30 aa) EFFPNGD-LKNFTKNNCIVTEDIARFFYQCARGLQYLHKNG--------YIHRDISPRNIFIDINRN--------------ASLGDLEYST-NNPDASSR |. |.|. | ... . . |. ...|||..||| .. ||||. ..||..| | . . ..|. |. .... .. EYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMN IIS-----------------------KYSAPEI-----------------KEVPNTKKSDIYSIG .. . |||. |. . ..|.|.|| | DTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG |
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| Kinase | 93835.m00194.AA | NEK | 79-138 | 29 | 1.2e-12 | 41.19 | In-house | 91-167 (286) | Show / Hide |
Range on Protein: 79-138 Range on HMM: 91-167/286 Sequence Identity: 29% (23 aa) NGDLKNF---TKNN-----CIVTEDIARFFYQCARGLQYLHKN-----GYIHRDISPRNIFIDINRN----ASLGDL .||| .. |.. . | | ..|.| . .|.|.|.. .|||| | |||.. |.| . .||. GGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDF |
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| Kinase | 93835.m00194.AA | TK | 75-159 | 10 | 5.8e-12 | 35.63 | In-house | 135-355 (486) | Show / Hide |
Range on Protein: 75-159
Range on HMM: 135-355/486
Sequence Identity: 10% (24 aa)
EFFPNGD----LKNFTKNN---------------------------------------------------------CIVTEDIAR---------------
|. |.|| |... ... . | | .
EYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTM
----FFYQCARGLQYLHKN------GYIHRDISPRNIFIDINRN-----------ASLGDLE-------------------YSTNNPDA-----------
. .| |.|..|||.. ...|||. ||. .. | . . ..| |.......
HQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDP
---------SSRIISKYSAPE
. .. .. |||
WQDYYRQQSGGKLPIRWMAPE
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| Kinase | 93835.m00194.AA | STE | 96-177 | 26 | 8.5e-12 | 38.06 | In-house | 153-257 (359) | Show / Hide |
Range on Protein: 96-177
Range on HMM: 153-257/359
Sequence Identity: 26% (30 aa)
IARFFYQCARG-LQYLHKNGYIHRDISPRNIFIDINRNASLGD------LEYS------------------TNNPDASSRIISKYSAPEIKEVPNTK---
||.. .|. .| |.|||....||||| | ||.. . | | |. | .| .. . . |||. . ...
IAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDK
----KSDIYSIGAT
|.||.|.| |
GYDTKCDIWSLGCT
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| Kinase | 93835.m00194.AA | ULK | 57-128 | 32 | 9.5e-12 | 37.38 | In-house | 80-164 (329) | Show / Hide |
Range on Protein: 57-128 Range on HMM: 80-164/329 Sequence Identity: 32% (28 aa) IIQLYYVENID--NELEFYQEFFPNGDLKNFTKNN----------CIVTEDIAR-FFYQCARGLQYLHKNGYIHRDISPRNIFID |..|| . . . | . . .|. . |||... |.| . .|..|. ||.| . |...|||...||||| | || |. IVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIH |
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| S_TKc | 93835.m00194.AA | S_TKc | 7-224 | 19 | 1.6e-11 | -7.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-224 Range on HMM: 1-231/231 Sequence Identity: 19% (49 aa) VTDGNNITDLSSGNIQLLFHYATENFYTKKRVVISDLPYQTNR-----MNLRFPSIIQLYYVENIDNELEFYQEFFPN--GDLKNFTKNNCI------VT . .. | . | . | | . |.. .. | .. . | |..||.| ..| . |. .. |||. . |.. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP EDIARFFYQCARGLQYLHKNGYIHRDISPRNIFIDINRNASLGDLEYSTNNPDASSRIISKYSAPEIKEVPNTK-KSDIYSIGATF-----GKY------ |......|| ...|.|.|..| ||||. | ||..| . ..| .. . | |||. . .| |.|..|.| .. |. EHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFPQMQ -ILKYLEDDDLKNEFLNIVSQTKAEEPDNRISADELVG-----QIEDLL ..| . |....... .|..|..| |. . . MMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 93835.m00194.AA | ULK | 57-127 | 33 | 1.8e-11 | 37.04 | In-house | 77-159 (324) | Show / Hide |
Range on Protein: 57-127 Range on HMM: 77-159/324 Sequence Identity: 33% (28 aa) IIQLYYVENID--NELEFYQEFFPNGDLKNFTKNN---------CIVTEDIAR-FFYQCARGLQYLHKNGYIHRDISPRNIFI |..|| . . . | . . .|. . |||... |.| . .|..|. ||.| . |...|||...||||| | || | IVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI |
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| Kinase | 93835.m00194.AA | Ciliate-E6 | 102-137 | 36 | 1.6e-09 | 26.83 | In-house | 61-96 (154) | Show / Hide |
Range on Protein: 102-137 Range on HMM: 61-96/154 Sequence Identity: 36% (13 aa) QCARGLQYLHKNGYIHRDISPRNIFIDINRNASLGD | . ...|||...|.. |...|||.| | |. . | QLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICD |
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| Kinase | 93835.m00194.AA | MLK | 96-128 | 44 | 2.6e-09 | 28.61 | In-house | 126-161 (291) | Show / Hide |
Range on Protein: 96-128 Range on HMM: 126-161/291 Sequence Identity: 44% (16 aa) IARFFYQCARGLQYLHKNG---YIHRDISPRNIFID .... .|||||..|||.. .||||. ..|| || AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILID |
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| Kinase | 93835.m00194.AA | Pkinase | 57-128 | 30 | 3.9e-09 | 33.4 | Pfam | 62-142 (293) | Show / Hide |
Range on Protein: 57-128 Range on HMM: 62-142/293 Sequence Identity: 30% (25 aa) IIQLYYVENIDNELEFYQEFFPNG----DLKNFTK---NNCI--VTEDIARFFYQCARGLQYLHKNGYIHRDISPRNIFID |..||.. .... . .|. ..| ||. . . ..|. ... ...|| .|||.|.|..| ||||. | ||.|| IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID |
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| Kinase | 93835.m00194.AA | Pkinase_Tyr | 75-131 | 29 | 1.1e-07 | 26.71 | Pfam | 87-148 (270) | Show / Hide |
Range on Protein: 75-131 Range on HMM: 87-148/270 Sequence Identity: 29% (18 aa) EFFPNGDLKNFTKNN-----CIVTEDIARFFYQCARGLQYLHKNGYIHRDISPRNIFIDINR |. |.|||... ... . ..|. . .| |.|..||. ...||||. ||. .. |. EYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN |
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| Kinase | 93835.m00194.AA | TyrKc | 39-220 | 17 | 7.4e-07 | -111.74 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-220 Range on HMM: 1-280/280 Sequence Identity: 17% (49 aa) VISDLPYQ-------------------TNR--------------MNL--RFPSIIQLYYVENID-------NELEFYQEFFPNGDLKNFTKNNC--IVTE . . . . ..| . | |..|| | . | |. |.||||.. ... . .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK DIARFFYQCARGLQYLHKNGYIHRDISPRNIFIDINRNASLGD-----LEYST-------NNPDA----SSR--IISKYSAPEIKEVPN--TKKSDIYSI | | .| |.| .|||....||||. ||. .. |. . .| |. .. ... . . ||| . | |||..| DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSF G------ATFGK--------------YILKYLEDD-------D--------LKNEFLNIVSQTKAEEPDNRISADELVGQI | |.|. ...|... . | .| .| .|.|..| . |.. .. GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 93835.m00194.AA | MLK | 157-175 | 30 | 0.001984 | 7.91 | In-house | 201-223 (291) | Show / Hide |
Range on Protein: 157-175 Range on HMM: 201-223/291 Sequence Identity: 30% (7 aa) APEI----KEVPNTKKSDIYSIG |||. .. ....|.|..|.| APEVIQQFRCEKYSEKCDVWSWG |
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| Kinase | 93835.m00194.AA | Ciliate-E6 | 166-175 | 40 | 0.002371 | 6.94 | In-house | 145-154 (154) | Show / Hide |
Range on Protein: 166-175 Range on HMM: 145-154/154 Sequence Identity: 40% (4 aa) TKKSDIYSIG |...||.|.. TQEGDIWSVC |
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| Kinase | 93835.m00194.AA | ULK | 155-175 | 33 | 0.050782 | 2.95 | In-house | 217-243 (329) | Show / Hide |
Range on Protein: 155-175 Range on HMM: 217-243/329 Sequence Identity: 33% (9 aa) YSAPEIKE------VPNTKKSDIYSIG | ||.| . ....|.||.|.| YMAPQILQGQGEQKPYYDYKCDIWSLG |
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| Kinase | 93835.m00194.AA | ULK | 155-175 | 33 | 0.060592 | 2.76 | In-house | 213-239 (324) | Show / Hide |
Range on Protein: 155-175 Range on HMM: 213-239/324 Sequence Identity: 33% (9 aa) YSAPEIKE------VPNTKKSDIYSIG | ||.| . ....|.||.|.| YMAPQILQGQGEQKPYYDYKCDIWSLG |
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