Gene 81737.m00079 (T.vaginalis)
81737.m00079
Species: T.vaginalis
Alias: 81737.m00079, TvagK0946
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 81737.m00079.AA | Protein | None | 500 | None | Fasta, JSON |
| 81737.m00079.kin_dom | Protein Kinase Domain | None | 193 | None | Fasta, JSON |
Protein domains of 81737.m00079.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 81737.m00079.AA | CAMKL | 272-464 | 30 | 3.7e-46 | 145.2 | In-house | 76-297 (297) | Show / Hide |
Range on Protein: 272-464 Range on HMM: 76-297/297 Sequence Identity: 30% (68 aa) NILKVVKMMEDELF------YYVIFPFTEEME--LSAILQRG----GKLPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILY-NG--KIKLYDFSY || | ..|.. . .| . . | | ... |..||. || .|||...|....||.|||| | | || | || .||. || NIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGF CHFAKRG-EKKGQILN----STAYACPDSLKG--RVFDGTAADIWSAGVILFELLTGKPLFNAK--------NSDVLKNKVLRCTIVYPKEFSP-SIIPL . . ... ..|| |. | .|..| ..| . .|| ..||||.||||. ...|. |.. | |..|. .. .|. ... . . | SNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDL LRGILNPLPQERLTIEQILSHAWM .|..|.. | .| ||.||..| || IRKMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | 81737.m00079.AA | CAMK | 272-464 | 20 | 1.7e-44 | 140.85 | In-house | 99-425 (425) | Show / Hide |
Range on Protein: 272-464
Range on HMM: 99-425/425
Sequence Identity: 20% (68 aa)
NILKVVKMMED-------------------ELFYYVIF---PFTE--EM--E-LSAILQRGG--------------KLPEEAARPIFRQLMHAIQHLHSL
||.| ..|| . ..| .. . . |. . .. | ..|. ...|. || .|||. |....||.
NIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH
GIVHGHITPQNIIL-YN-----------------GKIKLYDFSYCHFAKR------------------------GEKKGQILNSTAYAC-PDSLKG----
.||| . | || | .| ..||. || . .. |.| . .|.. | |.|
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
---------RVFDGTAADIWSAGVILFELLTGKPLFNAK-------------NSDVLKNKVLRCTIV-YPKEFSP-----------------------SI
. .| ..|.||.||||. .|.|.| |... | |. |.... .|..||| .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
IPLLRGILNPLPQERLTIEQILSHAWM
. |.|..|.. |..|.||||.|.| ||
KDLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | 81737.m00079.AA | Ciliate-E2 | 272-464 | 20 | 4.9e-37 | 124.68 | In-house | 93-365 (365) | Show / Hide |
Range on Protein: 272-464 Range on HMM: 93-365/365 Sequence Identity: 20% (59 aa) NILKVVKMME--DELFYYVIFPFTEEMELSAILQ-----RGGKLP------EEAARPIFRQLMH---------------AIQHLHSLG-IVHGHITPQNI ||.| . . |. .| .. . . ..| ... |. ... |. .. |..|. |...||| . |.| | |.|| NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENI ILYNGKIKLYDFSYCHFAKRGEKKGQILNSTA---------------------------------YACPDSLKGRVFDG--------TAADIWSAGVILF .. ||. || .. ... ...... .. . | .| |.| |. ...||||.||||. LF----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY ELLTGKPLFNAKNSDVLKNKVLRCTIVYP------------------KEFSPSIIPLLRG----ILNPLPQERLT-IEQILSHAWM |.|.||| | .. . | | .| |. |.. . |.. .|. |..|.| .|||| | |. EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 81737.m00079.AA | Ciliate-E2-Unclassified | 213-464 | 19 | 7e-35 | 118.43 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 213-464
Range on HMM: 1-352/352
Sequence Identity: 19% (70 aa)
YLFMKIKAHDFFGTVSEAFKPDTGDRY----KAHIISKVSNRSQLYTDQIKIML---EATRK-----------------SPNINILKVVKMMEDELFYYV
| . |. . ||.| .. . ... | .. | ... ..... | .... . .| .|...|.| . . .|. |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
IFPFTEEMELSAILQRGGK-----------------LPEEAAR-----PIFRQLMHAIQHLHSLG-IVHGHITPQNIILYNG----KIKLYDFSYCHFAK
. . | .|. ... .| ..|..|. .|.|. ....||. . |.| |.|.||.. |. .||. ||. . . .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
-----RGEK--------KGQILNSTA----YA----CPDSLKGRVFDG---TAADIWSAGVILFELLTGKPLFNAKNSDV----------------LKNK
. .. | |...... | | |.| |. ..|||| ||||.|.|.|.. |...|.. |...
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN
VLRCTIVYPK--------EFSPSIIPLLR----GILNPLPQERLTIEQILSHAWM
. . | .|| ||. . ... .|. | .|.|.|||| | |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
|
|||||||||
| Kinase | 81737.m00079.AA | MELK | 213-464 | 26 | 2.3e-34 | 114.64 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 213-464 Range on HMM: 1-254/254 Sequence Identity: 26% (69 aa) YLFMKIKAHDFFGTVSEAFKPDTGDRYKAHIISKVSNRSQLYTDQIKIMLEATRKSPNINILKVVKMMEDELFYYVIFPFTEEMELSAILQRGGKLPEEA | . |. | | |... |. | . | ..| ..| .. .| .. ..| | ..... . |. . | .| || YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDL--PRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEE ARPIFRQLMHAIQHLHSLGIVHGHITPQNIILY-NGKIKLYDFSYCHFAKRGEKKGQILN----STAYACPDSLKGRVFDGTAADIWSAGVILFELLTGK .| .|||.. || ..|| | | . |.|... . ..|| || | . .|.| |. | ||| |. ..|. . | ||.|| |..|. |. | TRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGF PLFNAKNSDVLKNKVLRCTIVYPKEFSPSIIPLLRGILNPLPQERLTIEQILSHAWM |. | .. |... || ||. . ||| .| |. |. . ..| | |. LPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
|||||||||
| Kinase | 81737.m00079.AA | S_TKc | 213-464 | 22 | 1.2e-32 | 115.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 213-464 Range on HMM: 1-231/231 Sequence Identity: 22% (61 aa) YLFMKIKAHDFFGTVSEAFKPDTGDRYKAHIISKVSNRSQLYTDQIKIMLEATRKSPNINILKVVKMMEDELFYYVIFPFTEE--MELSAILQRGGK--- | .... . ||.| . . .|| .. ||. . |.|. . || | ...| ..|... . . .| .... |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILYNGKIKLYDFSYCHFAKRGEKKGQILNSTAYACPDSLKGRVFDGTAADIWSAGVILFELL .|| || ...|. |....||.||.| . |.|| | . ||. || . . . . | | | ... ..|.|| |.||.|.| RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TGKPLFNAKNSDVLKNKVLRCTIVYPKEFSPSIIPLLRGILNPLPQERLTIEQILS-------HAWM .|.|.| . ... .|.. ||. . ..|..|. |..|.|. ..| | |. CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | 81737.m00079.AA | Pkinase | 224-464 | 22 | 9.9e-32 | 113.27 | Pfam | 12-293 (293) | Show / Hide |
Range on Protein: 224-464 Range on HMM: 12-293/293 Sequence Identity: 22% (64 aa) FGTVSEAFKPDTGDRYKAHIISKVSNRS-QLYTD----QIKIMLEATRKSPNINILKVVKMMEDELFYYVIFPFTEEM----ELSAILQ--RGGKL--PE ||.| .. . .||... ||.|....| ...|. |.||.. . .||| .. ..||. .|..... | .|..... |.|.. .| FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-HPNI--VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSE EAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILY-NGKI----KLYDFSYCHF--AKRGEKKGQILNSTAYACPDSLKGRVFDGTAADIWSAGVILFEL . .. ...|. .....|| ||.| . |.|| . || | |. || . . ... . . |. | ..|. .|...|.||.|.||.|. WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM LTGKPLFNAK------NSDVLKNKVLRCTIVYPKEFS---------------------PSIIPLLRGILNPLPQERLTIEQILSHAWM |.|.|.| . . ... ...... . .. . . .. . .....|.. |..|.|.|||| | |. LCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 81737.m00079.AA | SNRK | 308-464 | 35 | 4.4e-31 | 98.82 | In-house | 96-254 (254) | Show / Hide |
Range on Protein: 308-464 Range on HMM: 96-254/254 Sequence Identity: 35% (56 aa) LPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILYN--GKIKLYDFSYCHFAKRGEKKGQILNSTAYACPDSLKGRVFDGTAADIWSAGVILFELLT | |. || |.|.||||. | | .|| . | |.. .. | .|| || . . ||| | ||. |. | | .| | |||| ||||. |. LCEDLARKYFCQIMHAIDYCHQLHVVHRDLKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVC GKPLFNAKNSDVLKNKVLRCTIVYPKEFSPSIIPLLRGILNPLPQERLTIEQILSHAWM |.. |. | ... | |.. | |. .| |. | ..|.| ||.|. GQAPFQEANDSETLTMIMDCKYTVPDHVSDECRDLIQSMLVRDPKKRASLEEIVSHSWV |
|||||||||
| Kinase | 81737.m00079.AA | GIN4 | 272-464 | 30 | 7.2e-31 | 95.5 | In-house | 95-293 (293) | Show / Hide |
Range on Protein: 272-464 Range on HMM: 95-293/293 Sequence Identity: 30% (60 aa) NILKVVKMMEDELFYYVIFPFTEEMELSAILQRGGKLPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIIL--YNGKIKLYDFSYCHFAKRGEKKGQI |.... . | . |.. . |. || .| |.||| | .|||.. . |...|.| . | |..| . .||. || .. NVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLETS LNSTAYACPDSLKGRVFDGTAADIWSAGVILFELLTGKPLFNAK--NSDVLKNKVLRCTIVYPKE--FSPSIIPLLRGILNPLPQERLTIEQILSHAWM | || |. |. ..| |.|.|| ||||| ||||. |. | | || . | . | |.| || |. |... .||.| . CGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI |
|||||||||
| Kinase | 81737.m00079.AA | QIK | 272-464 | 29 | 7.6e-28 | 98.84 | In-house | 59-272 (272) | Show / Hide |
Range on Protein: 272-464 Range on HMM: 59-272/272 Sequence Identity: 29% (63 aa) NILKVVKMMEDELFYYVIFPFTEEMELSAILQRGGK--------------------LPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIIL-YNGKIK .| | || . |.. . .. |. | |. ..|..|| .| |.. |....|...||| . || | | || HIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIK LYDFSYCHFAKRGEKKGQILNSTAYACPDSLKGRVFDGTAADIWSAGVILFELLTGKPLFNAKNSDVLKNKVLRCTIVYPKEFSPSIIPLLRGILNPLPQ . || . . | |. | .|| | ..|. .|| .|||| ||.|. | .|. | |. |...|| | | | | | |. IADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPE ERLTIEQILSHAWM |.||.||. | || HRYTIMQICQHRWM |
|||||||||
| Kinase | 81737.m00079.AA | RSK | 297-464 | 27 | 6.9e-26 | 91.79 | In-house | 87-278 (278) | Show / Hide |
Range on Protein: 297-464 Range on HMM: 87-278/278 Sequence Identity: 27% (53 aa) ELSAILQRGGK---LPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILYN----GKIKLYDFSYCHF--AKRGEKKGQILNSTAYACPDSLK---GR || ||. . . |. |. ..... |..|||..||.| . | ||.. . | ||| || | .. ... . .|. | || .. ELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQ V-FDGTAADIWSAGVILFELLTGKPLFNA---KNSDVLKNKVLRCT--IVYP--KEFSPSIIPLLRGILNPLPQERLT-----IEQILSHAWM . | |.|.|| ||...|.|||.| | . .|.... ....... | .. |. |.|. | |. ||. .|.|..|.|. GGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
| Kinase | 81737.m00079.AA | MARK | 372-464 | 32 | 3.8e-24 | 75.98 | In-house | 168-262 (262) | Show / Hide |
Range on Protein: 372-464 Range on HMM: 168-262/262 Sequence Identity: 32% (31 aa) STAYACPDSLKGRVFDGTAADIWSAGVILFELLTGKPLFNAKN--SDVLKNKVLRCTIVYPKEFSPSIIPLLRGILNPLPQERLTIEQILSHAWM . .|..| .... ||...|||| ||.|. ...|. | ... |. |.||. .| |... |.. .|.. | || |||.|..| || TPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
|||||||||
| Kinase | 81737.m00079.AA | MARK | 301-354 | 46 | 7.6e-15 | 45.13 | In-house | 93-150 (262) | Show / Hide |
Range on Protein: 301-354 Range on HMM: 93-150/262 Sequence Identity: 46% (27 aa) ILQR-GGKLPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIIL-YNG--KIKLYDF | .. .|.|.|| || ||||. .|.. .|| .||| | |.|| . || .||. || IKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDF |
|||||||||
| Kinase | 81737.m00079.AA | TyrKc | 213-462 | 14 | 8e-06 | -128.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 213-462 Range on HMM: 1-280/280 Sequence Identity: 14% (43 aa) YLFMKIKAHDFFGTVSEAFKPDTGDRYKAHIIS---KVSNRSQLYTDQIKIMLEAT--RKS--PNINILKVVKMMEDE-------LFYYVIFPFTEEMEL . |. . .||.| .. | |. . . . .| || .| . ||.. . .. ..... . . | ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL SAILQRGGK-LPEEAARPIFRQLMHAIQHLHSLGIVHGHITPQNIILYNGK-IKLYDFSYCHFAKRGEKKGQILNSTAYA-----CPD-----------S |.. .. |. . . | ..||| ...| . |. . ... .| || . . . . ..| .. | . . . KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPEC LKGRVFDGTAADIWSAGVILFELLT--GKPLFN-----AKNSDVLKNKVLRCTIVYPKE--------FSPSIIPLLRGILNPLPQERLTIEQILSHA .. ..| |. |.|| || ..|..| ..| . .|..|... . |.. .. . . . . | .| | ..| . INYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||