Gene 88808.m00152 (T.vaginalis)

88808.m00152

Species: T.vaginalis
Alias: TvagK0628, 88808.m00152
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
88808.m00152.AA Protein None 2251 None Fasta, JSON
88808.m00152.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of 88808.m00152.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88808.m00152.AA PIKK 1877-2149 33 1.7e-89 303.64 In-house 1-290 (290) Show / Hide 
Range on Protein: 1877-2149
Range on HMM: 1-290/290
Sequence Identity: 33% (99 aa)

NISYFEPVLKFFPSKQRPRLLIIVDTNGQKHLNLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSLLS
 |  . ...   ..||.|. ..|   .|  .  |.|| ||||.|.|.||.|.|.|     |      .|.| .||..| | |.|||| |....|.  .. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRKIKN--TDPILEN-----------------HCIEKIVECNIDSLSVIQRYEVLKEVKNQTKENEDDLKNIMWYKSPSAADWVLHLVNFSQSCAMMSM
.... |.   ....                   . ...    . ....  ...||. |... |.   |..|.. | |.|....|     |.  | | |.|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTP--PDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCM

IGYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEVNKIKVRFPETIPFRLTRMFVNAFGPTKIEGNFRITCKEVLSLMRTHKDSIMAVLDIF
 |||.|||||||.|||| . ||  .|||||.|||. .   ..||..||||||..||| ||...||.|| .|  |. .|| |....|.|.. |
VGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 88808.m00152.AA FRAP 1906-2159 45 1e-88 301.06 In-house 1-251 (251) Show / Hide 
Range on Protein: 1906-2159
Range on HMM: 1-251/251
Sequence Identity: 45% (116 aa)

KHLNLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSLLSEYRKIKNTDPILENHCIEKIVECNIDSLS
 .  |||| ||.| |||.|| |||||. .. . . .  .|.| |||| |.| ..|||  | . ||.  |. .||| ..     | . | .    . | | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIE-YNIMDRMCNDYDHLP

VIQRYEVLKEVKNQTKENEDDLKNIMWYKSPSAADWVLHLVNFSQSCAMMSMIGYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEVNKIKVRFPETIPF
 ... |. . . | ||   .||| ..| |||.   |     |.  | | |||.|||.|||||||||||.   || ..||||||||||   . .||| |||
LMNKVEIFRYIMNNTK--GEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPF

RLTRMFVNAFGPTKIEGNFRITCKEVLSLMRTHKDSIMAVLDIFLQEPLDIDVI
||||| |||   . ||||.|.||  |.  .| ||.|.||||. |   ||    .
RLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 88808.m00152.AA PI3Kc 1910-2206 24 2.1e-60 207.89 SMART 3-336 (336) Show / Hide 
Range on Protein: 1910-2206
Range on HMM: 3-336/336
Sequence Identity: 24% (81 aa)

LLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSLLSEYRKIKNTDPILENHCIEKIVECN---------
..|. .||| |.|.||.|.|.|   . |    .  | ...|.. |.. ..|.||.|....|. .....|.| |. ..... . . .  .           
IFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYH-QWFMFDML-VPEIQKNMYM

----------IDSLSVIQRYEVLKEVKNQTK-ENEDDLKNIMWYKSPSA-ADWVLHLVNFSQSCAMMSMIGYIIGLGDRHPSNIMIHQRTGSMIHIDFGD
          ...     . | ||    .|. .....|.. .| ..|..  ||.    || .||| ..|..|| |.||||..|||..  || ..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVNKIKVRFP----ETIPFRLTRMFVNAFG----PTKIEGNFRITCKEVLSLMRTHKDSIMAVLDIFLQEPL--DIDVI-PAKENNKENEEGQ-VNDE
.|.  . |. |.    |. |||||...|.. |    |.. .|.|| .|.... .|| |...||... ...  |.  ...    .... ..  . . ..||
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

ENFNFGDN----FSLQSN--DDEEVMIPIIESMNRV
| ... ..      ....       |. ... ..  
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 88808.m00152.AA PI3_PI4_kinase 1909-2154 23 1.3e-57 202.53 Pfam 1-295 (300) Show / Hide 
Range on Protein: 1909-2154
Range on HMM: 1-295/300
Sequence Identity: 23% (72 aa)

NL---LKGCEDLR--LDERIMQFF-----------------------GLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSLLSEYR-
.    .|| .|||   |.|.||..                       .|.|   | |    ....... |.. | . ..|.||.| ...|.  ....|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

--------KIKNTDPILENHCIEKIVECNIDSLSVIQRYEVLKEVKNQTKENEDDLKNIMWYKSPSA-ADWVLHLVNFSQSCAMMSMIGYIIGLGDRHPS
        | ..    .. .....            .  .|... ....|.  ..| .  | ..|.|  .|     ||  ||| |....||.|.||||..
KCKHKHFNKEHKMWMKMWPDWWHLM-----------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHND

NIMI--HQRTGSMIHIDFGDCFE-VNKIKVRFPETIPFRLTR------MFVNAF------GPTKIEGNFRITCKEVLSLMRTHKDSIMAVL-------DI
|||.  .  || ..|||||.||. ..     .||..|||.|.      ..|.|.      .|.. .| || .| ... ..| |....|..|       ..
NIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGEC

FLQEPL
... .|
MVHDGL
Kinase 88808.m00152.AA ATR 2047-2149 44 3.1e-34 113.76 In-house 166-267 (267) Show / Hide 
Range on Protein: 2047-2149
Range on HMM: 166-267/267
Sequence Identity: 44% (46 aa)

NFSQSCAMMSMIGYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEV-NKIKVRFPETIPFRLTRMFVNAFGPTKIEGNFRITCKEVLSLMRTHKDSIMAV
|.  | | ..|.||||||||||  ||.| . .| ..|.|.   |   ....|  ||..|||||.  |...|| | .| ||  | ... .|| |.| ||.|
NYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV--PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSV

LDIF
.| |
WDCF
Kinase 88808.m00152.AA ATM 2048-2154 42 4.6e-29 89.68 In-house 140-245 (304) Show / Hide 
Range on Protein: 2048-2154
Range on HMM: 140-245/304
Sequence Identity: 42% (45 aa)

FSQSCAMMSMIGYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEVNKIKVRFPETIPFRLTRMFVNAFGPTKIEGNFRITCKEVLSLMRTHKDSIMAVLD
.  | |  |..|||.||||||  ||.|      ..||| |  ||  || .  |||.||||||  |   | | .|| ||  |   .  ||  .. .. . .
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVE

IFLQEPL
. | .||
VLLYDPL
Kinase 88808.m00152.AA SMG1 2048-2101 53 8.4e-18 55.41 In-house 190-242 (242) Show / Hide 
Range on Protein: 2048-2101
Range on HMM: 190-242/242
Sequence Identity: 53% (29 aa)

FSQSCAMMSMIGYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEVNKIKVRFPE
.  | |.|||.||||||||||  |..|   || ..|||.  |||  | |.. ||
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 88808.m00152.AA DNAPK 2059-2160 33 1.1e-15 53.4 In-house 201-301 (301) Show / Hide 
Range on Protein: 2059-2160
Range on HMM: 201-301/301
Sequence Identity: 33% (34 aa)

GYIIGLGDRHPSNIMIHQRTGSMIHIDFGDCFEVNKIKVRFPETIPFRLTRMFVNAFGPTKIEGNFRITCKEVLSLMRTHKDSIMAVLDIFLQEPLDIDV
..| | ||||  | |.   .|  | ||||  |         ||  |||||| |.|   | || | ..      .  .|  .   .   |.| ..|. .| 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPS-FDW

IP
  
KN
Kinase 88808.m00152.AA SMG1 1885-1974 35 3.5e-15 46.58 In-house 1-90 (242) Show / Hide 
Range on Protein: 1885-1974
Range on HMM: 1-90/242
Sequence Identity: 35% (32 aa)

LKFFPSKQRPRLLIIVDTNGQKHLNLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSL
.   | | .|. |. .   |.    | || ||| ||||||||  ..|       .          ||.||.  ||||| .|  |  .. |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 88808.m00152.AA ATR 1876-1982 25 1.6e-12 38.58 In-house 1-107 (267) Show / Hide 
Range on Protein: 1876-1982
Range on HMM: 1-107/267
Sequence Identity: 25% (27 aa)

SNISYFEPVLKFFPSKQRPRLLIIVDTNGQKHLNLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVTDADTIYSLL
. |. |. ... . | |.|. . .  ..|. .. . |  .||| | | |.|  |||.  . | . .  ....  |.. |.  ....||.| .  |. ..|
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

SEYRKIK
 .  | |
DKLWKEK
Kinase 88808.m00152.AA DNAPK 1877-1965 35 1.1e-11 38.68 In-house 3-91 (301) Show / Hide 
Range on Protein: 1877-1965
Range on HMM: 3-91/301
Sequence Identity: 35% (32 aa)

NISYFEPVLKFFPSKQRPRLLIIVDTNGQKHLNLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFV
 |  |.       |  ||. .||       |  . || ||||.| || | |   |  .  |      ||.   |.| |   | |||| |
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV
Kinase 88808.m00152.AA ATM 1909-1966 34 4.5e-08 21.45 In-house 2-59 (304) Show / Hide 
Range on Protein: 1909-1966
Range on HMM: 2-59/304
Sequence Identity: 34% (20 aa)

NLLKGCEDLRLDERIMQFFGLINQHIKHDLKYKNHELNIFRYSITPISRRSGLIEFVT
 | || .||| |  . | | . |  ..     .   | |  | . |.| ||| .|. |
QLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT
FATC 88808.m00152.AA FATC 2219-2251 48 2.6e-17 58.5 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2219-2251
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

SELDIPQQVDQLIRDATDMYNLAHLFHGWSPLW
 .|...||||.||..||| .||.....||.| |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW