Gene 85337.m00276 (T.vaginalis)

85337.m00276

Species: T.vaginalis
Alias: 85337.m00276, TvagK0384
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
85337.m00276.AA Protein None 380 None Fasta, JSON
85337.m00276.kin_dom Protein Kinase Domain None 185 None Fasta, JSON

Protein domain

Protein domains of 85337.m00276.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 85337.m00276.AA PH 7-100 34 5.5e-23 85.54 Pfam 1-92 (92) Show / Hide 
Range on Protein: 7-100
Range on HMM: 1-92/92
Sequence Identity: 34% (33 aa)

VIKEGWLTKRGGLFKTWHKRWFYIIGKTLFYAKEPGIGEKGKILLDKKVSIAIAPESKKSFSFKIITPAR-IYIISAPDEATRASWVKILSSVID
|||||||.|.|  .|.|.|||| . ...|.| |...   ||.| |..  .. ..|..|. ..|.|.|  |  |...|..|  . .|.. ..|.. 
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDC-QVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 85337.m00276.AA PH 7-102 29 3.2e-22 81.05 SMART 1-82 (82) Show / Hide 
Range on Protein: 7-102
Range on HMM: 1-82/82
Sequence Identity: 29% (28 aa)

VIKEGWLTKRGGLFKTWHKRWFYIIGKTLFYAKEPGIGEKGKILLDKKVSIAIAPESKKSFSFKIITPARIYIISAPDEATRASWVKILSSVIDES
|||||||.|..  . .|.||||.. ...|.| |..    ||.| |..  ..   |      .|.|..  | |......| .. .|.. . ..|...
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK--KPKGSIPLSDC-TVRE-P------CFEIHH-DRTYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 85337.m00276.AA AGC 264-358 29 6.3e-44 110.28 In-house 272-395 (395) Show / Hide 
Range on Protein: 264-358
Range on HMM: 272-395/395
Sequence Identity: 29% (38 aa)

EYVAPEVIKSLPITESADWYS--AGIILYEMICGLPPYWEKN----------QDALTKVIL------NGTLRFP----------HHVSRKAKNICARLLE
||.|||..     . ..||.|   |...|||..|.||.  .|          .. . . |.      |  ..||           ..|  ||... .||.
EYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLC

KSPDKRLGAGEL-----GFEEIKRDEFF
| |.||||.|.      |.||||. ..|
KDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 85337.m00276.AA Ciliate-E2 175-358 19 8.1e-42 141.31 In-house 97-365 (365) Show / Hide 
Range on Protein: 175-358
Range on HMM: 97-365/365
Sequence Identity: 19% (55 aa)

IKYILQ--TDNDVKLFYEYLPYGSLSKKIENE-----------GNLSEDSARMYIAQVLT---------------CLDNLHKNR-IIYKDLKMSNVLINK
...  |  .|| . |  ||. .|.| . |.|            ....|  .. ...|.|                .|  ||..  ||. |.| .|.|.  
MYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

EGLIIVTDPGL--HLQPE----------------------------------------ISEYVAPEVIKSLP---------ITESADWYSAGIILYEMIC
   | ..| ||   ....                                          .|.|||.... .          ....|..|.|.|||||..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GLPPYWEKNQDALTKVILNGTLRFP------------------HHVSRKAKNICAR----LLEKSPDKRLGAGELGFEEIKRDEFF
| ||.         . |... ..||                  ...| ..|... .    .|.| |.||..    |.|.|.  ..|
GKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase 85337.m00276.AA RSK 190-358 32 1.4e-40 141.12 In-house 81-278 (278) Show / Hide 
Range on Protein: 190-358
Range on HMM: 81-278/278
Sequence Identity: 32% (64 aa)

EYLPYGSLSKKIENEGN---LSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINK---EGLIIVTDPGLHLQPEIS------------EYVAPEVI
||.. | | .....|.    .||| |..|.|..   .. ||.  ||. ||| .|.| .    || | .|| |.  |  ..            ||.|||..
EYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEML

K---SLP-ITESADWYSAGIILYEMICGLPPYWE---KNQDALTKVILNGT--LRFP--HHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
|        ....||.| |...|||  | ||.     .|.. . | |..|.  |..|  . .|. ||..  ..|.. | ||||.|  . ||||....|
KRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 85337.m00276.AA Akt 264-358 37 2.2e-39 123.49 In-house 167-264 (264) Show / Hide 
Range on Protein: 264-358
Range on HMM: 167-264/264
Sequence Identity: 37% (37 aa)

EYVAPEVIKSLPITESADWYS-AGIILYEMICGLPPYWEKNQDALTKVILNGTLRFP--HHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
|| |||...    | ..||..  |...|||.||.||. ..... . | |.|. ..||  . .| ..|..  .||.| |.||||.|. . .||||...|
EYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 85337.m00276.AA Ciliate-E2-Unclassified 113-358 18 3.7e-39 133.47 In-house 1-352 (352) Show / Hide 
Range on Protein: 113-358
Range on HMM: 1-352/352
Sequence Identity: 18% (66 aa)

IQVVHPIDNNNLHIIQTISRKDNPIELYIMKAYNKVPSDP-RFQEQVQIRTSFLKTRLSYFN------------------------PIKYILQTDNDVKL
  ... | . .  ...   .|..  ..|.||  .|. ..  . ..... . .. ....   .                           |. |... . .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FYEYLPYGSLSKKIENEGN-----------------LSEDSAR-----MYIAQVLTCLDNLHKN-RIIYKDLKMSNVLINKEG---LIIVTDPGL-----
 .||...|.|.. |.. ..                 ..|  |.      |.||.| .|. ||..  ||. |.| .|.|....|    | ..| |.     
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------------HLQPEIS---EYV----APEVIKSLPITES----ADWYSAGIILYEMICGLPPYWEKNQDA----------------LTKVI
                  ...  ..   .|     ||||...    .|    .|..| |.|||||. | .|.  .|..                 | . |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LNGTLRFPH--------HVSRKAKNICA----RLLEKSPDKRLGAGELGFEEIKRDEFF
... . ||.        |.| .||...     ..|.| |.||.     .||.|.   .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-----TFEQILNHPWF
Kinase 85337.m00276.AA SGK 264-358 41 1.9e-34 103.43 In-house 190-283 (283) Show / Hide 
Range on Protein: 264-358
Range on HMM: 190-283/283
Sequence Identity: 41% (39 aa)

EYVAPEVIKSLPITESADWYSAGIILYEMICGLPPYWEKNQDALTKVILNGTLRFPHHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
|| ||||..  |   . ||.. |..||||. ||||.  .|   .   |.|. |..|. .| .|. .   ||.| |.||||. . .|.|||.  ||
EYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR-DFMEIKNHPFF
Kinase 85337.m00276.AA Delta 180-358 33 4.3e-34 119.58 In-house 70-259 (259) Show / Hide 
Range on Protein: 180-358
Range on HMM: 70-259/259
Sequence Identity: 33% (63 aa)

QTDNDVKLFYEYLPYGSLSKKIENEGNLSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGLHLQPEISE-----------YVAP
||.. .    |||  | |   | . .  .|  || | . ..  |  |||. |||.|||. |||. ..| | . | |.  .  . |           |.||
QTKEHLFFVMEYLNGGDLMYHIQQCHRFDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAP

EVIKSLPITESADWYSAGIILYEMICGLPPYWEKNQDALTKVILNGTLRFPHHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
|.||    ..| ||.| |...|||. |  |.  .. | | . |.| .  .|..... ||..  .|.|. |.||||  .    .|..  ||
EIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase 85337.m00276.AA PKC 264-358 30 2.6e-30 95.31 In-house 165-262 (262) Show / Hide 
Range on Protein: 264-358
Range on HMM: 165-262/262
Sequence Identity: 30% (30 aa)

EYVAPEVIKSLPITESADWYSAGIILYEMICGLPPYWEKNQDALTKVILNGTLRFPHHVSRKAKNICARLLEKSPDKRLGAGELG---FEEIKRDEFF
.|.|||...  . ..| || . |. .||| .| .|   .. | | ..|.. . ..| . |..|..||  ...| | ||||... .   ...|..  ||
DYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 85337.m00276.AA RSK-Unclassified 264-358 36 1.6e-29 89.52 In-house 187-283 (283) Show / Hide 
Range on Protein: 264-358
Range on HMM: 187-283/283
Sequence Identity: 36% (35 aa)

EYVAPEVIKSLPITESADWYSAGIILYEMICGLPPYWEKNQDALTKVILNGTLRFP--HHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
||.|||.|.    |   ||.  ||..|||  |.|||   |.. . . |. . ..||    .|....    .||.. | ||||..    ..|||  ||
EYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 85337.m00276.AA S_TKc 124-358 24 5.7e-24 86.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 124-358
Range on HMM: 1-231/231
Sequence Identity: 24% (65 aa)

LHIIQTI----------SRKDNPIELYIMKAYNKVPSDPRFQEQVQIRTSFLKTRLSYFNPIKYILQTDNDVKLFYEYLPY--GSLSKKIENEGN-----
 .|...|           |. .  ... .|  .      ...  .||  .    .  .   .... |. ... .. ||..   |.| . |.. |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGLHLQPEIS-----EYVAPEVIKSLPITE-SADWYSAGIILYEMICGLPPY
 ..|  || |..|..  |. .|...||. ||| .|.|...   | ..| ||  |   .     .|.||||.   . .  ..||.| |.|||||.|| ||.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPF

WEKNQDALTKVILNGTLRFPHHVSRKAKNICARLLEKSPDKRLGAGELGF--EEIKRDEFF
.  ..... |.|.          |. ||..  ..|.| |.||..| |.    ..|| ...|
P--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85337.m00276.AA Pkinase 263-358 25 8.4e-24 85.25 Pfam 175-293 (293) Show / Hide 
Range on Protein: 263-358
Range on HMM: 175-293/293
Sequence Identity: 25% (31 aa)

SEYVAPEVIK-SLPITESADWYSAGIILYEMICGLPPYWEK------NQDALTKVILNGTLRFPHHVS---------------------RKAKNICARLL
..|.|||||. . ... ..|..|.|.|||||.|| ||....      .|... . |. . |.|.   .                     . .| .. ..|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

EKSPDKRLGAGELGFEEIKRDEFF
.| | ||..     .|.|. ...|
CKDPKKRPT-----AEQILQHPWF
Kinase 85337.m00276.AA PKN 264-358 38 6.2e-23 75.29 In-house 166-260 (260) Show / Hide 
Range on Protein: 264-358
Range on HMM: 166-260/260
Sequence Identity: 38% (37 aa)

EYVAPEVIKSLPITESADWYSAGIILYEMICGLPPYWEKNQDALTKVILNGTLRFPHHVSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEFF
|..||||.     |   ||.  |...|||. | .|.   . . .   |.|   |.|...| .| .|  ||| |.|..||||||   |.||  .||
EFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGECPFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase 85337.m00276.AA AGC 190-253 27 5.3e-19 44.34 In-house 113-198 (395) Show / Hide 
Range on Protein: 190-253
Range on HMM: 113-198/395
Sequence Identity: 27% (24 aa)

EYLP----------Y-GSLSKKIE--NEGNLSEDSARMYIAQ-------VLTCLDNLHK-NRIIYKD-LKMSNVLINKEGLIIVTD
||.|             ... . .  .|| ..|. || |.|.       .. .|. ||. . ||. | ||  |.|....| |  ||
EYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD
Kinase 85337.m00276.AA SGK 204-256 43 5.4e-14 39.15 In-house 119-171 (283) Show / Hide 
Range on Protein: 204-256
Range on HMM: 119-171/283
Sequence Identity: 43% (23 aa)

EGNLSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGL
|. ..|| || | |..   |. ||.  ||| |||  |.|   .| .. || ||
EKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGL
Kinase 85337.m00276.AA PKN 179-256 38 3.8e-13 41.21 In-house 71-147 (260) Show / Hide 
Range on Protein: 179-256
Range on HMM: 71-147/260
Sequence Identity: 38% (30 aa)

LQTDNDVKLFYEYLPYGSLSKKIENEGNLSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGL
.||.. |    ||.. | |  .| ..   ||  |. | | |   |. ||...|||.|||. |.|. .|| . . | ||
FQTEEHVCFVMEYAMGGDLMMHIHED-VFSEPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGL
Kinase 85337.m00276.AA Pkinase 175-247 27 6.8e-13 46.67 Pfam 65-145 (293) Show / Hide 
Range on Protein: 175-247
Range on HMM: 65-145/293
Sequence Identity: 27% (22 aa)

IKYILQTDNDVKLFYEYLPYG----SLSKKIE--NEGNL--SEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEG
.... ...... .  ||.. |    .|.  |.  ..|..  ||. ...|. |.|  |. .|...||. ||| .|.||...|
LYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG
Kinase 85337.m00276.AA RSK-Unclassified 180-259 34 2.6e-12 34.46 In-house 69-150 (283) Show / Hide 
Range on Protein: 180-259
Range on HMM: 69-150/283
Sequence Identity: 34% (28 aa)

QTDNDVKLFYEYLPYGSLSKKIE--NEGNLSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGLHLQ
||     |  || . | . .      |  ..|| .|.|.. |   |  |||  .|| |||  |..  .|| .  || .|  |
QTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQ
Kinase 85337.m00276.AA Akt 204-256 44 1.7e-10 29.69 In-house 94-147 (264) Show / Hide 
Range on Protein: 204-256
Range on HMM: 94-147/264
Sequence Identity: 44% (24 aa)

EGNLSEDSARMYIAQVLTCLDNLHKNRIIYKD-LKMSNVLINKEGLIIVTDPGL
..  ||| || |.|..   .. ||.. ||| | ||  |.|. |.| | .|| ||
KRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGL
Kinase 85337.m00276.AA PKC 205-256 42 1.6e-09 26.88 In-house 95-146 (262) Show / Hide 
Range on Protein: 205-256
Range on HMM: 95-146/262
Sequence Identity: 42% (22 aa)

GNLSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGL
. ..|  || | | ..  |  ||.. ||| |||  |||. .|| |  .| |.
RRFKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGM
Kinase 85337.m00276.AA TyrKc 137-357 15 2e-05 -134.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 137-357
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

IELY----------IMKAYN------KVPSDPRFQEQVQIRTSFLK--TRLSYF--N-----PIKYILQTD-------NDVKLFYEYLPYGSLSKKIENE
|.|           ..|.        |.  .         |  |..    .. .  .      .  .  ..         . .  || |.|.| . . . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GN-LSEDSARMYIAQVLTCLDNLHKNRIIYKDLKMSNVLINKEGLIIVTDPGLHLQPEIS-------EYV-----------------APEVIKSLPITES
.. |. .    .  |.    . ||....|  ||   |.|..... . ..| ||    .         .|                  |||.|.    |. 
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADWYSAGIILYEMI-CGLPPYWE------KNQDALTKVILNGTLRFPHH--------VSRKAKNICARLLEKSPDKRLGAGELGFEEIKRDEF
 | .| |. ..|.   | .||..      .||... .|   . .. |..         . .  .|  .  .  |..|    |.      ...|
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF